Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers
Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – caus...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Reitz, Christiane [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Schlagwörter: |
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| Umfang: |
12 |
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| Übergeordnetes Werk: |
Enthalten in: Mussel-inspired adhesive friction-controlled lubricating coating for titanium alloy used in artificial joint replacement - Chen, Zhuo ELSEVIER, 2023, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:88 ; year:2014 ; number:4 ; day:15 ; month:04 ; pages:640-651 ; extent:12 |
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| DOI / URN: |
10.1016/j.bcp.2013.12.024 |
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| 520 | |a Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. | ||
| 520 | |a Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. | ||
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10.1016/j.bcp.2013.12.024 doi GBVA2014019000001.pica (DE-627)ELV034169709 (ELSEVIER)S0006-2952(13)00808-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 670 530 660 VZ 33.68 bkl 35.18 bkl 52.78 bkl Reitz, Christiane verfasserin aut Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers 2014transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. Neurofibrillary tangles Elsevier Biomarkers Elsevier Neuropathological Elsevier Mayeux, Richard oth Enthalten in Elsevier Science Chen, Zhuo ELSEVIER Mussel-inspired adhesive friction-controlled lubricating coating for titanium alloy used in artificial joint replacement 2023 Amsterdam [u.a.] (DE-627)ELV010068619 volume:88 year:2014 number:4 day:15 month:04 pages:640-651 extent:12 https://doi.org/10.1016/j.bcp.2013.12.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_24 GBV_ILN_2002 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2018 GBV_ILN_2032 GBV_ILN_2037 GBV_ILN_2043 GBV_ILN_2091 GBV_ILN_2140 GBV_ILN_2165 GBV_ILN_2227 GBV_ILN_2285 GBV_ILN_2305 GBV_ILN_2421 GBV_ILN_2430 GBV_ILN_2520 GBV_ILN_2552 GBV_ILN_2568 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 35.18 Kolloidchemie Grenzflächenchemie VZ 52.78 Oberflächentechnik Wärmebehandlung VZ AR 88 2014 4 15 0415 640-651 12 045F 610 |
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10.1016/j.bcp.2013.12.024 doi GBVA2014019000001.pica (DE-627)ELV034169709 (ELSEVIER)S0006-2952(13)00808-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 670 530 660 VZ 33.68 bkl 35.18 bkl 52.78 bkl Reitz, Christiane verfasserin aut Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers 2014transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. Neurofibrillary tangles Elsevier Biomarkers Elsevier Neuropathological Elsevier Mayeux, Richard oth Enthalten in Elsevier Science Chen, Zhuo ELSEVIER Mussel-inspired adhesive friction-controlled lubricating coating for titanium alloy used in artificial joint replacement 2023 Amsterdam [u.a.] (DE-627)ELV010068619 volume:88 year:2014 number:4 day:15 month:04 pages:640-651 extent:12 https://doi.org/10.1016/j.bcp.2013.12.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_24 GBV_ILN_2002 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2018 GBV_ILN_2032 GBV_ILN_2037 GBV_ILN_2043 GBV_ILN_2091 GBV_ILN_2140 GBV_ILN_2165 GBV_ILN_2227 GBV_ILN_2285 GBV_ILN_2305 GBV_ILN_2421 GBV_ILN_2430 GBV_ILN_2520 GBV_ILN_2552 GBV_ILN_2568 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 35.18 Kolloidchemie Grenzflächenchemie VZ 52.78 Oberflächentechnik Wärmebehandlung VZ AR 88 2014 4 15 0415 640-651 12 045F 610 |
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10.1016/j.bcp.2013.12.024 doi GBVA2014019000001.pica (DE-627)ELV034169709 (ELSEVIER)S0006-2952(13)00808-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 670 530 660 VZ 33.68 bkl 35.18 bkl 52.78 bkl Reitz, Christiane verfasserin aut Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers 2014transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. Neurofibrillary tangles Elsevier Biomarkers Elsevier Neuropathological Elsevier Mayeux, Richard oth Enthalten in Elsevier Science Chen, Zhuo ELSEVIER Mussel-inspired adhesive friction-controlled lubricating coating for titanium alloy used in artificial joint replacement 2023 Amsterdam [u.a.] (DE-627)ELV010068619 volume:88 year:2014 number:4 day:15 month:04 pages:640-651 extent:12 https://doi.org/10.1016/j.bcp.2013.12.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_24 GBV_ILN_2002 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2018 GBV_ILN_2032 GBV_ILN_2037 GBV_ILN_2043 GBV_ILN_2091 GBV_ILN_2140 GBV_ILN_2165 GBV_ILN_2227 GBV_ILN_2285 GBV_ILN_2305 GBV_ILN_2421 GBV_ILN_2430 GBV_ILN_2520 GBV_ILN_2552 GBV_ILN_2568 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 35.18 Kolloidchemie Grenzflächenchemie VZ 52.78 Oberflächentechnik Wärmebehandlung VZ AR 88 2014 4 15 0415 640-651 12 045F 610 |
