Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases
The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlappi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Guerreiro, Rita [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
|---|
| Schlagwörter: |
|---|
| Umfang: |
19264 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors - Zidane, Mustapha ELSEVIER, 2021, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:38 ; year:2016 ; pages:2147-21410 ; extent:19264 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.neurobiolaging.2015.10.028 |
|---|
| Katalog-ID: |
ELV035230339 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV035230339 | ||
| 003 | DE-627 | ||
| 005 | 20230625203602.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180603s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.neurobiolaging.2015.10.028 |2 doi | |
| 028 | 5 | 2 | |a GBVA2016008000028.pica |
| 035 | |a (DE-627)ELV035230339 | ||
| 035 | |a (ELSEVIER)S0197-4580(15)00540-0 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 610 | |
| 082 | 0 | 4 | |a 610 |q DE-600 |
| 082 | 0 | 4 | |a 550 |a 520 |q VZ |
| 084 | |a 38.70 |2 bkl | ||
| 084 | |a 39.53 |2 bkl | ||
| 100 | 1 | |a Guerreiro, Rita |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| 264 | 1 | |c 2016transfer abstract | |
| 300 | |a 19264 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. | ||
| 520 | |a The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. | ||
| 650 | 7 | |a Parkinson's disease |2 Elsevier | |
| 650 | 7 | |a Genetic correlation |2 Elsevier | |
| 650 | 7 | |a Alzheimer's disease |2 Elsevier | |
| 650 | 7 | |a Dementia with Lewy bodies |2 Elsevier | |
| 700 | 1 | |a Escott-Price, Valentina |4 oth | |
| 700 | 1 | |a Darwent, Lee |4 oth | |
| 700 | 1 | |a Parkkinen, Laura |4 oth | |
| 700 | 1 | |a Ansorge, Olaf |4 oth | |
| 700 | 1 | |a Hernandez, Dena G. |4 oth | |
| 700 | 1 | |a Nalls, Michael A. |4 oth | |
| 700 | 1 | |a Clark, Lorraine |4 oth | |
| 700 | 1 | |a Honig, Lawrence |4 oth | |
| 700 | 1 | |a Marder, Karen |4 oth | |
| 700 | 1 | |a van der Flier, Wiesje |4 oth | |
| 700 | 1 | |a Holstege, Henne |4 oth | |
| 700 | 1 | |a Louwersheimer, Eva |4 oth | |
| 700 | 1 | |a Lemstra, Afina |4 oth | |
| 700 | 1 | |a Scheltens, Philip |4 oth | |
| 700 | 1 | |a Rogaeva, Ekaterina |4 oth | |
| 700 | 1 | |a St George-Hyslop, Peter |4 oth | |
| 700 | 1 | |a Londos, Elisabet |4 oth | |
| 700 | 1 | |a Zetterberg, Henrik |4 oth | |
| 700 | 1 | |a Ortega-Cubero, Sara |4 oth | |
| 700 | 1 | |a Pastor, Pau |4 oth | |
| 700 | 1 | |a Ferman, Tanis J. |4 oth | |
| 700 | 1 | |a Graff-Radford, Neill R. |4 oth | |
| 700 | 1 | |a Ross, Owen A. |4 oth | |
| 700 | 1 | |a Barber, Imelda |4 oth | |
| 700 | 1 | |a Braae, Anne |4 oth | |
| 700 | 1 | |a Brown, Kristelle |4 oth | |
| 700 | 1 | |a Morgan, Kevin |4 oth | |
| 700 | 1 | |a Maetzler, Walter |4 oth | |
| 700 | 1 | |a Berg, Daniela |4 oth | |
| 700 | 1 | |a Troakes, Claire |4 oth | |
| 700 | 1 | |a Al-Sarraj, Safa |4 oth | |
| 700 | 1 | |a Lashley, Tammaryn |4 oth | |
| 700 | 1 | |a Compta, Yaroslau |4 oth | |
| 700 | 1 | |a Revesz, Tamas |4 oth | |
| 700 | 1 | |a Lees, Andrew |4 oth | |
| 700 | 1 | |a Cairns, Nigel J. |4 oth | |
| 700 | 1 | |a Halliday, Glenda M. |4 oth | |
| 700 | 1 | |a Mann, David |4 oth | |
| 700 | 1 | |a Pickering-Brown, Stuart |4 oth | |
| 700 | 1 | |a Powell, John |4 oth | |
| 700 | 1 | |a Lunnon, Katie |4 oth | |
| 700 | 1 | |a Lupton, Michelle K. |4 oth | |
| 700 | 1 | |a Dickson, Dennis |4 oth | |
| 700 | 1 | |a Hardy, John |4 oth | |
| 700 | 1 | |a Singleton, Andrew |4 oth | |
| 700 | 1 | |a Bras, Jose |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Zidane, Mustapha ELSEVIER |t Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors |d 2021 |g Amsterdam [u.a.] |w (DE-627)ELV005660645 |
| 773 | 1 | 8 | |g volume:38 |g year:2016 |g pages:2147-21410 |g extent:19264 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.neurobiolaging.2015.10.028 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 912 | |a SSG-OPC-GGO | ||
| 912 | |a SSG-OPC-GEO | ||
| 912 | |a SSG-OPC-AST | ||
| 936 | b | k | |a 38.70 |j Geophysik: Allgemeines |q VZ |
| 936 | b | k | |a 39.53 |j Planeten |q VZ |
| 951 | |a AR | ||
| 952 | |d 38 |j 2016 |h 2147-21410 |g 19264 |y 38.2016, 214.e7-, (19264 S.) | ||
| 953 | |2 045F |a 610 | ||
| author_variant |
r g rg |
|---|---|
| matchkey_str |
guerreiroritaescottpricevalentinadarwent:2016----:eoeienlssfeeicreainneetaiheyoisakn |
| hierarchy_sort_str |
2016transfer abstract |
