Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin
In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design ha...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wang, Pin-Wen [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
|---|
| Schlagwörter: |
|---|
| Umfang: |
18 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model - 2011transfer abstract, JSPI, Amsterdam |
|---|---|
| Übergeordnetes Werk: |
volume:183 ; year:2017 ; pages:44-61 ; extent:18 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.jspi.2016.10.001 |
|---|
| Katalog-ID: |
ELV035937262 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV035937262 | ||
| 003 | DE-627 | ||
| 005 | 20230625210111.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180603s2017 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jspi.2016.10.001 |2 doi | |
| 028 | 5 | 2 | |a GBVA2017012000030.pica |
| 035 | |a (DE-627)ELV035937262 | ||
| 035 | |a (ELSEVIER)S0378-3758(16)30123-9 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 510 |a 000 |a 310 | |
| 082 | 0 | 4 | |a 510 |q DE-600 |
| 082 | 0 | 4 | |a 000 |q DE-600 |
| 082 | 0 | 4 | |a 310 |q DE-600 |
| 082 | 0 | 4 | |a 530 |q VZ |
| 082 | 0 | 4 | |a 540 |q VZ |
| 084 | |a 51.30 |2 bkl | ||
| 100 | 1 | |a Wang, Pin-Wen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin |
| 264 | 1 | |c 2017transfer abstract | |
| 300 | |a 18 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. | ||
| 520 | |a In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. | ||
| 650 | 7 | |a Adaptive design |2 Elsevier | |
| 650 | 7 | |a Two-stage design |2 Elsevier | |
| 650 | 7 | |a Non-inferiority trials |2 Elsevier | |
| 700 | 1 | |a Lu, Shou-En |4 oth | |
| 700 | 1 | |a Lin, Yong |4 oth | |
| 700 | 1 | |a Shih, Weichung J. |4 oth | |
| 700 | 1 | |a Lan, K.K. Gordon |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n North-Holland Publ. Co |t Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model |d 2011transfer abstract |d JSPI |g Amsterdam |w (DE-627)ELV020955464 |
| 773 | 1 | 8 | |g volume:183 |g year:2017 |g pages:44-61 |g extent:18 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.jspi.2016.10.001 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 912 | |a SSG-OLC-PHA | ||
| 912 | |a GBV_ILN_26 | ||
| 912 | |a GBV_ILN_60 | ||
| 912 | |a GBV_ILN_160 | ||
| 912 | |a GBV_ILN_2009 | ||
| 912 | |a GBV_ILN_2099 | ||
| 936 | b | k | |a 51.30 |j Werkstoffprüfung |j Werkstoffuntersuchung |q VZ |
| 951 | |a AR | ||
| 952 | |d 183 |j 2017 |h 44-61 |g 18 | ||
| 953 | |2 045F |a 510 | ||
| author_variant |
p w w pww |
|---|---|
| matchkey_str |
wangpinwenlushouenlinyongshihweichungjla:2017----:wsaeinreinfroifroiyrasihrseiid |
| hierarchy_sort_str |
2017transfer abstract |
| bklnumber |
51.30 |
| publishDate |
2017 |
| allfields |
10.1016/j.jspi.2016.10.001 doi GBVA2017012000030.pica (DE-627)ELV035937262 (ELSEVIER)S0378-3758(16)30123-9 DE-627 ger DE-627 rakwb eng 510 000 310 510 DE-600 000 DE-600 310 DE-600 530 VZ 540 VZ 51.30 bkl Wang, Pin-Wen verfasserin aut Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin 2017transfer abstract 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. Adaptive design Elsevier Two-stage design Elsevier Non-inferiority trials Elsevier Lu, Shou-En oth Lin, Yong oth Shih, Weichung J. oth Lan, K.K. Gordon oth Enthalten in North-Holland Publ. Co Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model 2011transfer abstract JSPI Amsterdam (DE-627)ELV020955464 volume:183 year:2017 pages:44-61 extent:18 https://doi.org/10.1016/j.jspi.2016.10.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_26 GBV_ILN_60 GBV_ILN_160 GBV_ILN_2009 GBV_ILN_2099 51.30 Werkstoffprüfung Werkstoffuntersuchung VZ AR 183 2017 44-61 18 045F 510 |
| spelling |
10.1016/j.jspi.2016.10.001 doi GBVA2017012000030.pica (DE-627)ELV035937262 (ELSEVIER)S0378-3758(16)30123-9 DE-627 ger DE-627 rakwb eng 510 000 310 510 DE-600 000 DE-600 310 DE-600 530 VZ 540 VZ 51.30 bkl Wang, Pin-Wen verfasserin aut Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin 2017transfer abstract 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. Adaptive design Elsevier Two-stage design Elsevier Non-inferiority trials Elsevier Lu, Shou-En oth Lin, Yong oth Shih, Weichung J. oth Lan, K.K. Gordon oth Enthalten in North-Holland Publ. Co Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model 2011transfer abstract JSPI Amsterdam (DE-627)ELV020955464 volume:183 year:2017 pages:44-61 extent:18 https://doi.org/10.1016/j.jspi.2016.10.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_26 GBV_ILN_60 GBV_ILN_160 GBV_ILN_2009 GBV_ILN_2099 51.30 Werkstoffprüfung Werkstoffuntersuchung VZ AR 183 2017 44-61 18 045F 510 |
| allfields_unstemmed |
