Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients
Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there...
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Gespeichert in:
| Autor*in: |
Squassina, Alessio [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
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| Schlagwörter: |
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| Umfang: |
7 |
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| Übergeordnetes Werk: |
Enthalten in: Social insurance premiums and corporate cash holdings: Evidence from social insurance law in China - Deng, Lixing ELSEVIER, 2022, the official journal of the Italian Pharmacological Society, London |
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| Übergeordnetes Werk: |
volume:73 ; year:2013 ; pages:1-7 ; extent:7 |
| Links: |
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| DOI / URN: |
10.1016/j.phrs.2013.04.004 |
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ELV039007766 |
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| 245 | 1 | 0 | |a Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients |
| 264 | 1 | |c 2013transfer abstract | |
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| 520 | |a Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. | ||
| 520 | |a Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. | ||
| 650 | 7 | |a BD |2 Elsevier | |
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| 650 | 7 | |a PLD1 |2 Elsevier | |
| 650 | 7 | |a PIK3CG |2 Elsevier | |
| 650 | 7 | |a PI3K/AKT |2 Elsevier | |
| 650 | 7 | |a RDC |2 Elsevier | |
| 650 | 7 | |a GSK-3β |2 Elsevier | |
| 650 | 7 | |a R |2 Elsevier | |
| 650 | 7 | |a FDR |2 Elsevier | |
| 650 | 7 | |a EBV |2 Elsevier | |
| 650 | 7 | |a KEGG |2 Elsevier | |
| 650 | 7 | |a HSPA1A/1B |2 Elsevier | |
| 650 | 7 | |a MAPK3 |2 Elsevier | |
| 650 | 7 | |a IGFR1 |2 Elsevier | |
| 650 | 7 | |a BDNF |2 Elsevier | |
| 650 | 7 | |a qRT-PCR |2 Elsevier | |
| 650 | 7 | |a RMA |2 Elsevier | |
| 650 | 7 | |a IGF-1 |2 Elsevier | |
| 650 | 7 | |a IGFP4 |2 Elsevier | |
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| 700 | 1 | |a Costa, Marta |4 oth | |
| 700 | 1 | |a Congiu, Donatella |4 oth | |
| 700 | 1 | |a Manchia, Mirko |4 oth | |
| 700 | 1 | |a Angius, Andrea |4 oth | |
| 700 | 1 | |a Deiana, Valeria |4 oth | |
| 700 | 1 | |a Ardau, Raffaella |4 oth | |
| 700 | 1 | |a Chillotti, Caterina |4 oth | |
| 700 | 1 | |a Severino, Giovanni |4 oth | |
| 700 | 1 | |a Calza, Stefano |4 oth | |
| 700 | 1 | |a Del Zompo, Maria |4 oth | |
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10.1016/j.phrs.2013.04.004 doi GBVA2013017000029.pica (DE-627)ELV039007766 (ELSEVIER)S1043-6618(13)00072-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 330 VZ Squassina, Alessio verfasserin aut Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. BD Elsevier DSM-IV Elsevier LiCl Elsevier FLT1 Elsevier NR Elsevier BDI Elsevier PARD6G Elsevier SADS-L Elsevier PLD1 Elsevier PIK3CG Elsevier PI3K/AKT Elsevier RDC Elsevier GSK-3β Elsevier R Elsevier FDR Elsevier EBV Elsevier KEGG Elsevier HSPA1A/1B Elsevier MAPK3 Elsevier IGFR1 Elsevier BDNF Elsevier qRT-PCR Elsevier RMA Elsevier IGF-1 Elsevier IGFP4 Elsevier MAPK Elsevier SYN2 Elsevier CCNA1 Elsevier CREB1 Elsevier IL2RA Elsevier LCLs Elsevier FC Elsevier HLA-DQB1 Elsevier Costa, Marta oth Congiu, Donatella oth Manchia, Mirko oth Angius, Andrea oth Deiana, Valeria oth Ardau, Raffaella oth Chillotti, Caterina oth Severino, Giovanni oth Calza, Stefano oth Del Zompo, Maria oth Enthalten in Academic Press Deng, Lixing ELSEVIER Social insurance premiums and corporate cash holdings: Evidence from social insurance law in China 2022 the official journal of the Italian Pharmacological Society London (DE-627)ELV008224951 volume:73 year:2013 pages:1-7 extent:7 https://doi.org/10.1016/j.phrs.2013.04.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 73 2013 1-7 7 045F 610 |
| spelling |