| bklnumber |
38.70 39.53 |
| publishDate |
2016 |
| allfields |
10.1016/j.neurobiolaging.2015.10.028 doi GBVA2016008000028.pica (DE-627)ELV035230339 (ELSEVIER)S0197-4580(15)00540-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl Guerreiro, Rita verfasserin aut Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases 2016transfer abstract 19264 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. Parkinson's disease Elsevier Genetic correlation Elsevier Alzheimer's disease Elsevier Dementia with Lewy bodies Elsevier Escott-Price, Valentina oth Darwent, Lee oth Parkkinen, Laura oth Ansorge, Olaf oth Hernandez, Dena G. oth Nalls, Michael A. oth Clark, Lorraine oth Honig, Lawrence oth Marder, Karen oth van der Flier, Wiesje oth Holstege, Henne oth Louwersheimer, Eva oth Lemstra, Afina oth Scheltens, Philip oth Rogaeva, Ekaterina oth St George-Hyslop, Peter oth Londos, Elisabet oth Zetterberg, Henrik oth Ortega-Cubero, Sara oth Pastor, Pau oth Ferman, Tanis J. oth Graff-Radford, Neill R. oth Ross, Owen A. oth Barber, Imelda oth Braae, Anne oth Brown, Kristelle oth Morgan, Kevin oth Maetzler, Walter oth Berg, Daniela oth Troakes, Claire oth Al-Sarraj, Safa oth Lashley, Tammaryn oth Compta, Yaroslau oth Revesz, Tamas oth Lees, Andrew oth Cairns, Nigel J. oth Halliday, Glenda M. oth Mann, David oth Pickering-Brown, Stuart oth Powell, John oth Lunnon, Katie oth Lupton, Michelle K. oth Dickson, Dennis oth Hardy, John oth Singleton, Andrew oth Bras, Jose oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:38 year:2016 pages:2147-21410 extent:19264 https://doi.org/10.1016/j.neurobiolaging.2015.10.028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 38 2016 2147-21410 19264 38.2016, 214.e7-, (19264 S.) 045F 610 |
| spelling |
10.1016/j.neurobiolaging.2015.10.028 doi GBVA2016008000028.pica (DE-627)ELV035230339 (ELSEVIER)S0197-4580(15)00540-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl Guerreiro, Rita verfasserin aut Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases 2016transfer abstract 19264 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. Parkinson's disease Elsevier Genetic correlation Elsevier Alzheimer's disease Elsevier Dementia with Lewy bodies Elsevier Escott-Price, Valentina oth Darwent, Lee oth Parkkinen, Laura oth Ansorge, Olaf oth Hernandez, Dena G. oth Nalls, Michael A. oth Clark, Lorraine oth Honig, Lawrence oth Marder, Karen oth van der Flier, Wiesje oth Holstege, Henne oth Louwersheimer, Eva oth Lemstra, Afina oth Scheltens, Philip oth Rogaeva, Ekaterina oth St George-Hyslop, Peter oth Londos, Elisabet oth Zetterberg, Henrik oth Ortega-Cubero, Sara oth Pastor, Pau oth Ferman, Tanis J. oth Graff-Radford, Neill R. oth Ross, Owen A. oth Barber, Imelda oth Braae, Anne oth Brown, Kristelle oth Morgan, Kevin oth Maetzler, Walter oth Berg, Daniela oth Troakes, Claire oth Al-Sarraj, Safa oth Lashley, Tammaryn oth Compta, Yaroslau oth Revesz, Tamas oth Lees, Andrew oth Cairns, Nigel J. oth Halliday, Glenda M. oth Mann, David oth Pickering-Brown, Stuart oth Powell, John oth Lunnon, Katie oth Lupton, Michelle K. oth Dickson, Dennis oth Hardy, John oth Singleton, Andrew oth Bras, Jose oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:38 year:2016 pages:2147-21410 extent:19264 https://doi.org/10.1016/j.neurobiolaging.2015.10.028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 38 2016 2147-21410 19264 38.2016, 214.e7-, (19264 S.) 045F 610 |
| allfields_unstemmed |
10.1016/j.neurobiolaging.2015.10.028 doi GBVA2016008000028.pica (DE-627)ELV035230339 (ELSEVIER)S0197-4580(15)00540-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl Guerreiro, Rita verfasserin aut Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases 2016transfer abstract 19264 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. Parkinson's disease Elsevier Genetic correlation Elsevier Alzheimer's disease Elsevier Dementia with Lewy bodies Elsevier Escott-Price, Valentina oth Darwent, Lee oth Parkkinen, Laura oth Ansorge, Olaf oth Hernandez, Dena G. oth Nalls, Michael A. oth Clark, Lorraine oth Honig, Lawrence oth Marder, Karen oth van der Flier, Wiesje oth Holstege, Henne oth Louwersheimer, Eva oth Lemstra, Afina oth Scheltens, Philip oth Rogaeva, Ekaterina oth St George-Hyslop, Peter oth Londos, Elisabet oth Zetterberg, Henrik oth Ortega-Cubero, Sara oth Pastor, Pau oth Ferman, Tanis J. oth Graff-Radford, Neill R. oth Ross, Owen A. oth Barber, Imelda oth Braae, Anne oth Brown, Kristelle oth Morgan, Kevin oth Maetzler, Walter oth Berg, Daniela oth Troakes, Claire oth Al-Sarraj, Safa oth Lashley, Tammaryn oth Compta, Yaroslau oth Revesz, Tamas oth Lees, Andrew oth Cairns, Nigel J. oth Halliday, Glenda M. oth Mann, David oth Pickering-Brown, Stuart oth Powell, John oth Lunnon, Katie oth Lupton, Michelle K. oth Dickson, Dennis oth Hardy, John oth Singleton, Andrew oth Bras, Jose oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:38 year:2016 pages:2147-21410 extent:19264 https://doi.org/10.1016/j.neurobiolaging.2015.10.028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 38 2016 2147-21410 19264 38.2016, 214.e7-, (19264 S.) 045F 610 |
