Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy
The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients c...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Compta, Yaroslau [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2018transfer abstract |
|---|
| Schlagwörter: |
|---|
| Umfang: |
8 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Parkinsonism & related disorders - Aral, Efecan ELSEVIER, 2022, official journal of the World Federation of Neurology Research Committee on Parkinsonism and Related Disorders, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:46 ; year:2018 ; pages:16-23 ; extent:8 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.parkreldis.2017.10.010 |
|---|
| Katalog-ID: |
ELV041563425 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV041563425 | ||
| 003 | DE-627 | ||
| 005 | 20230625235012.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180726s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.parkreldis.2017.10.010 |2 doi | |
| 028 | 5 | 2 | |a GBV00000000000089A.pica |
| 035 | |a (DE-627)ELV041563425 | ||
| 035 | |a (ELSEVIER)S1353-8020(17)30381-4 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 610 | |
| 082 | 0 | 4 | |a 610 |q DE-600 |
| 082 | 0 | 4 | |a 610 |q VZ |
| 084 | |a 42.13 |2 bkl | ||
| 084 | |a 44.33 |2 bkl | ||
| 100 | 1 | |a Compta, Yaroslau |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy |
| 264 | 1 | |c 2018transfer abstract | |
| 300 | |a 8 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. | ||
| 520 | |a The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. | ||
| 650 | 7 | |a Biomarker |2 Elsevier | |
| 650 | 7 | |a Parkinson's disease |2 Elsevier | |
| 650 | 7 | |a Progressive supranuclear palsy |2 Elsevier | |
| 650 | 7 | |a Atypical parkinsonisms |2 Elsevier | |
| 650 | 7 | |a Coenzyme Q10 |2 Elsevier | |
| 650 | 7 | |a Multiple system atrophy |2 Elsevier | |
| 650 | 7 | |a Cerebrospinal fluid |2 Elsevier | |
| 700 | 1 | |a Giraldo, Darly M. |4 oth | |
| 700 | 1 | |a Muñoz, Esteban |4 oth | |
| 700 | 1 | |a Antonelli, Francesca |4 oth | |
| 700 | 1 | |a Fernández, Manel |4 oth | |
| 700 | 1 | |a Bravo, Paloma |4 oth | |
| 700 | 1 | |a Soto, Marta |4 oth | |
| 700 | 1 | |a Cámara, Ana |4 oth | |
| 700 | 1 | |a Torres, Ferran |4 oth | |
| 700 | 1 | |a Martí, María José |4 oth | |
| 700 | 1 | |a Ávila, Asunción |4 oth | |
| 700 | 1 | |a Bayés, Àngels |4 oth | |
| 700 | 1 | |a Botta-Orfila, Teresa |4 oth | |
| 700 | 1 | |a Caballol, Núria |4 oth | |
| 700 | 1 | |a Calopa, Matilde |4 oth | |
| 700 | 1 | |a Campdelacreu, Jaume |4 oth | |
| 700 | 1 | |a Ezquerra, Mario |4 oth | |
| 700 | 1 | |a de Fàbregues, Oriol |4 oth | |
| 700 | 1 | |a Fernández-Santiago, Rubén |4 oth | |
| 700 | 1 | |a Hernández-Vara, Jorge |4 oth | |
| 700 | 1 | |a Jaumà, Serge |4 oth | |
| 700 | 1 | |a Marchese, Domenica |4 oth | |
| 700 | 1 | |a Pagonabarraga, Javier |4 oth | |
| 700 | 1 | |a Pastor, Pau |4 oth | |
| 700 | 1 | |a Planellas, Lluís |4 oth | |
| 700 | 1 | |a Pont-Sunyer, Claustre |4 oth | |
| 700 | 1 | |a Puente, Víctor |4 oth | |
| 700 | 1 | |a Pujol, Montserrat |4 oth | |
| 700 | 1 | |a Saura, Josep |4 oth | |
| 700 | 1 | |a Tartaglia, Gian Gaetano |4 oth | |
| 700 | 1 | |a Tolosa, Eduard |4 oth | |
| 700 | 1 | |a Valldeoriola, Francesc |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Aral, Efecan ELSEVIER |t Parkinsonism & related disorders |d 2022 |d official journal of the World Federation of Neurology Research Committee on Parkinsonism and Related Disorders |g Amsterdam [u.a.] |w (DE-627)ELV009218491 |
| 773 | 1 | 8 | |g volume:46 |g year:2018 |g pages:16-23 |g extent:8 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.parkreldis.2017.10.010 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 912 | |a SSG-OLC-PHA | ||
| 936 | b | k | |a 42.13 |j Molekularbiologie |q VZ |
| 936 | b | k | |a 44.33 |j Physiologische Chemie |q VZ |
| 951 | |a AR | ||
| 952 | |d 46 |j 2018 |h 16-23 |g 8 | ||
