Exosomes as Reconfigurable Therapeutic Systems
Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or ‘exosomes’. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moi...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Conlan, R. Steven [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
|---|
| Umfang: |
15 |
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| Übergeordnetes Werk: |
Enthalten in: Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements - 2011transfer abstract, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:23 ; year:2017 ; number:7 ; pages:636-650 ; extent:15 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.molmed.2017.05.003 |
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| 520 | |a Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or ‘exosomes’. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases. | ||
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10.1016/j.molmed.2017.05.003 doi GBV00000000000148A.pica (DE-627)ELV04030633X (ELSEVIER)S1471-4914(17)30081-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 050 VZ 550 VZ 660 VZ 660 VZ 530 600 670 VZ 51.00 bkl Conlan, R. Steven verfasserin aut Exosomes as Reconfigurable Therapeutic Systems 2017transfer abstract 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or ‘exosomes’. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases. Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or ‘exosomes’. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases. Pisano, Simone oth Oliveira, Marta I. oth Ferrari, Mauro oth Mendes Pinto, Inês oth Enthalten in Elsevier Science Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV026173794 volume:23 year:2017 number:7 pages:636-650 extent:15 https://doi.org/10.1016/j.molmed.2017.05.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 51.00 Werkstoffkunde: Allgemeines VZ AR 23 2017 7 636-650 15 045F 610 |
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10.1016/j.molmed.2017.05.003 doi GBV00000000000148A.pica (DE-627)ELV04030633X (ELSEVIER)S1471-4914(17)30081-3 DE-627 ger DE-627 rakwb eng 610 610 DE-600 050 VZ 550 VZ 660 VZ 660 VZ 530 600 670 VZ 51.00 bkl Conlan, R. Steven verfasserin aut Exosomes as Reconfigurable Therapeutic Systems 2017transfer abstract 15 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or ‘exosomes’. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases. Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or ‘exosomes’. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases. Pisano, Simone oth Oliveira, Marta I. oth Ferrari, Mauro oth Mendes Pinto, Inês oth Enthalten in Elsevier Science Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements 2011transfer abstract Amsterdam [u.a.] (DE-627)ELV026173794 volume:23 year:2017 number:7 pages:636-650 extent:15 https://doi.org/10.1016/j.molmed.2017.05.003 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U GBV_ILN_73 GBV_ILN_252 51.00 Werkstoffkunde: Allgemeines VZ AR 23 2017 7 636-650 15 045F 610 |
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Exosomes as Reconfigurable Therapeutic Systems |
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(DE-627)ELV04030633X (ELSEVIER)S1471-4914(17)30081-3 |
| title_full |
Exosomes as Reconfigurable Therapeutic Systems |
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Conlan, R. Steven |
| journal |
Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements |
| journalStr |
Ocean sand ridge signatures in the Bohai Sea observed by satellite ocean color and synthetic aperture radar measurements |
| lang_code |
eng |
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false |
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600 - Technology 000 - Computer science, information & general works 500 - Science |
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marc |
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2017 |
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636 |
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Conlan, R. Steven |
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23 |
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Elektronische Aufsätze |
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Conlan, R. Steven |
| doi_str_mv |
10.1016/j.molmed.2017.05.003 |
| dewey-full |
610 050 550 660 530 600 670 |
| title_sort |
exosomes as reconfigurable therapeutic systems |
| title_auth |
Exosomes as Reconfigurable Therapeutic Systems |
| abstract |
Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or ‘exosomes’. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases. |
| abstractGer |
Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or ‘exosomes’. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases. |
| abstract_unstemmed |
Historically, small molecules, including steroid hormones and cytokines, have been attributed a role in paracrine and endocrine signaling, and now include a new player: biological nanoparticles, or ‘exosomes’. Generated intracellularly, and defined simply as nanoparticulate packages of signaling moieties, exosomes have emerged as vehicles for highly specialized local and distant intercellular communication. Exosomes are increasingly being recognized as contributing factors in many diseases, and their potential as biomarkers and in therapeutics is rapidly emerging. This review highlights recent advances in the exploitation of exosomes in diagnostic and therapeutic applications. We discuss various facets of nanoparticles, namely the isolation and manipulation of exosomes, the construction of synthetic exosome-like particles in vivo, and their potential use in the treatment of various diseases. |
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| title_short |
Exosomes as Reconfigurable Therapeutic Systems |
| url |
https://doi.org/10.1016/j.molmed.2017.05.003 |
| remote_bool |
true |
| author2 |
Pisano, Simone Oliveira, Marta I. Ferrari, Mauro Mendes Pinto, Inês |
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Pisano, Simone Oliveira, Marta I. Ferrari, Mauro Mendes Pinto, Inês |
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| doi_str |
10.1016/j.molmed.2017.05.003 |
| up_date |
2024-07-06T17:09:52.410Z |
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