Impaired oligodendrocyte maturation in preterm infants: Potential therapeutic targets
• Diffuse white matter injury in the brain is a highly prevalent morbidity in babies born prematurely. • Perinatal inflammation and imbalanced oxygen supply are important risk factors for diffuse white matter injury. • In perinatal diffuse white matter injury, arrested maturation of oligodendrocytes...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
van Tilborg, Erik [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016 |
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| Schlagwörter: |
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| Umfang: |
22 |
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| Übergeordnetes Werk: |
Enthalten in: Influences of mine water on the properties of construction and demolition waste-based cemented paste backfill - Zhou, Nan ELSEVIER, 2021, an international review journal, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:136 ; year:2016 ; pages:28-49 ; extent:22 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.pneurobio.2015.11.002 |
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ELV040065995 |
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| 520 | |a • Diffuse white matter injury in the brain is a highly prevalent morbidity in babies born prematurely. • Perinatal inflammation and imbalanced oxygen supply are important risk factors for diffuse white matter injury. • In perinatal diffuse white matter injury, arrested maturation of oligodendrocytes causes impaired myelination. • The interplay between active microglia/astrocytes and oligodendrocyte precursors contributes to diffuse white matter injury. • Promising therapeutic strategies include growth factor treatment, mesenchymal stem cell therapy and anti-inflammatory drugs. | ||
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• Diffuse white matter injury in the brain is a highly prevalent morbidity in babies born prematurely. • Perinatal inflammation and imbalanced oxygen supply are important risk factors for diffuse white matter injury. • In perinatal diffuse white matter injury, arrested maturation of oligodendrocytes causes impaired myelination. • The interplay between active microglia/astrocytes and oligodendrocyte precursors contributes to diffuse white matter injury. • Promising therapeutic strategies include growth factor treatment, mesenchymal stem cell therapy and anti-inflammatory drugs. |
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• Diffuse white matter injury in the brain is a highly prevalent morbidity in babies born prematurely. • Perinatal inflammation and imbalanced oxygen supply are important risk factors for diffuse white matter injury. • In perinatal diffuse white matter injury, arrested maturation of oligodendrocytes causes impaired myelination. • The interplay between active microglia/astrocytes and oligodendrocyte precursors contributes to diffuse white matter injury. • Promising therapeutic strategies include growth factor treatment, mesenchymal stem cell therapy and anti-inflammatory drugs. |
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• Diffuse white matter injury in the brain is a highly prevalent morbidity in babies born prematurely. • Perinatal inflammation and imbalanced oxygen supply are important risk factors for diffuse white matter injury. • In perinatal diffuse white matter injury, arrested maturation of oligodendrocytes causes impaired myelination. • The interplay between active microglia/astrocytes and oligodendrocyte precursors contributes to diffuse white matter injury. • Promising therapeutic strategies include growth factor treatment, mesenchymal stem cell therapy and anti-inflammatory drugs. |
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