Analysis of the in vitro and in vivo effects of photodynamic therapy on prostate cancer by using new photosensitizers, protoporphyrin IX-polyamine derivatives
Photodynamic therapy, using porphyrins as photosensitizers (PS), has been approved in treatment of several solid tumors. However, commonly used PS induce death but also resistance pathways in cancer cells and an alteration of surrounding normal tissues. Because polyamines (PA) are actively accumulat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Fidanzi-Dugas, Chloë [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Umfang: |
15 |
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| Übergeordnetes Werk: |
Enthalten in: Numerical simulation of the effect of cement particle shapes on capillary pore structures in hardened cement pastes - Liu, Cheng ELSEVIER, 2018, BBA, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:1861 ; year:2017 ; number:7 ; pages:1676-1690 ; extent:15 |
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| DOI / URN: |
10.1016/j.bbagen.2017.02.003 |
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Analysis of the in vitro and in vivo effects of photodynamic therapy on prostate cancer by using new photosensitizers, protoporphyrin IX-polyamine derivatives |
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Photodynamic therapy, using porphyrins as photosensitizers (PS), has been approved in treatment of several solid tumors. However, commonly used PS induce death but also resistance pathways in cancer cells and an alteration of surrounding normal tissues. Because polyamines (PA) are actively accumulated in cancer cells by the Polyamine Transport System (PTS), they may enable PS to specifically target cancer cells. Here, we investigated whether new protoporphyrin IX-polyamine derivatives were effective PS against prostate cancer and whether PA increased PDT specificity after 630nm irradiation. |
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Photodynamic therapy, using porphyrins as photosensitizers (PS), has been approved in treatment of several solid tumors. However, commonly used PS induce death but also resistance pathways in cancer cells and an alteration of surrounding normal tissues. Because polyamines (PA) are actively accumulated in cancer cells by the Polyamine Transport System (PTS), they may enable PS to specifically target cancer cells. Here, we investigated whether new protoporphyrin IX-polyamine derivatives were effective PS against prostate cancer and whether PA increased PDT specificity after 630nm irradiation. |
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Photodynamic therapy, using porphyrins as photosensitizers (PS), has been approved in treatment of several solid tumors. However, commonly used PS induce death but also resistance pathways in cancer cells and an alteration of surrounding normal tissues. Because polyamines (PA) are actively accumulated in cancer cells by the Polyamine Transport System (PTS), they may enable PS to specifically target cancer cells. Here, we investigated whether new protoporphyrin IX-polyamine derivatives were effective PS against prostate cancer and whether PA increased PDT specificity after 630nm irradiation. |
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Analysis of the in vitro and in vivo effects of photodynamic therapy on prostate cancer by using new photosensitizers, protoporphyrin IX-polyamine derivatives |
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Liagre, Bertrand Chemin, Guillaume Perraud, Aurélie Carrion, Claire Couquet, Claude-Yves Granet, Robert Sol, Vincent Léger, David Yannick |
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Liagre, Bertrand Chemin, Guillaume Perraud, Aurélie Carrion, Claire Couquet, Claude-Yves Granet, Robert Sol, Vincent Léger, David Yannick |
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10.1016/j.bbagen.2017.02.003 |
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2024-07-06T17:25:31.692Z |
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