| allfieldsGer |
10.1016/j.neurobiolaging.2015.10.028 doi GBVA2016008000028.pica (DE-627)ELV035230339 (ELSEVIER)S0197-4580(15)00540-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl Guerreiro, Rita verfasserin aut Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases 2016transfer abstract 19264 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. Parkinson's disease Elsevier Genetic correlation Elsevier Alzheimer's disease Elsevier Dementia with Lewy bodies Elsevier Escott-Price, Valentina oth Darwent, Lee oth Parkkinen, Laura oth Ansorge, Olaf oth Hernandez, Dena G. oth Nalls, Michael A. oth Clark, Lorraine oth Honig, Lawrence oth Marder, Karen oth van der Flier, Wiesje oth Holstege, Henne oth Louwersheimer, Eva oth Lemstra, Afina oth Scheltens, Philip oth Rogaeva, Ekaterina oth St George-Hyslop, Peter oth Londos, Elisabet oth Zetterberg, Henrik oth Ortega-Cubero, Sara oth Pastor, Pau oth Ferman, Tanis J. oth Graff-Radford, Neill R. oth Ross, Owen A. oth Barber, Imelda oth Braae, Anne oth Brown, Kristelle oth Morgan, Kevin oth Maetzler, Walter oth Berg, Daniela oth Troakes, Claire oth Al-Sarraj, Safa oth Lashley, Tammaryn oth Compta, Yaroslau oth Revesz, Tamas oth Lees, Andrew oth Cairns, Nigel J. oth Halliday, Glenda M. oth Mann, David oth Pickering-Brown, Stuart oth Powell, John oth Lunnon, Katie oth Lupton, Michelle K. oth Dickson, Dennis oth Hardy, John oth Singleton, Andrew oth Bras, Jose oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:38 year:2016 pages:2147-21410 extent:19264 https://doi.org/10.1016/j.neurobiolaging.2015.10.028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 38 2016 2147-21410 19264 38.2016, 214.e7-, (19264 S.) 045F 610 |
| allfieldsSound |
10.1016/j.neurobiolaging.2015.10.028 doi GBVA2016008000028.pica (DE-627)ELV035230339 (ELSEVIER)S0197-4580(15)00540-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl Guerreiro, Rita verfasserin aut Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases 2016transfer abstract 19264 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. Parkinson's disease Elsevier Genetic correlation Elsevier Alzheimer's disease Elsevier Dementia with Lewy bodies Elsevier Escott-Price, Valentina oth Darwent, Lee oth Parkkinen, Laura oth Ansorge, Olaf oth Hernandez, Dena G. oth Nalls, Michael A. oth Clark, Lorraine oth Honig, Lawrence oth Marder, Karen oth van der Flier, Wiesje oth Holstege, Henne oth Louwersheimer, Eva oth Lemstra, Afina oth Scheltens, Philip oth Rogaeva, Ekaterina oth St George-Hyslop, Peter oth Londos, Elisabet oth Zetterberg, Henrik oth Ortega-Cubero, Sara oth Pastor, Pau oth Ferman, Tanis J. oth Graff-Radford, Neill R. oth Ross, Owen A. oth Barber, Imelda oth Braae, Anne oth Brown, Kristelle oth Morgan, Kevin oth Maetzler, Walter oth Berg, Daniela oth Troakes, Claire oth Al-Sarraj, Safa oth Lashley, Tammaryn oth Compta, Yaroslau oth Revesz, Tamas oth Lees, Andrew oth Cairns, Nigel J. oth Halliday, Glenda M. oth Mann, David oth Pickering-Brown, Stuart oth Powell, John oth Lunnon, Katie oth Lupton, Michelle K. oth Dickson, Dennis oth Hardy, John oth Singleton, Andrew oth Bras, Jose oth Enthalten in Elsevier Science Zidane, Mustapha ELSEVIER Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors 2021 Amsterdam [u.a.] (DE-627)ELV005660645 volume:38 year:2016 pages:2147-21410 extent:19264 https://doi.org/10.1016/j.neurobiolaging.2015.10.028 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST 38.70 Geophysik: Allgemeines VZ 39.53 Planeten VZ AR 38 2016 2147-21410 19264 38.2016, 214.e7-, (19264 S.) 045F 610 |
| language |
English |
| source |
Enthalten in Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors Amsterdam [u.a.] volume:38 year:2016 pages:2147-21410 extent:19264 |
| sourceStr |
Enthalten in Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors Amsterdam [u.a.] volume:38 year:2016 pages:2147-21410 extent:19264 |
| format_phy_str_mv |