10.1016/j.jspi.2016.10.001 doi GBVA2017012000030.pica (DE-627)ELV035937262 (ELSEVIER)S0378-3758(16)30123-9 DE-627 ger DE-627 rakwb eng 510 000 310 510 DE-600 000 DE-600 310 DE-600 530 VZ 540 VZ 51.30 bkl Wang, Pin-Wen verfasserin aut Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin 2017transfer abstract 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. Adaptive design Elsevier Two-stage design Elsevier Non-inferiority trials Elsevier Lu, Shou-En oth Lin, Yong oth Shih, Weichung J. oth Lan, K.K. Gordon oth Enthalten in North-Holland Publ. Co Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model 2011transfer abstract JSPI Amsterdam (DE-627)ELV020955464 volume:183 year:2017 pages:44-61 extent:18 https://doi.org/10.1016/j.jspi.2016.10.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_26 GBV_ILN_60 GBV_ILN_160 GBV_ILN_2009 GBV_ILN_2099 51.30 Werkstoffprüfung Werkstoffuntersuchung VZ AR 183 2017 44-61 18 045F 510 |
| allfieldsGer |
10.1016/j.jspi.2016.10.001 doi GBVA2017012000030.pica (DE-627)ELV035937262 (ELSEVIER)S0378-3758(16)30123-9 DE-627 ger DE-627 rakwb eng 510 000 310 510 DE-600 000 DE-600 310 DE-600 530 VZ 540 VZ 51.30 bkl Wang, Pin-Wen verfasserin aut Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin 2017transfer abstract 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. Adaptive design Elsevier Two-stage design Elsevier Non-inferiority trials Elsevier Lu, Shou-En oth Lin, Yong oth Shih, Weichung J. oth Lan, K.K. Gordon oth Enthalten in North-Holland Publ. Co Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model 2011transfer abstract JSPI Amsterdam (DE-627)ELV020955464 volume:183 year:2017 pages:44-61 extent:18 https://doi.org/10.1016/j.jspi.2016.10.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_26 GBV_ILN_60 GBV_ILN_160 GBV_ILN_2009 GBV_ILN_2099 51.30 Werkstoffprüfung Werkstoffuntersuchung VZ AR 183 2017 44-61 18 045F 510 |
| allfieldsSound |
10.1016/j.jspi.2016.10.001 doi GBVA2017012000030.pica (DE-627)ELV035937262 (ELSEVIER)S0378-3758(16)30123-9 DE-627 ger DE-627 rakwb eng 510 000 310 510 DE-600 000 DE-600 310 DE-600 530 VZ 540 VZ 51.30 bkl Wang, Pin-Wen verfasserin aut Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin 2017transfer abstract 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. Adaptive design Elsevier Two-stage design Elsevier Non-inferiority trials Elsevier Lu, Shou-En oth Lin, Yong oth Shih, Weichung J. oth Lan, K.K. Gordon oth Enthalten in North-Holland Publ. Co Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model 2011transfer abstract JSPI Amsterdam (DE-627)ELV020955464 volume:183 year:2017 pages:44-61 extent:18 https://doi.org/10.1016/j.jspi.2016.10.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_26 GBV_ILN_60 GBV_ILN_160 GBV_ILN_2009 GBV_ILN_2099 51.30 Werkstoffprüfung Werkstoffuntersuchung VZ AR 183 2017 44-61 18 045F 510 |
| language |
English |
| source |
Enthalten in Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model Amsterdam volume:183 year:2017 pages:44-61 extent:18 |
| sourceStr |
Enthalten in Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model Amsterdam volume:183 year:2017 pages:44-61 extent:18 |
| format_phy_str_mv |
Article |
| bklname |
Werkstoffprüfung Werkstoffuntersuchung |
| institution |
findex.gbv.de |
| topic_facet |
Adaptive design Two-stage design Non-inferiority trials |
| dewey-raw |
510 |
| isfreeaccess_bool |
false |
| container_title |
Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model |
| authorswithroles_txt_mv |
Wang, Pin-Wen @@aut@@ Lu, Shou-En @@oth@@ Lin, Yong @@oth@@ Shih, Weichung J. @@oth@@ Lan, K.K. Gordon @@oth@@ |
| publishDateDaySort_date |
2017-01-01T00:00:00Z |
| hierarchy_top_id |
ELV020955464 |
| dewey-sort |
3510 |
| id |
ELV035937262 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV035937262</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625210111.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2017 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jspi.2016.10.001</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2017012000030.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV035937262</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0378-3758(16)30123-9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">510</subfield><subfield code="a">000</subfield><subfield code="a">310</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">510</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">000</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">310</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">530</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">540</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">51.30</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Wang, Pin-Wen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">18</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Adaptive