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10.1016/j.bcp.2013.12.024 doi GBVA2014019000001.pica (DE-627)ELV034169709 (ELSEVIER)S0006-2952(13)00808-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 670 530 660 VZ 33.68 bkl 35.18 bkl 52.78 bkl Reitz, Christiane verfasserin aut Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers 2014transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. Neurofibrillary tangles Elsevier Biomarkers Elsevier Neuropathological Elsevier Mayeux, Richard oth Enthalten in Elsevier Science Chen, Zhuo ELSEVIER Mussel-inspired adhesive friction-controlled lubricating coating for titanium alloy used in artificial joint replacement 2023 Amsterdam [u.a.] (DE-627)ELV010068619 volume:88 year:2014 number:4 day:15 month:04 pages:640-651 extent:12 https://doi.org/10.1016/j.bcp.2013.12.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_24 GBV_ILN_2002 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2018 GBV_ILN_2032 GBV_ILN_2037 GBV_ILN_2043 GBV_ILN_2091 GBV_ILN_2140 GBV_ILN_2165 GBV_ILN_2227 GBV_ILN_2285 GBV_ILN_2305 GBV_ILN_2421 GBV_ILN_2430 GBV_ILN_2520 GBV_ILN_2552 GBV_ILN_2568 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 35.18 Kolloidchemie Grenzflächenchemie VZ 52.78 Oberflächentechnik Wärmebehandlung VZ AR 88 2014 4 15 0415 640-651 12 045F 610 |
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10.1016/j.bcp.2013.12.024 doi GBVA2014019000001.pica (DE-627)ELV034169709 (ELSEVIER)S0006-2952(13)00808-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 670 530 660 VZ 33.68 bkl 35.18 bkl 52.78 bkl Reitz, Christiane verfasserin aut Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers 2014transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. Neurofibrillary tangles Elsevier Biomarkers Elsevier Neuropathological Elsevier Mayeux, Richard oth Enthalten in Elsevier Science Chen, Zhuo ELSEVIER Mussel-inspired adhesive friction-controlled lubricating coating for titanium alloy used in artificial joint replacement 2023 Amsterdam [u.a.] (DE-627)ELV010068619 volume:88 year:2014 number:4 day:15 month:04 pages:640-651 extent:12 https://doi.org/10.1016/j.bcp.2013.12.024 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_24 GBV_ILN_2002 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2018 GBV_ILN_2032 GBV_ILN_2037 GBV_ILN_2043 GBV_ILN_2091 GBV_ILN_2140 GBV_ILN_2165 GBV_ILN_2227 GBV_ILN_2285 GBV_ILN_2305 GBV_ILN_2421 GBV_ILN_2430 GBV_ILN_2520 GBV_ILN_2552 GBV_ILN_2568 33.68 Oberflächen Dünne Schichten Grenzflächen Physik VZ 35.18 Kolloidchemie Grenzflächenchemie VZ 52.78 Oberflächentechnik Wärmebehandlung VZ AR 88 2014 4 15 0415 640-651 12 045F 610 |
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Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. |
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Abstract The global prevalence of dementia is as high as 24 million, and has been predicted to quadruple by the year 2050. In the US alone, Alzheimer disease (AD) – the most frequent cause of dementia characterized by a progressive decline in cognitive function in particular the memory domain – causes estimated health-care costs of $ 172 billion per year. Key neuropathological hallmarks of the AD brain are diffuse and neuritic extracellular amyloid plaques – often surrounded by dystrophic neurites – and intracellular neurofibrillary tangles. These pathological changes are frequently accompanied by reactive microgliosis and loss of neurons, white matter and synapses. The etiological mechanisms underlying these neuropathological changes remain unclear, but are probably caused by both environmental and genetic factors. In this review article, we provide an overview of the epidemiology of AD, review the biomarkers that may be used for risk assessment and in diagnosis, and give suggestions for future research. |
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| score |
7.4008503 |