Early exercise training improves ischemic outcome in rats by cerebral hemodynamics
This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Tian, Shan [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2013transfer abstract |
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| Schlagwörter: |
Brain microvascular endothelial cells |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: DNA methylation mediates gonadal development via regulating the expression levels of - Su, Junxiao ELSEVIER, 2023, an international multidisciplinary journal devoted to fundamental research in the brain sciences, Amsterdam |
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| Übergeordnetes Werk: |
volume:1533 ; year:2013 ; day:2 ; month:10 ; pages:114-121 ; extent:8 |
| Links: |
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| DOI / URN: |
10.1016/j.brainres.2013.07.049 |
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ELV039060551 |
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| 245 | 1 | 0 | |a Early exercise training improves ischemic outcome in rats by cerebral hemodynamics |
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| 520 | |a This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. | ||
| 520 | |a This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. | ||
| 650 | 7 | |a Brain microvascular endothelial cells |2 Elsevier | |
| 650 | 7 | |a Very early initiated physical rehabilitation |2 Elsevier | |
| 650 | 7 | |a Cerebral blood flow |2 Elsevier | |
| 650 | 7 | |a Ischemic stroke |2 Elsevier | |
| 650 | 7 | |a Apoptosis |2 Elsevier | |
| 700 | 1 | |a Zhang, Youcan |4 oth | |
| 700 | 1 | |a Tian, Song |4 oth | |
| 700 | 1 | |a Yang, Xiaojiao |4 oth | |
| 700 | 1 | |a Yu, Kewei |4 oth | |
| 700 | 1 | |a Zhang, Yuling |4 oth | |
| 700 | 1 | |a Shen, Xiafeng |4 oth | |
| 700 | 1 | |a Zhang, Liping |4 oth | |
| 700 | 1 | |a Sun, Yu |4 oth | |
| 700 | 1 | |a Xie, Hongyu |4 oth | |
| 700 | 1 | |a He, Zhijie |4 oth | |
| 700 | 1 | |a Guo, Zhenzhen |4 oth | |
| 700 | 1 | |a Jia, Jie |4 oth | |
| 700 | 1 | |a Wu, Yi |4 oth | |
| 700 | 1 | |a Bai, Yulong |4 oth | |
| 700 | 1 | |a Zhu, Yulian |4 oth | |
| 700 | 1 | |a Cheng, Yong |4 oth | |
| 700 | 1 | |a Wang, Xinggang |4 oth | |
| 700 | 1 | |a Wu, Junfa |4 oth | |
| 700 | 1 | |a Wang, Nianhong |4 oth | |
| 700 | 1 | |a Yu, Huixian |4 oth | |
| 700 | 1 | |a Hu, Yongshan |4 oth | |
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10.1016/j.brainres.2013.07.049 doi GBVA2013019000006.pica (DE-627)ELV039060551 (ELSEVIER)S0006-8993(13)01057-3 DE-627 ger DE-627 rakwb eng 150 610 150 DE-600 610 DE-600 540 570 VZ BIODIV DE-30 fid 35.80 bkl 58.30 bkl Tian, Shan verfasserin aut Early exercise training improves ischemic outcome in rats by cerebral hemodynamics 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. Brain microvascular endothelial cells Elsevier Very early initiated physical rehabilitation Elsevier Cerebral blood flow Elsevier Ischemic stroke Elsevier Apoptosis Elsevier Zhang, Youcan oth Tian, Song oth Yang, Xiaojiao oth Yu, Kewei oth Zhang, Yuling oth Shen, Xiafeng oth Zhang, Liping oth Sun, Yu oth Xie, Hongyu oth He, Zhijie oth Guo, Zhenzhen oth Jia, Jie oth Wu, Yi oth Bai, Yulong oth Zhu, Yulian oth Cheng, Yong oth Wang, Xinggang oth Wu, Junfa oth Wang, Nianhong oth Yu, Huixian oth Hu, Yongshan oth Enthalten in Elsevier Su, Junxiao ELSEVIER DNA methylation mediates gonadal development via regulating the expression levels of 2023 an international multidisciplinary journal devoted to fundamental research in the brain sciences Amsterdam (DE-627)ELV010071113 volume:1533 year:2013 day:2 month:10 pages:114-121 extent:8 https://doi.org/10.1016/j.brainres.2013.07.049 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.80 Makromolekulare Chemie VZ 58.30 Biotechnologie VZ AR 1533 2013 2 1002 114-121 8 045F 150 |
