CTL induction by DNA vaccine with Toxoplasma gondii-HSP70 gene
Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (d...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chu, Deyong [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Invasive Right Ventricular to Pulmonary Artery Coupling in Patients Undergoing Transcatheter Edge-to-Edge Tricuspid Valve Repair - Stolz, Lukas ELSEVIER, 2023, the official, international journal of the Japanese Society of Parasitology, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:63 ; year:2014 ; number:2 ; pages:408-416 ; extent:9 |
| Links: |
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| DOI / URN: |
10.1016/j.parint.2014.01.002 |
|---|
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| 520 | |a Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. | ||
| 520 | |a Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. | ||
| 700 | 1 | |a Moroda, Masataka |4 oth | |
| 700 | 1 | |a Piao, Lian-Xun |4 oth | |
| 700 | 1 | |a Aosai, Fumie |4 oth | |
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10.1016/j.parint.2014.01.002 doi GBVA2014002000028.pica (DE-627)ELV033656932 (ELSEVIER)S1383-5769(14)00005-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.85 bkl 44.64 bkl Chu, Deyong verfasserin aut CTL induction by DNA vaccine with Toxoplasma gondii-HSP70 gene 2014transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. Moroda, Masataka oth Piao, Lian-Xun oth Aosai, Fumie oth Enthalten in Elsevier Science Stolz, Lukas ELSEVIER Invasive Right Ventricular to Pulmonary Artery Coupling in Patients Undergoing Transcatheter Edge-to-Edge Tricuspid Valve Repair 2023 the official, international journal of the Japanese Society of Parasitology Amsterdam [u.a.] (DE-627)ELV009498850 volume:63 year:2014 number:2 pages:408-416 extent:9 https://doi.org/10.1016/j.parint.2014.01.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ 44.64 Radiologie VZ AR 63 2014 2 408-416 9 045F 610 |
| spelling |
10.1016/j.parint.2014.01.002 doi GBVA2014002000028.pica (DE-627)ELV033656932 (ELSEVIER)S1383-5769(14)00005-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.85 bkl 44.64 bkl Chu, Deyong verfasserin aut CTL induction by DNA vaccine with Toxoplasma gondii-HSP70 gene 2014transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. Moroda, Masataka oth Piao, Lian-Xun oth Aosai, Fumie oth Enthalten in Elsevier Science Stolz, Lukas ELSEVIER Invasive Right Ventricular to Pulmonary Artery Coupling in Patients Undergoing Transcatheter Edge-to-Edge Tricuspid Valve Repair 2023 the official, international journal of the Japanese Society of Parasitology Amsterdam [u.a.] (DE-627)ELV009498850 volume:63 year:2014 number:2 pages:408-416 extent:9 https://doi.org/10.1016/j.parint.2014.01.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ 44.64 Radiologie VZ AR 63 2014 2 408-416 9 045F 610 |
| allfields_unstemmed |
10.1016/j.parint.2014.01.002 doi GBVA2014002000028.pica (DE-627)ELV033656932 (ELSEVIER)S1383-5769(14)00005-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.85 bkl 44.64 bkl Chu, Deyong verfasserin aut CTL induction by DNA vaccine with Toxoplasma gondii-HSP70 gene 2014transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. Moroda, Masataka oth Piao, Lian-Xun oth Aosai, Fumie oth Enthalten in Elsevier Science Stolz, Lukas ELSEVIER Invasive Right Ventricular to Pulmonary Artery Coupling in Patients Undergoing Transcatheter Edge-to-Edge Tricuspid Valve Repair 2023 the official, international journal of the Japanese Society of Parasitology Amsterdam [u.a.] (DE-627)ELV009498850 volume:63 year:2014 number:2 pages:408-416 extent:9 https://doi.org/10.1016/j.parint.2014.01.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ 44.64 Radiologie VZ AR 63 2014 2 408-416 9 045F 610 |
| allfieldsGer |
