Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue
Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 1...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhao, Hua [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
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| Schlagwörter: |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: 3203 – IDENTIFICATION OF DIFFERENTIATION ROOTS OF HEMATOPOIETIC STEM CELLS BY A PAIRED-DAUGHTER ASSAY COMBINED WITH MULTIPLE BARCODING - Tanaka, Yosuke ELSEVIER, 2022, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:217 ; year:2013 ; number:1 ; day:15 ; month:07 ; pages:67-74 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.jneumeth.2013.04.008 |
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| 520 | |a Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. | ||
| 520 | |a Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. | ||
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10.1016/j.jneumeth.2013.04.008 doi GBVA2013004000030.pica (DE-627)ELV038615991 (ELSEVIER)S0165-0270(13)00146-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.86 bkl Zhao, Hua verfasserin aut Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. THF Elsevier MS Elsevier LAMP2 Elsevier LER Elsevier MeCbl Elsevier VDAC1 Elsevier Cbl Elsevier Met Elsevier AdoCbl Elsevier MMCM Elsevier 5-methyl-THF Elsevier Hcy Elsevier Ruberu, Kalani oth Li, Hongyun oth Garner, Brett oth Enthalten in Elsevier Science Tanaka, Yosuke ELSEVIER 3203 – IDENTIFICATION OF DIFFERENTIATION ROOTS OF HEMATOPOIETIC STEM CELLS BY A PAIRED-DAUGHTER ASSAY COMBINED WITH MULTIPLE BARCODING 2022 Amsterdam [u.a.] (DE-627)ELV008620644 volume:217 year:2013 number:1 day:15 month:07 pages:67-74 extent:8 https://doi.org/10.1016/j.jneumeth.2013.04.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.86 Hämatologie VZ AR 217 2013 1 15 0715 67-74 8 045F 610 |
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10.1016/j.jneumeth.2013.04.008 doi GBVA2013004000030.pica (DE-627)ELV038615991 (ELSEVIER)S0165-0270(13)00146-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.86 bkl Zhao, Hua verfasserin aut Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. THF Elsevier MS Elsevier LAMP2 Elsevier LER Elsevier MeCbl Elsevier VDAC1 Elsevier Cbl Elsevier Met Elsevier AdoCbl Elsevier MMCM Elsevier 5-methyl-THF Elsevier Hcy Elsevier Ruberu, Kalani oth Li, Hongyun oth Garner, Brett oth Enthalten in Elsevier Science Tanaka, Yosuke ELSEVIER 3203 – IDENTIFICATION OF DIFFERENTIATION ROOTS OF HEMATOPOIETIC STEM CELLS BY A PAIRED-DAUGHTER ASSAY COMBINED WITH MULTIPLE BARCODING 2022 Amsterdam [u.a.] (DE-627)ELV008620644 volume:217 year:2013 number:1 day:15 month:07 pages:67-74 extent:8 https://doi.org/10.1016/j.jneumeth.2013.04.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.86 Hämatologie VZ AR 217 2013 1 15 0715 67-74 8 045F 610 |
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10.1016/j.jneumeth.2013.04.008 doi GBVA2013004000030.pica (DE-627)ELV038615991 (ELSEVIER)S0165-0270(13)00146-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.86 bkl Zhao, Hua verfasserin aut Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. THF Elsevier MS Elsevier LAMP2 Elsevier LER Elsevier MeCbl Elsevier VDAC1 Elsevier Cbl Elsevier Met Elsevier AdoCbl Elsevier MMCM Elsevier 5-methyl-THF Elsevier Hcy Elsevier Ruberu, Kalani oth Li, Hongyun oth Garner, Brett oth Enthalten in Elsevier Science Tanaka, Yosuke ELSEVIER 3203 – IDENTIFICATION OF DIFFERENTIATION ROOTS OF HEMATOPOIETIC STEM CELLS BY A PAIRED-DAUGHTER ASSAY COMBINED WITH MULTIPLE BARCODING 2022 Amsterdam [u.a.] (DE-627)ELV008620644 volume:217 year:2013 number:1 day:15 month:07 pages:67-74 extent:8 https://doi.org/10.1016/j.jneumeth.2013.04.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.86 Hämatologie VZ AR 217 2013 1 15 0715 67-74 8 045F 610 |
