Post-Translational Peptide Splicing and T Cell Responses
CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the cell surface. These epitopes are mainly produced via degradation of proteins by the proteasome, generating fragments of the original sequence. However, it is now clear that proteasomes can produce a significan...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Mishto, Michele [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2017transfer abstract |
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| Umfang: |
12 |
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| Übergeordnetes Werk: |
Enthalten in: The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy - Thomas, Brandon ELSEVIER, 2023, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:38 ; year:2017 ; number:12 ; pages:904-915 ; extent:12 |
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| DOI / URN: |
10.1016/j.it.2017.07.011 |
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| 520 | |a CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the cell surface. These epitopes are mainly produced via degradation of proteins by the proteasome, generating fragments of the original sequence. However, it is now clear that proteasomes can produce a significant portion of epitopes by reshuffling the antigen sequence, thus expanding the potential antigenic repertoire. MHC class I-restricted spliced epitopes have been described in tumors and infections, suggesting an unpredicted relevance of these peculiar peptides. We review current knowledge about proteasome-catalyzed peptide splicing (PCPS), the emerging rules governing this process, and the potential implications for our understanding and therapeutic use of CD8+ T cells, as well as mechanisms generating other non-canonical antigenic epitopes targeted by the T cell response. | ||
| 520 | |a CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the cell surface. These epitopes are mainly produced via degradation of proteins by the proteasome, generating fragments of the original sequence. However, it is now clear that proteasomes can produce a significant portion of epitopes by reshuffling the antigen sequence, thus expanding the potential antigenic repertoire. MHC class I-restricted spliced epitopes have been described in tumors and infections, suggesting an unpredicted relevance of these peculiar peptides. We review current knowledge about proteasome-catalyzed peptide splicing (PCPS), the emerging rules governing this process, and the potential implications for our understanding and therapeutic use of CD8+ T cells, as well as mechanisms generating other non-canonical antigenic epitopes targeted by the T cell response. | ||
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10.1016/j.it.2017.07.011 doi GBV00000000000148A.pica (DE-627)ELV041229967 (ELSEVIER)S1471-4906(17)30149-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 Mishto, Michele verfasserin aut Post-Translational Peptide Splicing and T Cell Responses 2017transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the cell surface. These epitopes are mainly produced via degradation of proteins by the proteasome, generating fragments of the original sequence. However, it is now clear that proteasomes can produce a significant portion of epitopes by reshuffling the antigen sequence, thus expanding the potential antigenic repertoire. MHC class I-restricted spliced epitopes have been described in tumors and infections, suggesting an unpredicted relevance of these peculiar peptides. We review current knowledge about proteasome-catalyzed peptide splicing (PCPS), the emerging rules governing this process, and the potential implications for our understanding and therapeutic use of CD8+ T cells, as well as mechanisms generating other non-canonical antigenic epitopes targeted by the T cell response. CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the cell surface. These epitopes are mainly produced via degradation of proteins by the proteasome, generating fragments of the original sequence. However, it is now clear that proteasomes can produce a significant portion of epitopes by reshuffling the antigen sequence, thus expanding the potential antigenic repertoire. MHC class I-restricted spliced epitopes have been described in tumors and infections, suggesting an unpredicted relevance of these peculiar peptides. We review current knowledge about proteasome-catalyzed peptide splicing (PCPS), the emerging rules governing this process, and the potential implications for our understanding and therapeutic use of CD8+ T cells, as well as mechanisms generating other non-canonical antigenic epitopes targeted by the T cell response. Liepe, Juliane oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:38 year:2017 number:12 pages:904-915 extent:12 https://doi.org/10.1016/j.it.2017.07.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 38 2017 12 904-915 12 045F 610 |
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10.1016/j.it.2017.07.011 doi GBV00000000000148A.pica (DE-627)ELV041229967 (ELSEVIER)S1471-4906(17)30149-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 Mishto, Michele verfasserin aut Post-Translational Peptide Splicing and T Cell Responses 2017transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the cell surface. These epitopes are mainly produced via degradation of proteins by the proteasome, generating fragments of the original sequence. However, it is now clear that proteasomes can produce a significant portion of epitopes by reshuffling the antigen sequence, thus expanding the potential antigenic repertoire. MHC class I-restricted spliced epitopes have been described in tumors and infections, suggesting an unpredicted relevance of these peculiar peptides. We review current knowledge about proteasome-catalyzed peptide splicing (PCPS), the emerging rules governing this process, and the potential implications for our understanding and therapeutic use of CD8+ T cells, as well as mechanisms generating other non-canonical antigenic epitopes targeted by the T cell response. CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the cell surface. These epitopes are mainly produced via degradation of proteins by the proteasome, generating fragments of the original sequence. However, it is now clear that proteasomes can produce a significant portion of epitopes by reshuffling the antigen sequence, thus expanding the potential antigenic repertoire. MHC class I-restricted spliced epitopes have been described in tumors and infections, suggesting an unpredicted relevance of these peculiar peptides. We review current knowledge about proteasome-catalyzed peptide splicing (PCPS), the emerging rules governing this process, and the potential implications for our understanding and therapeutic use of CD8+ T cells, as well as mechanisms generating other non-canonical antigenic epitopes targeted by the T cell response. Liepe, Juliane oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:38 year:2017 number:12 pages:904-915 extent:12 https://doi.org/10.1016/j.it.2017.07.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 38 2017 12 904-915 12 045F 610 |
