Allicin protects against cisplatin-induced vestibular dysfunction by inhibiting the apoptotic pathway
Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechani...
Ausführliche Beschreibung
Autor*in: |
Wu, Xianmin [verfasserIn] |
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Englisch |
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2017transfer abstract |
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10 |
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Übergeordnetes Werk: |
Enthalten in: Mexican student-teachers’ “English” language praxicum: Decolonizing attempts - López-Gopar, Mario E. ELSEVIER, 2022, EJP, New York, NY [u.a.] |
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Übergeordnetes Werk: |
volume:805 ; year:2017 ; day:15 ; month:06 ; pages:108-117 ; extent:10 |
Links: |
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DOI / URN: |
10.1016/j.ejphar.2017.02.052 |
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520 | |a Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. | ||
520 | |a Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. | ||
650 | 7 | |a Vestibular dysfunction |2 Elsevier | |
650 | 7 | |a Allicin |2 Elsevier | |
650 | 7 | |a Cisplatin |2 Elsevier | |
650 | 7 | |a Apoptosis |2 Elsevier | |
650 | 7 | |a Ototoxicity |2 Elsevier | |
700 | 1 | |a Cai, Jing |4 oth | |
700 | 1 | |a Li, Xiaofei |4 oth | |
700 | 1 | |a Li, He |4 oth | |
700 | 1 | |a Li, Jianfeng |4 oth | |
700 | 1 | |a Bai, Xiaohui |4 oth | |
700 | 1 | |a Liu, Wenwen |4 oth | |
700 | 1 | |a Han, Yuechen |4 oth | |
700 | 1 | |a Xu, Lei |4 oth | |
700 | 1 | |a Zhang, Daogong |4 oth | |
700 | 1 | |a Wang, Haibo |4 oth | |
700 | 1 | |a Fan, Zhaomin |4 oth | |
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10.1016/j.ejphar.2017.02.052 doi GBVA2017020000023.pica (DE-627)ELV03616352X (ELSEVIER)S0014-2999(17)30137-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn Wu, Xianmin verfasserin aut Allicin protects against cisplatin-induced vestibular dysfunction by inhibiting the apoptotic pathway 2017transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. Vestibular dysfunction Elsevier Allicin Elsevier Cisplatin Elsevier Apoptosis Elsevier Ototoxicity Elsevier Cai, Jing oth Li, Xiaofei oth Li, He oth Li, Jianfeng oth Bai, Xiaohui oth Liu, Wenwen oth Han, Yuechen oth Xu, Lei oth Zhang, Daogong oth Wang, Haibo oth Fan, Zhaomin oth Enthalten in Elsevier López-Gopar, Mario E. ELSEVIER Mexican student-teachers’ “English” language praxicum: Decolonizing attempts 2022 EJP New York, NY [u.a.] (DE-627)ELV008405875 volume:805 year:2017 day:15 month:06 pages:108-117 extent:10 https://doi.org/10.1016/j.ejphar.2017.02.052 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 805 2017 15 0615 108-117 10 045F 610 |
spelling |
10.1016/j.ejphar.2017.02.052 doi GBVA2017020000023.pica (DE-627)ELV03616352X (ELSEVIER)S0014-2999(17)30137-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn Wu, Xianmin verfasserin aut Allicin protects against cisplatin-induced vestibular dysfunction by inhibiting the apoptotic pathway 2017transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. Vestibular dysfunction Elsevier Allicin Elsevier Cisplatin Elsevier Apoptosis Elsevier Ototoxicity Elsevier Cai, Jing oth Li, Xiaofei oth Li, He oth Li, Jianfeng oth Bai, Xiaohui oth Liu, Wenwen oth Han, Yuechen oth Xu, Lei oth Zhang, Daogong oth Wang, Haibo oth Fan, Zhaomin oth Enthalten in Elsevier López-Gopar, Mario E. ELSEVIER Mexican student-teachers’ “English” language praxicum: Decolonizing attempts 2022 EJP New York, NY [u.a.] (DE-627)ELV008405875 volume:805 year:2017 day:15 month:06 pages:108-117 extent:10 https://doi.org/10.1016/j.ejphar.2017.02.052 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 805 2017 15 0615 108-117 10 045F 610 |
allfields_unstemmed |
10.1016/j.ejphar.2017.02.052 doi GBVA2017020000023.pica (DE-627)ELV03616352X (ELSEVIER)S0014-2999(17)30137-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn Wu, Xianmin verfasserin aut Allicin protects against cisplatin-induced vestibular dysfunction by inhibiting the apoptotic pathway 2017transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. Vestibular dysfunction Elsevier Allicin Elsevier Cisplatin Elsevier Apoptosis Elsevier Ototoxicity Elsevier Cai, Jing oth Li, Xiaofei oth Li, He oth Li, Jianfeng oth Bai, Xiaohui oth Liu, Wenwen oth Han, Yuechen oth Xu, Lei oth Zhang, Daogong oth Wang, Haibo oth Fan, Zhaomin oth Enthalten in Elsevier López-Gopar, Mario E. ELSEVIER Mexican student-teachers’ “English” language praxicum: Decolonizing attempts 2022 EJP New York, NY [u.a.] (DE-627)ELV008405875 volume:805 year:2017 day:15 month:06 pages:108-117 extent:10 https://doi.org/10.1016/j.ejphar.2017.02.052 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 805 2017 15 0615 108-117 10 045F 610 |
