Inhibition of IL-6 family cytokines by SOCS3
• SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK...
Ausführliche Beschreibung
Autor*in: |
Babon, Jeffrey J. [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2014 |
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Schlagwörter: |
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Umfang: |
7 |
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Übergeordnetes Werk: |
Enthalten in: 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists - Fabritius, Charles-Henry ELSEVIER, 2016, London |
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Übergeordnetes Werk: |
volume:26 ; year:2014 ; number:1 ; pages:13-19 ; extent:7 |
Links: |
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DOI / URN: |
10.1016/j.smim.2013.12.004 |
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Katalog-ID: |
ELV034120289 |
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520 | |a • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. | ||
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10.1016/j.smim.2013.12.004 doi GBVA2014017000021.pica (DE-627)ELV034120289 (ELSEVIER)S1044-5323(13)00159-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Babon, Jeffrey J. verfasserin aut Inhibition of IL-6 family cytokines by SOCS3 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. CNTF Elsevier IL-27 Elsevier OSM Elsevier LIF Elsevier SOCS Elsevier CT-1 Elsevier MAPK Elsevier IL-11 Elsevier G-CSF Elsevier IL-6 Elsevier IL-10 Elsevier SHP2 Elsevier STAT Elsevier PI3K Elsevier KIR Elsevier gp130 Elsevier SH2 Elsevier JAKs Elsevier IL-6Rα Elsevier ERK Elsevier Varghese, Leila N. oth Nicola, Nicos A. oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:26 year:2014 number:1 pages:13-19 extent:7 https://doi.org/10.1016/j.smim.2013.12.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 26 2014 1 13-19 7 045F 610 |
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10.1016/j.smim.2013.12.004 doi GBVA2014017000021.pica (DE-627)ELV034120289 (ELSEVIER)S1044-5323(13)00159-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Babon, Jeffrey J. verfasserin aut Inhibition of IL-6 family cytokines by SOCS3 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. CNTF Elsevier IL-27 Elsevier OSM Elsevier LIF Elsevier SOCS Elsevier CT-1 Elsevier MAPK Elsevier IL-11 Elsevier G-CSF Elsevier IL-6 Elsevier IL-10 Elsevier SHP2 Elsevier STAT Elsevier PI3K Elsevier KIR Elsevier gp130 Elsevier SH2 Elsevier JAKs Elsevier IL-6Rα Elsevier ERK Elsevier Varghese, Leila N. oth Nicola, Nicos A. oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:26 year:2014 number:1 pages:13-19 extent:7 https://doi.org/10.1016/j.smim.2013.12.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 26 2014 1 13-19 7 045F 610 |
allfields_unstemmed |
10.1016/j.smim.2013.12.004 doi GBVA2014017000021.pica (DE-627)ELV034120289 (ELSEVIER)S1044-5323(13)00159-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Babon, Jeffrey J. verfasserin aut Inhibition of IL-6 family cytokines by SOCS3 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. CNTF Elsevier IL-27 Elsevier OSM Elsevier LIF Elsevier SOCS Elsevier CT-1 Elsevier MAPK Elsevier IL-11 Elsevier G-CSF Elsevier IL-6 Elsevier IL-10 Elsevier SHP2 Elsevier STAT Elsevier PI3K Elsevier KIR Elsevier gp130 Elsevier SH2 Elsevier JAKs Elsevier IL-6Rα Elsevier ERK Elsevier Varghese, Leila N. oth Nicola, Nicos A. oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:26 year:2014 number:1 pages:13-19 extent:7 https://doi.org/10.1016/j.smim.2013.12.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 26 2014 1 13-19 7 045F 610 |
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10.1016/j.smim.2013.12.004 doi GBVA2014017000021.pica (DE-627)ELV034120289 (ELSEVIER)S1044-5323(13)00159-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Babon, Jeffrey J. verfasserin aut Inhibition of IL-6 family cytokines by SOCS3 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. CNTF Elsevier IL-27 Elsevier OSM Elsevier LIF Elsevier SOCS Elsevier CT-1 Elsevier MAPK Elsevier IL-11 Elsevier G-CSF Elsevier IL-6 Elsevier IL-10 Elsevier SHP2 Elsevier STAT Elsevier PI3K Elsevier KIR Elsevier gp130 Elsevier SH2 Elsevier JAKs Elsevier IL-6Rα Elsevier ERK Elsevier Varghese, Leila N. oth Nicola, Nicos A. oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:26 year:2014 number:1 pages:13-19 extent:7 https://doi.org/10.1016/j.smim.2013.12.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 26 2014 1 13-19 7 045F 610 |
allfieldsSound |
10.1016/j.smim.2013.12.004 doi GBVA2014017000021.pica (DE-627)ELV034120289 (ELSEVIER)S1044-5323(13)00159-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Babon, Jeffrey J. verfasserin aut Inhibition of IL-6 family cytokines by SOCS3 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. CNTF Elsevier IL-27 Elsevier OSM Elsevier LIF Elsevier SOCS Elsevier CT-1 Elsevier MAPK Elsevier IL-11 Elsevier G-CSF Elsevier IL-6 Elsevier IL-10 Elsevier SHP2 Elsevier STAT Elsevier PI3K Elsevier KIR Elsevier gp130 Elsevier SH2 Elsevier JAKs Elsevier IL-6Rα Elsevier ERK Elsevier Varghese, Leila N. oth Nicola, Nicos A. oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:26 year:2014 number:1 pages:13-19 extent:7 https://doi.org/10.1016/j.smim.2013.12.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 26 2014 1 13-19 7 045F 610 |
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1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists |
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ELV01964275X |
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1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists |
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Inhibition of IL-6 family cytokines by SOCS3 |
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(DE-627)ELV034120289 (ELSEVIER)S1044-5323(13)00159-0 |
title_full |
Inhibition of IL-6 family cytokines by SOCS3 |
author_sort |
Babon, Jeffrey J. |
journal |
1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists |
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1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists |
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eng |
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2014 |
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13 |
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Babon, Jeffrey J. |
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26 |
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Elektronische Aufsätze |
author-letter |
Babon, Jeffrey J. |
doi_str_mv |
10.1016/j.smim.2013.12.004 |
dewey-full |
610 540 630 |
title_sort |
inhibition of il-6 family cytokines by socs3 |
title_auth |
Inhibition of IL-6 family cytokines by SOCS3 |
abstract |
• SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. |
abstractGer |
• SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. |
abstract_unstemmed |
• SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. |
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title_short |
Inhibition of IL-6 family cytokines by SOCS3 |
url |
https://doi.org/10.1016/j.smim.2013.12.004 |
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Varghese, Leila N. Nicola, Nicos A. |
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Varghese, Leila N. Nicola, Nicos A. |
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10.1016/j.smim.2013.12.004 |
up_date |
2024-07-06T20:19:30.290Z |
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