Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK
• Ampelopsin reduces cell viability and induces apoptosis in HepG2 cells. • Induction of apoptosis through both the extrinsic and intrinsic pathways. • Ampelopsin increases phosphor-P38 and phosphor-ERK MAPK proteins levels. • U0126 and SB203580 have opposite effects on ampelopsin induced apoptosis....
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Qi, Shimei [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Evaluation of the proposed reporting system of the European LeukemiaNet and recommendations for prognosis of acute myeloid leukemia - 2013transfer abstract, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:40 ; year:2015 ; number:3 ; pages:847-854 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.etap.2015.09.015 |
|---|
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ampelopsin induces apoptosis in hepg2 human hepatoma cell line through extrinsic and intrinsic pathways: involvement of p38 and erk |
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Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK |
| abstract |
• Ampelopsin reduces cell viability and induces apoptosis in HepG2 cells. • Induction of apoptosis through both the extrinsic and intrinsic pathways. • Ampelopsin increases phosphor-P38 and phosphor-ERK MAPK proteins levels. • U0126 and SB203580 have opposite effects on ampelopsin induced apoptosis. • Ampelopsin downregulates COX-2 and iNOS in a ROS independent way. |
| abstractGer |
• Ampelopsin reduces cell viability and induces apoptosis in HepG2 cells. • Induction of apoptosis through both the extrinsic and intrinsic pathways. • Ampelopsin increases phosphor-P38 and phosphor-ERK MAPK proteins levels. • U0126 and SB203580 have opposite effects on ampelopsin induced apoptosis. • Ampelopsin downregulates COX-2 and iNOS in a ROS independent way. |
| abstract_unstemmed |
• Ampelopsin reduces cell viability and induces apoptosis in HepG2 cells. • Induction of apoptosis through both the extrinsic and intrinsic pathways. • Ampelopsin increases phosphor-P38 and phosphor-ERK MAPK proteins levels. • U0126 and SB203580 have opposite effects on ampelopsin induced apoptosis. • Ampelopsin downregulates COX-2 and iNOS in a ROS independent way. |
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Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through extrinsic and intrinsic pathways: Involvement of P38 and ERK |
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