Redox status in a model of cancer stem cells
Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, i...
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| Autor*in: |
Zaccarin, Mattia [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
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2017transfer abstract |
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9 |
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Enthalten in: Breast conservation surgery without frozen section study control for intra operative margin status – a prospective study - Mohammed Ilyas, M.I. ELSEVIER, 2017, ABB, San Diego, Calif |
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| Übergeordnetes Werk: |
volume:617 ; year:2017 ; day:1 ; month:03 ; pages:120-128 ; extent:9 |
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| DOI / URN: |
10.1016/j.abb.2016.09.002 |
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| 520 | |a Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. | ||
| 520 | |a Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. | ||
| 650 | 7 | |a Redox state |2 Elsevier | |
| 650 | 7 | |a Redox proteomics |2 Elsevier | |
| 650 | 7 | |a Cancer stem cells |2 Elsevier | |
| 650 | 7 | |a Protein thiols |2 Elsevier | |
| 700 | 1 | |a Bosello-Travain, Valentina |4 oth | |
| 700 | 1 | |a Di Paolo, Maria Luisa |4 oth | |
| 700 | 1 | |a Falda, Marco |4 oth | |
| 700 | 1 | |a Maiorino, Matilde |4 oth | |
| 700 | 1 | |a Miotto, Giovanni |4 oth | |
| 700 | 1 | |a Piccolo, Stefano |4 oth | |
| 700 | 1 | |a Roveri, Antonella |4 oth | |
| 700 | 1 | |a Ursini, Fulvio |4 oth | |
| 700 | 1 | |a Venerando, Rina |4 oth | |
| 700 | 1 | |a Toppo, Stefano |4 oth | |
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10.1016/j.abb.2016.09.002 doi GBVA2017019000026.pica (DE-627)ELV036125717 (ELSEVIER)S0003-9861(16)30319-8 DE-627 ger DE-627 rakwb eng 500 540 570 500 DE-600 540 DE-600 570 DE-600 610 VZ 610 VZ 44.52 bkl Zaccarin, Mattia verfasserin aut Redox status in a model of cancer stem cells 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. Redox state Elsevier Redox proteomics Elsevier Cancer stem cells Elsevier Protein thiols Elsevier Bosello-Travain, Valentina oth Di Paolo, Maria Luisa oth Falda, Marco oth Maiorino, Matilde oth Miotto, Giovanni oth Piccolo, Stefano oth Roveri, Antonella oth Ursini, Fulvio oth Venerando, Rina oth Toppo, Stefano oth Enthalten in Elsevier Mohammed Ilyas, M.I. ELSEVIER Breast conservation surgery without frozen section study control for intra operative margin status – a prospective study 2017 ABB San Diego, Calif (DE-627)ELV020434308 volume:617 year:2017 day:1 month:03 pages:120-128 extent:9 https://doi.org/10.1016/j.abb.2016.09.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_60 GBV_ILN_72 GBV_ILN_162 44.52 Therapie Medizin VZ AR 617 2017 1 0301 120-128 9 045F 500 |
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10.1016/j.abb.2016.09.002 doi GBVA2017019000026.pica (DE-627)ELV036125717 (ELSEVIER)S0003-9861(16)30319-8 DE-627 ger DE-627 rakwb eng 500 540 570 500 DE-600 540 DE-600 570 DE-600 610 VZ 610 VZ 44.52 bkl Zaccarin, Mattia verfasserin aut Redox status in a model of cancer stem cells 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. Redox state Elsevier Redox proteomics Elsevier Cancer stem cells Elsevier Protein thiols Elsevier Bosello-Travain, Valentina oth Di Paolo, Maria Luisa oth Falda, Marco oth Maiorino, Matilde oth Miotto, Giovanni oth Piccolo, Stefano oth Roveri, Antonella oth Ursini, Fulvio oth Venerando, Rina oth Toppo, Stefano oth Enthalten in Elsevier Mohammed Ilyas, M.I. ELSEVIER Breast conservation surgery without frozen section study control for intra operative margin status – a prospective study 2017 ABB San Diego, Calif (DE-627)ELV020434308 volume:617 year:2017 day:1 month:03 pages:120-128 extent:9 https://doi.org/10.1016/j.abb.2016.09.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_60 GBV_ILN_72 GBV_ILN_162 44.52 Therapie Medizin VZ AR 617 2017 1 0301 120-128 9 045F 500 |
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10.1016/j.abb.2016.09.002 doi GBVA2017019000026.pica (DE-627)ELV036125717 (ELSEVIER)S0003-9861(16)30319-8 DE-627 ger DE-627 rakwb eng 500 540 570 500 DE-600 540 DE-600 570 DE-600 610 VZ 610 VZ 44.52 bkl Zaccarin, Mattia verfasserin aut Redox status in a model of cancer stem cells 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. Redox state Elsevier Redox proteomics Elsevier Cancer stem cells Elsevier Protein thiols Elsevier Bosello-Travain, Valentina oth Di Paolo, Maria Luisa oth Falda, Marco oth Maiorino, Matilde oth Miotto, Giovanni oth Piccolo, Stefano oth Roveri, Antonella oth Ursini, Fulvio oth Venerando, Rina oth Toppo, Stefano oth Enthalten in Elsevier Mohammed Ilyas, M.I. ELSEVIER Breast conservation surgery without frozen section study control for intra operative margin status – a prospective study 2017 ABB San Diego, Calif (DE-627)ELV020434308 volume:617 year:2017 day:1 month:03 pages:120-128 extent:9 https://doi.org/10.1016/j.abb.2016.09.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_60 GBV_ILN_72 GBV_ILN_162 44.52 Therapie Medizin VZ AR 617 2017 1 0301 120-128 9 045F 500 |
