The accelerated path of ceritinib: Translating pre-clinical development into clinical efficacy
• Resistance to crizotinib, the first ALK inhibitor for NSCLC, inevitably develops. • Next-generation ALK inhibitors are already approved and in development. • Ceritinib potently overcomes many crizotinib resistance mutations in vitro. • Ceritinib is effective in ALK-inhibitor–pre-treated and –naïve...
Ausführliche Beschreibung
Autor*in: |
Mok, Tony S.K. [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2017 |
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Schlagwörter: |
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Umfang: |
9 |
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Übergeordnetes Werk: |
Enthalten in: Using regression analysis to predict the future energy consumption of a supermarket in the UK - Braun, M.R. ELSEVIER, 2014, Amsterdam [u.a.] |
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Übergeordnetes Werk: |
volume:55 ; year:2017 ; pages:181-189 ; extent:9 |
Links: |
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DOI / URN: |
10.1016/j.ctrv.2017.03.006 |
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ELV035863692 |
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10.1016/j.ctrv.2017.03.006 doi GBVA2017010000007.pica (DE-627)ELV035863692 (ELSEVIER)S0305-7372(17)30043-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 620 VZ 150 300 VZ 77.52 bkl Mok, Tony S.K. verfasserin aut The accelerated path of ceritinib: Translating pre-clinical development into clinical efficacy 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Resistance to crizotinib, the first ALK inhibitor for NSCLC, inevitably develops. • Next-generation ALK inhibitors are already approved and in development. • Ceritinib potently overcomes many crizotinib resistance mutations in vitro. • Ceritinib is effective in ALK-inhibitor–pre-treated and –naïve NSCLC patients. • GI toxicity with ceritinib is manageable with dose interruptions/reductions. Neoplasm Elsevier Carcinoma Elsevier Non–small-cell lung Elsevier Drug resistance Elsevier Anaplastic lymphoma kinase Elsevier Ceritinib Elsevier Crino, Lucio oth Felip, Enriqueta oth Salgia, Ravi oth De Pas, Tommaso oth Tan, Daniel S.W. oth Chow, Laura Q.M. oth Enthalten in Elsevier Braun, M.R. ELSEVIER Using regression analysis to predict the future energy consumption of a supermarket in the UK 2014 Amsterdam [u.a.] (DE-627)ELV01225004X volume:55 year:2017 pages:181-189 extent:9 https://doi.org/10.1016/j.ctrv.2017.03.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 77.52 Differentielle Psychologie VZ AR 55 2017 181-189 9 045F 610 |
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10.1016/j.ctrv.2017.03.006 doi GBVA2017010000007.pica (DE-627)ELV035863692 (ELSEVIER)S0305-7372(17)30043-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 620 VZ 150 300 VZ 77.52 bkl Mok, Tony S.K. verfasserin aut The accelerated path of ceritinib: Translating pre-clinical development into clinical efficacy 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Resistance to crizotinib, the first ALK inhibitor for NSCLC, inevitably develops. • Next-generation ALK inhibitors are already approved and in development. • Ceritinib potently overcomes many crizotinib resistance mutations in vitro. • Ceritinib is effective in ALK-inhibitor–pre-treated and –naïve NSCLC patients. • GI toxicity with ceritinib is manageable with dose interruptions/reductions. Neoplasm Elsevier Carcinoma Elsevier Non–small-cell lung Elsevier Drug resistance Elsevier Anaplastic lymphoma kinase Elsevier Ceritinib Elsevier Crino, Lucio oth Felip, Enriqueta oth Salgia, Ravi oth De Pas, Tommaso oth Tan, Daniel S.W. oth Chow, Laura Q.M. oth Enthalten in Elsevier Braun, M.R. ELSEVIER Using regression analysis to predict the future energy consumption of a supermarket in the UK 2014 Amsterdam [u.a.] (DE-627)ELV01225004X volume:55 year:2017 pages:181-189 extent:9 https://doi.org/10.1016/j.ctrv.2017.03.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 77.52 Differentielle Psychologie VZ AR 55 2017 181-189 9 045F 610 |
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10.1016/j.ctrv.2017.03.006 doi GBVA2017010000007.pica (DE-627)ELV035863692 (ELSEVIER)S0305-7372(17)30043-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 620 VZ 150 300 VZ 77.52 bkl Mok, Tony S.K. verfasserin aut The accelerated path of ceritinib: Translating pre-clinical development into clinical efficacy 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Resistance to crizotinib, the first ALK inhibitor for NSCLC, inevitably develops. • Next-generation ALK inhibitors are already approved and in development. • Ceritinib potently overcomes many crizotinib resistance mutations in vitro. • Ceritinib is effective in ALK-inhibitor–pre-treated and –naïve NSCLC patients. • GI toxicity with ceritinib is manageable with dose interruptions/reductions. Neoplasm Elsevier Carcinoma Elsevier Non–small-cell lung Elsevier Drug resistance Elsevier Anaplastic lymphoma kinase Elsevier Ceritinib Elsevier Crino, Lucio oth Felip, Enriqueta oth Salgia, Ravi oth De Pas, Tommaso oth Tan, Daniel S.W. oth Chow, Laura Q.M. oth Enthalten in Elsevier Braun, M.R. ELSEVIER Using regression analysis to predict the future energy consumption of a supermarket in the UK 2014 Amsterdam [u.a.] (DE-627)ELV01225004X volume:55 year:2017 pages:181-189 extent:9 https://doi.org/10.1016/j.ctrv.2017.03.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 77.52 Differentielle Psychologie VZ AR 55 2017 181-189 9 045F 610 |
