Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine
Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of d...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Nguyen, Minh Khanh [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014transfer abstract |
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| Schlagwörter: |
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| Umfang: |
31 |
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| Übergeordnetes Werk: |
Enthalten in: LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY - Ruff, Christian T. ELSEVIER, 2012, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:39 ; year:2014 ; number:7 ; pages:1235-1265 ; extent:31 |
| Links: |
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| DOI / URN: |
10.1016/j.progpolymsci.2013.12.001 |
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| Katalog-ID: |
ELV03914755X |
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| 520 | |a Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. | ||
| 520 | |a Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. | ||
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10.1016/j.progpolymsci.2013.12.001 doi GBVA2014001000028.pica (DE-627)ELV03914755X (ELSEVIER)S0079-6700(13)00146-9 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Nguyen, Minh Khanh verfasserin aut Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine 2014transfer abstract 31 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. MPC Elsevier AlCl3 Elsevier NaBH4 Elsevier APS Elsevier PVL Elsevier CDI Elsevier Pluronic® Elsevier BMP-2 Elsevier BSA Elsevier (PNIPAm) Elsevier DEX-SH Elsevier CaCl2 Elsevier PEGLADA Elsevier CMC Elsevier RAFT Elsevier APMA Elsevier NaOCl Elsevier TFP Elsevier Me4Cyclam Elsevier AC Elsevier PNIPAm-PMMA Elsevier S-chitosan Elsevier AD Elsevier MCPDB Elsevier AAD Elsevier PHEMA Elsevier PGA Elsevier DOX Elsevier NCA Elsevier IleOEt Elsevier bFGF Elsevier HA-CHO Elsevier GAR IgG Elsevier β-NGF Elsevier LCST Elsevier BDA Elsevier Ig Elsevier NaBH3CN Elsevier AAc Elsevier PAEU Elsevier PPG Elsevier PPF Elsevier G Elsevier PHB Elsevier PDLA Elsevier cAMP Elsevier AAm Elsevier MBA Elsevier PPO Elsevier Na2B4O7 Elsevier SD Elsevier PLLA Elsevier macro-CTA Elsevier DMAP Elsevier TEMED Elsevier GOD Elsevier P(DEGMMA-co-MAA) Elsevier CD Elsevier NaIO4(NH4)2S2O8 Elsevier DEX-CHO Elsevier PEGDA Elsevier AIBN Elsevier ICG Elsevier NASI Elsevier PAA Elsevier PEO-PPO-PEO Elsevier PAC Elsevier PAUU Elsevier GDNF Elsevier GFs Elsevier PAE Elsevier AmB Elsevier Cu(I)Br Elsevier ALG Elsevier PEGDM Elsevier 5-FU Elsevier PDGF-BB Elsevier EDC Elsevier HRP Elsevier PBA Elsevier CaM Elsevier SPDP Elsevier CMDX-ADH Elsevier ZnCl2 Elsevier SPR Elsevier NORB Elsevier LeuOEt Elsevier AMF Elsevier MPEG Elsevier EG Elsevier PNIPMAAm Elsevier DCC Elsevier AEMA Elsevier PKA Elsevier Irgacure 2959 Elsevier BGP Elsevier GAG Elsevier DEX-VS Elsevier ATRP Elsevier MMP Elsevier ROP Elsevier p-TSA Elsevier DTB Elsevier PCL Elsevier DEGDVE Elsevier CMC-CHO Elsevier DEDBA Elsevier HPMA Elsevier PCR Elsevier ALG-MA Elsevier DTP Elsevier PLA Elsevier PPxY Elsevier DTT Elsevier DDD Elsevier