Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern
• High doses of SIFs affect ovarian follicle development by inhibiting steroidogenesis. • The mechanism may be related to SIF-induced decreases in the expression of the key genes involved in hormone synthesis. • Aberrant DNA methylation patterns of the SF-1 promoter may contribute to the downregulat...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wang, Wenxiang [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017 |
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| Schlagwörter: |
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| Umfang: |
9 |
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| Übergeordnetes Werk: |
Enthalten in: Toxicology letters - Chen, Yun-Ru ELSEVIER, 2019, an international journal for the rapid publication of short reports on all aspects of toxicology especially mechanisms of toxicity, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:281 ; year:2017 ; day:5 ; month:11 ; pages:175-183 ; extent:9 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.toxlet.2017.09.021 |
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| 245 | 1 | 0 | |a Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern |
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| 520 | |a • High doses of SIFs affect ovarian follicle development by inhibiting steroidogenesis. • The mechanism may be related to SIF-induced decreases in the expression of the key genes involved in hormone synthesis. • Aberrant DNA methylation patterns of the SF-1 promoter may contribute to the downregulation of steroidogenesis-related genes. | ||
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Elektronische Aufsätze |
| author-letter |
Wang, Wenxiang |
| doi_str_mv |
10.1016/j.toxlet.2017.09.021 |
| dewey-full |
570 540 610 |
| title_sort |
continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in dna methylation pattern |
| title_auth |
Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern |
| abstract |
• High doses of SIFs affect ovarian follicle development by inhibiting steroidogenesis. • The mechanism may be related to SIF-induced decreases in the expression of the key genes involved in hormone synthesis. • Aberrant DNA methylation patterns of the SF-1 promoter may contribute to the downregulation of steroidogenesis-related genes. |
| abstractGer |
• High doses of SIFs affect ovarian follicle development by inhibiting steroidogenesis. • The mechanism may be related to SIF-induced decreases in the expression of the key genes involved in hormone synthesis. • Aberrant DNA methylation patterns of the SF-1 promoter may contribute to the downregulation of steroidogenesis-related genes. |
| abstract_unstemmed |
• High doses of SIFs affect ovarian follicle development by inhibiting steroidogenesis. • The mechanism may be related to SIF-induced decreases in the expression of the key genes involved in hormone synthesis. • Aberrant DNA methylation patterns of the SF-1 promoter may contribute to the downregulation of steroidogenesis-related genes. |
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GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA |
| title_short |
Continuous soy isoflavones exposure from weaning to maturity induces downregulation of ovarian steroidogenic factor 1 gene expression and corresponding changes in DNA methylation pattern |
| url |
https://doi.org/10.1016/j.toxlet.2017.09.021 |
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true |
| author2 |
Sun, Yan Guo, Yiwei Cai, Ping Li, Yuchen Liu, Jin Cai, Guoxi Kiyoshi, Aoyagi Zhang, Wenchang |
| author2Str |
Sun, Yan Guo, Yiwei Cai, Ping Li, Yuchen Liu, Jin Cai, Guoxi Kiyoshi, Aoyagi Zhang, Wenchang |
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ELV003574431 |
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| doi_str |
10.1016/j.toxlet.2017.09.021 |
| up_date |
2024-07-06T18:02:49.141Z |
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