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10.1016/j.ctrv.2017.03.006 doi GBVA2017010000007.pica (DE-627)ELV035863692 (ELSEVIER)S0305-7372(17)30043-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 620 VZ 150 300 VZ 77.52 bkl Mok, Tony S.K. verfasserin aut The accelerated path of ceritinib: Translating pre-clinical development into clinical efficacy 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Resistance to crizotinib, the first ALK inhibitor for NSCLC, inevitably develops. • Next-generation ALK inhibitors are already approved and in development. • Ceritinib potently overcomes many crizotinib resistance mutations in vitro. • Ceritinib is effective in ALK-inhibitor–pre-treated and –naïve NSCLC patients. • GI toxicity with ceritinib is manageable with dose interruptions/reductions. Neoplasm Elsevier Carcinoma Elsevier Non–small-cell lung Elsevier Drug resistance Elsevier Anaplastic lymphoma kinase Elsevier Ceritinib Elsevier Crino, Lucio oth Felip, Enriqueta oth Salgia, Ravi oth De Pas, Tommaso oth Tan, Daniel S.W. oth Chow, Laura Q.M. oth Enthalten in Elsevier Braun, M.R. ELSEVIER Using regression analysis to predict the future energy consumption of a supermarket in the UK 2014 Amsterdam [u.a.] (DE-627)ELV01225004X volume:55 year:2017 pages:181-189 extent:9 https://doi.org/10.1016/j.ctrv.2017.03.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 77.52 Differentielle Psychologie VZ AR 55 2017 181-189 9 045F 610 |
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10.1016/j.ctrv.2017.03.006 doi GBVA2017010000007.pica (DE-627)ELV035863692 (ELSEVIER)S0305-7372(17)30043-9 DE-627 ger DE-627 rakwb eng 610 610 DE-600 620 VZ 150 300 VZ 77.52 bkl Mok, Tony S.K. verfasserin aut The accelerated path of ceritinib: Translating pre-clinical development into clinical efficacy 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • Resistance to crizotinib, the first ALK inhibitor for NSCLC, inevitably develops. • Next-generation ALK inhibitors are already approved and in development. • Ceritinib potently overcomes many crizotinib resistance mutations in vitro. • Ceritinib is effective in ALK-inhibitor–pre-treated and –naïve NSCLC patients. • GI toxicity with ceritinib is manageable with dose interruptions/reductions. Neoplasm Elsevier Carcinoma Elsevier Non–small-cell lung Elsevier Drug resistance Elsevier Anaplastic lymphoma kinase Elsevier Ceritinib Elsevier Crino, Lucio oth Felip, Enriqueta oth Salgia, Ravi oth De Pas, Tommaso oth Tan, Daniel S.W. oth Chow, Laura Q.M. oth Enthalten in Elsevier Braun, M.R. ELSEVIER Using regression analysis to predict the future energy consumption of a supermarket in the UK 2014 Amsterdam [u.a.] (DE-627)ELV01225004X volume:55 year:2017 pages:181-189 extent:9 https://doi.org/10.1016/j.ctrv.2017.03.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 77.52 Differentielle Psychologie VZ AR 55 2017 181-189 9 045F 610 |
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• Resistance to crizotinib, the first ALK inhibitor for NSCLC, inevitably develops. • Next-generation ALK inhibitors are already approved and in development. • Ceritinib potently overcomes many crizotinib resistance mutations in vitro. • Ceritinib is effective in ALK-inhibitor–pre-treated and –naïve NSCLC patients. • GI toxicity with ceritinib is manageable with dose interruptions/reductions. |
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• Resistance to crizotinib, the first ALK inhibitor for NSCLC, inevitably develops. • Next-generation ALK inhibitors are already approved and in development. • Ceritinib potently overcomes many crizotinib resistance mutations in vitro. • Ceritinib is effective in ALK-inhibitor–pre-treated and –naïve NSCLC patients. • GI toxicity with ceritinib is manageable with dose interruptions/reductions. |
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• Resistance to crizotinib, the first ALK inhibitor for NSCLC, inevitably develops. • Next-generation ALK inhibitors are already approved and in development. • Ceritinib potently overcomes many crizotinib resistance mutations in vitro. • Ceritinib is effective in ALK-inhibitor–pre-treated and –naïve NSCLC patients. • GI toxicity with ceritinib is manageable with dose interruptions/reductions. |
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