Mendelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence
Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being su...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Franić, Sanja [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Umfang: |
13 |
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| Übergeordnetes Werk: |
Enthalten in: EP-2075: Evaluation of conventional versus IMRT based Prophylactic Cranial Irradiation treatment planning - Thøgersen, E.H. ELSEVIER, 2016, a multidisciplinary journal, Greenwich, Conn |
|---|---|
| Übergeordnetes Werk: |
volume:49 ; year:2015 ; pages:10-22 ; extent:13 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.intell.2014.12.001 |
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ELV034366075 |
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| 245 | 1 | 0 | |a Mendelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence |
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| 520 | |a Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. | ||
| 520 | |a Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. | ||
| 700 | 1 | |a Dolan, Conor V. |4 oth | |
| 700 | 1 | |a Broxholme, John |4 oth | |
| 700 | 1 | |a Hu, Hao |4 oth | |
| 700 | 1 | |a Zemojtel, Tomasz |4 oth | |
| 700 | 1 | |a Davies, Garreth E. |4 oth | |
| 700 | 1 | |a Nelson, Kelly A. |4 oth | |
| 700 | 1 | |a Ehli, Erik A. |4 oth | |
| 700 | 1 | |a Pool, René |4 oth | |
| 700 | 1 | |a Hottenga, Jouke-Jan |4 oth | |
| 700 | 1 | |a Ropers, H.-Hilger |4 oth | |
| 700 | 1 | |a Boomsma, Dorret I. |4 oth | |
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10.1016/j.intell.2014.12.001 doi GBVA2015002000025.pica (DE-627)ELV034366075 (ELSEVIER)S0160-2896(14)00170-6 DE-627 ger DE-627 rakwb eng 150 150 DE-600 610 VZ 570 540 VZ Franić, Sanja verfasserin aut Mendelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence 2015transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. Dolan, Conor V. oth Broxholme, John oth Hu, Hao oth Zemojtel, Tomasz oth Davies, Garreth E. oth Nelson, Kelly A. oth Ehli, Erik A. oth Pool, René oth Hottenga, Jouke-Jan oth Ropers, H.-Hilger oth Boomsma, Dorret I. oth Enthalten in Ablex Thøgersen, E.H. ELSEVIER EP-2075: Evaluation of conventional versus IMRT based Prophylactic Cranial Irradiation treatment planning 2016 a multidisciplinary journal Greenwich, Conn (DE-627)ELV013733052 volume:49 year:2015 pages:10-22 extent:13 https://doi.org/10.1016/j.intell.2014.12.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_40 AR 49 2015 10-22 13 045F 150 |
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10.1016/j.intell.2014.12.001 doi GBVA2015002000025.pica (DE-627)ELV034366075 (ELSEVIER)S0160-2896(14)00170-6 DE-627 ger DE-627 rakwb eng 150 150 DE-600 610 VZ 570 540 VZ Franić, Sanja verfasserin aut Mendelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence 2015transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. Dolan, Conor V. oth Broxholme, John oth Hu, Hao oth Zemojtel, Tomasz oth Davies, Garreth E. oth Nelson, Kelly A. oth Ehli, Erik A. oth Pool, René oth Hottenga, Jouke-Jan oth Ropers, H.-Hilger oth Boomsma, Dorret I. oth Enthalten in Ablex Thøgersen, E.H. ELSEVIER EP-2075: Evaluation of conventional versus IMRT based Prophylactic Cranial Irradiation treatment planning 2016 a multidisciplinary journal Greenwich, Conn (DE-627)ELV013733052 volume:49 year:2015 pages:10-22 extent:13 https://doi.org/10.1016/j.intell.2014.12.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_40 AR 49 2015 10-22 13 045F 150 |
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10.1016/j.intell.2014.12.001 doi GBVA2015002000025.pica (DE-627)ELV034366075 (ELSEVIER)S0160-2896(14)00170-6 DE-627 ger DE-627 rakwb eng 150 150 DE-600 610 VZ 570 540 VZ Franić, Sanja verfasserin aut Mendelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence 2015transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. Dolan, Conor V. oth Broxholme, John oth Hu, Hao oth Zemojtel, Tomasz oth Davies, Garreth E. oth Nelson, Kelly A. oth Ehli, Erik A. oth Pool, René oth Hottenga, Jouke-Jan oth Ropers, H.-Hilger oth Boomsma, Dorret I. oth Enthalten in Ablex Thøgersen, E.H. ELSEVIER EP-2075: Evaluation of conventional versus IMRT based Prophylactic Cranial Irradiation treatment planning 2016 a multidisciplinary journal Greenwich, Conn (DE-627)ELV013733052 volume:49 year:2015 pages:10-22 extent:13 https://doi.org/10.1016/j.intell.2014.12.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_40 AR 49 2015 10-22 13 045F 150 |