AKAP Elsevier AFP Elsevier HDI Elsevier PANHS Elsevier o-NBE Elsevier Irgacure 651 Elsevier NHS Elsevier GA Elsevier PHPMAlac Elsevier DLLA Elsevier PLX Elsevier SELEX Elsevier TGase Elsevier TMDP Elsevier GLP-1 Elsevier VEGF Elsevier Con A Elsevier OSM Elsevier DMT Elsevier siRNA Elsevier P(PF-co-EG) Elsevier XG Elsevier PA Elsevier semi-IPN Elsevier HEP Elsevier CaSO4 Elsevier PEG Elsevier PLGA Elsevier ValOEt Elsevier PEI Elsevier DEX Elsevier UCNP Elsevier HA Elsevier CaCO3 Elsevier TGF-β1 Elsevier HB Elsevier PVA Elsevier PEO Elsevier Alsberg, Eben oth Enthalten in Elsevier Science Ruff, Christian T. ELSEVIER LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY 2012 Amsterdam [u.a.] (DE-627)ELV011160764 volume:39 year:2014 number:7 pages:1235-1265 extent:31 https://doi.org/10.1016/j.progpolymsci.2013.12.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_11 GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_74 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2021 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 39 2014 7 1235-1265 31 045F 540 |
| spelling |
10.1016/j.progpolymsci.2013.12.001 doi GBVA2014001000028.pica (DE-627)ELV03914755X (ELSEVIER)S0079-6700(13)00146-9 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Nguyen, Minh Khanh verfasserin aut Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine 2014transfer abstract 31 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. MPC Elsevier AlCl3 Elsevier NaBH4 Elsevier APS Elsevier PVL Elsevier CDI Elsevier Pluronic® Elsevier BMP-2 Elsevier BSA Elsevier (PNIPAm) Elsevier DEX-SH Elsevier CaCl2 Elsevier PEGLADA Elsevier CMC Elsevier RAFT Elsevier APMA Elsevier NaOCl Elsevier TFP Elsevier Me4Cyclam Elsevier AC Elsevier PNIPAm-PMMA Elsevier S-chitosan Elsevier AD Elsevier MCPDB Elsevier AAD Elsevier PHEMA Elsevier PGA Elsevier DOX Elsevier NCA Elsevier IleOEt Elsevier bFGF Elsevier HA-CHO Elsevier GAR IgG Elsevier β-NGF Elsevier LCST Elsevier BDA Elsevier Ig Elsevier NaBH3CN Elsevier AAc Elsevier PAEU Elsevier PPG Elsevier PPF Elsevier G Elsevier PHB Elsevier PDLA Elsevier cAMP Elsevier AAm Elsevier MBA Elsevier PPO Elsevier Na2B4O7 Elsevier SD Elsevier PLLA Elsevier macro-CTA Elsevier DMAP Elsevier TEMED Elsevier GOD Elsevier P(DEGMMA-co-MAA) Elsevier CD Elsevier NaIO4(NH4)2S2O8 Elsevier DEX-CHO Elsevier PEGDA Elsevier AIBN Elsevier ICG Elsevier NASI Elsevier PAA Elsevier PEO-PPO-PEO Elsevier PAC Elsevier PAUU Elsevier GDNF Elsevier GFs Elsevier PAE Elsevier AmB Elsevier Cu(I)Br Elsevier ALG Elsevier PEGDM Elsevier 5-FU Elsevier PDGF-BB Elsevier EDC Elsevier HRP Elsevier PBA Elsevier CaM Elsevier SPDP Elsevier CMDX-ADH Elsevier ZnCl2 Elsevier SPR Elsevier NORB Elsevier LeuOEt Elsevier AMF Elsevier MPEG Elsevier EG Elsevier PNIPMAAm Elsevier DCC Elsevier AEMA Elsevier PKA Elsevier Irgacure 2959 Elsevier BGP Elsevier GAG Elsevier DEX-VS Elsevier ATRP Elsevier MMP Elsevier ROP Elsevier p-TSA Elsevier DTB Elsevier PCL Elsevier DEGDVE Elsevier CMC-CHO Elsevier DEDBA Elsevier HPMA Elsevier PCR Elsevier ALG-MA Elsevier DTP Elsevier PLA Elsevier PPxY Elsevier DTT Elsevier DDD Elsevier AKAP Elsevier AFP Elsevier HDI Elsevier PANHS