Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis
Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexe...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Itoh, Noriko [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process - Li, Kuo ELSEVIER, 2020, official journal of the International Society for Neuroimmunology, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:304 ; year:2017 ; day:15 ; month:03 ; pages:63-71 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.jneuroim.2016.09.017 |
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| 520 | |a Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. | ||
| 520 | |a Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. | ||
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10.1016/j.jneuroim.2016.09.017 doi GBVA2017005000019.pica (DE-627)ELV035747439 (ELSEVIER)S0165-5728(16)30308-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Itoh, Noriko verfasserin aut Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. Kim, Roy oth Peng, Mavis oth DiFilippo, Emma oth Johnsonbaugh, Hadley oth MacKenzie-Graham, Allan oth Voskuhl, Rhonda R. oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:304 year:2017 day:15 month:03 pages:63-71 extent:9 https://doi.org/10.1016/j.jneuroim.2016.09.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 304 2017 15 0315 63-71 9 045F 610 |
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10.1016/j.jneuroim.2016.09.017 doi GBVA2017005000019.pica (DE-627)ELV035747439 (ELSEVIER)S0165-5728(16)30308-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Itoh, Noriko verfasserin aut Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. Kim, Roy oth Peng, Mavis oth DiFilippo, Emma oth Johnsonbaugh, Hadley oth MacKenzie-Graham, Allan oth Voskuhl, Rhonda R. oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:304 year:2017 day:15 month:03 pages:63-71 extent:9 https://doi.org/10.1016/j.jneuroim.2016.09.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 304 2017 15 0315 63-71 9 045F 610 |
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10.1016/j.jneuroim.2016.09.017 doi GBVA2017005000019.pica (DE-627)ELV035747439 (ELSEVIER)S0165-5728(16)30308-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Itoh, Noriko verfasserin aut Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. Kim, Roy oth Peng, Mavis oth DiFilippo, Emma oth Johnsonbaugh, Hadley oth MacKenzie-Graham, Allan oth Voskuhl, Rhonda R. oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:304 year:2017 day:15 month:03 pages:63-71 extent:9 https://doi.org/10.1016/j.jneuroim.2016.09.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 304 2017 15 0315 63-71 9 045F 610 |
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10.1016/j.jneuroim.2016.09.017 doi GBVA2017005000019.pica (DE-627)ELV035747439 (ELSEVIER)S0165-5728(16)30308-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Itoh, Noriko verfasserin aut Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. Kim, Roy oth Peng, Mavis oth DiFilippo, Emma oth Johnsonbaugh, Hadley oth MacKenzie-Graham, Allan oth Voskuhl, Rhonda R. oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:304 year:2017 day:15 month:03 pages:63-71 extent:9 https://doi.org/10.1016/j.jneuroim.2016.09.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 304 2017 15 0315 63-71 9 045F 610 |
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10.1016/j.jneuroim.2016.09.017 doi GBVA2017005000019.pica (DE-627)ELV035747439 (ELSEVIER)S0165-5728(16)30308-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Itoh, Noriko verfasserin aut Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. Kim, Roy oth Peng, Mavis oth DiFilippo, Emma oth Johnsonbaugh, Hadley oth MacKenzie-Graham, Allan oth Voskuhl, Rhonda R. oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:304 year:2017 day:15 month:03 pages:63-71 extent:9 https://doi.org/10.1016/j.jneuroim.2016.09.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 304 2017 15 0315 63-71 9 045F 610 |
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Enthalten in Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process Amsterdam [u.a.] volume:304 year:2017 day:15 month:03 pages:63-71 extent:9 |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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Itoh, Noriko |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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bedside to bench to bedside research: estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis |
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Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis |
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Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. |
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Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. |
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Protective effects of pregnancy during MS have led to clinical trials of estriol, the pregnancy estrogen, in MS. Since estriol binds to estrogen receptor (ER) beta, ER beta ligand could represent a “next generation estriol” treatment. Here, ER beta ligand treatment was protective in EAE in both sexes and across genetic backgrounds. Neuroprotection was shown in spinal cord, sparing myelin and axons, and in brain, sparing neurons and synapses. Longitudinal in vivo MRIs showed decreased brain atrophy in cerebral cortex gray matter and cerebellum during EAE. Investigation of ER beta ligand as a neuroprotective treatment for MS is warranted. |
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Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis |
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Kim, Roy Peng, Mavis DiFilippo, Emma Johnsonbaugh, Hadley MacKenzie-Graham, Allan Voskuhl, Rhonda R. |
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