Norovirus P particle: An excellent vaccine platform for antibody production against Alzheimer’s disease
• Alzheimer disease (AD) vaccine using the epitope Aβ1–6 is safe and effective. • P particle-based AD vaccine induced antibodies to Aβ42 without T-cell activation. • Antigen insertion into three loops of P particle vaccine improved immunogenicity. • Aβ antibodies induced by chimeric P particles bloc...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Fu, Lu [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2015 |
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| Schlagwörter: |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Time-management Changes After Implementation of Data Mining Software - Wick, Kelsey ELSEVIER, 2014, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:168 ; year:2015 ; number:1 ; pages:22-30 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.imlet.2015.09.002 |
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• Alzheimer disease (AD) vaccine using the epitope Aβ1–6 is safe and effective. • P particle-based AD vaccine induced antibodies to Aβ42 without T-cell activation. • Antigen insertion into three loops of P particle vaccine improved immunogenicity. • Aβ antibodies induced by chimeric P particles blocked Aβ42 toxicity in PC12 cells. |
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