Elsevier o-NBE Elsevier Irgacure 651 Elsevier NHS Elsevier GA Elsevier PHPMAlac Elsevier DLLA Elsevier PLX Elsevier SELEX Elsevier TGase Elsevier TMDP Elsevier GLP-1 Elsevier VEGF Elsevier Con A Elsevier OSM Elsevier DMT Elsevier siRNA Elsevier P(PF-co-EG) Elsevier XG Elsevier PA Elsevier semi-IPN Elsevier HEP Elsevier CaSO4 Elsevier PEG Elsevier PLGA Elsevier ValOEt Elsevier PEI Elsevier DEX Elsevier UCNP Elsevier HA Elsevier CaCO3 Elsevier TGF-β1 Elsevier HB Elsevier PVA Elsevier PEO Elsevier Alsberg, Eben oth Enthalten in Elsevier Science Ruff, Christian T. ELSEVIER LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY 2012 Amsterdam [u.a.] (DE-627)ELV011160764 volume:39 year:2014 number:7 pages:1235-1265 extent:31 https://doi.org/10.1016/j.progpolymsci.2013.12.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_11 GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_74 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2021 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 39 2014 7 1235-1265 31 045F 540 |
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10.1016/j.progpolymsci.2013.12.001 doi GBVA2014001000028.pica (DE-627)ELV03914755X (ELSEVIER)S0079-6700(13)00146-9 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Nguyen, Minh Khanh verfasserin aut Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine 2014transfer abstract 31 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. MPC Elsevier AlCl3 Elsevier NaBH4 Elsevier APS Elsevier PVL Elsevier CDI Elsevier Pluronic® Elsevier BMP-2 Elsevier BSA Elsevier (PNIPAm) Elsevier DEX-SH Elsevier CaCl2 Elsevier PEGLADA Elsevier CMC Elsevier RAFT Elsevier APMA Elsevier NaOCl Elsevier TFP Elsevier Me4Cyclam Elsevier AC Elsevier PNIPAm-PMMA Elsevier S-chitosan Elsevier AD Elsevier MCPDB Elsevier AAD Elsevier PHEMA Elsevier PGA Elsevier DOX Elsevier NCA Elsevier IleOEt Elsevier bFGF Elsevier HA-CHO Elsevier GAR IgG Elsevier β-NGF Elsevier LCST Elsevier BDA Elsevier Ig Elsevier NaBH3CN Elsevier AAc Elsevier PAEU Elsevier PPG Elsevier PPF Elsevier G Elsevier PHB Elsevier PDLA Elsevier cAMP Elsevier AAm Elsevier MBA Elsevier PPO Elsevier Na2B4O7 Elsevier SD Elsevier PLLA Elsevier macro-CTA Elsevier DMAP Elsevier TEMED Elsevier GOD Elsevier P(DEGMMA-co-MAA) Elsevier CD Elsevier NaIO4(NH4)2S2O8 Elsevier DEX-CHO Elsevier PEGDA Elsevier AIBN Elsevier ICG Elsevier NASI Elsevier PAA Elsevier PEO-PPO-PEO Elsevier PAC Elsevier PAUU Elsevier GDNF Elsevier GFs Elsevier PAE Elsevier AmB Elsevier Cu(I)Br Elsevier ALG Elsevier PEGDM Elsevier 5-FU Elsevier PDGF-BB Elsevier EDC Elsevier HRP Elsevier PBA Elsevier CaM Elsevier SPDP Elsevier CMDX-ADH Elsevier ZnCl2 Elsevier SPR Elsevier NORB Elsevier LeuOEt Elsevier AMF Elsevier MPEG Elsevier EG Elsevier PNIPMAAm Elsevier DCC Elsevier AEMA Elsevier PKA Elsevier Irgacure 2959 Elsevier BGP Elsevier GAG Elsevier DEX-VS Elsevier ATRP Elsevier MMP Elsevier ROP Elsevier p-TSA Elsevier DTB Elsevier PCL Elsevier DEGDVE Elsevier CMC-CHO Elsevier DEDBA Elsevier HPMA Elsevier PCR Elsevier ALG-MA Elsevier DTP Elsevier PLA Elsevier PPxY Elsevier DTT Elsevier DDD Elsevier AKAP Elsevier AFP Elsevier HDI Elsevier PANHS Elsevier