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10.1016/j.jneumeth.2013.04.008 doi GBVA2013004000030.pica (DE-627)ELV038615991 (ELSEVIER)S0165-0270(13)00146-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.86 bkl Zhao, Hua verfasserin aut Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. THF Elsevier MS Elsevier LAMP2 Elsevier LER Elsevier MeCbl Elsevier VDAC1 Elsevier Cbl Elsevier Met Elsevier AdoCbl Elsevier MMCM Elsevier 5-methyl-THF Elsevier Hcy Elsevier Ruberu, Kalani oth Li, Hongyun oth Garner, Brett oth Enthalten in Elsevier Science Tanaka, Yosuke ELSEVIER 3203 – IDENTIFICATION OF DIFFERENTIATION ROOTS OF HEMATOPOIETIC STEM CELLS BY A PAIRED-DAUGHTER ASSAY COMBINED WITH MULTIPLE BARCODING 2022 Amsterdam [u.a.] (DE-627)ELV008620644 volume:217 year:2013 number:1 day:15 month:07 pages:67-74 extent:8 https://doi.org/10.1016/j.jneumeth.2013.04.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.86 Hämatologie VZ AR 217 2013 1 15 0715 67-74 8 045F 610 |
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10.1016/j.jneumeth.2013.04.008 doi GBVA2013004000030.pica (DE-627)ELV038615991 (ELSEVIER)S0165-0270(13)00146-5 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 44.86 bkl Zhao, Hua verfasserin aut Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. THF Elsevier MS Elsevier LAMP2 Elsevier LER Elsevier MeCbl Elsevier VDAC1 Elsevier Cbl Elsevier Met Elsevier AdoCbl Elsevier MMCM Elsevier 5-methyl-THF Elsevier Hcy Elsevier Ruberu, Kalani oth Li, Hongyun oth Garner, Brett oth Enthalten in Elsevier Science Tanaka, Yosuke ELSEVIER 3203 – IDENTIFICATION OF DIFFERENTIATION ROOTS OF HEMATOPOIETIC STEM CELLS BY A PAIRED-DAUGHTER ASSAY COMBINED WITH MULTIPLE BARCODING 2022 Amsterdam [u.a.] (DE-627)ELV008620644 volume:217 year:2013 number:1 day:15 month:07 pages:67-74 extent:8 https://doi.org/10.1016/j.jneumeth.2013.04.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 44.86 Hämatologie VZ AR 217 2013 1 15 0715 67-74 8 045F 610 |
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analysis of subcellular [57co] cobalamin distribution in sh-sy5y neurons and brain tissue |
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Analysis of subcellular [57Co] cobalamin distribution in SH-SY5Y neurons and brain tissue |
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Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. |
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Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. |
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Highlights • Methods were developed that can be used to accurately measure [57Co] Cbl levels in lysosomes, mitochondria and cytosol obtained from neuronal and fibroblast cell lines and mouse brain tissue. • The relative distribution of [57Co] Cbl in neurons and fibroblasts was 6% in the lysosomes, 14% in the mitochondria and 80% in the cytosol. • This technique was also used to fractionate organelles obtained from mouse brain, and the relative distribution of [57Co] Cbl was 12% in the lysosomes, 15% in the mitochondria and 73% in the cytosol. • The establishment of subcellular fractionation methods herein provides a useful tool for the investigation of intracellular Cbl trafficking. This method can be adapted to study the effects of age- or neuropathology-related lysosomal dysfunction on intracellular [57Co] Cbl transport in cells and animal brain tissues. |
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