| 953 | |2 045F |a 610 | ||
| author_variant |
y c yc |
|---|---|
| matchkey_str |
comptayaroslaugiraldodarlymmuozestebanan:2018----:eersiafudeesfonye1aeeueim |
| hierarchy_sort_str |
2018transfer abstract |
| bklnumber |
42.13 44.33 |
| publishDate |
2018 |
| allfields |
10.1016/j.parkreldis.2017.10.010 doi GBV00000000000089A.pica (DE-627)ELV041563425 (ELSEVIER)S1353-8020(17)30381-4 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Compta, Yaroslau verfasserin aut Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy 2018transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. Biomarker Elsevier Parkinson's disease Elsevier Progressive supranuclear palsy Elsevier Atypical parkinsonisms Elsevier Coenzyme Q10 Elsevier Multiple system atrophy Elsevier Cerebrospinal fluid Elsevier Giraldo, Darly M. oth Muñoz, Esteban oth Antonelli, Francesca oth Fernández, Manel oth Bravo, Paloma oth Soto, Marta oth Cámara, Ana oth Torres, Ferran oth Martí, María José oth Ávila, Asunción oth Bayés, Àngels oth Botta-Orfila, Teresa oth Caballol, Núria oth Calopa, Matilde oth Campdelacreu, Jaume oth Ezquerra, Mario oth de Fàbregues, Oriol oth Fernández-Santiago, Rubén oth Hernández-Vara, Jorge oth Jaumà, Serge oth Marchese, Domenica oth Pagonabarraga, Javier oth Pastor, Pau oth Planellas, Lluís oth Pont-Sunyer, Claustre oth Puente, Víctor oth Pujol, Montserrat oth Saura, Josep oth Tartaglia, Gian Gaetano oth Tolosa, Eduard oth Valldeoriola, Francesc oth Enthalten in Elsevier Science Aral, Efecan ELSEVIER Parkinsonism & related disorders 2022 official journal of the World Federation of Neurology Research Committee on Parkinsonism and Related Disorders Amsterdam [u.a.] (DE-627)ELV009218491 volume:46 year:2018 pages:16-23 extent:8 https://doi.org/10.1016/j.parkreldis.2017.10.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 46 2018 16-23 8 045F 610 |
| spelling |
10.1016/j.parkreldis.2017.10.010 doi GBV00000000000089A.pica (DE-627)ELV041563425 (ELSEVIER)S1353-8020(17)30381-4 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Compta, Yaroslau verfasserin aut Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy 2018transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. Biomarker Elsevier Parkinson's disease Elsevier Progressive supranuclear palsy Elsevier Atypical parkinsonisms Elsevier Coenzyme Q10 Elsevier Multiple system atrophy Elsevier Cerebrospinal fluid Elsevier Giraldo, Darly M. oth Muñoz, Esteban oth Antonelli, Francesca oth Fernández, Manel oth Bravo, Paloma oth Soto, Marta oth Cámara, Ana oth Torres, Ferran oth Martí, María José oth Ávila, Asunción oth Bayés, Àngels oth Botta-Orfila, Teresa oth Caballol, Núria oth Calopa, Matilde oth Campdelacreu, Jaume oth Ezquerra, Mario oth de Fàbregues, Oriol oth Fernández-Santiago, Rubén oth Hernández-Vara, Jorge oth Jaumà, Serge oth Marchese, Domenica oth Pagonabarraga, Javier oth Pastor, Pau oth Planellas, Lluís oth Pont-Sunyer, Claustre oth Puente, Víctor oth Pujol, Montserrat oth Saura, Josep oth Tartaglia, Gian Gaetano oth Tolosa, Eduard oth Valldeoriola, Francesc oth Enthalten in Elsevier Science Aral, Efecan ELSEVIER Parkinsonism & related disorders 2022 official journal of the World Federation of Neurology Research Committee on Parkinsonism and Related Disorders Amsterdam [u.a.] (DE-627)ELV009218491 volume:46 year:2018 pages:16-23 extent:8 https://doi.org/10.1016/j.parkreldis.2017.10.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 46 2018 16-23 8 045F 610 |
| allfields_unstemmed |