allfieldsGer |
10.1016/j.ejphar.2017.02.052 doi GBVA2017020000023.pica (DE-627)ELV03616352X (ELSEVIER)S0014-2999(17)30137-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn Wu, Xianmin verfasserin aut Allicin protects against cisplatin-induced vestibular dysfunction by inhibiting the apoptotic pathway 2017transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. Vestibular dysfunction Elsevier Allicin Elsevier Cisplatin Elsevier Apoptosis Elsevier Ototoxicity Elsevier Cai, Jing oth Li, Xiaofei oth Li, He oth Li, Jianfeng oth Bai, Xiaohui oth Liu, Wenwen oth Han, Yuechen oth Xu, Lei oth Zhang, Daogong oth Wang, Haibo oth Fan, Zhaomin oth Enthalten in Elsevier López-Gopar, Mario E. ELSEVIER Mexican student-teachers’ “English” language praxicum: Decolonizing attempts 2022 EJP New York, NY [u.a.] (DE-627)ELV008405875 volume:805 year:2017 day:15 month:06 pages:108-117 extent:10 https://doi.org/10.1016/j.ejphar.2017.02.052 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 805 2017 15 0615 108-117 10 045F 610 |
allfieldsSound |
10.1016/j.ejphar.2017.02.052 doi GBVA2017020000023.pica (DE-627)ELV03616352X (ELSEVIER)S0014-2999(17)30137-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 370 VZ 5,3 ssgn Wu, Xianmin verfasserin aut Allicin protects against cisplatin-induced vestibular dysfunction by inhibiting the apoptotic pathway 2017transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. Vestibular dysfunction Elsevier Allicin Elsevier Cisplatin Elsevier Apoptosis Elsevier Ototoxicity Elsevier Cai, Jing oth Li, Xiaofei oth Li, He oth Li, Jianfeng oth Bai, Xiaohui oth Liu, Wenwen oth Han, Yuechen oth Xu, Lei oth Zhang, Daogong oth Wang, Haibo oth Fan, Zhaomin oth Enthalten in Elsevier López-Gopar, Mario E. ELSEVIER Mexican student-teachers’ “English” language praxicum: Decolonizing attempts 2022 EJP New York, NY [u.a.] (DE-627)ELV008405875 volume:805 year:2017 day:15 month:06 pages:108-117 extent:10 https://doi.org/10.1016/j.ejphar.2017.02.052 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 805 2017 15 0615 108-117 10 045F 610 |
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Enthalten in Mexican student-teachers’ “English” language praxicum: Decolonizing attempts New York, NY [u.a.] volume:805 year:2017 day:15 month:06 pages:108-117 extent:10 |
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Mexican student-teachers’ “English” language praxicum: Decolonizing attempts |
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allicin protects against cisplatin-induced vestibular dysfunction by inhibiting the apoptotic pathway |
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Allicin protects against cisplatin-induced vestibular dysfunction by inhibiting the apoptotic pathway |
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Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. |
abstractGer |
Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. |
abstract_unstemmed |
Cisplatin is an anticancer drug that causes the impairment of inner ear function as side effects, including hearing loss and balance dysfunction. The purpose of this study was to investigate the effects of allicin against cisplatin-induced vestibular dysfunction in mice and to make clear the mechanism underlying the protective effects of allicin on oto-vestibulotoxicity. Mice intraperitoneally injected with cisplatin exhibited vestibular dysfunction in swimming test, which agreed with impairment in vestibule. However, these impairments were significantly prevented by pre-treatment with allicin. Allicin markedly reduced cisplatin-activated expression of cleaved-caspase-3 in hair cells and vascular layer cells of utricule, saccule and ampulla, but also decreased AIF nuclear translocation of hair cells in utricule, saccule and ampulla. These results showed that allicin played an effective role in protecting vestibular dysfunction induced by cisplatin via inhibiting caspase-dependent and caspase-independent apoptotic pathways. Therefore, allicin may be useful in preventing oto-vestibulotoxicity mediated by cisplatin. |
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Allicin protects against cisplatin-induced vestibular dysfunction by inhibiting the apoptotic pathway |
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