10.1016/j.phrs.2013.04.004 doi GBVA2013017000029.pica (DE-627)ELV039007766 (ELSEVIER)S1043-6618(13)00072-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 330 VZ Squassina, Alessio verfasserin aut Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. BD Elsevier DSM-IV Elsevier LiCl Elsevier FLT1 Elsevier NR Elsevier BDI Elsevier PARD6G Elsevier SADS-L Elsevier PLD1 Elsevier PIK3CG Elsevier PI3K/AKT Elsevier RDC Elsevier GSK-3β Elsevier R Elsevier FDR Elsevier EBV Elsevier KEGG Elsevier HSPA1A/1B Elsevier MAPK3 Elsevier IGFR1 Elsevier BDNF Elsevier qRT-PCR Elsevier RMA Elsevier IGF-1 Elsevier IGFP4 Elsevier MAPK Elsevier SYN2 Elsevier CCNA1 Elsevier CREB1 Elsevier IL2RA Elsevier LCLs Elsevier FC Elsevier HLA-DQB1 Elsevier Costa, Marta oth Congiu, Donatella oth Manchia, Mirko oth Angius, Andrea oth Deiana, Valeria oth Ardau, Raffaella oth Chillotti, Caterina oth Severino, Giovanni oth Calza, Stefano oth Del Zompo, Maria oth Enthalten in Academic Press Deng, Lixing ELSEVIER Social insurance premiums and corporate cash holdings: Evidence from social insurance law in China 2022 the official journal of the Italian Pharmacological Society London (DE-627)ELV008224951 volume:73 year:2013 pages:1-7 extent:7 https://doi.org/10.1016/j.phrs.2013.04.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 73 2013 1-7 7 045F 610 |
| allfields_unstemmed |
10.1016/j.phrs.2013.04.004 doi GBVA2013017000029.pica (DE-627)ELV039007766 (ELSEVIER)S1043-6618(13)00072-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 330 VZ Squassina, Alessio verfasserin aut Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. BD Elsevier DSM-IV Elsevier LiCl Elsevier FLT1 Elsevier NR Elsevier BDI Elsevier PARD6G Elsevier SADS-L Elsevier PLD1 Elsevier PIK3CG Elsevier PI3K/AKT Elsevier RDC Elsevier GSK-3β Elsevier R Elsevier FDR Elsevier EBV Elsevier KEGG Elsevier HSPA1A/1B Elsevier MAPK3 Elsevier IGFR1 Elsevier BDNF Elsevier qRT-PCR Elsevier RMA Elsevier IGF-1 Elsevier IGFP4 Elsevier MAPK Elsevier SYN2 Elsevier CCNA1 Elsevier CREB1 Elsevier IL2RA Elsevier LCLs Elsevier FC Elsevier HLA-DQB1 Elsevier Costa, Marta oth Congiu, Donatella oth Manchia, Mirko oth Angius, Andrea oth Deiana, Valeria oth Ardau, Raffaella oth Chillotti, Caterina oth Severino, Giovanni oth Calza, Stefano oth Del Zompo, Maria oth Enthalten in Academic Press Deng, Lixing ELSEVIER Social insurance premiums and corporate cash holdings: Evidence from social insurance law in China 2022 the official journal of the Italian Pharmacological Society London (DE-627)ELV008224951 volume:73 year:2013 pages:1-7 extent:7 https://doi.org/10.1016/j.phrs.2013.04.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 73 2013 1-7 7 045F 610 |
| allfieldsGer |
10.1016/j.phrs.2013.04.004 doi GBVA2013017000029.pica (DE-627)ELV039007766 (ELSEVIER)S1043-6618(13)00072-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 330 VZ Squassina, Alessio verfasserin aut Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. BD Elsevier DSM-IV Elsevier LiCl Elsevier FLT1 Elsevier NR Elsevier BDI Elsevier PARD6G Elsevier SADS-L Elsevier PLD1 Elsevier PIK3CG Elsevier PI3K/AKT Elsevier RDC Elsevier GSK-3β Elsevier R Elsevier FDR Elsevier EBV Elsevier KEGG Elsevier HSPA1A/1B Elsevier MAPK3 Elsevier IGFR1 Elsevier BDNF Elsevier qRT-PCR Elsevier RMA Elsevier IGF-1 Elsevier IGFP4 Elsevier MAPK Elsevier SYN2 Elsevier CCNA1 Elsevier CREB1 Elsevier IL2RA Elsevier LCLs Elsevier FC Elsevier HLA-DQB1 Elsevier Costa, Marta oth Congiu, Donatella oth Manchia, Mirko oth Angius, Andrea oth Deiana, Valeria oth Ardau, Raffaella oth Chillotti, Caterina oth Severino, Giovanni oth Calza, Stefano oth Del Zompo, Maria oth Enthalten in Academic Press Deng, Lixing ELSEVIER Social insurance premiums and corporate cash holdings: Evidence from social insurance law in China 2022 the official journal of the Italian Pharmacological Society London (DE-627)ELV008224951 volume:73 year:2013 pages:1-7 extent:7 https://doi.org/10.1016/j.phrs.2013.04.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 73 2013 1-7 7 045F 610 |
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10.1016/j.phrs.2013.04.004 doi GBVA2013017000029.pica (DE-627)ELV039007766 (ELSEVIER)S1043-6618(13)00072-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 330 VZ Squassina, Alessio verfasserin aut Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients 2013transfer abstract 7 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. BD Elsevier DSM-IV Elsevier LiCl Elsevier FLT1 Elsevier NR Elsevier BDI Elsevier PARD6G Elsevier SADS-L Elsevier PLD1 Elsevier PIK3CG Elsevier PI3K/AKT Elsevier RDC Elsevier GSK-3β Elsevier R Elsevier FDR Elsevier EBV Elsevier KEGG Elsevier HSPA1A/1B Elsevier MAPK3 Elsevier IGFR1 Elsevier BDNF Elsevier qRT-PCR Elsevier RMA Elsevier IGF-1 Elsevier IGFP4 Elsevier MAPK Elsevier SYN2 Elsevier CCNA1 Elsevier CREB1 Elsevier IL2RA Elsevier LCLs Elsevier FC Elsevier HLA-DQB1 Elsevier Costa, Marta oth Congiu, Donatella oth Manchia, Mirko oth Angius, Andrea oth Deiana, Valeria oth Ardau, Raffaella oth Chillotti, Caterina oth Severino, Giovanni oth Calza, Stefano oth Del Zompo, Maria oth Enthalten in Academic Press Deng, Lixing ELSEVIER Social insurance premiums and corporate cash holdings: Evidence from social insurance law in China 2022 the official journal of the Italian Pharmacological Society London (DE-627)ELV008224951 volume:73 year:2013 pages:1-7 extent:7 https://doi.org/10.1016/j.phrs.2013.04.004 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 73 2013 1-7 7 045F 610 |
