Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice
• First study to explore the effect of expressing CuZnSOD in liver on mice lacking CuZnSOD in all other tissues. • Expressing CuZnSOD in the liver of Sod1−/− mice reduced oxidative damage in liver and prevented liver dysfunction and the expression several genes involved in liver tumorigenesis were a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Zhang, Yiqiang [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Umfang: |
8 |
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| Übergeordnetes Werk: |
Enthalten in: Effects of olanzapine on extracellular concentrations and tissue content of neurotensin in rat brain regions - 2011transfer abstract, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:154 ; year:2016 ; pages:1-8 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.mad.2016.01.005 |
|---|
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ELV039935698 |
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| 520 | |a • First study to explore the effect of expressing CuZnSOD in liver on mice lacking CuZnSOD in all other tissues. • Expressing CuZnSOD in the liver of Sod1−/− mice reduced oxidative damage in liver and prevented liver dysfunction and the expression several genes involved in liver tumorigenesis were altered. • Expressing CuZnSOD in the liver of Sod1−/− mice significantly increased the lifespan of the mice but had no effect on the accelerated sarcopenia phenotype of the Sod1−/− mice. | ||
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| 700 | 1 | |a Perez, Viviana I. |4 oth | |
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10.1016/j.mad.2016.01.005 doi GBVA2016001000014.pica (DE-627)ELV039935698 (ELSEVIER)S0047-6374(16)30005-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 150 VZ 610 VZ 530 VZ 33.00 bkl Zhang, Yiqiang verfasserin aut Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice 2016 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • First study to explore the effect of expressing CuZnSOD in liver on mice lacking CuZnSOD in all other tissues. • Expressing CuZnSOD in the liver of Sod1−/− mice reduced oxidative damage in liver and prevented liver dysfunction and the expression several genes involved in liver tumorigenesis were altered. • Expressing CuZnSOD in the liver of Sod1−/− mice significantly increased the lifespan of the mice but had no effect on the accelerated sarcopenia phenotype of the Sod1−/− mice. Oxidative stress Elsevier CuZnSOD Elsevier Liver-specific transgenic mice Elsevier Lifespan Elsevier Liu, Yuhong oth Walsh, Michael oth Bokov, Alex oth Ikeno, Yuji oth Jang, Young C. oth Perez, Viviana I. oth Van Remmen, Holly oth Richardson, Arlan oth Enthalten in Elsevier Science Effects of olanzapine on extracellular concentrations and tissue content of neurotensin in rat brain regions 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV025959964 volume:154 year:2016 pages:1-8 extent:8 https://doi.org/10.1016/j.mad.2016.01.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_40 33.00 Physik: Allgemeines VZ AR 154 2016 1-8 8 045F 610 |
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Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice |
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• First study to explore the effect of expressing CuZnSOD in liver on mice lacking CuZnSOD in all other tissues. • Expressing CuZnSOD in the liver of Sod1−/− mice reduced oxidative damage in liver and prevented liver dysfunction and the expression several genes involved in liver tumorigenesis were altered. • Expressing CuZnSOD in the liver of Sod1−/− mice significantly increased the lifespan of the mice but had no effect on the accelerated sarcopenia phenotype of the Sod1−/− mice. |
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• First study to explore the effect of expressing CuZnSOD in liver on mice lacking CuZnSOD in all other tissues. • Expressing CuZnSOD in the liver of Sod1−/− mice reduced oxidative damage in liver and prevented liver dysfunction and the expression several genes involved in liver tumorigenesis were altered. • Expressing CuZnSOD in the liver of Sod1−/− mice significantly increased the lifespan of the mice but had no effect on the accelerated sarcopenia phenotype of the Sod1−/− mice. |
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• First study to explore the effect of expressing CuZnSOD in liver on mice lacking CuZnSOD in all other tissues. • Expressing CuZnSOD in the liver of Sod1−/− mice reduced oxidative damage in liver and prevented liver dysfunction and the expression several genes involved in liver tumorigenesis were altered. • Expressing CuZnSOD in the liver of Sod1−/− mice significantly increased the lifespan of the mice but had no effect on the accelerated sarcopenia phenotype of the Sod1−/− mice. |
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| title_short |
Liver specific expression of Cu/ZnSOD extends the lifespan of Sod1 null mice |
| url |
https://doi.org/10.1016/j.mad.2016.01.005 |
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true |
| author2 |
Liu, Yuhong Walsh, Michael Bokov, Alex Ikeno, Yuji Jang, Young C. Perez, Viviana I. Van Remmen, Holly Richardson, Arlan |
| author2Str |
Liu, Yuhong Walsh, Michael Bokov, Alex Ikeno, Yuji Jang, Young C. Perez, Viviana I. Van Remmen, Holly Richardson, Arlan |
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ELV025959964 |
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| doi_str |
10.1016/j.mad.2016.01.005 |
| up_date |
2024-07-06T21:52:19.438Z |
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1803868165309988864 |
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