design</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Two-stage design</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Non-inferiority trials</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lu, Shou-En</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lin, Yong</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shih, Weichung J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lan, K.K. Gordon</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">North-Holland Publ. Co</subfield><subfield code="t">Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model</subfield><subfield code="d">2011transfer abstract</subfield><subfield code="d">JSPI</subfield><subfield code="g">Amsterdam</subfield><subfield code="w">(DE-627)ELV020955464</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:183</subfield><subfield code="g">year:2017</subfield><subfield code="g">pages:44-61</subfield><subfield code="g">extent:18</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.jspi.2016.10.001</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_26</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_160</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2099</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">51.30</subfield><subfield code="j">Werkstoffprüfung</subfield><subfield code="j">Werkstoffuntersuchung</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">183</subfield><subfield code="j">2017</subfield><subfield code="h">44-61</subfield><subfield code="g">18</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">510</subfield></datafield></record></collection>
|
| author |
Wang, Pin-Wen |
| spellingShingle |
Wang, Pin-Wen ddc 510 ddc 000 ddc 310 ddc 530 ddc 540 bkl 51.30 Elsevier Adaptive design Elsevier Two-stage design Elsevier Non-inferiority trials Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin |
| authorStr |
Wang, Pin-Wen |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV020955464 |
| format |
electronic Article |
| dewey-ones |
510 - Mathematics 000 - Computer science, information & general works 310 - Collections of general statistics 530 - Physics 540 - Chemistry & allied sciences |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
510 000 310 510 DE-600 000 DE-600 310 DE-600 530 VZ 540 VZ 51.30 bkl Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin Adaptive design Elsevier Two-stage design Elsevier Non-inferiority trials Elsevier |
| topic |
ddc 510 ddc 000 ddc 310 ddc 530 ddc 540 bkl 51.30 Elsevier Adaptive design Elsevier Two-stage design Elsevier Non-inferiority trials |
| topic_unstemmed |
ddc 510 ddc 000 ddc 310 ddc 530 ddc 540 bkl 51.30 Elsevier Adaptive design Elsevier Two-stage design Elsevier Non-inferiority trials |
| topic_browse |
ddc 510 ddc 000 ddc 310 ddc 530 ddc 540 bkl 51.30 Elsevier Adaptive design Elsevier Two-stage design Elsevier Non-inferiority trials |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
s e l sel y l yl w j s wj wjs k g l kg kgl |
| hierarchy_parent_title |
Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model |
| hierarchy_parent_id |
ELV020955464 |
| dewey-tens |
510 - Mathematics 000 - Computer science, knowledge & systems 310 - Statistics 530 - Physics 540 - Chemistry |
| hierarchy_top_title |
Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV020955464 |
| title |
Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin |
| ctrlnum |
(DE-627)ELV035937262 (ELSEVIER)S0378-3758(16)30123-9 |
| title_full |
Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin |
| author_sort |
Wang, Pin-Wen |
| journal |
Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model |
| journalStr |
Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
500 - Science 000 - Computer science, information & general works 300 - Social sciences |
| recordtype |
marc |
| publishDateSort |
2017 |
| contenttype_str_mv |
zzz |
| container_start_page |
44 |
| author_browse |
Wang, Pin-Wen |
| container_volume |
183 |
| physical |
18 |
| class |
510 000 310 510 DE-600 000 DE-600 310 DE-600 530 VZ 540 VZ 51.30 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Wang, Pin-Wen |
| doi_str_mv |
10.1016/j.jspi.2016.10.001 |
| dewey-full |
510 000 310 530 540 |
| title_sort |
two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin |
| title_auth |
Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin |
| abstract |
In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. |
| abstractGer |
In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. |
| abstract_unstemmed |
In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_26 GBV_ILN_60 GBV_ILN_160 GBV_ILN_2009 GBV_ILN_2099 |
| title_short |
Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin |
| url |