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10.1016/j.intell.2014.12.001 doi GBVA2015002000025.pica (DE-627)ELV034366075 (ELSEVIER)S0160-2896(14)00170-6 DE-627 ger DE-627 rakwb eng 150 150 DE-600 610 VZ 570 540 VZ Franić, Sanja verfasserin aut Mendelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence 2015transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. Dolan, Conor V. oth Broxholme, John oth Hu, Hao oth Zemojtel, Tomasz oth Davies, Garreth E. oth Nelson, Kelly A. oth Ehli, Erik A. oth Pool, René oth Hottenga, Jouke-Jan oth Ropers, H.-Hilger oth Boomsma, Dorret I. oth Enthalten in Ablex Thøgersen, E.H. ELSEVIER EP-2075: Evaluation of conventional versus IMRT based Prophylactic Cranial Irradiation treatment planning 2016 a multidisciplinary journal Greenwich, Conn (DE-627)ELV013733052 volume:49 year:2015 pages:10-22 extent:13 https://doi.org/10.1016/j.intell.2014.12.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_40 AR 49 2015 10-22 13 045F 150 |
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10.1016/j.intell.2014.12.001 doi GBVA2015002000025.pica (DE-627)ELV034366075 (ELSEVIER)S0160-2896(14)00170-6 DE-627 ger DE-627 rakwb eng 150 150 DE-600 610 VZ 570 540 VZ Franić, Sanja verfasserin aut Mendelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence 2015transfer abstract 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. Dolan, Conor V. oth Broxholme, John oth Hu, Hao oth Zemojtel, Tomasz oth Davies, Garreth E. oth Nelson, Kelly A. oth Ehli, Erik A. oth Pool, René oth Hottenga, Jouke-Jan oth Ropers, H.-Hilger oth Boomsma, Dorret I. oth Enthalten in Ablex Thøgersen, E.H. ELSEVIER EP-2075: Evaluation of conventional versus IMRT based Prophylactic Cranial Irradiation treatment planning 2016 a multidisciplinary journal Greenwich, Conn (DE-627)ELV013733052 volume:49 year:2015 pages:10-22 extent:13 https://doi.org/10.1016/j.intell.2014.12.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_40 AR 49 2015 10-22 13 045F 150 |
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Franić, Sanja @@aut@@ Dolan, Conor V. @@oth@@ Broxholme, John @@oth@@ Hu, Hao @@oth@@ Zemojtel, Tomasz @@oth@@ Davies, Garreth E. @@oth@@ Nelson, Kelly A. @@oth@@ Ehli, Erik A. @@oth@@ Pool, René @@oth@@ Hottenga, Jouke-Jan @@oth@@ Ropers, H.-Hilger @@oth@@ Boomsma, Dorret I. @@oth@@ |
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mendelian and polygenic inheritance of intelligence: a common set of causal genes? using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence |
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Mendelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence |
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Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. |
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Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. |
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Despite twin and family studies having demonstrated a substantial heritability of individual differences in intelligence, no genetic variants have been robustly associated with normal-range intelligence to date. This is largely ascribed to the high polygenicity of intelligence, i.e., to its being subject to the effects of a large number of genes of individually small effect. Intellectual disability, on the other hand, frequently involves large effects of single genetic mutations, many of which have been identified. The present paper aims to 1) introduce the reader to the current state of genetic intelligence research, including next-generation sequencing and the analysis of rare genetic variants, and 2) examine the possible effects of known disability genes on normal-range intelligence. The rationale for the latter rests on the fact that genetic variants affecting continuous, polygenic traits are often concentrated in the same areas of the genome as those underlying related monogenic phenotypes. Using an existing pool of known intellectual disability genes, we constructed a set of 168 candidate genes for normal-range intelligence, and tested their association with intelligence in 191 individuals (aged 5–18) sampled from the high and low ends of the IQ distribution. In particular, we 1) employed exon sequencing to examine the possible effects of rare genetic variants in the 168 genes, and 2) used polygenic prediction to examine the overall effect of common genetic variants in the candidate gene set in a larger sample (N=2125, mean age 20.4, SD=14.1). No significant association between the candidate gene set and intelligence was detected. |
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Mendelian and polygenic inheritance of intelligence: A common set of causal genes? Using next-generation sequencing to examine the effects of 168 intellectual disability genes on normal-range intelligence |
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