o-NBE Elsevier Irgacure 651 Elsevier NHS Elsevier GA Elsevier PHPMAlac Elsevier DLLA Elsevier PLX Elsevier SELEX Elsevier TGase Elsevier TMDP Elsevier GLP-1 Elsevier VEGF Elsevier Con A Elsevier OSM Elsevier DMT Elsevier siRNA Elsevier P(PF-co-EG) Elsevier XG Elsevier PA Elsevier semi-IPN Elsevier HEP Elsevier CaSO4 Elsevier PEG Elsevier PLGA Elsevier ValOEt Elsevier PEI Elsevier DEX Elsevier UCNP Elsevier HA Elsevier CaCO3 Elsevier TGF-β1 Elsevier HB Elsevier PVA Elsevier PEO Elsevier Alsberg, Eben oth Enthalten in Elsevier Science Ruff, Christian T. ELSEVIER LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY 2012 Amsterdam [u.a.] (DE-627)ELV011160764 volume:39 year:2014 number:7 pages:1235-1265 extent:31 https://doi.org/10.1016/j.progpolymsci.2013.12.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_11 GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_74 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2021 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 39 2014 7 1235-1265 31 045F 540 |
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10.1016/j.progpolymsci.2013.12.001 doi GBVA2014001000028.pica (DE-627)ELV03914755X (ELSEVIER)S0079-6700(13)00146-9 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Nguyen, Minh Khanh verfasserin aut Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine 2014transfer abstract 31 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. MPC Elsevier AlCl3 Elsevier NaBH4 Elsevier APS Elsevier PVL Elsevier CDI Elsevier Pluronic® Elsevier BMP-2 Elsevier BSA Elsevier (PNIPAm) Elsevier DEX-SH Elsevier CaCl2 Elsevier PEGLADA Elsevier CMC Elsevier RAFT Elsevier APMA Elsevier NaOCl Elsevier TFP Elsevier Me4Cyclam Elsevier AC Elsevier PNIPAm-PMMA Elsevier S-chitosan Elsevier AD Elsevier MCPDB Elsevier AAD Elsevier PHEMA Elsevier PGA Elsevier DOX Elsevier NCA Elsevier IleOEt Elsevier bFGF Elsevier HA-CHO Elsevier GAR IgG Elsevier β-NGF Elsevier LCST Elsevier BDA Elsevier Ig Elsevier NaBH3CN Elsevier AAc Elsevier PAEU Elsevier PPG Elsevier PPF Elsevier G Elsevier PHB Elsevier PDLA Elsevier cAMP Elsevier AAm Elsevier MBA Elsevier PPO Elsevier Na2B4O7 Elsevier SD Elsevier PLLA Elsevier macro-CTA Elsevier DMAP Elsevier TEMED Elsevier GOD Elsevier P(DEGMMA-co-MAA) Elsevier CD Elsevier NaIO4(NH4)2S2O8 Elsevier DEX-CHO Elsevier PEGDA Elsevier AIBN Elsevier ICG Elsevier NASI Elsevier PAA Elsevier PEO-PPO-PEO Elsevier PAC Elsevier PAUU Elsevier GDNF Elsevier GFs Elsevier PAE Elsevier AmB Elsevier Cu(I)Br Elsevier ALG Elsevier PEGDM Elsevier 5-FU Elsevier PDGF-BB Elsevier EDC Elsevier HRP Elsevier PBA Elsevier CaM Elsevier SPDP Elsevier CMDX-ADH Elsevier ZnCl2 Elsevier SPR Elsevier NORB Elsevier LeuOEt Elsevier AMF Elsevier MPEG Elsevier EG Elsevier PNIPMAAm Elsevier DCC Elsevier AEMA Elsevier PKA Elsevier Irgacure 2959 Elsevier BGP Elsevier GAG Elsevier DEX-VS Elsevier ATRP Elsevier MMP Elsevier ROP Elsevier p-TSA Elsevier DTB Elsevier PCL Elsevier DEGDVE Elsevier CMC-CHO Elsevier DEDBA Elsevier HPMA Elsevier PCR Elsevier ALG-MA Elsevier DTP Elsevier PLA Elsevier PPxY Elsevier DTT Elsevier DDD Elsevier AKAP Elsevier AFP Elsevier HDI Elsevier PANHS Elsevier o-NBE