EFIS Lecture: Understanding the CTLA-4 checkpoint in the maintenance of immune homeostasis
• CTLA-4 is a critical negative regulator of the T cell immune responses. • CTLA-4 can function in a cell-extrinsic manner. • CTLA-4 is required for regulatory T cell function in certain settings. • CTLA-4 can downregulate its ligands by a process of trans-endocytosis. • By controlling follicular he...
Ausführliche Beschreibung
Autor*in: |
Walker, Lucy S.K. [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2017 |
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Schlagwörter: |
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Umfang: |
8 |
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Übergeordnetes Werk: |
Enthalten in: Time-management Changes After Implementation of Data Mining Software - Wick, Kelsey ELSEVIER, 2014, Amsterdam [u.a.] |
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Übergeordnetes Werk: |
volume:184 ; year:2017 ; pages:43-50 ; extent:8 |
Links: |
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DOI / URN: |
10.1016/j.imlet.2017.02.007 |
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10.1016/j.imlet.2017.02.007 doi GBV00000000000059A.pica (DE-627)ELV035743522 (ELSEVIER)S0165-2478(17)30073-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 540 VZ 35.18 bkl Walker, Lucy S.K. verfasserin aut EFIS Lecture: Understanding the CTLA-4 checkpoint in the maintenance of immune homeostasis 2017 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • CTLA-4 is a critical negative regulator of the T cell immune responses. • CTLA-4 can function in a cell-extrinsic manner. • CTLA-4 is required for regulatory T cell function in certain settings. • CTLA-4 can downregulate its ligands by a process of trans-endocytosis. • By controlling follicular helper T cell differentiation, CTLA-4 can regulate B-cell as well as T-cell responses. Autoimmunity Elsevier T-cells Elsevier Costimulation Elsevier CD28 Elsevier Tolerance Elsevier CTLA-4 Elsevier Enthalten in Elsevier Science Wick, Kelsey ELSEVIER Time-management Changes After Implementation of Data Mining Software 2014 Amsterdam [u.a.] (DE-627)ELV022562427 volume:184 year:2017 pages:43-50 extent:8 https://doi.org/10.1016/j.imlet.2017.02.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_120 GBV_ILN_130 35.18 Kolloidchemie Grenzflächenchemie VZ AR 184 2017 43-50 8 045F 610 |
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10.1016/j.imlet.2017.02.007 doi GBV00000000000059A.pica (DE-627)ELV035743522 (ELSEVIER)S0165-2478(17)30073-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 540 VZ 35.18 bkl Walker, Lucy S.K. verfasserin aut EFIS Lecture: Understanding the CTLA-4 checkpoint in the maintenance of immune homeostasis 2017 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • CTLA-4 is a critical negative regulator of the T cell immune responses. • CTLA-4 can function in a cell-extrinsic manner. • CTLA-4 is required for regulatory T cell function in certain settings. • CTLA-4 can downregulate its ligands by a process of trans-endocytosis. • By controlling follicular helper T cell differentiation, CTLA-4 can regulate B-cell as well as T-cell responses. Autoimmunity Elsevier T-cells Elsevier Costimulation Elsevier CD28 Elsevier Tolerance Elsevier CTLA-4 Elsevier Enthalten in Elsevier Science Wick, Kelsey ELSEVIER Time-management Changes After Implementation of Data Mining Software 2014 Amsterdam [u.a.] (DE-627)ELV022562427 volume:184 year:2017 pages:43-50 extent:8 https://doi.org/10.1016/j.imlet.2017.02.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_120 GBV_ILN_130 35.18 Kolloidchemie Grenzflächenchemie VZ AR 184 2017 43-50 8 045F 610 |
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• CTLA-4 is a critical negative regulator of the T cell immune responses. • CTLA-4 can function in a cell-extrinsic manner. • CTLA-4 is required for regulatory T cell function in certain settings. • CTLA-4 can downregulate its ligands by a process of trans-endocytosis. • By controlling follicular helper T cell differentiation, CTLA-4 can regulate B-cell as well as T-cell responses. |
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• CTLA-4 is a critical negative regulator of the T cell immune responses. • CTLA-4 can function in a cell-extrinsic manner. • CTLA-4 is required for regulatory T cell function in certain settings. • CTLA-4 can downregulate its ligands by a process of trans-endocytosis. • By controlling follicular helper T cell differentiation, CTLA-4 can regulate B-cell as well as T-cell responses. |
abstract_unstemmed |
• CTLA-4 is a critical negative regulator of the T cell immune responses. • CTLA-4 can function in a cell-extrinsic manner. • CTLA-4 is required for regulatory T cell function in certain settings. • CTLA-4 can downregulate its ligands by a process of trans-endocytosis. • By controlling follicular helper T cell differentiation, CTLA-4 can regulate B-cell as well as T-cell responses. |
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