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Social insurance premiums and corporate cash holdings: Evidence from social insurance law in China |
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Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients |
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Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients |
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Squassina, Alessio |
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Social insurance premiums and corporate cash holdings: Evidence from social insurance law in China |
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Social insurance premiums and corporate cash holdings: Evidence from social insurance law in China |
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Squassina, Alessio |
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Squassina, Alessio |
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10.1016/j.phrs.2013.04.004 |
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insulin-like growth factor 1 (igf-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients |
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Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients |
| abstract |
Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. |
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Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. |
| abstract_unstemmed |
Abstract Bipolar disorder (BD) is a debilitating psychiatric disease characterized by alternating episodes of mania and depression. Among mood stabilizers, lithium is the mainstay for the treatment of BD, with approximately one-third of patients showing remission from episode recurrence. While there is evidence suggesting genetic load for lithium response in BD, its molecular underpinnings are still not completely understood. To identify genes potentially involved in (or correlated with) lithium response, we carried out a genome-wide expression analysis on lymphoblastoid cell lines (LCLs) from 10 BD patients responders (R) and 10 non-responders (NR) to lithium. We compared expression levels of the two groups and tested whether in vitro lithium treatment had different effects in LCLs of R compared to NR. At basal, 2060 genes were differentially expressed between R and NR while no genes were differentially regulated by lithium in the two groups. After pathway analysis based on the 2060 genes, 9 genes were selected for validation with qRT-PCR. Eight genes were validated in the same sample of LCLs while only insulin-like growth factor 1 (IGF-1) was significantly over-expressed in R compared to NR in the same sample as well as in an independent sample comprised of 6 R and 6 NR (sample 1, fold change=1.94; p =0.005; sample 2, fold change=2.21; p =0.005). IGF-1 was also significantly over-expressed in R but not in NR when compared to a sample of non-psychiatric controls. Our findings suggest that IGF-1 may be involved in lithium response, supporting further investigation on its potential as a biomarker. |
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Insulin-like growth factor 1 (IGF-1) expression is up-regulated in lymphoblastoid cell lines of lithium responsive bipolar disorder patients |
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https://doi.org/10.1016/j.phrs.2013.04.004 |
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Costa, Marta Congiu, Donatella Manchia, Mirko Angius, Andrea Deiana, Valeria Ardau, Raffaella Chillotti, Caterina Severino, Giovanni Calza, Stefano Del Zompo, Maria |
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Costa, Marta Congiu, Donatella Manchia, Mirko Angius, Andrea Deiana, Valeria Ardau, Raffaella Chillotti, Caterina Severino, Giovanni Calza, Stefano Del Zompo, Maria |
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