10.1016/j.parint.2014.01.002 doi GBVA2014002000028.pica (DE-627)ELV033656932 (ELSEVIER)S1383-5769(14)00005-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.85 bkl 44.64 bkl Chu, Deyong verfasserin aut CTL induction by DNA vaccine with Toxoplasma gondii-HSP70 gene 2014transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. Moroda, Masataka oth Piao, Lian-Xun oth Aosai, Fumie oth Enthalten in Elsevier Science Stolz, Lukas ELSEVIER Invasive Right Ventricular to Pulmonary Artery Coupling in Patients Undergoing Transcatheter Edge-to-Edge Tricuspid Valve Repair 2023 the official, international journal of the Japanese Society of Parasitology Amsterdam [u.a.] (DE-627)ELV009498850 volume:63 year:2014 number:2 pages:408-416 extent:9 https://doi.org/10.1016/j.parint.2014.01.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ 44.64 Radiologie VZ AR 63 2014 2 408-416 9 045F 610 |
| allfieldsSound |
10.1016/j.parint.2014.01.002 doi GBVA2014002000028.pica (DE-627)ELV033656932 (ELSEVIER)S1383-5769(14)00005-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.85 bkl 44.64 bkl Chu, Deyong verfasserin aut CTL induction by DNA vaccine with Toxoplasma gondii-HSP70 gene 2014transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. Moroda, Masataka oth Piao, Lian-Xun oth Aosai, Fumie oth Enthalten in Elsevier Science Stolz, Lukas ELSEVIER Invasive Right Ventricular to Pulmonary Artery Coupling in Patients Undergoing Transcatheter Edge-to-Edge Tricuspid Valve Repair 2023 the official, international journal of the Japanese Society of Parasitology Amsterdam [u.a.] (DE-627)ELV009498850 volume:63 year:2014 number:2 pages:408-416 extent:9 https://doi.org/10.1016/j.parint.2014.01.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ 44.64 Radiologie VZ AR 63 2014 2 408-416 9 045F 610 |
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Enthalten in Invasive Right Ventricular to Pulmonary Artery Coupling in Patients Undergoing Transcatheter Edge-to-Edge Tricuspid Valve Repair Amsterdam [u.a.] volume:63 year:2014 number:2 pages:408-416 extent:9 |
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Enthalten in Invasive Right Ventricular to Pulmonary Artery Coupling in Patients Undergoing Transcatheter Edge-to-Edge Tricuspid Valve Repair Amsterdam [u.a.] volume:63 year:2014 number:2 pages:408-416 extent:9 |
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Invasive Right Ventricular to Pulmonary Artery Coupling in Patients Undergoing Transcatheter Edge-to-Edge Tricuspid Valve Repair |
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The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. 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Invasive Right Ventricular to Pulmonary Artery Coupling in Patients Undergoing Transcatheter Edge-to-Edge Tricuspid Valve Repair |
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ctl induction by dna vaccine with toxoplasma gondii-hsp70 gene |
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CTL induction by DNA vaccine with Toxoplasma gondii-HSP70 gene |
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Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. |
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Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. |
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Toxoplasma gondii-derived heat shock protein 70 (T.g.HSP70) is a tachyzoite-specific virulent molecule. The DNA vaccine with T.g.HSP70 gene targeting peripheral epidermal or dermal dendritic cells (DC) induces in vivo DC maturation and successive early Th1 polarization at the draining lymph nodes (dLN) of C57BL/6 mice. In the present study, induction of cytotoxic T lymphocytes (CTL) has been explored. The CTL specific for a syngeneic DC line, DC2.4, either transfected with T. g.HSP70 gene or pulsed with recombinant T. g.HSP70 are induced in the spleen of the vaccinated mice. This CTL lyses T. gondii-infected, but not uninfected, DC2.4. Both CD8+ and CD4+ CTL are induced by the vaccine, and Fas/Fas ligand-mediated cytolysis dominantly participates in their CTL activities. Adoptive transfer experiments reveal that the vaccine-induced CD8+ or CD4+ T cells possess a protective role for toxoplasmosis at both acute and chronic phases of infection. |
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CTL induction by DNA vaccine with Toxoplasma gondii-HSP70 gene |
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