Substrate-dependent fluorinations of highly functionalized cycloalkanes
Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nu...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kiss, Loránd [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
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| Schlagwörter: |
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| Umfang: |
7 |
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| Übergeordnetes Werk: |
Enthalten in: Therapeutic Advances in Pediatric Multiple Sclerosis - 2013, the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:72 ; year:2016 ; number:6 ; day:11 ; month:02 ; pages:781-787 ; extent:7 |
| Links: |
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| DOI / URN: |
10.1016/j.tet.2015.12.017 |
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ELV034990976 |
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| 520 | |a Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. | ||
| 520 | |a Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. | ||
| 650 | 7 | |a Stereoisomers |2 Elsevier | |
| 650 | 7 | |a Deoxygenation |2 Elsevier | |
| 650 | 7 | |a Amino acids |2 Elsevier | |
| 650 | 7 | |a Selectivity |2 Elsevier | |
| 650 | 7 | |a Fluorination |2 Elsevier | |
| 700 | 1 | |a Remete, Attila Márió |4 oth | |
| 700 | 1 | |a Nonn, Melinda |4 oth | |
| 700 | 1 | |a Fustero, Santos |4 oth | |
| 700 | 1 | |a Sillanpää, Reijo |4 oth | |
| 700 | 1 | |a Fülöp, Ferenc |4 oth | |
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10.1016/j.tet.2015.12.017 doi GBVA2016001000024.pica (DE-627)ELV034990976 (ELSEVIER)S0040-4020(15)30268-4 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 150 VZ LING DE-30 fid 77.00 bkl Kiss, Loránd verfasserin aut Substrate-dependent fluorinations of highly functionalized cycloalkanes 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. Stereoisomers Elsevier Deoxygenation Elsevier Amino acids Elsevier Selectivity Elsevier Fluorination Elsevier Remete, Attila Márió oth Nonn, Melinda oth Fustero, Santos oth Sillanpää, Reijo oth Fülöp, Ferenc oth Enthalten in Elsevier Science Therapeutic Advances in Pediatric Multiple Sclerosis 2013 the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry Amsterdam [u.a.] (DE-627)ELV011938943 volume:72 year:2016 number:6 day:11 month:02 pages:781-787 extent:7 https://doi.org/10.1016/j.tet.2015.12.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING 77.00 Psychologie: Allgemeines VZ AR 72 2016 6 11 0211 781-787 7 045F 540 |
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10.1016/j.tet.2015.12.017 doi GBVA2016001000024.pica (DE-627)ELV034990976 (ELSEVIER)S0040-4020(15)30268-4 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 150 VZ LING DE-30 fid 77.00 bkl Kiss, Loránd verfasserin aut Substrate-dependent fluorinations of highly functionalized cycloalkanes 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. Stereoisomers Elsevier Deoxygenation Elsevier Amino acids Elsevier Selectivity Elsevier Fluorination Elsevier Remete, Attila Márió oth Nonn, Melinda oth Fustero, Santos oth Sillanpää, Reijo oth Fülöp, Ferenc oth Enthalten in Elsevier Science Therapeutic Advances in Pediatric Multiple Sclerosis 2013 the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry Amsterdam [u.a.] (DE-627)ELV011938943 volume:72 year:2016 number:6 day:11 month:02 pages:781-787 extent:7 https://doi.org/10.1016/j.tet.2015.12.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING 77.00 Psychologie: Allgemeines VZ AR 72 2016 6 11 0211 781-787 7 045F 540 |
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10.1016/j.tet.2015.12.017 doi GBVA2016001000024.pica (DE-627)ELV034990976 (ELSEVIER)S0040-4020(15)30268-4 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 150 VZ LING DE-30 fid 77.00 bkl Kiss, Loránd verfasserin aut Substrate-dependent fluorinations of highly functionalized cycloalkanes 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. Stereoisomers Elsevier Deoxygenation Elsevier Amino acids Elsevier Selectivity Elsevier Fluorination Elsevier Remete, Attila Márió oth Nonn, Melinda oth Fustero, Santos oth Sillanpää, Reijo oth Fülöp, Ferenc oth Enthalten in Elsevier Science Therapeutic Advances in Pediatric Multiple Sclerosis 2013 the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry Amsterdam [u.a.] (DE-627)ELV011938943 volume:72 year:2016 number:6 day:11 month:02 pages:781-787 extent:7 https://doi.org/10.1016/j.tet.2015.12.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING 77.00 Psychologie: Allgemeines VZ AR 72 2016 6 11 0211 781-787 7 045F 540 |
