Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation
• ICOS costimulation activates mTOR pathway in activated T cells through PI3K. • ICOS-PI3K-mTOR signaling enhances polysome formation on IL-4 mRNA. • PI3K-mediated ICOS costimulation may facilitate delivery of IL-4 to cognate B cells.
Gespeichert in:
| Autor*in: |
Gigoux, Mathieu [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Umfang: |
9 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Letter regarding the article: Changes in BNP and cardiac troponin I after high-intensity interval and endurance exercise in heart failure patients and healthy controls - Gayda, Mathieu ELSEVIER, 2015, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:59 ; year:2014 ; number:1 ; pages:46-54 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.molimm.2014.01.008 |
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Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation |
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• ICOS costimulation activates mTOR pathway in activated T cells through PI3K. • ICOS-PI3K-mTOR signaling enhances polysome formation on IL-4 mRNA. • PI3K-mediated ICOS costimulation may facilitate delivery of IL-4 to cognate B cells. |
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• ICOS costimulation activates mTOR pathway in activated T cells through PI3K. • ICOS-PI3K-mTOR signaling enhances polysome formation on IL-4 mRNA. • PI3K-mediated ICOS costimulation may facilitate delivery of IL-4 to cognate B cells. |
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• ICOS costimulation activates mTOR pathway in activated T cells through PI3K. • ICOS-PI3K-mTOR signaling enhances polysome formation on IL-4 mRNA. • PI3K-mediated ICOS costimulation may facilitate delivery of IL-4 to cognate B cells. |
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Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation |
| url |
https://doi.org/10.1016/j.molimm.2014.01.008 |
| remote_bool |
true |
| author2 |
Lovato, Amanda Leconte, Julien Leung, Joanne Sonenberg, Nahum Suh, Woong-Kyung |
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Lovato, Amanda Leconte, Julien Leung, Joanne Sonenberg, Nahum Suh, Woong-Kyung |
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| doi_str |
10.1016/j.molimm.2014.01.008 |
| up_date |
2024-07-06T19:11:50.490Z |
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1803858068627259392 |
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