Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation
• ICOS costimulation activates mTOR pathway in activated T cells through PI3K. • ICOS-PI3K-mTOR signaling enhances polysome formation on IL-4 mRNA. • PI3K-mediated ICOS costimulation may facilitate delivery of IL-4 to cognate B cells.
Autor*in: |
Gigoux, Mathieu [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2014 |
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Schlagwörter: |
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Umfang: |
9 |
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Übergeordnetes Werk: |
Enthalten in: Letter regarding the article: Changes in BNP and cardiac troponin I after high-intensity interval and endurance exercise in heart failure patients and healthy controls - Gayda, Mathieu ELSEVIER, 2015, Amsterdam [u.a.] |
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Übergeordnetes Werk: |
volume:59 ; year:2014 ; number:1 ; pages:46-54 ; extent:9 |
Links: |
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DOI / URN: |
10.1016/j.molimm.2014.01.008 |
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ELV033685533 |
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• ICOS costimulation activates mTOR pathway in activated T cells through PI3K. • ICOS-PI3K-mTOR signaling enhances polysome formation on IL-4 mRNA. • PI3K-mediated ICOS costimulation may facilitate delivery of IL-4 to cognate B cells. |
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• ICOS costimulation activates mTOR pathway in activated T cells through PI3K. • ICOS-PI3K-mTOR signaling enhances polysome formation on IL-4 mRNA. • PI3K-mediated ICOS costimulation may facilitate delivery of IL-4 to cognate B cells. |
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• ICOS costimulation activates mTOR pathway in activated T cells through PI3K. • ICOS-PI3K-mTOR signaling enhances polysome formation on IL-4 mRNA. • PI3K-mediated ICOS costimulation may facilitate delivery of IL-4 to cognate B cells. |
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