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10.1016/j.tet.2015.12.017 doi GBVA2016001000024.pica (DE-627)ELV034990976 (ELSEVIER)S0040-4020(15)30268-4 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 150 VZ LING DE-30 fid 77.00 bkl Kiss, Loránd verfasserin aut Substrate-dependent fluorinations of highly functionalized cycloalkanes 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. Stereoisomers Elsevier Deoxygenation Elsevier Amino acids Elsevier Selectivity Elsevier Fluorination Elsevier Remete, Attila Márió oth Nonn, Melinda oth Fustero, Santos oth Sillanpää, Reijo oth Fülöp, Ferenc oth Enthalten in Elsevier Science Therapeutic Advances in Pediatric Multiple Sclerosis 2013 the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry Amsterdam [u.a.] (DE-627)ELV011938943 volume:72 year:2016 number:6 day:11 month:02 pages:781-787 extent:7 https://doi.org/10.1016/j.tet.2015.12.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING 77.00 Psychologie: Allgemeines VZ AR 72 2016 6 11 0211 781-787 7 045F 540 |
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10.1016/j.tet.2015.12.017 doi GBVA2016001000024.pica (DE-627)ELV034990976 (ELSEVIER)S0040-4020(15)30268-4 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 150 VZ LING DE-30 fid 77.00 bkl Kiss, Loránd verfasserin aut Substrate-dependent fluorinations of highly functionalized cycloalkanes 2016transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. Stereoisomers Elsevier Deoxygenation Elsevier Amino acids Elsevier Selectivity Elsevier Fluorination Elsevier Remete, Attila Márió oth Nonn, Melinda oth Fustero, Santos oth Sillanpää, Reijo oth Fülöp, Ferenc oth Enthalten in Elsevier Science Therapeutic Advances in Pediatric Multiple Sclerosis 2013 the international journal for the rapid publication of full original research papers and critical reviews in organic chemistry Amsterdam [u.a.] (DE-627)ELV011938943 volume:72 year:2016 number:6 day:11 month:02 pages:781-787 extent:7 https://doi.org/10.1016/j.tet.2015.12.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-LING 77.00 Psychologie: Allgemeines VZ AR 72 2016 6 11 0211 781-787 7 045F 540 |
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Enthalten in Therapeutic Advances in Pediatric Multiple Sclerosis Amsterdam [u.a.] volume:72 year:2016 number:6 day:11 month:02 pages:781-787 extent:7 |
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Substrate-dependent fluorinations of highly functionalized cycloalkanes |
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Substrate-dependent fluorinations of highly functionalized cycloalkanes |
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Therapeutic Advances in Pediatric Multiple Sclerosis |
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substrate-dependent fluorinations of highly functionalized cycloalkanes |
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Substrate-dependent fluorinations of highly functionalized cycloalkanes |
| abstract |
Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. |
| abstractGer |
Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. |
| abstract_unstemmed |
Substrate-dependent fluorinations of several highly functionalized cycloalkanes with multiple stereocentres were investigated. The synthetic transformations were based on selective functionalization of the ring CC bonds of the readily available bicyclic β-lactams by epoxidation and regioselective nucleophilic oxirane opening with azide or cyanide, followed by hydroxy–fluorine exchange with Deoxofluor. Depending on the substituents and their relative steric arrangement, the attempted fluorinations produced different types of substituted cycloalkanes. These selective, substrate-directed synthetic procedures and their presumed pathways towards interesting highly functionalized fluorinated cycloalkane scaffolds were investigated. |
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Substrate-dependent fluorinations of highly functionalized cycloalkanes |
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Remete, Attila Márió Nonn, Melinda Fustero, Santos Sillanpää, Reijo Fülöp, Ferenc |
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