Elsevier Irgacure 651 Elsevier NHS Elsevier GA Elsevier PHPMAlac Elsevier DLLA Elsevier PLX Elsevier SELEX Elsevier TGase Elsevier TMDP Elsevier GLP-1 Elsevier VEGF Elsevier Con A Elsevier OSM Elsevier DMT Elsevier siRNA Elsevier P(PF-co-EG) Elsevier XG Elsevier PA Elsevier semi-IPN Elsevier HEP Elsevier CaSO4 Elsevier PEG Elsevier PLGA Elsevier ValOEt Elsevier PEI Elsevier DEX Elsevier UCNP Elsevier HA Elsevier CaCO3 Elsevier TGF-β1 Elsevier HB Elsevier PVA Elsevier PEO Elsevier Alsberg, Eben oth Enthalten in Elsevier Science Ruff, Christian T. ELSEVIER LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY 2012 Amsterdam [u.a.] (DE-627)ELV011160764 volume:39 year:2014 number:7 pages:1235-1265 extent:31 https://doi.org/10.1016/j.progpolymsci.2013.12.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_11 GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_74 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2021 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 39 2014 7 1235-1265 31 045F 540 |
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10.1016/j.progpolymsci.2013.12.001 doi GBVA2014001000028.pica (DE-627)ELV03914755X (ELSEVIER)S0079-6700(13)00146-9 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Nguyen, Minh Khanh verfasserin aut Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine 2014transfer abstract 31 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. MPC Elsevier AlCl3 Elsevier NaBH4 Elsevier APS Elsevier PVL Elsevier CDI Elsevier Pluronic® Elsevier BMP-2 Elsevier BSA Elsevier (PNIPAm) Elsevier DEX-SH Elsevier CaCl2 Elsevier PEGLADA Elsevier CMC Elsevier RAFT Elsevier APMA Elsevier NaOCl Elsevier TFP Elsevier Me4Cyclam Elsevier AC Elsevier PNIPAm-PMMA Elsevier S-chitosan Elsevier AD Elsevier MCPDB Elsevier AAD Elsevier PHEMA Elsevier PGA Elsevier DOX Elsevier NCA Elsevier IleOEt Elsevier bFGF Elsevier HA-CHO Elsevier GAR IgG Elsevier β-NGF Elsevier LCST Elsevier BDA Elsevier Ig Elsevier NaBH3CN Elsevier AAc Elsevier PAEU Elsevier PPG Elsevier PPF Elsevier G Elsevier PHB Elsevier PDLA Elsevier cAMP Elsevier AAm Elsevier MBA Elsevier PPO Elsevier Na2B4O7 Elsevier SD Elsevier PLLA Elsevier macro-CTA Elsevier DMAP Elsevier TEMED Elsevier GOD Elsevier P(DEGMMA-co-MAA) Elsevier CD Elsevier NaIO4(NH4)2S2O8 Elsevier DEX-CHO Elsevier PEGDA Elsevier AIBN Elsevier ICG Elsevier NASI Elsevier PAA Elsevier PEO-PPO-PEO Elsevier PAC Elsevier PAUU Elsevier GDNF Elsevier GFs Elsevier PAE Elsevier AmB Elsevier Cu(I)Br Elsevier ALG Elsevier PEGDM Elsevier 5-FU Elsevier PDGF-BB Elsevier EDC Elsevier HRP Elsevier PBA Elsevier CaM Elsevier SPDP Elsevier CMDX-ADH Elsevier ZnCl2 Elsevier SPR Elsevier NORB Elsevier LeuOEt Elsevier AMF Elsevier MPEG Elsevier EG Elsevier PNIPMAAm Elsevier DCC Elsevier AEMA Elsevier PKA Elsevier Irgacure 2959 Elsevier BGP Elsevier GAG Elsevier DEX-VS Elsevier ATRP Elsevier MMP Elsevier ROP Elsevier p-TSA Elsevier DTB Elsevier PCL Elsevier DEGDVE Elsevier CMC-CHO Elsevier DEDBA Elsevier HPMA Elsevier PCR Elsevier ALG-MA Elsevier DTP Elsevier PLA Elsevier PPxY Elsevier DTT Elsevier DDD Elsevier AKAP Elsevier AFP Elsevier HDI Elsevier PANHS Elsevier o-NBE Elsevier