Safety and efficacy of eculizumab in anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis (REGAIN): a phase 3, randomised, double-blind, placebo-controlled, multicentre study

Complement is likely to have a role in refractory generalised myasthenia gravis, but no approved therapies specifically target this system. Results from a phase 2 study suggested that eculizumab, a terminal complement inhibitor, produced clinically meaningful improvements in patients with anti-acety...
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Autor*in:

Howard, James F [verfasserIn]

Utsugisawa, Kimiaki

Benatar, Michael

Murai, Hiroyuki

Barohn, Richard J

Illa, Isabel

Jacob, Saiju

Vissing, John

Burns, Ted M

Kissel, John T

Muppidi, Srikanth

Nowak, Richard J

O'Brien, Fanny

Wang, Jing-Jing

Mantegazza, Renato

Mazia, Claudio Gabriel

Wilken, Miguel

Ortea, Carolina

Saba, Juliet

Rugiero, Marcelo

Bettini, Mariela

Vidal, Gonzalo

Garcia, Alejandra Dalila

Lamont, Phillipa

Leong, Wai-Kuen

Boterhoven, Heidi

Fyfe, Beverly

Roberts, Leslie

Jasinarachchi, Mahi

Willlems, Natasha

Wanschitz, Julia

Löscher, Wolfgang

De Bleecker, Jan

Van den Abeele, Guy

de Koning, Kathy

De Mey, Katrien

Mercelis, Rudy

Wagemaekers, Linda

Mahieu, Delphine

Van Damme, Philip

Smetcoren, Charlotte

Stevens, Olivier

Verjans, Sarah

D'Hondt, Ann

Tilkin, Petra

Alves de Siqueira Carvalho, Alzira

Hasan, Rosa

Dias Brockhausen, Igor

Feder, David

Ambrosio, Daniel

Melo, Ana Paula

Rocha, Rosana

Rosa, Bruno

Veiga, Thabata

Augusto da Silva, Luiz

Gonçalves Geraldo, Jordana

da Penha Morita Ananias, Maria

Nogueira Coelho, Erica

Paiva, Gabriel

Pozo, Marina

Prando, Natalia

Dada Martineli Torres, Debora

Fernanda Butinhao, Cristiani

Coelho, Erica

Renata Cubas Volpe, Luciana

Duran, Gustavo

Gomes da Silva, Tamires Cristina

Otavio Maia Gonçalves, Luiz

Pazetto, Lucas Eduardo

Souza Duca, Luciana

Suriane Fialho, Tomás Augusto

Gheller Friedrich, Maurício André

Guerreiro, Alexandre

Mohr, Henrique

Pereira Martins, Maurer

da Cruz Pacheco, Daiane

Macagnan, Ana Paula

de Cassia Santos, Aline

Bulle Oliveira, Acary Souza

Amaral de Andrade, Ana Carolina

Annes, Marcelo

Cavalcante Lino, Valeria

Pinto, Wladimir

Miranda, Carolina

Carrara, Fernanda

Souza, Iandra

Genge, Angela

Massie, Rami

Campbell, Natasha

Bril, Vera

Katzberg, Hans

Soltani, Mehran

Ng, Eduardo

Siddiqi, Zaeem

Phan, Celile

Blackmore, Derrick

Vohanka, Stanislav

Bednarik, Josef

Chmelikova, Magda

Cierny, Marek

Toncrova, Stanislava

Junkerova, Jana

Kurkova, Barbora

Reguliova, Katarina

Zapletalova, Olga

Pitha, Jiri

Novakova, Iveta

Tyblova, Michaela

Wolfova, Marcela

Jurajdova, Ivana

Andersen, Henning

Harbo, Thomas

Vinge, Lotte

Mogensen, Anita

Højgaard, Joan

Witting, Nanna

Autzen, Anne Mette

Pedersen, Jane

Färkkilä, Markus

Atula, Sari

Nyrhinen, Anne

Erälinna, Juha-Pekka

Laaksonen, Mikko

Oksaranta, Olli

Eriksson, Jaana

Harrison, Tuula

Desnuelle, Claude

Sacconi, Sabrina

Soriani, Marie-Hélène