Article |
| bklname |
Geophysik: Allgemeines Planeten |
| institution |
findex.gbv.de |
| topic_facet |
Parkinson's disease Genetic correlation Alzheimer's disease Dementia with Lewy bodies |
| dewey-raw |
610 |
| isfreeaccess_bool |
false |
| container_title |
Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors |
| authorswithroles_txt_mv |
Guerreiro, Rita @@aut@@ Escott-Price, Valentina @@oth@@ Darwent, Lee @@oth@@ Parkkinen, Laura @@oth@@ Ansorge, Olaf @@oth@@ Hernandez, Dena G. @@oth@@ Nalls, Michael A. @@oth@@ Clark, Lorraine @@oth@@ Honig, Lawrence @@oth@@ Marder, Karen @@oth@@ van der Flier, Wiesje @@oth@@ Holstege, Henne @@oth@@ Louwersheimer, Eva @@oth@@ Lemstra, Afina @@oth@@ Scheltens, Philip @@oth@@ Rogaeva, Ekaterina @@oth@@ St George-Hyslop, Peter @@oth@@ Londos, Elisabet @@oth@@ Zetterberg, Henrik @@oth@@ Ortega-Cubero, Sara @@oth@@ Pastor, Pau @@oth@@ Ferman, Tanis J. @@oth@@ Graff-Radford, Neill R. @@oth@@ Ross, Owen A. @@oth@@ Barber, Imelda @@oth@@ Braae, Anne @@oth@@ Brown, Kristelle @@oth@@ Morgan, Kevin @@oth@@ Maetzler, Walter @@oth@@ Berg, Daniela @@oth@@ Troakes, Claire @@oth@@ Al-Sarraj, Safa @@oth@@ Lashley, Tammaryn @@oth@@ Compta, Yaroslau @@oth@@ Revesz, Tamas @@oth@@ Lees, Andrew @@oth@@ Cairns, Nigel J. @@oth@@ Halliday, Glenda M. @@oth@@ Mann, David @@oth@@ Pickering-Brown, Stuart @@oth@@ Powell, John @@oth@@ Lunnon, Katie @@oth@@ Lupton, Michelle K. @@oth@@ Dickson, Dennis @@oth@@ Hardy, John @@oth@@ Singleton, Andrew @@oth@@ Bras, Jose @@oth@@ |
| publishDateDaySort_date |
2016-01-01T00:00:00Z |
| hierarchy_top_id |
ELV005660645 |
| dewey-sort |
3610 |
| id |
ELV035230339 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV035230339</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625203602.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2016 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.neurobiolaging.2015.10.028</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2016008000028.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV035230339</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0197-4580(15)00540-0</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">550</subfield><subfield code="a">520</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">38.70</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">39.53</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Guerreiro, Rita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">19264</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Parkinson's disease</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Genetic correlation</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Alzheimer's disease</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Dementia with Lewy bodies</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Escott-Price, Valentina</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Darwent, Lee</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Parkkinen, Laura</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ansorge, Olaf</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hernandez, Dena G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nalls, Michael A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Clark, Lorraine</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Honig, Lawrence</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Marder, Karen</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">van der Flier, Wiesje</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Holstege, Henne</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Louwersheimer, Eva</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lemstra, Afina</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Scheltens, Philip</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rogaeva, Ekaterina</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">St George-Hyslop, Peter</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Londos, Elisabet</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zetterberg, Henrik</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ortega-Cubero, Sara</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pastor, Pau</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ferman, Tanis J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Graff-Radford, Neill R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ross, Owen