Human Knockout Carriers: Dead, Diseased, Healthy, or Improved?
Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function t...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Narasimhan, Vagheesh M. [verfasserIn] |
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E-Artikel |
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Englisch |
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2016transfer abstract |
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11 |
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Enthalten in: Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements - 2011transfer abstract, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:22 ; year:2016 ; number:4 ; pages:341-351 ; extent:11 |
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10.1016/j.molmed.2016.02.006 |
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| 520 | |a Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. | ||
| 520 | |a Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. | ||
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Narasimhan, Vagheesh M. |
| doi_str_mv |
10.1016/j.molmed.2016.02.006 |
| dewey-full |
610 050 550 660 530 600 670 |
| title_sort |
human knockout carriers: dead, diseased, healthy, or improved? |
| title_auth |
Human Knockout Carriers: Dead, Diseased, Healthy, or Improved? |
| abstract |
Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. |
| abstractGer |
Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. |
| abstract_unstemmed |
Whole-genome and whole-exome sequence data from large numbers of individuals reveal that we all carry many variants predicted to inactivate genes (knockouts). This discovery raises questions about the phenotypic consequences of these knockouts and potentially allows us to study human gene function through the investigation of homozygous loss-of-function carriers. Here, we discuss strategies, recent results, and future prospects for large-scale human knockout studies. We examine their relevance to studying gene function, population genetics, and importantly, the implications for accurate clinical interpretations. |
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4 |
| title_short |
Human Knockout Carriers: Dead, Diseased, Healthy, or Improved? |
| url |
https://doi.org/10.1016/j.molmed.2016.02.006 |
| remote_bool |
true |
| author2 |
Xue, Yali Tyler-Smith, Chris |
| author2Str |
Xue, Yali Tyler-Smith, Chris |
| ppnlink |
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| isOA_txt |
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| hochschulschrift_bool |
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| author2_role |
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| doi_str |
10.1016/j.molmed.2016.02.006 |
| up_date |
2024-07-06T21:57:36.483Z |
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7.399768 |