Decressac, Sonia

Moutarde, Julie

Lahaut, Pauline

Solé, Guilhem

Le Masson, Gwendal

Wielanek-Bachelet, Anne-Cécile

Gaboreau, Morgane

Moreau, Caroline

Wilson, Amy

Vial, Christophe

Bouhour, Françoise

Gervais-Bernard, Helene

Merle, Hélène

Hourquin, Caroline

Lacour, Arnaud

Outteryck, Olivier

Vermersch, Patrick

Zephir, Hélène

Millois, Edouard

Deneve, Michel

Deruelle, Fabienne

Schoser, Benedikt

Wenninger, Stephan

Stangel, Martin

Alvermann, Sascha

Gingele, Stefan

Skripuletz, Thomas

Suehs, Kurt-Wolfram

Trebst, Corinna

Fricke, Karin

Papagiannopoulos, Sotirios

Bostantzopoulou, Sevasti

Vlaikidis, Nicholas

Zampaki, Martha

Papadopoulou, Nikoletta

Mitsikostas, Dimos-Dimitrios

Kasioti, Eleni

Mitropoulou, Efstathia

Charalambous, Despoina

Rozsa, Csilla

Horvath, Melinda

Lovas, Gabor

Matolcsi, Judit

Szabo, Gyorgyi

Szabadosne, Brigitta

Vecsei, Laszlo

Dezsi, Livia

Varga, Edina

Konyane, Monika

Gross, Bella

Azrilin, Olga

Greenbereg, Nelly

Bali Kuperman, Hila

Antonini, Giovanni

Garibaldi, Matteo

Morino, Stefania

Troili, Fernanda

Di Pasquale, Antonella

Filla, Alessandro

Costabile, Teresa

Marano, Enrico

Sacca, Francesco

Marsil, Angela

Puorro, Giorgia

Maestri Tassoni, Michelangelo

De Rosa, Anna

Bonanno, Silvia

Antozzi, Carlo

Maggi, Lorenzo

Campanella, Angela

Angelini, Corrado

Cudia, Paola

Pegoraro, Valentina

Pinzan, Elena

Bevilacqua, Francesca

Orrico, Daniele

Bonifati, Domenico Marco

Evoli, Amelia

Alboini, Paolo Emilio

D'Amato, Valentina

Iorio, Raffaele

Inghilleri, Maurizio

Fionda, Laura

Frasca, Vittorio

Giacomelli, Elena

Gori, Maria

Lopergolo, Diego

Onesti, Emanuela

Gabriele, Maria

Patti, Francesco

Salvatore Caramma, Andrea

Messina, Silvia

Reggio, Ester

Caserta, Cinzia

Uzawa, Akiyuki

Kanai, Tetsuya

Mori, Masahiro

Kaneko, Yoko

Kanzaki, Akiko

Kobayashi, Eri

Masaki, Katsuhisa

Matsuse, Dai

Matsushita, Takuya

Uehara, Taira

Shimpo, Misa

Jingu, Maki

Kikutake, Keiko

Nakamura, Yumiko

Sano, Yoshiko

Nagane, Yuriko

Kamegamori, Ikuko

Fujii, Yuko

Futono, Kazumi

Tsuda, Tomoko

Saito, Yuka

Suzuki, Hidekazu

Morikawa, Miyuki

Samukawa, Makoto

Kamakura, Sachiko

Shiraishi, Hirokazu

Mitazaki, Teiichiro

Motomura, Masakatsu

Mukaino, Akihiro

Yoshimura, Shunsuke

Asada, Shizuka

Kobashikawa, Tomomi

Koga, Megumi

Maeda, Yasuko

Takada, Kazumi

Takada, Mihoko Takada

Yamashita, Yumi

Yoshida, Seiko

Suzuki, Yasushi

Akiyama, Tetsuya

Narikawa, Koichi

Tsukita, Kenichi

Meguro, Fumie

Fukuda, Yusuke

Sato, Miwako

Matsuo, Hidenori

Fukudome, Takayasu

Gondo, Yuichiro

Maeda, Yasuhiro

Nagaishi, Akiko

Nakane, Shunya

Okubo, Yoshinori

Okumura, Meinoshin

Funaka, Soichiro

Kawamura, Tomohiro

Makamori, Masayuki

Takahashi, Masanori

Hasuike, Tomoya

Higuchi, Eriko

Kobayashi, Hisako

Osakada, Kaori

Taichi, Namie

Tsuda, Emiko

Hayashi, Takashi

Hisahara, Shin

Imai, Tomihiro

Kawamata, Jun

Murahara, Takashi

Saitoh, Masaki

Shimohama, Shun

Suzuki, Shuichiro

Yamamoto, Daisuke

Konno, Shingo