A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Barber, Imelda</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Braae, Anne</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brown, Kristelle</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Morgan, Kevin</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Maetzler, Walter</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Berg, Daniela</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Troakes, Claire</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Al-Sarraj, Safa</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lashley, Tammaryn</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Compta, Yaroslau</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Revesz, Tamas</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lees, Andrew</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cairns, Nigel J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Halliday, Glenda M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mann, David</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pickering-Brown, Stuart</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Powell, John</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lunnon, Katie</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lupton, Michelle K.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dickson, Dennis</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hardy, John</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Singleton, Andrew</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bras, Jose</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Zidane, Mustapha ELSEVIER</subfield><subfield code="t">Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors</subfield><subfield code="d">2021</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV005660645</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:38</subfield><subfield code="g">year:2016</subfield><subfield code="g">pages:2147-21410</subfield><subfield code="g">extent:19264</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.neurobiolaging.2015.10.028</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GGO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GEO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-AST</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">38.70</subfield><subfield code="j">Geophysik: Allgemeines</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">39.53</subfield><subfield code="j">Planeten</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">38</subfield><subfield code="j">2016</subfield><subfield code="h">2147-21410</subfield><subfield code="g">19264</subfield><subfield code="y">38.2016, 214.e7-, (19264 S.)</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| author |
Guerreiro, Rita |
| spellingShingle |
Guerreiro, Rita ddc 610 ddc 550 bkl 38.70 bkl 39.53 Elsevier Parkinson's disease Elsevier Genetic correlation Elsevier Alzheimer's disease Elsevier Dementia with Lewy bodies Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| authorStr |
Guerreiro, Rita |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV005660645 |
| format |
electronic Article |
| dewey-ones |
610 - Medicine & health 550 - Earth sciences 520 - Astronomy & allied sciences |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases Parkinson's disease Elsevier Genetic correlation Elsevier Alzheimer's disease Elsevier Dementia with Lewy bodies Elsevier |
| topic |
ddc 610 ddc 550 bkl 38.70 bkl 39.53 Elsevier Parkinson's disease Elsevier Genetic correlation Elsevier Alzheimer's disease Elsevier Dementia with Lewy bodies |
| topic_unstemmed |
ddc 610 ddc 550 bkl 38.70 bkl 39.53 Elsevier Parkinson's disease Elsevier Genetic correlation Elsevier Alzheimer's disease Elsevier Dementia with Lewy bodies |
| topic_browse |
ddc 610 ddc 550 bkl 38.70 bkl 39.53 Elsevier Parkinson's disease Elsevier Genetic correlation Elsevier Alzheimer's disease Elsevier Dementia with Lewy bodies |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
v e p vep l d ld l p lp o a oa d g h dg dgh m a n ma man l c lc l h lh k m km d f w v dfw dfwv h h hh e l el a l al p s ps e r er g h p s ghp ghps e l el h z hz s o c soc p p pp t j f tj tjf n r g r nrg nrgr o a r oa oar i b ib a b ab k b kb k m km w m wm d b db c t ct s a s sas t l tl y c yc t r tr a l al n j c nj njc g m h gm gmh d m dm s p b spb j p jp k l kl m k l mk mkl d d dd j h jh a s as j b jb |
| hierarchy_parent_title |
Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors |
| hierarchy_parent_id |
ELV005660645 |
| dewey-tens |
610 - Medicine & health 550 - Earth sciences & geology 520 - Astronomy |
