Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs
• The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints. • Morphology, motor activity, histopathology, kinetics and gene expression were studied. • A series of anti-epileptic drugs showed specific sensitivity for each endpoint. • This test strategy may contribute to...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Beker van Woudenberg, Anna [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2014 |
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| Schlagwörter: |
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| Umfang: |
16 |
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| Übergeordnetes Werk: |
Enthalten in: Porous silicon Bragg mirrors on single- and multi-crystalline silicon for solar cells - 2013transfer abstract, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:49 ; year:2014 ; pages:101-116 ; extent:16 |
| Links: |
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| DOI / URN: |
10.1016/j.reprotox.2014.07.082 |
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ELV039407462 |
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| 520 | |a • The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints. • Morphology, motor activity, histopathology, kinetics and gene expression were studied. • A series of anti-epileptic drugs showed specific sensitivity for each endpoint. • This test strategy may contribute to elucidate the mode of action for developmental toxicity in ZET. • This test strategy may contribute to better define the applicability domain of the ZET. | ||
| 650 | 7 | |a Histopathology |2 Elsevier | |
| 650 | 7 | |a Integrated test strategy |2 Elsevier | |
| 650 | 7 | |a Developmental (neuro)toxicity |2 Elsevier | |
| 650 | 7 | |a Kinetics |2 Elsevier | |
| 650 | 7 | |a Behavior |2 Elsevier | |
| 650 | 7 | |a Gene expression |2 Elsevier | |
| 650 | 7 | |a Zebrafish embryotoxicity test (ZET) |2 Elsevier | |
| 650 | 7 | |a Antiepileptic drugs |2 Elsevier | |
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| 700 | 1 | |a Hermsen, Sanne |4 oth | |
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| 700 | 1 | |a Wolterbeek, André |4 oth | |
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10.1016/j.reprotox.2014.07.082 doi GBVA2014014000006.pica (DE-627)ELV039407462 (ELSEVIER)S0890-6238(14)00203-2 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 620 VZ Beker van Woudenberg, Anna verfasserin aut Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs 2014 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints. • Morphology, motor activity, histopathology, kinetics and gene expression were studied. • A series of anti-epileptic drugs showed specific sensitivity for each endpoint. • This test strategy may contribute to elucidate the mode of action for developmental toxicity in ZET. • This test strategy may contribute to better define the applicability domain of the ZET. Histopathology Elsevier Integrated test strategy Elsevier Developmental (neuro)toxicity Elsevier Kinetics Elsevier Behavior Elsevier Gene expression Elsevier Zebrafish embryotoxicity test (ZET) Elsevier Antiepileptic drugs Elsevier Snel, Cor oth Rijkmans, Eke oth de Groot, Didima oth Bouma, Marga oth Hermsen, Sanne oth Piersma, Aldert oth Menke, Aswin oth Wolterbeek, André oth Enthalten in Elsevier Science Porous silicon Bragg mirrors on single- and multi-crystalline silicon for solar cells 2013transfer abstract Amsterdam [u.a.] (DE-627)ELV022089438 volume:49 year:2014 pages:101-116 extent:16 https://doi.org/10.1016/j.reprotox.2014.07.082 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_22 GBV_ILN_24 GBV_ILN_26 GBV_ILN_31 GBV_ILN_40 AR 49 2014 101-116 16 045F 610 |
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10.1016/j.reprotox.2014.07.082 doi GBVA2014014000006.pica (DE-627)ELV039407462 (ELSEVIER)S0890-6238(14)00203-2 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 620 VZ Beker van Woudenberg, Anna verfasserin aut Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs 2014 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints. • Morphology, motor activity, histopathology, kinetics and gene expression were studied. • A series of anti-epileptic drugs showed specific sensitivity for each endpoint. • This test strategy may contribute to elucidate the mode of action for developmental toxicity in ZET. • This test strategy may contribute to better define the applicability domain of the ZET. Histopathology Elsevier Integrated test strategy Elsevier Developmental (neuro)toxicity Elsevier Kinetics Elsevier Behavior Elsevier Gene expression Elsevier Zebrafish embryotoxicity test (ZET) Elsevier Antiepileptic drugs Elsevier Snel, Cor oth Rijkmans, Eke oth de Groot, Didima oth Bouma, Marga oth Hermsen, Sanne oth Piersma, Aldert oth Menke, Aswin oth Wolterbeek, André oth Enthalten in Elsevier Science Porous silicon Bragg mirrors on single- and multi-crystalline silicon for solar cells 2013transfer abstract Amsterdam [u.a.] (DE-627)ELV022089438 volume:49 year:2014 pages:101-116 extent:16 https://doi.org/10.1016/j.reprotox.2014.07.082 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_22 GBV_ILN_24 GBV_ILN_26 GBV_ILN_31 GBV_ILN_40 AR 49 2014 101-116 16 045F 610 |