Imamura, Tomomi

Inoue, Masashi

Murata, Mayumi

Nakazora, Hiroshi

Nakayama, Ritsu

Ikeda, Yasuko

Ogawa, Miki

Shirane, Maoko

Kanda, Takashi

Kawai, Motoharu

Koga, Michiaki

Ogasawara, Junichi

Omoto, Masatoshi

Sano, Yasuteru

Arima, Hideki

Fukui, Sachie

Shimose, Shigemi

Shinozaki, Hirokazu

Watanabe, Masanori

Yoshikawa, Chieko

van der Kooi, Anneke

de Visser, Marianne

Gibson, Tamar

Maessen, Jos

de Baets, Marc

Faber, Catherine

Keijzers, Maria Johanna

Miesen, Monique

Kostera-Pruszczyk, Anna

Kaminska, Anna

Kim, Byung-Jo

Lee, Chang Nyoung

Koo, Yong Seo

Seok, Hung Youl

Kang, Hoo Nam

Ra, HyeJin

Kim, Byoung Joon

Cho, Eun Bin

Lee, HyeLim

Min, Ju-Hong

Seok, Jinmyoung

Koh, Da Yoon

Kwon, JuYoung

Lee, JiEun

Park, SangAe

Hong, Yoon-Ho

Lim, Jae-Sung

Kim, MiRi

Kim, Seung Min

Kim, Yool-hee

Lee, Hyung Seok

Shin, Ha Young

Hwang, Eun Bi

Shin, MiJu

Sazonov, Denis

Yarmoschuk, Asya

Babenko, Larisa

Malkova, Nadezhda

Melnikova, Anna

Korobko, Denis

Kosykh, Evgeniya

Pokhabov, Dmitry

Nesterova, Yulia

Abramov, Vladislav

Balyazin, Victor

Casasnovas Pons, Carlos

Alberti Aguilo, Maria

Homedes-Pedret, Christian

Palacios, Natalia Julia

Lazaro, Ana

Diez Tejedor, Exuperio

Fernandez-Fournier, Mireya

Lopez Ruiz, Pedro

Rodriguez de Rivera, Francisco Javier

Salvado Figueras, Maria

Gamez, Josep

Salvado, Maria

Cortes Vicente, Elena

Diaz-Manera, Jordi

Querol Gutierrez, Luis

Rojas Garcia, Ricardo

Vidal, Nuria

Arribas-Ibar, Elisabet

Piehl, Fredrik

Hietala, Albert

Bjarbo, Lena

Lindberg, Christopher

Jons, Daniel

Andersson, Blanka

Sengun, Ihsan

Ozcelik, Pinar

Tuga, Celal

Ugur, Muzeyyen

Boz, Cavit

Altiparmak, Didem

Gazioglu, Sibel

Ozen Aydin, Cigdem

Erdem-Ozdamar, Sevim

Bekircan-Kurt, Can Ebru

Yilmaz, Ezgi

Acar, Nazire Pinar

Caliskan, Yagmur

Efendi, Husnu

Aydinlik, Seda

Cavus, Hakan

Semiz, Cansu

Tun, Ozlem

Terzi, Murat

Dogan, Baki

Onar, Musa Kazim

Sen, Sedat

Cavdar, Tugce Kirbas

Norwood, Fiona

Dimitriou, Aikaterini

Gollogly, Jakit

Mahdi-Rogers, Mohamed

Seddigh, Arshira

Maier, Gal

Sohail, Faisal

Sathasivam, Sivakumar

Arndt, Heike

Davies, Debbie

Watling, Dave

Rivner, Michael

Hartmann, J. Edward

Quarles, Brandy

Smalley, Nicole

Amato, Anthony

Cochrane, Thomas

Salajegheh, Mohammed

Roe, Kristen

Amato, Katherine

Toska, Shirli

Wolfe, Gil

Silvestri, Nicholas

Patrick, Kara

Zakalik, Karen

Katz, Jonathan

Miller, Robert

Engel, Marguerite

Bravver, Elena

Brooks, Benjamin

Plevka, Sarah

Burdette, Maryanne

Sanjak, Mohammad

Kramer, Megan

Nemeth, Joanne

Schommer, Clara

Juel, Vern

Guptill, Jeffrey

Hobson-Webb, Lisa

Beck, Kate

Carnes, Donna

Loor, John

Anderson, Amanda

Lange, Dale

Agopian, Eliz

Goldstein, Jonathan

Manning, Erin

Kaplan, Lindsay

Holzberg, Shara

Kassebaum, Nicole

Pascuzzi, Robert

Bodkin, Cynthia

Kincaid, John

Snook, Riley

Guinrich, Sandra

Micheels, Angela

Chaudhry, Vinay

Corse, Andrea

Mosmiller, Betsy

Ho, Doreen

Srinivasan, Jayashri

Vytopil, Michael

Ventura, Nicholas