| hierarchy_top_title |
Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV005660645 |
| title |
Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| ctrlnum |
(DE-627)ELV035230339 (ELSEVIER)S0197-4580(15)00540-0 |
| title_full |
Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| author_sort |
Guerreiro, Rita |
| journal |
Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors |
| journalStr |
Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology 500 - Science |
| recordtype |
marc |
| publishDateSort |
2016 |
| contenttype_str_mv |
zzz |
| container_start_page |
2147 |
| author_browse |
Guerreiro, Rita |
| container_volume |
38 |
| physical |
19264 |
| class |
610 610 DE-600 550 520 VZ 38.70 bkl 39.53 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Guerreiro, Rita |
| doi_str_mv |
10.1016/j.neurobiolaging.2015.10.028 |
| dewey-full |
610 550 520 |
| title_sort |
genome-wide analysis of genetic correlation in dementia with lewy bodies, parkinson's and alzheimer's diseases |
| title_auth |
Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| abstract |
The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. |
| abstractGer |
The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. |
| abstract_unstemmed |
The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO SSG-OPC-GEO SSG-OPC-AST |
| title_short |
Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| url |
https://doi.org/10.1016/j.neurobiolaging.2015.10.028 |
| remote_bool |
true |
| author2 |
Escott-Price, Valentina Darwent, Lee Parkkinen, Laura Ansorge, Olaf Hernandez, Dena G. Nalls, Michael A. Clark, Lorraine Honig, Lawrence Marder, Karen van der Flier, Wiesje Holstege, Henne Louwersheimer, Eva Lemstra, Afina Scheltens, Philip Rogaeva, Ekaterina St George-Hyslop, Peter Londos, Elisabet Zetterberg, Henrik Ortega-Cubero, Sara Pastor, Pau Ferman, Tanis J. Graff-Radford, Neill R. Ross, Owen A. Barber, Imelda Braae, Anne Brown, Kristelle Morgan, Kevin Maetzler, Walter Berg, Daniela Troakes, Claire Al-Sarraj, Safa Lashley, Tammaryn Compta, Yaroslau Revesz, Tamas Lees, Andrew Cairns, Nigel J. Halliday, Glenda M. Mann, David Pickering-Brown, Stuart Powell, John Lunnon, Katie Lupton, Michelle K. Dickson, Dennis Hardy, John Singleton, Andrew Bras, Jose |
| author2Str |
Escott-Price, Valentina Darwent, Lee Parkkinen, Laura Ansorge, Olaf Hernandez, Dena G. Nalls, Michael A. Clark, Lorraine Honig, Lawrence Marder, Karen van der Flier, Wiesje Holstege, Henne Louwersheimer, Eva Lemstra, Afina Scheltens, Philip Rogaeva, Ekaterina St George-Hyslop, Peter Londos, Elisabet Zetterberg, Henrik Ortega-Cubero, Sara Pastor, Pau Ferman, Tanis J. Graff-Radford, Neill R. Ross, Owen A. Barber, Imelda Braae, Anne Brown, Kristelle Morgan, Kevin Maetzler, Walter Berg, Daniela Troakes, Claire Al-Sarraj, Safa Lashley, Tammaryn Compta, Yaroslau Revesz, Tamas Lees, Andrew Cairns, Nigel J. Halliday, Glenda M. Mann, David Pickering-Brown, Stuart Powell, John Lunnon, Katie Lupton, Michelle K. Dickson, Dennis Hardy, John Singleton, Andrew Bras, Jose |
| ppnlink |
ELV005660645 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth |
| doi_str |
10.1016/j.neurobiolaging.2015.10.028 |
| up_date |
2024-07-06T17:01:45.998Z |
| _version_ |
1803849885026353152 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV035230339</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625203602.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2016 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.neurobiolaging.2015.10.028</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2016008000028.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV035230339</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0197-4580(15)00540-0</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">550</subfield><subfield code="a">520</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">38.70</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">39.53</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Guerreiro, Rita</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2016transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">19264</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Parkinson's disease</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Genetic correlation</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Alzheimer's disease</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Dementia with Lewy bodies</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Escott-Price, Valentina</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Darwent, Lee</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Parkkinen, Laura</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ansorge, Olaf</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hernandez, Dena G.