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10.1016/j.reprotox.2014.07.082 doi GBVA2014014000006.pica (DE-627)ELV039407462 (ELSEVIER)S0890-6238(14)00203-2 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 620 VZ Beker van Woudenberg, Anna verfasserin aut Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs 2014 16 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints. • Morphology, motor activity, histopathology, kinetics and gene expression were studied. • A series of anti-epileptic drugs showed specific sensitivity for each endpoint. • This test strategy may contribute to elucidate the mode of action for developmental toxicity in ZET. • This test strategy may contribute to better define the applicability domain of the ZET. Histopathology Elsevier Integrated test strategy Elsevier Developmental (neuro)toxicity Elsevier Kinetics Elsevier Behavior Elsevier Gene expression Elsevier Zebrafish embryotoxicity test (ZET) Elsevier Antiepileptic drugs Elsevier Snel, Cor oth Rijkmans, Eke oth de Groot, Didima oth Bouma, Marga oth Hermsen, Sanne oth Piersma, Aldert oth Menke, Aswin oth Wolterbeek, André oth Enthalten in Elsevier Science Porous silicon Bragg mirrors on single- and multi-crystalline silicon for solar cells 2013transfer abstract Amsterdam [u.a.] (DE-627)ELV022089438 volume:49 year:2014 pages:101-116 extent:16 https://doi.org/10.1016/j.reprotox.2014.07.082 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_22 GBV_ILN_24 GBV_ILN_26 GBV_ILN_31 GBV_ILN_40 AR 49 2014 101-116 16 045F 610 |
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Beker van Woudenberg, Anna |
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10.1016/j.reprotox.2014.07.082 |
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610 530 620 |
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zebrafish embryotoxicity test for developmental (neuro)toxicity: demo case of an integrated screening approach system using anti-epileptic drugs |
| title_auth |
Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs |
| abstract |
• The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints. • Morphology, motor activity, histopathology, kinetics and gene expression were studied. • A series of anti-epileptic drugs showed specific sensitivity for each endpoint. • This test strategy may contribute to elucidate the mode of action for developmental toxicity in ZET. • This test strategy may contribute to better define the applicability domain of the ZET. |
| abstractGer |
• The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints. • Morphology, motor activity, histopathology, kinetics and gene expression were studied. • A series of anti-epileptic drugs showed specific sensitivity for each endpoint. • This test strategy may contribute to elucidate the mode of action for developmental toxicity in ZET. • This test strategy may contribute to better define the applicability domain of the ZET. |
| abstract_unstemmed |
• The zebrafish embryotoxicity test (ZET) was applied using integrated multiple endpoints. • Morphology, motor activity, histopathology, kinetics and gene expression were studied. • A series of anti-epileptic drugs showed specific sensitivity for each endpoint. • This test strategy may contribute to elucidate the mode of action for developmental toxicity in ZET. • This test strategy may contribute to better define the applicability domain of the ZET. |
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| title_short |
Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs |
| url |
https://doi.org/10.1016/j.reprotox.2014.07.082 |
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Snel, Cor Rijkmans, Eke de Groot, Didima Bouma, Marga Hermsen, Sanne Piersma, Aldert Menke, Aswin Wolterbeek, André |
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Snel, Cor Rijkmans, Eke de Groot, Didima Bouma, Marga Hermsen, Sanne Piersma, Aldert Menke, Aswin Wolterbeek, André |
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