Scala, Stephanie

Carter, Cynthia

Donahue, Craig

Herbert, Carol

Weiner, Elaine

McKinnon, Jonathan

Haar, Laura

McKinnon, Naya

Alcon, Karan

Daniels, Kevin

Sattar, Nadia

Jeffery, Dennis

McKenna, Kaitlyn

Guidon, Amanda

David, William

Dheel, Christina

Levine-Weinberg, Mark

Nigro, Catherine

Simpson, Ericka

Appel, Stanley H

Lai, Eugene

Lay, Jr, Luis

Pleitez, Milvia

Halton, Sharon

Faigle, Casey

Thompson, Lisa

Sivak, Mark

Shin, Susan

Bratton, Joan

Jacobs, Daniel

Brown, Gavin

Bandukwala, Ibrez

Brown, Morris

Kane, Jennifer

Blount, Ira

Freimer, Miriam

Hoyle, J. Chad

Agriesti, Julie

Khoury, Julie

Marburger, Tessa

Kaur, Harpreet

Dimitrova, Diana

Mellion, Michelle

Sachs, George

Crabtree, Brigid

Keo, Roseann

Perez, Ele Kim

Taber, Sandra

Gilchrist, James

Andoin, Angela

Darnell, Taylor

Goyal, Neelam

Sakamuri, Sarada

So, Yuen T

Welsh, Lesly Welsh

Bhavaraju-Sanka, Ratna

Tobon Gonzalez, Alejandro

Jones, Floyd

Saklad, Amy

Nations, Sharon

Trivedi, Jaya

Hopkins, Steve

Kazamel, Mohamed

Alsharabati, Mohammad

Lu, Liang

Mumfrey-Thomas, Sandi

Woodall, Amy

Richman, David

Butters, Janelle

Lindsay, Molly

Mozaffar, Tahseen

Cash, Tiyonnoh

Goyal, Namita

Roy, Gulmohor

Mathew, Veena

Maqsood, Fatima

Minton, Brian

Jones, H. James

Rosenfeld, Jeffrey

Garcia, Rebekah

Garcia, Sonia

Echevarria, Laura

Pulley, Michael

Aranke, Shachie

Berger, Alan Ross

Shah, Jaimin

Shabbir, Yasmeen

Smith, Lisa

Varghese, Mary

Gutmann, Laurie

Gutmann, Ludwig

Swenson, Andrea

Olalde, Heena

Hafer-Macko, Charlene

Kwan, Justin

Zilliox, Lindsay

Callison, Karen

DiSanzo, Beth

Naunton, Kerry

Bilsker, Martin

Sharma, Khema

Reyes, Eliana

Cooley, Anne

Michon, Sara-Claude

Steele, Julie

Karam, Chafic Karam

Chopra, Manisha

Bird, Shawn

Kaufman, Jacob

Gallatti, Nichole

Vu, Tuan

Katzin, Lara

McClain, Terry

Harvey, Brittany

Hart, Adam

Huynh, Kristin

Beydoun, Said

Chilingaryan, Amaiak

Droker, Brian

Lin, Frank

Shah, Akshay

Tran, Anh

Akhter, Salma

Malekniazi, Ali

Tandan, Rup

Hehir, Michael

Waheed, Waqar

Lucy, Shannon

Weiss, Michael

Distad, Jane

Downing, Sharon

Strom, Susan

Lisak, Robert

Bernitsas, Evanthia

Khan, Omar

Kumar Sriwastava, Shitiz

Tselis, Alexandros

Jia, Kelly

Bertorini, Tulio

Arnold, Thomas

Henderson, Kendrick

Pillai, Rekha

Liu, Ye

Wheeler, Lauren

Hewlett, Jasmine

Vanderhook, Mollie

Dicapua, Daniel

Keung, Benison

Kumar, Aditya

Patwa, Huned

Robeson, Kimberly

Nye, Joan

Vu, Hong

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2017

Umfang:

11

Übergeordnetes Werk:

Enthalten in: Rejection and modeling of arsenate by nanofiltration: Contributions of convection, diffusion and electromigration to arsenic transport - Fang, Jun ELSEVIER, 2014transfer abstract, London

Übergeordnetes Werk:

volume:16 ; year:2017 ; number:12 ; pages:976-986 ; extent:11

Links:

Volltext

DOI / URN:

10.1016/S1474-4422(17)30369-1

Katalog-ID:

ELV041032470

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