Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy
• Pregnant RAGE−/− mice produce offspring, which are indistinguishable from WT offspring. • Diabetes in pregnant WT mice yields fetal congenital malformations. • Diabetes in pregnant RAGE−/− mice yields fewer congenital malformations than WT mice. • Fetuses of diabetic RAGE−/− mice have lower NF-κB...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ejdesjö, Andreas [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Porous silicon Bragg mirrors on single- and multi-crystalline silicon for solar cells - 2013transfer abstract, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:62 ; year:2016 ; pages:62-70 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.reprotox.2016.04.015 |
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| 520 | |a • Pregnant RAGE−/− mice produce offspring, which are indistinguishable from WT offspring. • Diabetes in pregnant WT mice yields fetal congenital malformations. • Diabetes in pregnant RAGE−/− mice yields fewer congenital malformations than WT mice. • Fetuses of diabetic RAGE−/− mice have lower NF-κB activation and isoprostane levels than WT. • RAGE activation is involved in the teratogenicity of diabetic pregnancy. | ||
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receptor for advanced glycation end products (rage) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy |
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Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy |
| abstract |
• Pregnant RAGE−/− mice produce offspring, which are indistinguishable from WT offspring. • Diabetes in pregnant WT mice yields fetal congenital malformations. • Diabetes in pregnant RAGE−/− mice yields fewer congenital malformations than WT mice. • Fetuses of diabetic RAGE−/− mice have lower NF-κB activation and isoprostane levels than WT. • RAGE activation is involved in the teratogenicity of diabetic pregnancy. |
| abstractGer |
• Pregnant RAGE−/− mice produce offspring, which are indistinguishable from WT offspring. • Diabetes in pregnant WT mice yields fetal congenital malformations. • Diabetes in pregnant RAGE−/− mice yields fewer congenital malformations than WT mice. • Fetuses of diabetic RAGE−/− mice have lower NF-κB activation and isoprostane levels than WT. • RAGE activation is involved in the teratogenicity of diabetic pregnancy. |
| abstract_unstemmed |
• Pregnant RAGE−/− mice produce offspring, which are indistinguishable from WT offspring. • Diabetes in pregnant WT mice yields fetal congenital malformations. • Diabetes in pregnant RAGE−/− mice yields fewer congenital malformations than WT mice. • Fetuses of diabetic RAGE−/− mice have lower NF-κB activation and isoprostane levels than WT. • RAGE activation is involved in the teratogenicity of diabetic pregnancy. |
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Receptor for advanced glycation end products (RAGE) knockout reduces fetal dysmorphogenesis in murine diabetic pregnancy |
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Brings, Sebastian Fleming, Thomas Fred, Rikard G. Nawroth, Peter P. Eriksson, Ulf J. |
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