Microglia activation induced by serum of SLE patients
To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wang, Jianing [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process - Li, Kuo ELSEVIER, 2020, official journal of the International Society for Neuroimmunology, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:310 ; year:2017 ; day:15 ; month:09 ; pages:135-142 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.jneuroim.2017.07.010 |
|---|
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| 520 | |a To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. | ||
| 520 | |a To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. | ||
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| 700 | 1 | |a Yang, Pingting |4 oth | |
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10.1016/j.jneuroim.2017.07.010 doi GBVA2017005000019.pica (DE-627)ELV035745029 (ELSEVIER)S0165-5728(17)30075-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Wang, Jianing verfasserin aut Microglia activation induced by serum of SLE patients 2017transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. Yang, Chunshu oth Zhao, Qi oth Zhu, Ziwei oth Li, Yujia oth Yang, Pingting oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:310 year:2017 day:15 month:09 pages:135-142 extent:8 https://doi.org/10.1016/j.jneuroim.2017.07.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 310 2017 15 0915 135-142 8 045F 610 |
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10.1016/j.jneuroim.2017.07.010 doi GBVA2017005000019.pica (DE-627)ELV035745029 (ELSEVIER)S0165-5728(17)30075-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Wang, Jianing verfasserin aut Microglia activation induced by serum of SLE patients 2017transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. Yang, Chunshu oth Zhao, Qi oth Zhu, Ziwei oth Li, Yujia oth Yang, Pingting oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:310 year:2017 day:15 month:09 pages:135-142 extent:8 https://doi.org/10.1016/j.jneuroim.2017.07.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 310 2017 15 0915 135-142 8 045F 610 |
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10.1016/j.jneuroim.2017.07.010 doi GBVA2017005000019.pica (DE-627)ELV035745029 (ELSEVIER)S0165-5728(17)30075-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Wang, Jianing verfasserin aut Microglia activation induced by serum of SLE patients 2017transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. Yang, Chunshu oth Zhao, Qi oth Zhu, Ziwei oth Li, Yujia oth Yang, Pingting oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:310 year:2017 day:15 month:09 pages:135-142 extent:8 https://doi.org/10.1016/j.jneuroim.2017.07.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 310 2017 15 0915 135-142 8 045F 610 |
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10.1016/j.jneuroim.2017.07.010 doi GBVA2017005000019.pica (DE-627)ELV035745029 (ELSEVIER)S0165-5728(17)30075-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Wang, Jianing verfasserin aut Microglia activation induced by serum of SLE patients 2017transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. Yang, Chunshu oth Zhao, Qi oth Zhu, Ziwei oth Li, Yujia oth Yang, Pingting oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:310 year:2017 day:15 month:09 pages:135-142 extent:8 https://doi.org/10.1016/j.jneuroim.2017.07.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 310 2017 15 0915 135-142 8 045F 610 |
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10.1016/j.jneuroim.2017.07.010 doi GBVA2017005000019.pica (DE-627)ELV035745029 (ELSEVIER)S0165-5728(17)30075-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Wang, Jianing verfasserin aut Microglia activation induced by serum of SLE patients 2017transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. Yang, Chunshu oth Zhao, Qi oth Zhu, Ziwei oth Li, Yujia oth Yang, Pingting oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:310 year:2017 day:15 month:09 pages:135-142 extent:8 https://doi.org/10.1016/j.jneuroim.2017.07.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 310 2017 15 0915 135-142 8 045F 610 |
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Enthalten in Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process Amsterdam [u.a.] volume:310 year:2017 day:15 month:09 pages:135-142 extent:8 |
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Enthalten in Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process Amsterdam [u.a.] volume:310 year:2017 day:15 month:09 pages:135-142 extent:8 |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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ELV005164184 |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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Microglia activation induced by serum of SLE patients |
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(DE-627)ELV035745029 (ELSEVIER)S0165-5728(17)30075-9 |
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Microglia activation induced by serum of SLE patients |
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Wang, Jianing |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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eng |
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Wang, Jianing |
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Wang, Jianing |
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10.1016/j.jneuroim.2017.07.010 |
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microglia activation induced by serum of sle patients |
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Microglia activation induced by serum of SLE patients |
| abstract |
To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. |
| abstractGer |
To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. |
| abstract_unstemmed |
To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. |
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Microglia activation induced by serum of SLE patients |
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Yang, Chunshu Zhao, Qi Zhu, Ziwei Li, Yujia Yang, Pingting |
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Yang, Chunshu Zhao, Qi Zhu, Ziwei Li, Yujia Yang, Pingting |
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