Cardioprotective effects of Ficus religiosa in neonatal streptozotocin-induced diabetic cardiomyopathy in rats
Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induc...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Sharma, Raman [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Schlagwörter: |
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| Umfang: |
6 |
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| Übergeordnetes Werk: |
Enthalten in: Optimized design of impulse turbines in the micro-hydro sector concerning air detrainment processes - Kramer, Matthias ELSEVIER, 2015, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:4 ; year:2014 ; number:1 ; pages:53-58 ; extent:6 |
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| DOI / URN: |
10.1016/j.biomag.2013.10.008 |
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| 245 | 1 | 0 | |a Cardioprotective effects of Ficus religiosa in neonatal streptozotocin-induced diabetic cardiomyopathy in rats |
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| 520 | |a Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). | ||
| 520 | |a Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). | ||
| 650 | 7 | |a Oxidative stress |2 Elsevier | |
| 650 | 7 | |a LDH |2 Elsevier | |
| 650 | 7 | |a BNP |2 Elsevier | |
| 650 | 7 | |a Ficus religiosa |2 Elsevier | |
| 650 | 7 | |a Diabetic cardiomyopathy |2 Elsevier | |
| 650 | 7 | |a CK-MB |2 Elsevier | |
| 650 | 7 | |a Caspase-3 |2 Elsevier | |
| 700 | 1 | |a Kumar, Ashok |4 oth | |
| 700 | 1 | |a Srinivasan, Bharatur Parthasarathy |4 oth | |
| 700 | 1 | |a Chauhan, Anisha |4 oth | |
| 700 | 1 | |a Dubey, Kiran |4 oth | |
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10.1016/j.biomag.2013.10.008 doi GBVA2014011000019.pica (DE-627)ELV033934673 (ELSEVIER)S2210-5220(13)00055-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 600 VZ 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Sharma, Raman verfasserin aut Cardioprotective effects of Ficus religiosa in neonatal streptozotocin-induced diabetic cardiomyopathy in rats 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). Oxidative stress Elsevier LDH Elsevier BNP Elsevier Ficus religiosa Elsevier Diabetic cardiomyopathy Elsevier CK-MB Elsevier Caspase-3 Elsevier Kumar, Ashok oth Srinivasan, Bharatur Parthasarathy oth Chauhan, Anisha oth Dubey, Kiran oth Enthalten in Elsevier Masson Kramer, Matthias ELSEVIER Optimized design of impulse turbines in the micro-hydro sector concerning air detrainment processes 2015 Amsterdam [u.a.] (DE-627)ELV023620145 volume:4 year:2014 number:1 pages:53-58 extent:6 https://doi.org/10.1016/j.biomag.2013.10.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 4 2014 1 53-58 6 045F 610 |
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10.1016/j.biomag.2013.10.008 doi GBVA2014011000019.pica (DE-627)ELV033934673 (ELSEVIER)S2210-5220(13)00055-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 600 VZ 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Sharma, Raman verfasserin aut Cardioprotective effects of Ficus religiosa in neonatal streptozotocin-induced diabetic cardiomyopathy in rats 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). Oxidative stress Elsevier LDH Elsevier BNP Elsevier Ficus religiosa Elsevier Diabetic cardiomyopathy Elsevier CK-MB Elsevier Caspase-3 Elsevier Kumar, Ashok oth Srinivasan, Bharatur Parthasarathy oth Chauhan, Anisha oth Dubey, Kiran oth Enthalten in Elsevier Masson Kramer, Matthias ELSEVIER Optimized design of impulse turbines in the micro-hydro sector concerning air detrainment processes 2015 Amsterdam [u.a.] (DE-627)ELV023620145 volume:4 year:2014 number:1 pages:53-58 extent:6 https://doi.org/10.1016/j.biomag.2013.10.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 4 2014 1 53-58 6 045F 610 |
