Inhibition of IL-6 family cytokines by SOCS3

• SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Babon, Jeffrey J. [verfasserIn] Varghese, Leila N. Nicola, Nicos A.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2014

Schlagwörter:	CNTF IL-27 OSM LIF SOCS CT-1 MAPK IL-11 G-CSF IL-6 IL-10 SHP2 STAT PI3K KIR gp130 SH2 JAKs IL-6Rα ERK

Umfang:	7

Übergeordnetes Werk:	Enthalten in: 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists - Fabritius, Charles-Henry ELSEVIER, 2016, London
Übergeordnetes Werk:	volume:26 ; year:2014 ; number:1 ; pages:13-19 ; extent:7

Links:	Volltext

DOI / URN:	10.1016/j.smim.2013.12.004

Katalog-ID:	ELV034120289

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spelling	10.1016/j.smim.2013.12.004 doi GBVA2014017000021.pica (DE-627)ELV034120289 (ELSEVIER)S1044-5323(13)00159-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Babon, Jeffrey J. verfasserin aut Inhibition of IL-6 family cytokines by SOCS3 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. CNTF Elsevier IL-27 Elsevier OSM Elsevier LIF Elsevier SOCS Elsevier CT-1 Elsevier MAPK Elsevier IL-11 Elsevier G-CSF Elsevier IL-6 Elsevier IL-10 Elsevier SHP2 Elsevier STAT Elsevier PI3K Elsevier KIR Elsevier gp130 Elsevier SH2 Elsevier JAKs Elsevier IL-6Rα Elsevier ERK Elsevier Varghese, Leila N. oth Nicola, Nicos A. oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:26 year:2014 number:1 pages:13-19 extent:7 https://doi.org/10.1016/j.smim.2013.12.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 26 2014 1 13-19 7 045F 610
allfields_unstemmed	10.1016/j.smim.2013.12.004 doi GBVA2014017000021.pica (DE-627)ELV034120289 (ELSEVIER)S1044-5323(13)00159-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Babon, Jeffrey J. verfasserin aut Inhibition of IL-6 family cytokines by SOCS3 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. CNTF Elsevier IL-27 Elsevier OSM Elsevier LIF Elsevier SOCS Elsevier CT-1 Elsevier MAPK Elsevier IL-11 Elsevier G-CSF Elsevier IL-6 Elsevier IL-10 Elsevier SHP2 Elsevier STAT Elsevier PI3K Elsevier KIR Elsevier gp130 Elsevier SH2 Elsevier JAKs Elsevier IL-6Rα Elsevier ERK Elsevier Varghese, Leila N. oth Nicola, Nicos A. oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:26 year:2014 number:1 pages:13-19 extent:7 https://doi.org/10.1016/j.smim.2013.12.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 26 2014 1 13-19 7 045F 610
allfieldsGer	10.1016/j.smim.2013.12.004 doi GBVA2014017000021.pica (DE-627)ELV034120289 (ELSEVIER)S1044-5323(13)00159-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Babon, Jeffrey J. verfasserin aut Inhibition of IL-6 family cytokines by SOCS3 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. CNTF Elsevier IL-27 Elsevier OSM Elsevier LIF Elsevier SOCS Elsevier CT-1 Elsevier MAPK Elsevier IL-11 Elsevier G-CSF Elsevier IL-6 Elsevier IL-10 Elsevier SHP2 Elsevier STAT Elsevier PI3K Elsevier KIR Elsevier gp130 Elsevier SH2 Elsevier JAKs Elsevier IL-6Rα Elsevier ERK Elsevier Varghese, Leila N. oth Nicola, Nicos A. oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:26 year:2014 number:1 pages:13-19 extent:7 https://doi.org/10.1016/j.smim.2013.12.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 26 2014 1 13-19 7 045F 610
allfieldsSound	10.1016/j.smim.2013.12.004 doi GBVA2014017000021.pica (DE-627)ELV034120289 (ELSEVIER)S1044-5323(13)00159-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl Babon, Jeffrey J. verfasserin aut Inhibition of IL-6 family cytokines by SOCS3 2014 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes. CNTF Elsevier IL-27 Elsevier OSM Elsevier LIF Elsevier SOCS Elsevier CT-1 Elsevier MAPK Elsevier IL-11 Elsevier G-CSF Elsevier IL-6 Elsevier IL-10 Elsevier SHP2 Elsevier STAT Elsevier PI3K Elsevier KIR Elsevier gp130 Elsevier SH2 Elsevier JAKs Elsevier IL-6Rα Elsevier ERK Elsevier Varghese, Leila N. oth Nicola, Nicos A. oth Enthalten in Academic Press Fabritius, Charles-Henry ELSEVIER 1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists 2016 London (DE-627)ELV01964275X volume:26 year:2014 number:1 pages:13-19 extent:7 https://doi.org/10.1016/j.smim.2013.12.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 46.00 Tiermedizin: Allgemeines VZ AR 26 2014 1 13-19 7 045F 610
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title_full	Inhibition of IL-6 family cytokines by SOCS3
author_sort	Babon, Jeffrey J.
journal	1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists
journalStr	1-Sulfonyl-6-Piperazinyl-7-Azaindoles as potent and pseudo-selective 5-HT6 receptor antagonists
lang_code	eng
isOA_bool	false
dewey-hundreds	600 - Technology 500 - Science
recordtype	marc
publishDateSort	2014
contenttype_str_mv	zzz
container_start_page	13
author_browse	Babon, Jeffrey J.
container_volume	26
physical	7
class	610 610 DE-600 540 VZ 610 VZ 630 VZ 22 ssgn 46.00 bkl
format_se	Elektronische Aufsätze
author-letter	Babon, Jeffrey J.
doi_str_mv	10.1016/j.smim.2013.12.004
dewey-full	610 540 630
title_sort	inhibition of il-6 family cytokines by socs3
title_auth	Inhibition of IL-6 family cytokines by SOCS3
abstract	• SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes.
abstractGer	• SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes.
abstract_unstemmed	• SOCS3 is the primary feedback inhibitor of IL-6 family signalling. • SOCS3 controls the duration of IL-6 signalling and shapes the cells response to it. • SOCS3 binds to gp130, the shared IL-6 family co-receptor. • SOCS3 directly inhibits JAK1, JAK2 and TYK2 but not JAK3. • SOCS3 targets gp130/JAK complexes.
collection_details	GBV_USEFLAG_U GBV_ELV SYSFLAG_U
container_issue	1
title_short	Inhibition of IL-6 family cytokines by SOCS3
url	https://doi.org/10.1016/j.smim.2013.12.004
remote_bool	true
author2	Varghese, Leila N. Nicola, Nicos A.
author2Str	Varghese, Leila N. Nicola, Nicos A.
ppnlink	ELV01964275X
mediatype_str_mv	z
isOA_txt	false
hochschulschrift_bool	false
author2_role	oth oth
doi_str	10.1016/j.smim.2013.12.004
up_date	2024-07-06T20:19:30.290Z
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