Growth factors, aging and age-related diseases

Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We rec...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Balasubramanian, Priya [verfasserIn] Longo, Valter D.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2016transfer abstract

Umfang:	3

Übergeordnetes Werk:	Enthalten in: Research on Origins of Type 1 Diabetes Seeks Organ Donor Referrals From the ED - 2012, Burlington, Mass. [u.a.]
Übergeordnetes Werk:	volume:28 ; year:2016 ; pages:66-68 ; extent:3

Links:	Volltext

DOI / URN:	10.1016/j.ghir.2016.01.001

Katalog-ID:	ELV040181782

Internformat


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Indexfelder

author_variant	p b pb
matchkey_str	balasubramanianpriyalongovalterd:2016----:rwhatraignaee
hierarchy_sort_str	2016transfer abstract
bklnumber	43.13 50.17 58.53
publishDate	2016
allfields	10.1016/j.ghir.2016.01.001 doi GBVA2016019000012.pica (DE-627)ELV040181782 (ELSEVIER)S1096-6374(16)30001-6 DE-627 ger DE-627 rakwb eng 610 570 610 DE-600 570 DE-600 610 VZ 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Balasubramanian, Priya verfasserin aut Growth factors, aging and age-related diseases 2016transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases. Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases. Longo, Valter D. oth Enthalten in Harcourt Research on Origins of Type 1 Diabetes Seeks Organ Donor Referrals From the ED 2012 Burlington, Mass. [u.a.] (DE-627)ELV02124619X volume:28 year:2016 pages:66-68 extent:3 https://doi.org/10.1016/j.ghir.2016.01.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_55 GBV_ILN_60 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_130 GBV_ILN_131 GBV_ILN_170 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2012 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2047 GBV_ILN_2050 GBV_ILN_2111 GBV_ILN_2149 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 28 2016 66-68 3 045F 610
spelling	10.1016/j.ghir.2016.01.001 doi GBVA2016019000012.pica (DE-627)ELV040181782 (ELSEVIER)S1096-6374(16)30001-6 DE-627 ger DE-627 rakwb eng 610 570 610 DE-600 570 DE-600 610 VZ 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Balasubramanian, Priya verfasserin aut Growth factors, aging and age-related diseases 2016transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases. Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases. Longo, Valter D. oth Enthalten in Harcourt Research on Origins of Type 1 Diabetes Seeks Organ Donor Referrals From the ED 2012 Burlington, Mass. [u.a.] (DE-627)ELV02124619X volume:28 year:2016 pages:66-68 extent:3 https://doi.org/10.1016/j.ghir.2016.01.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_55 GBV_ILN_60 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_130 GBV_ILN_131 GBV_ILN_170 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2012 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2047 GBV_ILN_2050 GBV_ILN_2111 GBV_ILN_2149 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 28 2016 66-68 3 045F 610
allfields_unstemmed	10.1016/j.ghir.2016.01.001 doi GBVA2016019000012.pica (DE-627)ELV040181782 (ELSEVIER)S1096-6374(16)30001-6 DE-627 ger DE-627 rakwb eng 610 570 610 DE-600 570 DE-600 610 VZ 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Balasubramanian, Priya verfasserin aut Growth factors, aging and age-related diseases 2016transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases. Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases. Longo, Valter D. oth Enthalten in Harcourt Research on Origins of Type 1 Diabetes Seeks Organ Donor Referrals From the ED 2012 Burlington, Mass. [u.a.] (DE-627)ELV02124619X volume:28 year:2016 pages:66-68 extent:3 https://doi.org/10.1016/j.ghir.2016.01.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_55 GBV_ILN_60 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_130 GBV_ILN_131 GBV_ILN_170 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2012 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2047 GBV_ILN_2050 GBV_ILN_2111 GBV_ILN_2149 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 28 2016 66-68 3 045F 610
allfieldsGer	10.1016/j.ghir.2016.01.001 doi GBVA2016019000012.pica (DE-627)ELV040181782 (ELSEVIER)S1096-6374(16)30001-6 DE-627 ger DE-627 rakwb eng 610 570 610 DE-600 570 DE-600 610 VZ 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Balasubramanian, Priya verfasserin aut Growth factors, aging and age-related diseases 2016transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases. Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases. Longo, Valter D. oth Enthalten in Harcourt Research on Origins of Type 1 Diabetes Seeks Organ Donor Referrals From the ED 2012 Burlington, Mass. [u.a.] (DE-627)ELV02124619X volume:28 year:2016 pages:66-68 extent:3 https://doi.org/10.1016/j.ghir.2016.01.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_55 GBV_ILN_60 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_130 GBV_ILN_131 GBV_ILN_170 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2012 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2047 GBV_ILN_2050 GBV_ILN_2111 GBV_ILN_2149 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 28 2016 66-68 3 045F 610
allfieldsSound	10.1016/j.ghir.2016.01.001 doi GBVA2016019000012.pica (DE-627)ELV040181782 (ELSEVIER)S1096-6374(16)30001-6 DE-627 ger DE-627 rakwb eng 610 570 610 DE-600 570 DE-600 610 VZ 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Balasubramanian, Priya verfasserin aut Growth factors, aging and age-related diseases 2016transfer abstract 3 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases. Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases. Longo, Valter D. oth Enthalten in Harcourt Research on Origins of Type 1 Diabetes Seeks Organ Donor Referrals From the ED 2012 Burlington, Mass. [u.a.] (DE-627)ELV02124619X volume:28 year:2016 pages:66-68 extent:3 https://doi.org/10.1016/j.ghir.2016.01.001 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO GBV_ILN_20 GBV_ILN_21 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_30 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_55 GBV_ILN_60 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_74 GBV_ILN_90 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_130 GBV_ILN_131 GBV_ILN_170 GBV_ILN_2001 GBV_ILN_2002 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2012 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2047 GBV_ILN_2050 GBV_ILN_2111 GBV_ILN_2149 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 28 2016 66-68 3 045F 610
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source	Enthalten in Research on Origins of Type 1 Diabetes Seeks Organ Donor Referrals From the ED Burlington, Mass. [u.a.] volume:28 year:2016 pages:66-68 extent:3
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title_auth	Growth factors, aging and age-related diseases
abstract	Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases.
abstractGer	Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases.
abstract_unstemmed	Simple organisms including yeast and flies with mutations in the IGF-1 and Tor-S6K pathways are dwarfs, are highly protected from toxins, and survive up to 3 times longer. Similarly, dwarf mice with deficiencies in the growth hormone-IGF-I axis are also long lived and protected from diseases. We recently reported that humans with Growth Hormone Receptor Deficiency (GHRD) rarely develop cancer or diabetes. These findings are in agreement with the effect of defects in the Tor-S6K pathways in causing dwarfism and protection of DNA. Because protein restriction reduces both GHR-IGF-1 axis and Tor-S6K activity, we examined links between protein intake, disease, and mortality in over 6000 US subjects in the NHANES CDC database. Respondents aged 50–65 reporting a high protein intake displayed an increase in IGF-I levels, a 75% increased risk of overall mortality and a 3–4 fold increased risk of cancer mortality in agreement with findings in mouse experiments. These studies point to a conserved link between proteins and amino acids, GHR-IGF-1/insulin, Tor-S6k signaling, aging, and diseases.
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title_short	Growth factors, aging and age-related diseases
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