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10.1016/j.biomag.2013.10.008 doi GBVA2014011000019.pica (DE-627)ELV033934673 (ELSEVIER)S2210-5220(13)00055-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 600 VZ 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Sharma, Raman verfasserin aut Cardioprotective effects of Ficus religiosa in neonatal streptozotocin-induced diabetic cardiomyopathy in rats 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). Oxidative stress Elsevier LDH Elsevier BNP Elsevier Ficus religiosa Elsevier Diabetic cardiomyopathy Elsevier CK-MB Elsevier Caspase-3 Elsevier Kumar, Ashok oth Srinivasan, Bharatur Parthasarathy oth Chauhan, Anisha oth Dubey, Kiran oth Enthalten in Elsevier Masson Kramer, Matthias ELSEVIER Optimized design of impulse turbines in the micro-hydro sector concerning air detrainment processes 2015 Amsterdam [u.a.] (DE-627)ELV023620145 volume:4 year:2014 number:1 pages:53-58 extent:6 https://doi.org/10.1016/j.biomag.2013.10.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 4 2014 1 53-58 6 045F 610 |
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10.1016/j.biomag.2013.10.008 doi GBVA2014011000019.pica (DE-627)ELV033934673 (ELSEVIER)S2210-5220(13)00055-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 600 VZ 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Sharma, Raman verfasserin aut Cardioprotective effects of Ficus religiosa in neonatal streptozotocin-induced diabetic cardiomyopathy in rats 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). Oxidative stress Elsevier LDH Elsevier BNP Elsevier Ficus religiosa Elsevier Diabetic cardiomyopathy Elsevier CK-MB Elsevier Caspase-3 Elsevier Kumar, Ashok oth Srinivasan, Bharatur Parthasarathy oth Chauhan, Anisha oth Dubey, Kiran oth Enthalten in Elsevier Masson Kramer, Matthias ELSEVIER Optimized design of impulse turbines in the micro-hydro sector concerning air detrainment processes 2015 Amsterdam [u.a.] (DE-627)ELV023620145 volume:4 year:2014 number:1 pages:53-58 extent:6 https://doi.org/10.1016/j.biomag.2013.10.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 4 2014 1 53-58 6 045F 610 |
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10.1016/j.biomag.2013.10.008 doi GBVA2014011000019.pica (DE-627)ELV033934673 (ELSEVIER)S2210-5220(13)00055-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 600 VZ 610 VZ 15,3 ssgn PHARM DE-84 fid 44.40 bkl Sharma, Raman verfasserin aut Cardioprotective effects of Ficus religiosa in neonatal streptozotocin-induced diabetic cardiomyopathy in rats 2014transfer abstract 6 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). Oxidative stress Elsevier LDH Elsevier BNP Elsevier Ficus religiosa Elsevier Diabetic cardiomyopathy Elsevier CK-MB Elsevier Caspase-3 Elsevier Kumar, Ashok oth Srinivasan, Bharatur Parthasarathy oth Chauhan, Anisha oth Dubey, Kiran oth Enthalten in Elsevier Masson Kramer, Matthias ELSEVIER Optimized design of impulse turbines in the micro-hydro sector concerning air detrainment processes 2015 Amsterdam [u.a.] (DE-627)ELV023620145 volume:4 year:2014 number:1 pages:53-58 extent:6 https://doi.org/10.1016/j.biomag.2013.10.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-PHARM SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 4 2014 1 53-58 6 045F 610 |
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Cardioprotective effects of Ficus religiosa in neonatal streptozotocin-induced diabetic cardiomyopathy in rats |
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Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). |
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Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). |
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Diabetes mellitus is one of the major problems. In developing as well as developed countries. Uncontrolled blood glucose level and oxidative stress plays a vital role in pathogenesis of the diabetic cardiomyopathy. The present study was aimed to investigate the effect of Ficus religiosa in STZ-induced diabetic cardiomyopathy in rats. Streptozotocin (90mg/kg i.p.), administered to 2 days old neonates (10–12g), resulted in significant increase in fasting blood glucose, HbA1c, cardiac hypertrophic index, TGF-β1, TNFα, malondialdehyde, LDH, CK-MB, BNP and caspase-3, blood pressure. It caused significant reduction in plasma insulin, heart rate and superoxide dismutase. The eight-week treatment of F. religiosa started after induction of six weeks of diabetes, the treatment significantly improved diabetic markers, oxidative stress, inflammatory and cardiac markers. Results of the present study suggest that the cardioprotective effect of F. religiosa may be mediated through the control of diabetes, modulation of oxidative marker and cytokine (TGF-β1, TNFα). |
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