Irgacure 651 Elsevier NHS Elsevier GA Elsevier PHPMAlac Elsevier DLLA Elsevier PLX Elsevier SELEX Elsevier TGase Elsevier TMDP Elsevier GLP-1 Elsevier VEGF Elsevier Con A Elsevier OSM Elsevier DMT Elsevier siRNA Elsevier P(PF-co-EG) Elsevier XG Elsevier PA Elsevier semi-IPN Elsevier HEP Elsevier CaSO4 Elsevier PEG Elsevier PLGA Elsevier ValOEt Elsevier PEI Elsevier DEX Elsevier UCNP Elsevier HA Elsevier CaCO3 Elsevier TGF-β1 Elsevier HB Elsevier PVA Elsevier PEO Elsevier Alsberg, Eben oth Enthalten in Elsevier Science Ruff, Christian T. ELSEVIER LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY 2012 Amsterdam [u.a.] (DE-627)ELV011160764 volume:39 year:2014 number:7 pages:1235-1265 extent:31 https://doi.org/10.1016/j.progpolymsci.2013.12.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_11 GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_74 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2021 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 39 2014 7 1235-1265 31 045F 540 |
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Enthalten in LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY Amsterdam [u.a.] volume:39 year:2014 number:7 pages:1235-1265 extent:31 |
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| author |
Nguyen, Minh Khanh |
| spellingShingle |
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bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine |
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Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine |
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Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. |
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Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. |
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Polymer hydrogels have been widely explored as therapeutic delivery matrices because of their ability to present sustained, localized and controlled release of bioactive factors. Bioactive factor delivery from injectable biopolymer hydrogels provides a versatile approach to treat a wide variety of diseases, to direct cell function and to enhance tissue regeneration. The innovative development and modification of both natural- (e.g., alginate (ALG), chitosan, hyaluronic acid (HA), gelatin, heparin (HEP), etc.) and synthetic- (e.g., polyesters, polyethyleneimine (PEI), etc.) based polymers has resulted in a variety of approaches to design drug delivery hydrogel systems from which loaded therapeutics are released. This review presents the state-of-the-art in a wide range of hydrogels that are formed though self-assembly of polymers and peptides, chemical crosslinking, ionic crosslinking and biomolecule recognition. Hydrogel design for bioactive factor delivery is the focus of the first section. The second section then thoroughly discusses release strategies of payloads from hydrogels for therapeutic medicine, such as physical incorporation, covalent tethering, affinity interactions, on demand release and/or use of hybrid polymer scaffolds, with an emphasis on the last 5 years. |
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