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10.1016/j.brainres.2013.07.049 doi GBVA2013019000006.pica (DE-627)ELV039060551 (ELSEVIER)S0006-8993(13)01057-3 DE-627 ger DE-627 rakwb eng 150 610 150 DE-600 610 DE-600 540 570 VZ BIODIV DE-30 fid 35.80 bkl 58.30 bkl Tian, Shan verfasserin aut Early exercise training improves ischemic outcome in rats by cerebral hemodynamics 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. Brain microvascular endothelial cells Elsevier Very early initiated physical rehabilitation Elsevier Cerebral blood flow Elsevier Ischemic stroke Elsevier Apoptosis Elsevier Zhang, Youcan oth Tian, Song oth Yang, Xiaojiao oth Yu, Kewei oth Zhang, Yuling oth Shen, Xiafeng oth Zhang, Liping oth Sun, Yu oth Xie, Hongyu oth He, Zhijie oth Guo, Zhenzhen oth Jia, Jie oth Wu, Yi oth Bai, Yulong oth Zhu, Yulian oth Cheng, Yong oth Wang, Xinggang oth Wu, Junfa oth Wang, Nianhong oth Yu, Huixian oth Hu, Yongshan oth Enthalten in Elsevier Su, Junxiao ELSEVIER DNA methylation mediates gonadal development via regulating the expression levels of 2023 an international multidisciplinary journal devoted to fundamental research in the brain sciences Amsterdam (DE-627)ELV010071113 volume:1533 year:2013 day:2 month:10 pages:114-121 extent:8 https://doi.org/10.1016/j.brainres.2013.07.049 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.80 Makromolekulare Chemie VZ 58.30 Biotechnologie VZ AR 1533 2013 2 1002 114-121 8 045F 150 |
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10.1016/j.brainres.2013.07.049 doi GBVA2013019000006.pica (DE-627)ELV039060551 (ELSEVIER)S0006-8993(13)01057-3 DE-627 ger DE-627 rakwb eng 150 610 150 DE-600 610 DE-600 540 570 VZ BIODIV DE-30 fid 35.80 bkl 58.30 bkl Tian, Shan verfasserin aut Early exercise training improves ischemic outcome in rats by cerebral hemodynamics 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. Brain microvascular endothelial cells Elsevier Very early initiated physical rehabilitation Elsevier Cerebral blood flow Elsevier Ischemic stroke Elsevier Apoptosis Elsevier Zhang, Youcan oth Tian, Song oth Yang, Xiaojiao oth Yu, Kewei oth Zhang, Yuling oth Shen, Xiafeng oth Zhang, Liping oth Sun, Yu oth Xie, Hongyu oth He, Zhijie oth Guo, Zhenzhen oth Jia, Jie oth Wu, Yi oth Bai, Yulong oth Zhu, Yulian oth Cheng, Yong oth Wang, Xinggang oth Wu, Junfa oth Wang, Nianhong oth Yu, Huixian oth Hu, Yongshan oth Enthalten in Elsevier Su, Junxiao ELSEVIER DNA methylation mediates gonadal development via regulating the expression levels of 2023 an international multidisciplinary journal devoted to fundamental research in the brain sciences Amsterdam (DE-627)ELV010071113 volume:1533 year:2013 day:2 month:10 pages:114-121 extent:8 https://doi.org/10.1016/j.brainres.2013.07.049 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.80 Makromolekulare Chemie VZ 58.30 Biotechnologie VZ AR 1533 2013 2 1002 114-121 8 045F 150 |
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10.1016/j.brainres.2013.07.049 doi GBVA2013019000006.pica (DE-627)ELV039060551 (ELSEVIER)S0006-8993(13)01057-3 DE-627 ger DE-627 rakwb eng 150 610 150 DE-600 610 DE-600 540 570 VZ BIODIV DE-30 fid 35.80 bkl 58.30 bkl Tian, Shan verfasserin aut Early exercise training improves ischemic outcome in rats by cerebral hemodynamics 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. Brain microvascular endothelial cells Elsevier Very early initiated physical rehabilitation Elsevier Cerebral blood flow Elsevier Ischemic stroke Elsevier Apoptosis Elsevier Zhang, Youcan oth Tian, Song oth Yang, Xiaojiao oth Yu, Kewei oth Zhang, Yuling oth Shen, Xiafeng oth Zhang, Liping oth Sun, Yu oth Xie, Hongyu oth He, Zhijie oth Guo, Zhenzhen oth Jia, Jie oth Wu, Yi oth Bai, Yulong oth Zhu, Yulian oth Cheng, Yong oth Wang, Xinggang oth Wu, Junfa oth Wang, Nianhong oth Yu, Huixian oth Hu, Yongshan oth Enthalten in Elsevier Su, Junxiao ELSEVIER DNA methylation mediates gonadal development via regulating the expression levels of 2023 an international multidisciplinary journal devoted to fundamental research in the brain sciences Amsterdam (DE-627)ELV010071113 volume:1533 year:2013 day:2 month:10 pages:114-121 extent:8 https://doi.org/10.1016/j.brainres.2013.07.049 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.80 Makromolekulare Chemie VZ 58.30 Biotechnologie VZ AR 1533 2013 2 1002 114-121 8 045F 150 |
