Soluble endoglin modulates the pro-inflammatory mediators NF-κB and IL-6 in cultured human endothelial cells
Endoglin is a transmembrane glycoprotein, that plays an important role in regulating endothelium. Proteolytic cleavage of membrane endoglin releases soluble endoglin (sEng), whose increased plasma levels have been detected in diseases related to the cardiovascular system. It was proposed that sEng m...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Varejckova, Michala [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Umfang: |
9 |
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Enthalten in: Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling - Abd-Elhady, M.S. ELSEVIER, 2016, including pharmacology letters, New York, NY [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:175 ; year:2017 ; day:15 ; month:04 ; pages:52-60 ; extent:9 |
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| DOI / URN: |
10.1016/j.lfs.2017.03.014 |
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| 520 | |a Endoglin is a transmembrane glycoprotein, that plays an important role in regulating endothelium. Proteolytic cleavage of membrane endoglin releases soluble endoglin (sEng), whose increased plasma levels have been detected in diseases related to the cardiovascular system. It was proposed that sEng might damage vascular endothelium, but detailed information about the potential mechanisms involved is not available. Thus, we hypothesized that sEng contributes to endothelial dysfunction, leading to a pro-inflammatory phenotype by a possible modulation of the TGF-β and/or inflammatory pathways. | ||
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10.1016/j.lfs.2017.03.014 doi GBVA2017021000024.pica (DE-627)ELV036197017 (ELSEVIER)S0024-3205(17)30097-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 690 VZ 530 620 VZ 52.56 bkl Varejckova, Michala verfasserin aut Soluble endoglin modulates the pro-inflammatory mediators NF-κB and IL-6 in cultured human endothelial cells 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Endoglin is a transmembrane glycoprotein, that plays an important role in regulating endothelium. Proteolytic cleavage of membrane endoglin releases soluble endoglin (sEng), whose increased plasma levels have been detected in diseases related to the cardiovascular system. It was proposed that sEng might damage vascular endothelium, but detailed information about the potential mechanisms involved is not available. Thus, we hypothesized that sEng contributes to endothelial dysfunction, leading to a pro-inflammatory phenotype by a possible modulation of the TGF-β and/or inflammatory pathways. Gallardo-Vara, Eunate oth Vicen, Matej oth Vitverova, Barbora oth Fikrova, Petra oth Dolezelova, Eva oth Rathouska, Jana oth Prasnicka, Alena oth Blazickova, Katerina oth Micuda, Stanislav oth Bernabeu, Carmelo oth Nemeckova, Ivana oth Nachtigal, Petr oth Enthalten in Elsevier Science Abd-Elhady, M.S. ELSEVIER Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling 2016 including pharmacology letters New York, NY [u.a.] (DE-627)ELV014481960 volume:175 year:2017 day:15 month:04 pages:52-60 extent:9 https://doi.org/10.1016/j.lfs.2017.03.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 175 2017 15 0415 52-60 9 045F 570 |
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10.1016/j.lfs.2017.03.014 doi GBVA2017021000024.pica (DE-627)ELV036197017 (ELSEVIER)S0024-3205(17)30097-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 690 VZ 530 620 VZ 52.56 bkl Varejckova, Michala verfasserin aut Soluble endoglin modulates the pro-inflammatory mediators NF-κB and IL-6 in cultured human endothelial cells 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Endoglin is a transmembrane glycoprotein, that plays an important role in regulating endothelium. Proteolytic cleavage of membrane endoglin releases soluble endoglin (sEng), whose increased plasma levels have been detected in diseases related to the cardiovascular system. It was proposed that sEng might damage vascular endothelium, but detailed information about the potential mechanisms involved is not available. Thus, we hypothesized that sEng contributes to endothelial dysfunction, leading to a pro-inflammatory phenotype by a possible modulation of the TGF-β and/or inflammatory pathways. Gallardo-Vara, Eunate oth Vicen, Matej oth Vitverova, Barbora oth Fikrova, Petra oth Dolezelova, Eva oth Rathouska, Jana oth Prasnicka, Alena oth Blazickova, Katerina oth Micuda, Stanislav oth Bernabeu, Carmelo oth Nemeckova, Ivana oth Nachtigal, Petr oth Enthalten in Elsevier Science Abd-Elhady, M.S. ELSEVIER Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling 2016 including pharmacology letters New York, NY [u.a.] (DE-627)ELV014481960 volume:175 year:2017 day:15 month:04 pages:52-60 extent:9 https://doi.org/10.1016/j.lfs.2017.03.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 175 2017 15 0415 52-60 9 045F 570 |