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10.1016/j.it.2017.07.011 doi GBV00000000000148A.pica (DE-627)ELV041229967 (ELSEVIER)S1471-4906(17)30149-7 DE-627 ger DE-627 rakwb eng 610 610 DE-600 Mishto, Michele verfasserin aut Post-Translational Peptide Splicing and T Cell Responses 2017transfer abstract 12 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the cell surface. These epitopes are mainly produced via degradation of proteins by the proteasome, generating fragments of the original sequence. However, it is now clear that proteasomes can produce a significant portion of epitopes by reshuffling the antigen sequence, thus expanding the potential antigenic repertoire. MHC class I-restricted spliced epitopes have been described in tumors and infections, suggesting an unpredicted relevance of these peculiar peptides. We review current knowledge about proteasome-catalyzed peptide splicing (PCPS), the emerging rules governing this process, and the potential implications for our understanding and therapeutic use of CD8+ T cells, as well as mechanisms generating other non-canonical antigenic epitopes targeted by the T cell response. CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the cell surface. These epitopes are mainly produced via degradation of proteins by the proteasome, generating fragments of the original sequence. However, it is now clear that proteasomes can produce a significant portion of epitopes by reshuffling the antigen sequence, thus expanding the potential antigenic repertoire. MHC class I-restricted spliced epitopes have been described in tumors and infections, suggesting an unpredicted relevance of these peculiar peptides. We review current knowledge about proteasome-catalyzed peptide splicing (PCPS), the emerging rules governing this process, and the potential implications for our understanding and therapeutic use of CD8+ T cells, as well as mechanisms generating other non-canonical antigenic epitopes targeted by the T cell response. Liepe, Juliane oth Enthalten in Elsevier Science Thomas, Brandon ELSEVIER The journey of a mental health professional with co-morbid mental health and alcohol use disorder from despair, to acceptance, to advocacy 2023 Amsterdam [u.a.] (DE-627)ELV009586830 volume:38 year:2017 number:12 pages:904-915 extent:12 https://doi.org/10.1016/j.it.2017.07.011 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 38 2017 12 904-915 12 045F 610 |
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Post-Translational Peptide Splicing and T Cell Responses |
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CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the cell surface. These epitopes are mainly produced via degradation of proteins by the proteasome, generating fragments of the original sequence. However, it is now clear that proteasomes can produce a significant portion of epitopes by reshuffling the antigen sequence, thus expanding the potential antigenic repertoire. MHC class I-restricted spliced epitopes have been described in tumors and infections, suggesting an unpredicted relevance of these peculiar peptides. We review current knowledge about proteasome-catalyzed peptide splicing (PCPS), the emerging rules governing this process, and the potential implications for our understanding and therapeutic use of CD8+ T cells, as well as mechanisms generating other non-canonical antigenic epitopes targeted by the T cell response. |
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CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the cell surface. These epitopes are mainly produced via degradation of proteins by the proteasome, generating fragments of the original sequence. However, it is now clear that proteasomes can produce a significant portion of epitopes by reshuffling the antigen sequence, thus expanding the potential antigenic repertoire. MHC class I-restricted spliced epitopes have been described in tumors and infections, suggesting an unpredicted relevance of these peculiar peptides. We review current knowledge about proteasome-catalyzed peptide splicing (PCPS), the emerging rules governing this process, and the potential implications for our understanding and therapeutic use of CD8+ T cells, as well as mechanisms generating other non-canonical antigenic epitopes targeted by the T cell response. |
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CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the cell surface. These epitopes are mainly produced via degradation of proteins by the proteasome, generating fragments of the original sequence. However, it is now clear that proteasomes can produce a significant portion of epitopes by reshuffling the antigen sequence, thus expanding the potential antigenic repertoire. MHC class I-restricted spliced epitopes have been described in tumors and infections, suggesting an unpredicted relevance of these peculiar peptides. We review current knowledge about proteasome-catalyzed peptide splicing (PCPS), the emerging rules governing this process, and the potential implications for our understanding and therapeutic use of CD8+ T cells, as well as mechanisms generating other non-canonical antigenic epitopes targeted by the T cell response. |
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Post-Translational Peptide Splicing and T Cell Responses |
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false |
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| author2_role |
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| doi_str |
10.1016/j.it.2017.07.011 |
| up_date |
2024-07-06T19:34:12.001Z |
| _version_ |
1803859475300352000 |
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7.4017944 |