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10.1016/j.brainres.2013.07.049 doi GBVA2013019000006.pica (DE-627)ELV039060551 (ELSEVIER)S0006-8993(13)01057-3 DE-627 ger DE-627 rakwb eng 150 610 150 DE-600 610 DE-600 540 570 VZ BIODIV DE-30 fid 35.80 bkl 58.30 bkl Tian, Shan verfasserin aut Early exercise training improves ischemic outcome in rats by cerebral hemodynamics 2013transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. Brain microvascular endothelial cells Elsevier Very early initiated physical rehabilitation Elsevier Cerebral blood flow Elsevier Ischemic stroke Elsevier Apoptosis Elsevier Zhang, Youcan oth Tian, Song oth Yang, Xiaojiao oth Yu, Kewei oth Zhang, Yuling oth Shen, Xiafeng oth Zhang, Liping oth Sun, Yu oth Xie, Hongyu oth He, Zhijie oth Guo, Zhenzhen oth Jia, Jie oth Wu, Yi oth Bai, Yulong oth Zhu, Yulian oth Cheng, Yong oth Wang, Xinggang oth Wu, Junfa oth Wang, Nianhong oth Yu, Huixian oth Hu, Yongshan oth Enthalten in Elsevier Su, Junxiao ELSEVIER DNA methylation mediates gonadal development via regulating the expression levels of 2023 an international multidisciplinary journal devoted to fundamental research in the brain sciences Amsterdam (DE-627)ELV010071113 volume:1533 year:2013 day:2 month:10 pages:114-121 extent:8 https://doi.org/10.1016/j.brainres.2013.07.049 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA 35.80 Makromolekulare Chemie VZ 58.30 Biotechnologie VZ AR 1533 2013 2 1002 114-121 8 045F 150 |
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Tian, Shan @@aut@@ Zhang, Youcan @@oth@@ Tian, Song @@oth@@ Yang, Xiaojiao @@oth@@ Yu, Kewei @@oth@@ Zhang, Yuling @@oth@@ Shen, Xiafeng @@oth@@ Zhang, Liping @@oth@@ Sun, Yu @@oth@@ Xie, Hongyu @@oth@@ He, Zhijie @@oth@@ Guo, Zhenzhen @@oth@@ Jia, Jie @@oth@@ Wu, Yi @@oth@@ Bai, Yulong @@oth@@ Zhu, Yulian @@oth@@ Cheng, Yong @@oth@@ Wang, Xinggang @@oth@@ Wu, Junfa @@oth@@ Wang, Nianhong @@oth@@ Yu, Huixian @@oth@@ Hu, Yongshan @@oth@@ |
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This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. |
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This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. |
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This study examined whether very early initiated physical rehabilitation (VEIPR), as a recommended therapy for postischemia, could improve motor performance and cerebral blood flow (CBF). Adult male rats with ischemic injury caused by middle cerebral artery occlusion (MCAO) were trained to run on a treadmill for 30min per day at 12m/min. Through such exercise training for 3 days, the ischemic rats exhibited increased motor function and decreased infarct volume, as measured by a behavioral score and 2,3,5-triphenyltetrazolium chloride (TTC) staining method, as well as accelerated CBF, as detected with laser speckle imaging (LSI). Furthermore, to determine whether the observed improved CBF provided the protective factor for motor function recovery, we investigated the apoptosis of ischemic rat brain microvascular endothelial cells (rBMECs), which accepted the mechanical force of CBF directly, under flow intervention. The findings indicated that a modest flow decreased cell apoptosis in the ischemic condition and that this effect is magnitude dependent, as excessive flow increased apoptosis. |
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