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10.1016/j.lfs.2017.03.014 doi GBVA2017021000024.pica (DE-627)ELV036197017 (ELSEVIER)S0024-3205(17)30097-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 690 VZ 530 620 VZ 52.56 bkl Varejckova, Michala verfasserin aut Soluble endoglin modulates the pro-inflammatory mediators NF-κB and IL-6 in cultured human endothelial cells 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Endoglin is a transmembrane glycoprotein, that plays an important role in regulating endothelium. Proteolytic cleavage of membrane endoglin releases soluble endoglin (sEng), whose increased plasma levels have been detected in diseases related to the cardiovascular system. It was proposed that sEng might damage vascular endothelium, but detailed information about the potential mechanisms involved is not available. Thus, we hypothesized that sEng contributes to endothelial dysfunction, leading to a pro-inflammatory phenotype by a possible modulation of the TGF-β and/or inflammatory pathways. Gallardo-Vara, Eunate oth Vicen, Matej oth Vitverova, Barbora oth Fikrova, Petra oth Dolezelova, Eva oth Rathouska, Jana oth Prasnicka, Alena oth Blazickova, Katerina oth Micuda, Stanislav oth Bernabeu, Carmelo oth Nemeckova, Ivana oth Nachtigal, Petr oth Enthalten in Elsevier Science Abd-Elhady, M.S. ELSEVIER Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling 2016 including pharmacology letters New York, NY [u.a.] (DE-627)ELV014481960 volume:175 year:2017 day:15 month:04 pages:52-60 extent:9 https://doi.org/10.1016/j.lfs.2017.03.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 175 2017 15 0415 52-60 9 045F 570 |
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10.1016/j.lfs.2017.03.014 doi GBVA2017021000024.pica (DE-627)ELV036197017 (ELSEVIER)S0024-3205(17)30097-8 DE-627 ger DE-627 rakwb eng 570 570 DE-600 690 VZ 530 620 VZ 52.56 bkl Varejckova, Michala verfasserin aut Soluble endoglin modulates the pro-inflammatory mediators NF-κB and IL-6 in cultured human endothelial cells 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Endoglin is a transmembrane glycoprotein, that plays an important role in regulating endothelium. Proteolytic cleavage of membrane endoglin releases soluble endoglin (sEng), whose increased plasma levels have been detected in diseases related to the cardiovascular system. It was proposed that sEng might damage vascular endothelium, but detailed information about the potential mechanisms involved is not available. Thus, we hypothesized that sEng contributes to endothelial dysfunction, leading to a pro-inflammatory phenotype by a possible modulation of the TGF-β and/or inflammatory pathways. Gallardo-Vara, Eunate oth Vicen, Matej oth Vitverova, Barbora oth Fikrova, Petra oth Dolezelova, Eva oth Rathouska, Jana oth Prasnicka, Alena oth Blazickova, Katerina oth Micuda, Stanislav oth Bernabeu, Carmelo oth Nemeckova, Ivana oth Nachtigal, Petr oth Enthalten in Elsevier Science Abd-Elhady, M.S. ELSEVIER Transition of convective heat transfer to subcooled flow boiling due to crystallization fouling 2016 including pharmacology letters New York, NY [u.a.] (DE-627)ELV014481960 volume:175 year:2017 day:15 month:04 pages:52-60 extent:9 https://doi.org/10.1016/j.lfs.2017.03.014 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_40 52.56 Regenerative Energieformen alternative Energieformen VZ AR 175 2017 15 0415 52-60 9 045F 570 |
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| doi_str_mv |
10.1016/j.lfs.2017.03.014 |
| dewey-full |
570 690 530 620 |
| title_sort |
soluble endoglin modulates the pro-inflammatory mediators nf-κb and il-6 in cultured human endothelial cells |
| title_auth |
Soluble endoglin modulates the pro-inflammatory mediators NF-κB and IL-6 in cultured human endothelial cells |
| abstract |
Endoglin is a transmembrane glycoprotein, that plays an important role in regulating endothelium. Proteolytic cleavage of membrane endoglin releases soluble endoglin (sEng), whose increased plasma levels have been detected in diseases related to the cardiovascular system. It was proposed that sEng might damage vascular endothelium, but detailed information about the potential mechanisms involved is not available. Thus, we hypothesized that sEng contributes to endothelial dysfunction, leading to a pro-inflammatory phenotype by a possible modulation of the TGF-β and/or inflammatory pathways. |
| abstractGer |
Endoglin is a transmembrane glycoprotein, that plays an important role in regulating endothelium. Proteolytic cleavage of membrane endoglin releases soluble endoglin (sEng), whose increased plasma levels have been detected in diseases related to the cardiovascular system. It was proposed that sEng might damage vascular endothelium, but detailed information about the potential mechanisms involved is not available. Thus, we hypothesized that sEng contributes to endothelial dysfunction, leading to a pro-inflammatory phenotype by a possible modulation of the TGF-β and/or inflammatory pathways. |
| abstract_unstemmed |
Endoglin is a transmembrane glycoprotein, that plays an important role in regulating endothelium. Proteolytic cleavage of membrane endoglin releases soluble endoglin (sEng), whose increased plasma levels have been detected in diseases related to the cardiovascular system. It was proposed that sEng might damage vascular endothelium, but detailed information about the potential mechanisms involved is not available. Thus, we hypothesized that sEng contributes to endothelial dysfunction, leading to a pro-inflammatory phenotype by a possible modulation of the TGF-β and/or inflammatory pathways. |
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| title_short |
Soluble endoglin modulates the pro-inflammatory mediators NF-κB and IL-6 in cultured human endothelial cells |
| url |
https://doi.org/10.1016/j.lfs.2017.03.014 |
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Gallardo-Vara, Eunate Vicen, Matej Vitverova, Barbora Fikrova, Petra Dolezelova, Eva Rathouska, Jana Prasnicka, Alena Blazickova, Katerina Micuda, Stanislav Bernabeu, Carmelo Nemeckova, Ivana Nachtigal, Petr |
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Gallardo-Vara, Eunate Vicen, Matej Vitverova, Barbora Fikrova, Petra Dolezelova, Eva Rathouska, Jana Prasnicka, Alena Blazickova, Katerina Micuda, Stanislav Bernabeu, Carmelo Nemeckova, Ivana Nachtigal, Petr |
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| doi_str |
10.1016/j.lfs.2017.03.014 |
| up_date |
2024-07-06T19:33:46.942Z |
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