https://doi.org/10.1016/j.jspi.2016.10.001 |
| remote_bool |
true |
| author2 |
Lu, Shou-En Lin, Yong Shih, Weichung J. Lan, K.K. Gordon |
| author2Str |
Lu, Shou-En Lin, Yong Shih, Weichung J. Lan, K.K. Gordon |
| ppnlink |
ELV020955464 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth |
| doi_str |
10.1016/j.jspi.2016.10.001 |
| up_date |
2024-07-06T18:52:06.441Z |
| _version_ |
1803856827062943744 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV035937262</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625210111.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180603s2017 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.jspi.2016.10.001</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBVA2017012000030.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV035937262</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0378-3758(16)30123-9</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">510</subfield><subfield code="a">000</subfield><subfield code="a">310</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">510</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">000</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">310</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">530</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">540</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">51.30</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Wang, Pin-Wen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Two-stage winner designs for non-inferiority trials with pre-specified non-inferiority margin</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">18</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">In drug development, a two-stage winner design (Lan et al. 2005, Shun et al. 2008) can be cost-effective when the best treatment is to be determined from multiple experimental treatments in superiority trials. However, the statistical methods assessing non-inferiority in a two-stage winner design have not yet been studied, for which the complexity arises in determining the critical value when parameter space is not a single point under the null hypothesis. Because the maximum error may not occur at the vertex of the null space, it is unclear if naive use of critical values and distributional results from the test for superiority remains correct. In this paper, we provided rigorous justifications to determine the critical value for testing non-inferiority hypothesis, with a pre-specified non-inferiority margin, in a two-stage winner design with two experimental treatments and an active control. We studied the distribution of the test statistics, critical values, sample size and power calculations using the exact distribution of the test statistics as well as using normal approximations. Theoretical justifications and extensive numerical assessments were conducted to calculate the design parameters and evaluate the performance of our methods.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Adaptive design</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Two-stage design</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Non-inferiority trials</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lu, Shou-En</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lin, Yong</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shih, Weichung J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lan, K.K. Gordon</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">North-Holland Publ. Co</subfield><subfield code="t">Experimental investigation of long-wavelength optical lattice vibrations in quaternary Al x In y Ga1−x−y N alloys and comparison with results from the pseudo-unit cell model</subfield><subfield code="d">2011transfer abstract</subfield><subfield code="d">JSPI</subfield><subfield code="g">Amsterdam</subfield><subfield code="w">(DE-627)ELV020955464</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:183</subfield><subfield code="g">year:2017</subfield><subfield code="g">pages:44-61</subfield><subfield code="g">extent:18</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.jspi.2016.10.001</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_26</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_160</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2099</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">51.30</subfield><subfield code="j">Werkstoffprüfung</subfield><subfield code="j">Werkstoffuntersuchung</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">183</subfield><subfield code="j">2017</subfield><subfield code="h">44-61</subfield><subfield code="g">18</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">510</subfield></datafield></record></collection>
|
| score |
7.39876 |