Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that e...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Newland, Ben [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015transfer abstract |
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| Schlagwörter: |
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| Umfang: |
34 |
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| Übergeordnetes Werk: |
Enthalten in: LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY - Ruff, Christian T. ELSEVIER, 2012, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:44 ; year:2015 ; pages:79-112 ; extent:34 |
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| DOI / URN: |
10.1016/j.progpolymsci.2014.12.002 |
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| 520 | |a Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. | ||
| 520 | |a Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. | ||
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10.1016/j.progpolymsci.2014.12.002 doi GBVA2015001000018.pica (DE-627)ELV039564657 (ELSEVIER)S0079-6700(15)00010-6 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Newland, Ben verfasserin aut Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders 2015transfer abstract 34 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. AD Elsevier BBB Elsevier DMAEMA Elsevier MS Elsevier ALS Elsevier 6-OHDA Elsevier PAMAM Elsevier PLL Elsevier PEG Elsevier PLGA Elsevier PD Elsevier PEI Elsevier SCI Elsevier MPTP Elsevier HD Elsevier Newland, Heike oth Werner, Carsten oth Rosser, Anne oth Wang, Wenxin oth Enthalten in Elsevier Science Ruff, Christian T. ELSEVIER LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY 2012 Amsterdam [u.a.] (DE-627)ELV011160764 volume:44 year:2015 pages:79-112 extent:34 https://doi.org/10.1016/j.progpolymsci.2014.12.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_11 GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_74 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2021 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 44 2015 79-112 34 045F 540 |
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10.1016/j.progpolymsci.2014.12.002 doi GBVA2015001000018.pica (DE-627)ELV039564657 (ELSEVIER)S0079-6700(15)00010-6 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Newland, Ben verfasserin aut Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders 2015transfer abstract 34 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. AD Elsevier BBB Elsevier DMAEMA Elsevier MS Elsevier ALS Elsevier 6-OHDA Elsevier PAMAM Elsevier PLL Elsevier PEG Elsevier PLGA Elsevier PD Elsevier PEI Elsevier SCI Elsevier MPTP Elsevier HD Elsevier Newland, Heike oth Werner, Carsten oth Rosser, Anne oth Wang, Wenxin oth Enthalten in Elsevier Science Ruff, Christian T. ELSEVIER LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY 2012 Amsterdam [u.a.] (DE-627)ELV011160764 volume:44 year:2015 pages:79-112 extent:34 https://doi.org/10.1016/j.progpolymsci.2014.12.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_11 GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_74 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2021 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 44 2015 79-112 34 045F 540 |
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10.1016/j.progpolymsci.2014.12.002 doi GBVA2015001000018.pica (DE-627)ELV039564657 (ELSEVIER)S0079-6700(15)00010-6 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Newland, Ben verfasserin aut Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders 2015transfer abstract 34 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. AD Elsevier BBB Elsevier DMAEMA Elsevier MS Elsevier ALS Elsevier 6-OHDA Elsevier PAMAM Elsevier PLL Elsevier PEG Elsevier PLGA Elsevier PD Elsevier PEI Elsevier SCI Elsevier MPTP Elsevier HD Elsevier Newland, Heike oth Werner, Carsten oth Rosser, Anne oth Wang, Wenxin oth Enthalten in Elsevier Science Ruff, Christian T. ELSEVIER LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY 2012 Amsterdam [u.a.] (DE-627)ELV011160764 volume:44 year:2015 pages:79-112 extent:34 https://doi.org/10.1016/j.progpolymsci.2014.12.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_11 GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_74 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2021 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 44 2015 79-112 34 045F 540 |
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10.1016/j.progpolymsci.2014.12.002 doi GBVA2015001000018.pica (DE-627)ELV039564657 (ELSEVIER)S0079-6700(15)00010-6 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Newland, Ben verfasserin aut Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders 2015transfer abstract 34 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. AD Elsevier BBB Elsevier DMAEMA Elsevier MS Elsevier ALS Elsevier 6-OHDA Elsevier PAMAM Elsevier PLL Elsevier PEG Elsevier PLGA Elsevier PD Elsevier PEI Elsevier SCI Elsevier MPTP Elsevier HD Elsevier Newland, Heike oth Werner, Carsten oth Rosser, Anne oth Wang, Wenxin oth Enthalten in Elsevier Science Ruff, Christian T. ELSEVIER LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY 2012 Amsterdam [u.a.] (DE-627)ELV011160764 volume:44 year:2015 pages:79-112 extent:34 https://doi.org/10.1016/j.progpolymsci.2014.12.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_11 GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_74 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2021 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 44 2015 79-112 34 045F 540 |
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10.1016/j.progpolymsci.2014.12.002 doi GBVA2015001000018.pica (DE-627)ELV039564657 (ELSEVIER)S0079-6700(15)00010-6 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 600 690 VZ 51.00 bkl 51.32 bkl Newland, Ben verfasserin aut Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders 2015transfer abstract 34 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. AD Elsevier BBB Elsevier DMAEMA Elsevier MS Elsevier ALS Elsevier 6-OHDA Elsevier PAMAM Elsevier PLL Elsevier PEG Elsevier PLGA Elsevier PD Elsevier PEI Elsevier SCI Elsevier MPTP Elsevier HD Elsevier Newland, Heike oth Werner, Carsten oth Rosser, Anne oth Wang, Wenxin oth Enthalten in Elsevier Science Ruff, Christian T. ELSEVIER LONG-TERM RISK AND PROGNOSIS OF RECURRENT CARDIOVASCULAR EVENTS IN THE REACH REGISTRY 2012 Amsterdam [u.a.] (DE-627)ELV011160764 volume:44 year:2015 pages:79-112 extent:34 https://doi.org/10.1016/j.progpolymsci.2014.12.002 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_11 GBV_ILN_21 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_65 GBV_ILN_74 GBV_ILN_105 GBV_ILN_2010 GBV_ILN_2021 51.00 Werkstoffkunde: Allgemeines VZ 51.32 Werkstoffmechanik VZ AR 44 2015 79-112 34 045F 540 |
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Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders |
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Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. |
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Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. |
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Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design. |
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