Sphingosine Kinases: Emerging Structure–Function Insights
Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structur...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Adams, David R. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2016transfer abstract |
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| Schlagwörter: |
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| Umfang: |
15 |
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| Übergeordnetes Werk: |
Enthalten in: Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma - 2012, TIBS, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:41 ; year:2016 ; number:5 ; pages:395-409 ; extent:15 |
| Links: |
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| DOI / URN: |
10.1016/j.tibs.2016.02.007 |
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| 520 | |a Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. | ||
| 520 | |a Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. | ||
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10.1016/j.tibs.2016.02.007 doi GBV00000000000145A.pica (DE-627)ELV040130533 (ELSEVIER)S0968-0004(16)00030-X DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 570 630 VZ BIODIV DE-30 fid 58.34 bkl 48.59 bkl Adams, David R. verfasserin aut Sphingosine Kinases: Emerging Structure–Function Insights 2016transfer abstract 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. diacylglycerol kinase (DGK) Elsevier membrane curvature Elsevier sphingosine kinase (SK1 Elsevier DAGK_cat Elsevier SK2) Elsevier TRAF2 Elsevier Pyne, Susan oth Pyne, Nigel J. oth Enthalten in Elsevier Science Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma 2012 TIBS Amsterdam [u.a.] (DE-627)ELV016243919 volume:41 year:2016 number:5 pages:395-409 extent:15 https://doi.org/10.1016/j.tibs.2016.02.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_92 GBV_ILN_120 GBV_ILN_188 GBV_ILN_285 58.34 Lebensmitteltechnologie VZ 48.59 Pflanzenproduktion: Sonstiges VZ AR 41 2016 5 395-409 15 045F 540 |
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10.1016/j.tibs.2016.02.007 doi GBV00000000000145A.pica (DE-627)ELV040130533 (ELSEVIER)S0968-0004(16)00030-X DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 570 630 VZ BIODIV DE-30 fid 58.34 bkl 48.59 bkl Adams, David R. verfasserin aut Sphingosine Kinases: Emerging Structure–Function Insights 2016transfer abstract 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. diacylglycerol kinase (DGK) Elsevier membrane curvature Elsevier sphingosine kinase (SK1 Elsevier DAGK_cat Elsevier SK2) Elsevier TRAF2 Elsevier Pyne, Susan oth Pyne, Nigel J. oth Enthalten in Elsevier Science Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma 2012 TIBS Amsterdam [u.a.] (DE-627)ELV016243919 volume:41 year:2016 number:5 pages:395-409 extent:15 https://doi.org/10.1016/j.tibs.2016.02.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_92 GBV_ILN_120 GBV_ILN_188 GBV_ILN_285 58.34 Lebensmitteltechnologie VZ 48.59 Pflanzenproduktion: Sonstiges VZ AR 41 2016 5 395-409 15 045F 540 |
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10.1016/j.tibs.2016.02.007 doi GBV00000000000145A.pica (DE-627)ELV040130533 (ELSEVIER)S0968-0004(16)00030-X DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 570 630 VZ BIODIV DE-30 fid 58.34 bkl 48.59 bkl Adams, David R. verfasserin aut Sphingosine Kinases: Emerging Structure–Function Insights 2016transfer abstract 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. diacylglycerol kinase (DGK) Elsevier membrane curvature Elsevier sphingosine kinase (SK1 Elsevier DAGK_cat Elsevier SK2) Elsevier TRAF2 Elsevier Pyne, Susan oth Pyne, Nigel J. oth Enthalten in Elsevier Science Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma 2012 TIBS Amsterdam [u.a.] (DE-627)ELV016243919 volume:41 year:2016 number:5 pages:395-409 extent:15 https://doi.org/10.1016/j.tibs.2016.02.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_92 GBV_ILN_120 GBV_ILN_188 GBV_ILN_285 58.34 Lebensmitteltechnologie VZ 48.59 Pflanzenproduktion: Sonstiges VZ AR 41 2016 5 395-409 15 045F 540 |
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10.1016/j.tibs.2016.02.007 doi GBV00000000000145A.pica (DE-627)ELV040130533 (ELSEVIER)S0968-0004(16)00030-X DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 570 630 VZ BIODIV DE-30 fid 58.34 bkl 48.59 bkl Adams, David R. verfasserin aut Sphingosine Kinases: Emerging Structure–Function Insights 2016transfer abstract 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. diacylglycerol kinase (DGK) Elsevier membrane curvature Elsevier sphingosine kinase (SK1 Elsevier DAGK_cat Elsevier SK2) Elsevier TRAF2 Elsevier Pyne, Susan oth Pyne, Nigel J. oth Enthalten in Elsevier Science Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma 2012 TIBS Amsterdam [u.a.] (DE-627)ELV016243919 volume:41 year:2016 number:5 pages:395-409 extent:15 https://doi.org/10.1016/j.tibs.2016.02.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_92 GBV_ILN_120 GBV_ILN_188 GBV_ILN_285 58.34 Lebensmitteltechnologie VZ 48.59 Pflanzenproduktion: Sonstiges VZ AR 41 2016 5 395-409 15 045F 540 |
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10.1016/j.tibs.2016.02.007 doi GBV00000000000145A.pica (DE-627)ELV040130533 (ELSEVIER)S0968-0004(16)00030-X DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 570 630 VZ BIODIV DE-30 fid 58.34 bkl 48.59 bkl Adams, David R. verfasserin aut Sphingosine Kinases: Emerging Structure–Function Insights 2016transfer abstract 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. diacylglycerol kinase (DGK) Elsevier membrane curvature Elsevier sphingosine kinase (SK1 Elsevier DAGK_cat Elsevier SK2) Elsevier TRAF2 Elsevier Pyne, Susan oth Pyne, Nigel J. oth Enthalten in Elsevier Science Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma 2012 TIBS Amsterdam [u.a.] (DE-627)ELV016243919 volume:41 year:2016 number:5 pages:395-409 extent:15 https://doi.org/10.1016/j.tibs.2016.02.007 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U FID-BIODIV SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_40 GBV_ILN_61 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_92 GBV_ILN_120 GBV_ILN_188 GBV_ILN_285 58.34 Lebensmitteltechnologie VZ 48.59 Pflanzenproduktion: Sonstiges VZ AR 41 2016 5 395-409 15 045F 540 |
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Enthalten in Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma Amsterdam [u.a.] volume:41 year:2016 number:5 pages:395-409 extent:15 |
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Enthalten in Prognostic value of preoperative FDG-PET in stage IA lung adenocarcinoma Amsterdam [u.a.] volume:41 year:2016 number:5 pages:395-409 extent:15 |
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Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. |
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Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. |
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Sphingosine kinases (SK1 and SK2) catalyse the conversion of sphingosine into sphingosine 1-phosphate and control fundamental cellular processes, including cell survival, proliferation, differentiation, migration, and immune function. In this review, we highlight recent breakthroughs in the structural and functional characterisation of SK1 and these are contextualised by analysis of crystal structures for closely related prokaryotic lipid kinases. We identify a putative dimerisation interface and propose novel regulatory mechanisms governing structural plasticity induced by phosphorylation and interaction with phospholipids and proteins. Our analysis suggests that the catalytic function and regulation of the enzymes might be dependent on conformational mobility and it provides a roadmap for future interrogation of SK1 function and its role in physiology and disease. |
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