Human Knockout Carriers: Dead, Diseased, Healthy, or Improved?
Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function t...
Ausführliche Beschreibung
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Narasimhan, Vagheesh M. [verfasserIn] |
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Englisch |
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2016transfer abstract |
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11 |
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Enthalten in: Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements - 2011transfer abstract, Amsterdam [u.a.] |
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volume:22 ; year:2016 ; number:4 ; pages:341-351 ; extent:11 |
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10.1016/j.molmed.2016.02.006 |
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10.1016/j.molmed.2016.02.006 doi GBV00000000000148A.pica (DE-627)ELV03997376X (ELSEVIER)S1471-4914(16)00036-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 050 VZ 550 VZ 660 VZ 660 VZ 530 600 670 VZ 51.00 bkl Narasimhan, Vagheesh M. verfasserin aut Human Knockout Carriers: Dead, Diseased, Healthy, or Improved? 2016transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. loss-of-function variants Elsevier clinical interpretation Elsevier gene function Elsevier Xue, Yali oth Tyler-Smith, Chris oth Enthalten in Elsevier Science Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV026173794 volume:22 year:2016 number:4 pages:341-351 extent:11 https://doi.org/10.1016/j.molmed.2016.02.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 51.00 Werkstoffkunde: Allgemeines VZ AR 22 2016 4 341-351 11 045F 610 |
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10.1016/j.molmed.2016.02.006 doi GBV00000000000148A.pica (DE-627)ELV03997376X (ELSEVIER)S1471-4914(16)00036-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 050 VZ 550 VZ 660 VZ 660 VZ 530 600 670 VZ 51.00 bkl Narasimhan, Vagheesh M. verfasserin aut Human Knockout Carriers: Dead, Diseased, Healthy, or Improved? 2016transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. loss-of-function variants Elsevier clinical interpretation Elsevier gene function Elsevier Xue, Yali oth Tyler-Smith, Chris oth Enthalten in Elsevier Science Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV026173794 volume:22 year:2016 number:4 pages:341-351 extent:11 https://doi.org/10.1016/j.molmed.2016.02.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 51.00 Werkstoffkunde: Allgemeines VZ AR 22 2016 4 341-351 11 045F 610 |
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10.1016/j.molmed.2016.02.006 doi GBV00000000000148A.pica (DE-627)ELV03997376X (ELSEVIER)S1471-4914(16)00036-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 050 VZ 550 VZ 660 VZ 660 VZ 530 600 670 VZ 51.00 bkl Narasimhan, Vagheesh M. verfasserin aut Human Knockout Carriers: Dead, Diseased, Healthy, or Improved? 2016transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. loss-of-function variants Elsevier clinical interpretation Elsevier gene function Elsevier Xue, Yali oth Tyler-Smith, Chris oth Enthalten in Elsevier Science Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV026173794 volume:22 year:2016 number:4 pages:341-351 extent:11 https://doi.org/10.1016/j.molmed.2016.02.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 51.00 Werkstoffkunde: Allgemeines VZ AR 22 2016 4 341-351 11 045F 610 |
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10.1016/j.molmed.2016.02.006 doi GBV00000000000148A.pica (DE-627)ELV03997376X (ELSEVIER)S1471-4914(16)00036-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 050 VZ 550 VZ 660 VZ 660 VZ 530 600 670 VZ 51.00 bkl Narasimhan, Vagheesh M. verfasserin aut Human Knockout Carriers: Dead, Diseased, Healthy, or Improved? 2016transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. loss-of-function variants Elsevier clinical interpretation Elsevier gene function Elsevier Xue, Yali oth Tyler-Smith, Chris oth Enthalten in Elsevier Science Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV026173794 volume:22 year:2016 number:4 pages:341-351 extent:11 https://doi.org/10.1016/j.molmed.2016.02.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 51.00 Werkstoffkunde: Allgemeines VZ AR 22 2016 4 341-351 11 045F 610 |
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10.1016/j.molmed.2016.02.006 doi GBV00000000000148A.pica (DE-627)ELV03997376X (ELSEVIER)S1471-4914(16)00036-8 DE-627 ger DE-627 rakwb eng 610 610 DE-600 050 VZ 550 VZ 660 VZ 660 VZ 530 600 670 VZ 51.00 bkl Narasimhan, Vagheesh M. verfasserin aut Human Knockout Carriers: Dead, Diseased, Healthy, or Improved? 2016transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. loss-of-function variants Elsevier clinical interpretation Elsevier gene function Elsevier Xue, Yali oth Tyler-Smith, Chris oth Enthalten in Elsevier Science Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV026173794 volume:22 year:2016 number:4 pages:341-351 extent:11 https://doi.org/10.1016/j.molmed.2016.02.006 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 51.00 Werkstoffkunde: Allgemeines VZ AR 22 2016 4 341-351 11 045F 610 |
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Human Knockout Carriers: Dead, Diseased, Healthy, or Improved? |
abstract |
Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. |
abstractGer |
Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. |
abstract_unstemmed |
Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. |
collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 |
container_issue |
4 |
title_short |
Human Knockout Carriers: Dead, Diseased, Healthy, or Improved? |
url |
https://doi.org/10.1016/j.molmed.2016.02.006 |
remote_bool |
true |
author2 |
Xue, Yali Tyler-Smith, Chris |
author2Str |
Xue, Yali Tyler-Smith, Chris |
ppnlink |
ELV026173794 |
mediatype_str_mv |
z |
isOA_txt |
false |
hochschulschrift_bool |
false |
author2_role |
oth oth |
doi_str |
10.1016/j.molmed.2016.02.006 |
up_date |
2024-07-06T21:57:36.483Z |
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1803868497756815360 |
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score |
7.399768 |