EFIS Lecture: Understanding the CTLA-4 checkpoint in the maintenance of immune homeostasis
• CTLA-4 is a critical negative regulator of the T cell immune responses. • CTLA-4 can function in a cell-extrinsic manner. • CTLA-4 is required for regulatory T cell function in certain settings. • CTLA-4 can downregulate its ligands by a process of trans-endocytosis. • By controlling follicular he...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Walker, Lucy S.K. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Time-management Changes After Implementation of Data Mining Software - Wick, Kelsey ELSEVIER, 2014, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:184 ; year:2017 ; pages:43-50 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.imlet.2017.02.007 |
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| 520 | |a • CTLA-4 is a critical negative regulator of the T cell immune responses. • CTLA-4 can function in a cell-extrinsic manner. • CTLA-4 is required for regulatory T cell function in certain settings. • CTLA-4 can downregulate its ligands by a process of trans-endocytosis. • By controlling follicular helper T cell differentiation, CTLA-4 can regulate B-cell as well as T-cell responses. | ||
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• CTLA-4 is a critical negative regulator of the T cell immune responses. • CTLA-4 can function in a cell-extrinsic manner. • CTLA-4 is required for regulatory T cell function in certain settings. • CTLA-4 can downregulate its ligands by a process of trans-endocytosis. • By controlling follicular helper T cell differentiation, CTLA-4 can regulate B-cell as well as T-cell responses. |
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• CTLA-4 is a critical negative regulator of the T cell immune responses. • CTLA-4 can function in a cell-extrinsic manner. • CTLA-4 is required for regulatory T cell function in certain settings. • CTLA-4 can downregulate its ligands by a process of trans-endocytosis. • By controlling follicular helper T cell differentiation, CTLA-4 can regulate B-cell as well as T-cell responses. |
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• CTLA-4 is a critical negative regulator of the T cell immune responses. • CTLA-4 can function in a cell-extrinsic manner. • CTLA-4 is required for regulatory T cell function in certain settings. • CTLA-4 can downregulate its ligands by a process of trans-endocytosis. • By controlling follicular helper T cell differentiation, CTLA-4 can regulate B-cell as well as T-cell responses. |
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