Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: A potential role for heterologous immunity
The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Westerhuis, Geert [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Interfacing 2D M - Rawat, Ashima ELSEVIER, 2021, official publication of the International Society for Experimental Hematology, Amsterdam [u.a] |
|---|---|
| Übergeordnetes Werk: |
volume:42 ; year:2014 ; number:9 ; pages:753-760 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.exphem.2014.04.001 |
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| 520 | |a The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. | ||
| 520 | |a The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. | ||
| 700 | 1 | |a de Witte, Moniek |4 oth | |
| 700 | 1 | |a Schumacher, Ton N. |4 oth | |
| 700 | 1 | |a Toes, René E.M. |4 oth | |
| 700 | 1 | |a Fibbe, Willem E. |4 oth | |
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10.1016/j.exphem.2014.04.001 doi GBVA2014009000028.pica (DE-627)ELV033858977 (ELSEVIER)S0301-472X(14)00140-4 DE-627 ger DE-627 rakwb eng 610 610 DE-600 670 530 660 VZ 33.68 bkl 35.18 bkl 52.78 bkl Westerhuis, Geert verfasserin aut Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: A potential role for heterologous immunity 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. de Witte, Moniek oth Schumacher, Ton N. oth Toes, René E.M. oth Fibbe, Willem E. oth Enthalten in Elsevier Science Rawat, Ashima ELSEVIER Interfacing 2D M 2021 official publication of the International Society for Experimental Hematology Amsterdam [u.a] (DE-627)ELV006315852 volume:42 year:2014 number:9 pages:753-760 extent:8 https://doi.org/10.1016/j.exphem.2014.04.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 35.18 Kolloidchemie Grenzflächenchemie VZ 52.78 Oberflächentechnik Wärmebehandlung VZ AR 42 2014 9 753-760 8 045F 610 |
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10.1016/j.exphem.2014.04.001 doi GBVA2014009000028.pica (DE-627)ELV033858977 (ELSEVIER)S0301-472X(14)00140-4 DE-627 ger DE-627 rakwb eng 610 610 DE-600 670 530 660 VZ 33.68 bkl 35.18 bkl 52.78 bkl Westerhuis, Geert verfasserin aut Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: A potential role for heterologous immunity 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. de Witte, Moniek oth Schumacher, Ton N. oth Toes, René E.M. oth Fibbe, Willem E. oth Enthalten in Elsevier Science Rawat, Ashima ELSEVIER Interfacing 2D M 2021 official publication of the International Society for Experimental Hematology Amsterdam [u.a] (DE-627)ELV006315852 volume:42 year:2014 number:9 pages:753-760 extent:8 https://doi.org/10.1016/j.exphem.2014.04.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 35.18 Kolloidchemie Grenzflächenchemie VZ 52.78 Oberflächentechnik Wärmebehandlung VZ AR 42 2014 9 753-760 8 045F 610 |
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10.1016/j.exphem.2014.04.001 doi GBVA2014009000028.pica (DE-627)ELV033858977 (ELSEVIER)S0301-472X(14)00140-4 DE-627 ger DE-627 rakwb eng 610 610 DE-600 670 530 660 VZ 33.68 bkl 35.18 bkl 52.78 bkl Westerhuis, Geert verfasserin aut Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: A potential role for heterologous immunity 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. de Witte, Moniek oth Schumacher, Ton N. oth Toes, René E.M. oth Fibbe, Willem E. oth Enthalten in Elsevier Science Rawat, Ashima ELSEVIER Interfacing 2D M 2021 official publication of the International Society for Experimental Hematology Amsterdam [u.a] (DE-627)ELV006315852 volume:42 year:2014 number:9 pages:753-760 extent:8 https://doi.org/10.1016/j.exphem.2014.04.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 35.18 Kolloidchemie Grenzflächenchemie VZ 52.78 Oberflächentechnik Wärmebehandlung VZ AR 42 2014 9 753-760 8 045F 610 |
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10.1016/j.exphem.2014.04.001 doi GBVA2014009000028.pica (DE-627)ELV033858977 (ELSEVIER)S0301-472X(14)00140-4 DE-627 ger DE-627 rakwb eng 610 610 DE-600 670 530 660 VZ 33.68 bkl 35.18 bkl 52.78 bkl Westerhuis, Geert verfasserin aut Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: A potential role for heterologous immunity 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. de Witte, Moniek oth Schumacher, Ton N. oth Toes, René E.M. oth Fibbe, Willem E. oth Enthalten in Elsevier Science Rawat, Ashima ELSEVIER Interfacing 2D M 2021 official publication of the International Society for Experimental Hematology Amsterdam [u.a] (DE-627)ELV006315852 volume:42 year:2014 number:9 pages:753-760 extent:8 https://doi.org/10.1016/j.exphem.2014.04.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 35.18 Kolloidchemie Grenzflächenchemie VZ 52.78 Oberflächentechnik Wärmebehandlung VZ AR 42 2014 9 753-760 8 045F 610 |
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10.1016/j.exphem.2014.04.001 doi GBVA2014009000028.pica (DE-627)ELV033858977 (ELSEVIER)S0301-472X(14)00140-4 DE-627 ger DE-627 rakwb eng 610 610 DE-600 670 530 660 VZ 33.68 bkl 35.18 bkl 52.78 bkl Westerhuis, Geert verfasserin aut Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: A potential role for heterologous immunity 2014transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. de Witte, Moniek oth Schumacher, Ton N. oth Toes, René E.M. oth Fibbe, Willem E. oth Enthalten in Elsevier Science Rawat, Ashima ELSEVIER Interfacing 2D M 2021 official publication of the International Society for Experimental Hematology Amsterdam [u.a] (DE-627)ELV006315852 volume:42 year:2014 number:9 pages:753-760 extent:8 https://doi.org/10.1016/j.exphem.2014.04.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 35.18 Kolloidchemie Grenzflächenchemie VZ 52.78 Oberflächentechnik Wärmebehandlung VZ AR 42 2014 9 753-760 8 045F 610 |
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Barriers to chimerism after major histocompatibility complex-mismatched stem cell transplantation: A potential role for heterologous immunity |
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The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. |
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The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. |
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The induction of mixed hematopoietic chimerism following allogeneic stem cell transplantation is a potential treatment modality for numerous nonmalignant diseases and generates a robust state of donor-specific tolerance. However, despite several promising results in murine studies, the translation to nonhuman primate models and clinical trials has proven to be more difficult. In contrast to specific pathogen-free bred laboratory mice, the immune system of humans has been in repeated contact with numerous pathogens, resulting in a broad memory-T-cell repertoire. Crossreactivity of the virus-specific memory-T-cell pool against alloantigens has been described in a phenomenon called heterologous immunity. In this study, we demonstrate, in a murine stem cell transplantation model, that heterologous immunity is likely to be an important barrier for the induction of mixed hematopoietic chimerism after immunologic conditioning in the absence of cytoreduction. Additional T-cell depletion or a brief cyclosporine treatment can be applied to overcome the barrier of heterologous immunity. |
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