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nalls, Michael A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Clark, Lorraine</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Honig, Lawrence</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Marder, Karen</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">van der Flier, Wiesje</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Holstege, Henne</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Louwersheimer, Eva</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lemstra, Afina</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Scheltens, Philip</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rogaeva, Ekaterina</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">St George-Hyslop, Peter</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Londos, Elisabet</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Zetterberg, Henrik</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ortega-Cubero, Sara</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pastor, Pau</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ferman, Tanis J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Graff-Radford, Neill R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ross, Owen A.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Barber, Imelda</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Braae, Anne</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Brown, Kristelle</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Morgan, Kevin</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Maetzler, Walter</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Berg, Daniela</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Troakes, Claire</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Al-Sarraj, Safa</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lashley, Tammaryn</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Compta, Yaroslau</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Revesz, Tamas</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lees, Andrew</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cairns, Nigel J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Halliday, Glenda M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mann, David</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pickering-Brown, Stuart</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Powell, John</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lunnon, Katie</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lupton, Michelle K.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dickson, Dennis</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hardy, John</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Singleton, Andrew</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bras, Jose</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Zidane, Mustapha ELSEVIER</subfield><subfield code="t">Corrigendum to “Electrical and thermal transport properties of Fe–Ni based ternary alloys in the earth's inner core: An ab initio study” [Physics of the Earth and Planetary Interiors</subfield><subfield code="d">2021</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV005660645</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:38</subfield><subfield code="g">year:2016</subfield><subfield code="g">pages:2147-21410</subfield><subfield code="g">extent:19264</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.neurobiolaging.2015.10.028</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GGO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-GEO</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OPC-AST</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">38.70</subfield><subfield code="j">Geophysik: Allgemeines</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">39.53</subfield><subfield code="j">Planeten</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">38</subfield><subfield code="j">2016</subfield><subfield code="h">2147-21410</subfield><subfield code="g">19264</subfield><subfield code="y">38.2016, 214.e7-, (19264 S.)</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| score |
7.4027834 |