New immunotherapies targeting the PD-1 pathway
• PD-1 is a coinhibitory receptor found on T cells and other immune cells. • PD-L1 and PD-L2 are ligands for PD-1. • PD-1 ligation leads to impaired T cell function in cancer and chronic infections. • Blocking PD-1 and PD-L1 successfully treats some human cancers. • Blocking PD-1 can treat chronic v...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chinai, Jordan M. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2015 |
|---|
| Schlagwörter: |
|---|
| Umfang: |
9 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Covering the Cover - Chan, Andrew T. ELSEVIER, 2018, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:36 ; year:2015 ; number:9 ; pages:587-595 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.tips.2015.06.005 |
|---|
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ELV039658104 |
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• PD-1 is a coinhibitory receptor found on T cells and other immune cells. • PD-L1 and PD-L2 are ligands for PD-1. • PD-1 ligation leads to impaired T cell function in cancer and chronic infections. • Blocking PD-1 and PD-L1 successfully treats some human cancers. • Blocking PD-1 can treat chronic viral infections. |
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• PD-1 is a coinhibitory receptor found on T cells and other immune cells. • PD-L1 and PD-L2 are ligands for PD-1. • PD-1 ligation leads to impaired T cell function in cancer and chronic infections. • Blocking PD-1 and PD-L1 successfully treats some human cancers. • Blocking PD-1 can treat chronic viral infections. |
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