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10.1016/j.abb.2016.09.002 doi GBVA2017019000026.pica (DE-627)ELV036125717 (ELSEVIER)S0003-9861(16)30319-8 DE-627 ger DE-627 rakwb eng 500 540 570 500 DE-600 540 DE-600 570 DE-600 610 VZ 610 VZ 44.52 bkl Zaccarin, Mattia verfasserin aut Redox status in a model of cancer stem cells 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. Redox state Elsevier Redox proteomics Elsevier Cancer stem cells Elsevier Protein thiols Elsevier Bosello-Travain, Valentina oth Di Paolo, Maria Luisa oth Falda, Marco oth Maiorino, Matilde oth Miotto, Giovanni oth Piccolo, Stefano oth Roveri, Antonella oth Ursini, Fulvio oth Venerando, Rina oth Toppo, Stefano oth Enthalten in Elsevier Mohammed Ilyas, M.I. ELSEVIER Breast conservation surgery without frozen section study control for intra operative margin status – a prospective study 2017 ABB San Diego, Calif (DE-627)ELV020434308 volume:617 year:2017 day:1 month:03 pages:120-128 extent:9 https://doi.org/10.1016/j.abb.2016.09.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_60 GBV_ILN_72 GBV_ILN_162 44.52 Therapie Medizin VZ AR 617 2017 1 0301 120-128 9 045F 500 |
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10.1016/j.abb.2016.09.002 doi GBVA2017019000026.pica (DE-627)ELV036125717 (ELSEVIER)S0003-9861(16)30319-8 DE-627 ger DE-627 rakwb eng 500 540 570 500 DE-600 540 DE-600 570 DE-600 610 VZ 610 VZ 44.52 bkl Zaccarin, Mattia verfasserin aut Redox status in a model of cancer stem cells 2017transfer abstract 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. Redox state Elsevier Redox proteomics Elsevier Cancer stem cells Elsevier Protein thiols Elsevier Bosello-Travain, Valentina oth Di Paolo, Maria Luisa oth Falda, Marco oth Maiorino, Matilde oth Miotto, Giovanni oth Piccolo, Stefano oth Roveri, Antonella oth Ursini, Fulvio oth Venerando, Rina oth Toppo, Stefano oth Enthalten in Elsevier Mohammed Ilyas, M.I. ELSEVIER Breast conservation surgery without frozen section study control for intra operative margin status – a prospective study 2017 ABB San Diego, Calif (DE-627)ELV020434308 volume:617 year:2017 day:1 month:03 pages:120-128 extent:9 https://doi.org/10.1016/j.abb.2016.09.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_60 GBV_ILN_72 GBV_ILN_162 44.52 Therapie Medizin VZ AR 617 2017 1 0301 120-128 9 045F 500 |
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Enthalten in Breast conservation surgery without frozen section study control for intra operative margin status – a prospective study San Diego, Calif volume:617 year:2017 day:1 month:03 pages:120-128 extent:9 |
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Enthalten in Breast conservation surgery without frozen section study control for intra operative margin status – a prospective study San Diego, Calif volume:617 year:2017 day:1 month:03 pages:120-128 extent:9 |
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Breast conservation surgery without frozen section study control for intra operative margin status – a prospective study |
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Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. |
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Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. |
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Reversible oxidation of Cys residues is a crucial element of redox homeostasis and signaling. According to a popular concept in oxidative stress signaling, the oxidation of targets of signals can only take place following an overwhelming of the cellular antioxidant capacity. This concept, however, ignores the activation of feedback mechanisms possibly leading to a paradoxical effect. In a model of cancer stem cells (CSC), stably overexpressing the TAZ oncogene, we observed that the increased formation of oxidants is associated with a globally more reduced state of proteins. Redox proteomics revealed that several proteins, capable of undergoing reversible redox transitions, are indeed more reduced while just few are more oxidized. Among the proteins more oxidized, G6PDH emerges as both more expressed and activated by oxidation. This accounts for the observed more reduced state of the NADPH/NADP+ couple. The dynamic redox flux generating this apparently paradoxical effect is rationalized in a computational system biology model highlighting the crucial role of G6PDH activity on the rate of redox transitions eventually leading to the reduction of reversible redox switches. |
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