Squamous morula formation in colorectal adenoma: Immunohistochemical and molecular analyses
Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mochizuki, Kunio [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Schlagwörter: |
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| Umfang: |
4 |
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| Übergeordnetes Werk: |
Enthalten in: Concentration of trisodium citrate by electrodialysis - Fidaleo, Marcello ELSEVIER, 2013, München |
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| Übergeordnetes Werk: |
volume:211 ; year:2015 ; number:10 ; pages:797-800 ; extent:4 |
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| DOI / URN: |
10.1016/j.prp.2015.05.002 |
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| 520 | |a Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. | ||
| 520 | |a Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. | ||
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| 650 | 7 | |a Colorectal adenoma |2 Elsevier | |
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| 650 | 7 | |a Squamous morula |2 Elsevier | |
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| 700 | 1 | |a Kasai, Kazunari |4 oth | |
| 700 | 1 | |a Nakazawa, Tadao |4 oth | |
| 700 | 1 | |a Katoh, Ryohei |4 oth | |
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10.1016/j.prp.2015.05.002 doi GBVA2015010000017.pica (DE-627)ELV034550925 (ELSEVIER)S0344-0338(15)00096-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ 540 VZ 35.17 bkl 58.50 bkl 43.12 bkl Mochizuki, Kunio verfasserin aut Squamous morula formation in colorectal adenoma: Immunohistochemical and molecular analyses 2015transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. Ki-67 Elsevier Colorectal adenoma Elsevier Cytokeratin 5/6 Elsevier β-Catenin Elsevier Squamous morula Elsevier Kondo, Tetsuo oth Oishi, Naoki oth Tahara, Ippei oth Inoue, Tomohiro oth Kasai, Kazunari oth Nakazawa, Tadao oth Katoh, Ryohei oth Enthalten in Elsevier Fidaleo, Marcello ELSEVIER Concentration of trisodium citrate by electrodialysis 2013 München (DE-627)ELV016908384 volume:211 year:2015 number:10 pages:797-800 extent:4 https://doi.org/10.1016/j.prp.2015.05.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_70 35.17 Katalyse VZ 58.50 Umwelttechnik: Allgemeines VZ 43.12 Umweltchemie VZ AR 211 2015 10 797-800 4 045F 610 |
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10.1016/j.prp.2015.05.002 doi GBVA2015010000017.pica (DE-627)ELV034550925 (ELSEVIER)S0344-0338(15)00096-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ 540 VZ 35.17 bkl 58.50 bkl 43.12 bkl Mochizuki, Kunio verfasserin aut Squamous morula formation in colorectal adenoma: Immunohistochemical and molecular analyses 2015transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. Ki-67 Elsevier Colorectal adenoma Elsevier Cytokeratin 5/6 Elsevier β-Catenin Elsevier Squamous morula Elsevier Kondo, Tetsuo oth Oishi, Naoki oth Tahara, Ippei oth Inoue, Tomohiro oth Kasai, Kazunari oth Nakazawa, Tadao oth Katoh, Ryohei oth Enthalten in Elsevier Fidaleo, Marcello ELSEVIER Concentration of trisodium citrate by electrodialysis 2013 München (DE-627)ELV016908384 volume:211 year:2015 number:10 pages:797-800 extent:4 https://doi.org/10.1016/j.prp.2015.05.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_70 35.17 Katalyse VZ 58.50 Umwelttechnik: Allgemeines VZ 43.12 Umweltchemie VZ AR 211 2015 10 797-800 4 045F 610 |
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10.1016/j.prp.2015.05.002 doi GBVA2015010000017.pica (DE-627)ELV034550925 (ELSEVIER)S0344-0338(15)00096-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ 540 VZ 35.17 bkl 58.50 bkl 43.12 bkl Mochizuki, Kunio verfasserin aut Squamous morula formation in colorectal adenoma: Immunohistochemical and molecular analyses 2015transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. Ki-67 Elsevier Colorectal adenoma Elsevier Cytokeratin 5/6 Elsevier β-Catenin Elsevier Squamous morula Elsevier Kondo, Tetsuo oth Oishi, Naoki oth Tahara, Ippei oth Inoue, Tomohiro oth Kasai, Kazunari oth Nakazawa, Tadao oth Katoh, Ryohei oth Enthalten in Elsevier Fidaleo, Marcello ELSEVIER Concentration of trisodium citrate by electrodialysis 2013 München (DE-627)ELV016908384 volume:211 year:2015 number:10 pages:797-800 extent:4 https://doi.org/10.1016/j.prp.2015.05.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_70 35.17 Katalyse VZ 58.50 Umwelttechnik: Allgemeines VZ 43.12 Umweltchemie VZ AR 211 2015 10 797-800 4 045F 610 |
