Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern
• High doses of SIFs affect ovarian follicle development by inhibiting steroidogenesis. • The mechanism may be related to SIF-induced decreases in the expression of the key genes involved in hormone synthesis. • Aberrant DNA methylation patterns of the SF-1 promoter may contribute to the downregulat...
Ausführliche Beschreibung
Autor*in: |
Wang, Wenxiang [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2017 |
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Schlagwörter: |
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Umfang: |
9 |
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Übergeordnetes Werk: |
Enthalten in: Toxicology letters - Chen, Yun-Ru ELSEVIER, 2019, an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity, Amsterdam [u.a.] |
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Übergeordnetes Werk: |
volume:281 ; year:2017 ; day:5 ; month:11 ; pages:175-183 ; extent:9 |
Links: |
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DOI / URN: |
10.1016/j.toxlet.2017.09.021 |
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ELV040653838 |
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10.1016/j.toxlet.2017.09.021 doi GBV00000000000179A.pica (DE-627)ELV040653838 (ELSEVIER)S0378-4274(17)31376-0 DE-627 ger DE-627 rakwb eng 570 540 610 570 DE-600 540 DE-600 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Wang, Wenxiang verfasserin aut Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • High doses of SIFs affect ovarian follicle development by inhibiting steroidogenesis. • The mechanism may be related to SIF-induced decreases in the expression of the key genes involved in hormone synthesis. • Aberrant DNA methylation patterns of the SF-1 promoter may contribute to the downregulation of steroidogenesis-related genes. Ovary Elsevier Soy isoflavones Elsevier Steroidogenic factor-1 (SF-1) Elsevier DNA methylation Elsevier Steroidogenesis Elsevier Sun, Yan oth Guo, Yiwei oth Cai, Ping oth Li, Yuchen oth Liu, Jin oth Cai, Guoxi oth Kiyoshi, Aoyagi oth Zhang, Wenchang oth Enthalten in Elsevier Science Chen, Yun-Ru ELSEVIER Toxicology letters 2019 an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity Amsterdam [u.a.] (DE-627)ELV003574431 volume:281 year:2017 day:5 month:11 pages:175-183 extent:9 https://doi.org/10.1016/j.toxlet.2017.09.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 281 2017 5 1105 175-183 9 045F 570 |
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10.1016/j.toxlet.2017.09.021 doi GBV00000000000179A.pica (DE-627)ELV040653838 (ELSEVIER)S0378-4274(17)31376-0 DE-627 ger DE-627 rakwb eng 570 540 610 570 DE-600 540 DE-600 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Wang, Wenxiang verfasserin aut Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern 2017 9 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • High doses of SIFs affect ovarian follicle development by inhibiting steroidogenesis. • The mechanism may be related to SIF-induced decreases in the expression of the key genes involved in hormone synthesis. • Aberrant DNA methylation patterns of the SF-1 promoter may contribute to the downregulation of steroidogenesis-related genes. Ovary Elsevier Soy isoflavones Elsevier Steroidogenic factor-1 (SF-1) Elsevier DNA methylation Elsevier Steroidogenesis Elsevier Sun, Yan oth Guo, Yiwei oth Cai, Ping oth Li, Yuchen oth Liu, Jin oth Cai, Guoxi oth Kiyoshi, Aoyagi oth Zhang, Wenchang oth Enthalten in Elsevier Science Chen, Yun-Ru ELSEVIER Toxicology letters 2019 an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity Amsterdam [u.a.] (DE-627)ELV003574431 volume:281 year:2017 day:5 month:11 pages:175-183 extent:9 https://doi.org/10.1016/j.toxlet.2017.09.021 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 281 2017 5 1105 175-183 9 045F 570 |
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Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern |
abstract |
• High doses of SIFs affect ovarian follicle development by inhibiting steroidogenesis. • The mechanism may be related to SIF-induced decreases in the expression of the key genes involved in hormone synthesis. • Aberrant DNA methylation patterns of the SF-1 promoter may contribute to the downregulation of steroidogenesis-related genes. |
abstractGer |
• High doses of SIFs affect ovarian follicle development by inhibiting steroidogenesis. • The mechanism may be related to SIF-induced decreases in the expression of the key genes involved in hormone synthesis. • Aberrant DNA methylation patterns of the SF-1 promoter may contribute to the downregulation of steroidogenesis-related genes. |
abstract_unstemmed |
• High doses of SIFs affect ovarian follicle development by inhibiting steroidogenesis. • The mechanism may be related to SIF-induced decreases in the expression of the key genes involved in hormone synthesis. • Aberrant DNA methylation patterns of the SF-1 promoter may contribute to the downregulation of steroidogenesis-related genes. |
collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA |
title_short |
Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern |
url |
https://doi.org/10.1016/j.toxlet.2017.09.021 |
remote_bool |
true |
author2 |
Sun, Yan Guo, Yiwei Cai, Ping Li, Yuchen Liu, Jin Cai, Guoxi Kiyoshi, Aoyagi Zhang, Wenchang |
author2Str |
Sun, Yan Guo, Yiwei Cai, Ping Li, Yuchen Liu, Jin Cai, Guoxi Kiyoshi, Aoyagi Zhang, Wenchang |
ppnlink |
ELV003574431 |
mediatype_str_mv |
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isOA_txt |
false |
hochschulschrift_bool |
false |
author2_role |
oth oth oth oth oth oth oth oth |
doi_str |
10.1016/j.toxlet.2017.09.021 |
up_date |
2024-07-06T18:02:49.141Z |
_version_ |
1803853726108090368 |
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score |
7.3981485 |