Genotype–phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus
• The TR46/Y121F/T289A mutation has a high-level voriconazole (VOR) resistance. • The resistant phenotype is supported by the analysis of the CYP51A homology model. • The T289A mutation has no effect but moderates the phenotype in the presence of Y121F.
Gespeichert in:
| Autor*in: |
Snelders, Eveline [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Umfang: |
7 |
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| Übergeordnetes Werk: |
Enthalten in: IFC: EDITORIAL BOARD - 2014, FG&B : FGB, Orlando, Fla |
|---|---|
| Übergeordnetes Werk: |
volume:82 ; year:2015 ; pages:129-135 ; extent:7 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.fgb.2015.06.001 |
|---|
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ELV03477162X |
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| 520 | |a • The TR46/Y121F/T289A mutation has a high-level voriconazole (VOR) resistance. • The resistant phenotype is supported by the analysis of the CYP51A homology model. • The T289A mutation has no effect but moderates the phenotype in the presence of Y121F. | ||
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| 700 | 1 | |a Camps, Simone M.T. |4 oth | |
| 700 | 1 | |a Karawajczyk, Anna |4 oth | |
| 700 | 1 | |a Rijs, Antonius J.M.M. |4 oth | |
| 700 | 1 | |a Zoll, Jan |4 oth | |
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10.1016/j.fgb.2015.06.001 doi GBVA2015018000024.pica (DE-627)ELV03477162X (ELSEVIER)S1087-1845(15)00143-7 DE-627 ger DE-627 rakwb eng 580 610 580 DE-600 610 DE-600 620 VZ 600 VZ 51.79 bkl 51.45 bkl Snelders, Eveline verfasserin aut Genotype–phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus 2015 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • The TR46/Y121F/T289A mutation has a high-level voriconazole (VOR) resistance. • The resistant phenotype is supported by the analysis of the CYP51A homology model. • The T289A mutation has no effect but moderates the phenotype in the presence of Y121F. cyp51A Elsevier Multi-azole resistance Elsevier Homology modelling Elsevier Aspergillus fumigatus Elsevier Camps, Simone M.T. oth Karawajczyk, Anna oth Rijs, Antonius J.M.M. oth Zoll, Jan oth Verweij, Paul E. oth Melchers, Willem J.G. oth Enthalten in Academic Press IFC: EDITORIAL BOARD 2014 FG&B : FGB Orlando, Fla (DE-627)ELV017971675 volume:82 year:2015 pages:129-135 extent:7 https://doi.org/10.1016/j.fgb.2015.06.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_70 51.79 Sonstige Werkstoffe VZ 51.45 Werkstoffe mit besonderen Eigenschaften VZ AR 82 2015 129-135 7 045F 580 |
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10.1016/j.fgb.2015.06.001 doi GBVA2015018000024.pica (DE-627)ELV03477162X (ELSEVIER)S1087-1845(15)00143-7 DE-627 ger DE-627 rakwb eng 580 610 580 DE-600 610 DE-600 620 VZ 600 VZ 51.79 bkl 51.45 bkl Snelders, Eveline verfasserin aut Genotype–phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus 2015 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • The TR46/Y121F/T289A mutation has a high-level voriconazole (VOR) resistance. • The resistant phenotype is supported by the analysis of the CYP51A homology model. • The T289A mutation has no effect but moderates the phenotype in the presence of Y121F. cyp51A Elsevier Multi-azole resistance Elsevier Homology modelling Elsevier Aspergillus fumigatus Elsevier Camps, Simone M.T. oth Karawajczyk, Anna oth Rijs, Antonius J.M.M. oth Zoll, Jan oth Verweij, Paul E. oth Melchers, Willem J.G. oth Enthalten in Academic Press IFC: EDITORIAL BOARD 2014 FG&B : FGB Orlando, Fla (DE-627)ELV017971675 volume:82 year:2015 pages:129-135 extent:7 https://doi.org/10.1016/j.fgb.2015.06.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_70 51.79 Sonstige Werkstoffe VZ 51.45 Werkstoffe mit besonderen Eigenschaften VZ AR 82 2015 129-135 7 045F 580 |
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genotype–phenotype complexity of the tr46/y121f/t289a cyp51a azole resistance mechanism in aspergillus fumigatus |
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Genotype–phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus |
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• The TR46/Y121F/T289A mutation has a high-level voriconazole (VOR) resistance. • The resistant phenotype is supported by the analysis of the CYP51A homology model. • The T289A mutation has no effect but moderates the phenotype in the presence of Y121F. |
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• The TR46/Y121F/T289A mutation has a high-level voriconazole (VOR) resistance. • The resistant phenotype is supported by the analysis of the CYP51A homology model. • The T289A mutation has no effect but moderates the phenotype in the presence of Y121F. |
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• The TR46/Y121F/T289A mutation has a high-level voriconazole (VOR) resistance. • The resistant phenotype is supported by the analysis of the CYP51A homology model. • The T289A mutation has no effect but moderates the phenotype in the presence of Y121F. |
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Genotype–phenotype complexity of the TR46/Y121F/T289A cyp51A azole resistance mechanism in Aspergillus fumigatus |
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https://doi.org/10.1016/j.fgb.2015.06.001 |
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Camps, Simone M.T. Karawajczyk, Anna Rijs, Antonius J.M.M. Zoll, Jan Verweij, Paul E. Melchers, Willem J.G. |
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Camps, Simone M.T. Karawajczyk, Anna Rijs, Antonius J.M.M. Zoll, Jan Verweij, Paul E. Melchers, Willem J.G. |
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2024-07-06T21:57:50.278Z |
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