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10.1016/j.prp.2015.05.002 doi GBVA2015010000017.pica (DE-627)ELV034550925 (ELSEVIER)S0344-0338(15)00096-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ 540 VZ 35.17 bkl 58.50 bkl 43.12 bkl Mochizuki, Kunio verfasserin aut Squamous morula formation in colorectal adenoma: Immunohistochemical and molecular analyses 2015transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. Ki-67 Elsevier Colorectal adenoma Elsevier Cytokeratin 5/6 Elsevier β-Catenin Elsevier Squamous morula Elsevier Kondo, Tetsuo oth Oishi, Naoki oth Tahara, Ippei oth Inoue, Tomohiro oth Kasai, Kazunari oth Nakazawa, Tadao oth Katoh, Ryohei oth Enthalten in Elsevier Fidaleo, Marcello ELSEVIER Concentration of trisodium citrate by electrodialysis 2013 München (DE-627)ELV016908384 volume:211 year:2015 number:10 pages:797-800 extent:4 https://doi.org/10.1016/j.prp.2015.05.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_70 35.17 Katalyse VZ 58.50 Umwelttechnik: Allgemeines VZ 43.12 Umweltchemie VZ AR 211 2015 10 797-800 4 045F 610 |
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10.1016/j.prp.2015.05.002 doi GBVA2015010000017.pica (DE-627)ELV034550925 (ELSEVIER)S0344-0338(15)00096-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 570 VZ 540 VZ 35.17 bkl 58.50 bkl 43.12 bkl Mochizuki, Kunio verfasserin aut Squamous morula formation in colorectal adenoma: Immunohistochemical and molecular analyses 2015transfer abstract 4 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. Ki-67 Elsevier Colorectal adenoma Elsevier Cytokeratin 5/6 Elsevier β-Catenin Elsevier Squamous morula Elsevier Kondo, Tetsuo oth Oishi, Naoki oth Tahara, Ippei oth Inoue, Tomohiro oth Kasai, Kazunari oth Nakazawa, Tadao oth Katoh, Ryohei oth Enthalten in Elsevier Fidaleo, Marcello ELSEVIER Concentration of trisodium citrate by electrodialysis 2013 München (DE-627)ELV016908384 volume:211 year:2015 number:10 pages:797-800 extent:4 https://doi.org/10.1016/j.prp.2015.05.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_70 35.17 Katalyse VZ 58.50 Umwelttechnik: Allgemeines VZ 43.12 Umweltchemie VZ AR 211 2015 10 797-800 4 045F 610 |
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squamous morula formation in colorectal adenoma: immunohistochemical and molecular analyses |
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Squamous morula formation in colorectal adenoma: Immunohistochemical and molecular analyses |
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Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. |
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Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. |
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Little is known about the squamous morular component (SMC) in colorectal neoplasms because of its rarity. The aim of the present study is to elucidate the morphological, immunohistochemical and genetic characteristics of SMCs in colorectal adenomas. Five colorectal adenomas having SMCs were resected from five patients endoscopically. On immunohistochemical examination (four cases), all SMCs were positive for cytokeratin 5/6 in their cytoplasm and positive for β-catenin in their cytoplasm and nuclei. A nuclear positivity of p63 was detected in one SMC. All SMCs were negative for p53, chromogranin A, synaptophysin and NCAM. There was no Ki-67 expression in any of the SMCs. We detected none of mutations of β-catenin, KRAS and BRAF by microdissection and polymerase chain reaction-direct sequence in any of the four examined SMCs. SMCs are a rare but problematic finding in colorectal adenomas. Using immunohistochemistry for β-catenin, cytokeratin 5/6, Ki-67, p53, chromogranin A, synaptophysin and NCAM can facilitate the diagnosis of these peculiar cell nests. |
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