10.1016/j.parkreldis.2017.10.010 doi GBV00000000000089A.pica (DE-627)ELV041563425 (ELSEVIER)S1353-8020(17)30381-4 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Compta, Yaroslau verfasserin aut Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy 2018transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. Biomarker Elsevier Parkinson's disease Elsevier Progressive supranuclear palsy Elsevier Atypical parkinsonisms Elsevier Coenzyme Q10 Elsevier Multiple system atrophy Elsevier Cerebrospinal fluid Elsevier Giraldo, Darly M. oth Muñoz, Esteban oth Antonelli, Francesca oth Fernández, Manel oth Bravo, Paloma oth Soto, Marta oth Cámara, Ana oth Torres, Ferran oth Martí, María José oth Ávila, Asunción oth Bayés, Àngels oth Botta-Orfila, Teresa oth Caballol, Núria oth Calopa, Matilde oth Campdelacreu, Jaume oth Ezquerra, Mario oth de Fàbregues, Oriol oth Fernández-Santiago, Rubén oth Hernández-Vara, Jorge oth Jaumà, Serge oth Marchese, Domenica oth Pagonabarraga, Javier oth Pastor, Pau oth Planellas, Lluís oth Pont-Sunyer, Claustre oth Puente, Víctor oth Pujol, Montserrat oth Saura, Josep oth Tartaglia, Gian Gaetano oth Tolosa, Eduard oth Valldeoriola, Francesc oth Enthalten in Elsevier Science Aral, Efecan ELSEVIER Parkinsonism & related disorders 2022 official journal of the World Federation of Neurology Research Committee on Parkinsonism and Related Disorders Amsterdam [u.a.] (DE-627)ELV009218491 volume:46 year:2018 pages:16-23 extent:8 https://doi.org/10.1016/j.parkreldis.2017.10.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 46 2018 16-23 8 045F 610 |
| allfieldsGer |
10.1016/j.parkreldis.2017.10.010 doi GBV00000000000089A.pica (DE-627)ELV041563425 (ELSEVIER)S1353-8020(17)30381-4 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Compta, Yaroslau verfasserin aut Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy 2018transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. Biomarker Elsevier Parkinson's disease Elsevier Progressive supranuclear palsy Elsevier Atypical parkinsonisms Elsevier Coenzyme Q10 Elsevier Multiple system atrophy Elsevier Cerebrospinal fluid Elsevier Giraldo, Darly M. oth Muñoz, Esteban oth Antonelli, Francesca oth Fernández, Manel oth Bravo, Paloma oth Soto, Marta oth Cámara, Ana oth Torres, Ferran oth Martí, María José oth Ávila, Asunción oth Bayés, Àngels oth Botta-Orfila, Teresa oth Caballol, Núria oth Calopa, Matilde oth Campdelacreu, Jaume oth Ezquerra, Mario oth de Fàbregues, Oriol oth Fernández-Santiago, Rubén oth Hernández-Vara, Jorge oth Jaumà, Serge oth Marchese, Domenica oth Pagonabarraga, Javier oth Pastor, Pau oth Planellas, Lluís oth Pont-Sunyer, Claustre oth Puente, Víctor oth Pujol, Montserrat oth Saura, Josep oth Tartaglia, Gian Gaetano oth Tolosa, Eduard oth Valldeoriola, Francesc oth Enthalten in Elsevier Science Aral, Efecan ELSEVIER Parkinsonism & related disorders 2022 official journal of the World Federation of Neurology Research Committee on Parkinsonism and Related Disorders Amsterdam [u.a.] (DE-627)ELV009218491 volume:46 year:2018 pages:16-23 extent:8 https://doi.org/10.1016/j.parkreldis.2017.10.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 46 2018 16-23 8 045F 610 |
| allfieldsSound |
10.1016/j.parkreldis.2017.10.010 doi GBV00000000000089A.pica (DE-627)ELV041563425 (ELSEVIER)S1353-8020(17)30381-4 DE-627 ger DE-627 rakwb eng 610 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Compta, Yaroslau verfasserin aut Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy 2018transfer abstract 8 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. Biomarker Elsevier Parkinson's disease Elsevier Progressive supranuclear palsy Elsevier Atypical parkinsonisms Elsevier Coenzyme Q10 Elsevier Multiple system atrophy Elsevier Cerebrospinal fluid Elsevier Giraldo, Darly M. oth Muñoz, Esteban oth Antonelli, Francesca oth Fernández, Manel oth Bravo, Paloma oth Soto, Marta oth Cámara, Ana oth Torres, Ferran oth Martí, María José oth Ávila, Asunción oth Bayés, Àngels oth Botta-Orfila, Teresa oth Caballol, Núria oth Calopa, Matilde oth Campdelacreu, Jaume oth Ezquerra, Mario oth de Fàbregues, Oriol oth Fernández-Santiago, Rubén oth Hernández-Vara, Jorge oth Jaumà, Serge oth Marchese, Domenica oth Pagonabarraga, Javier oth Pastor, Pau oth Planellas, Lluís oth Pont-Sunyer, Claustre oth Puente, Víctor oth Pujol, Montserrat oth Saura, Josep oth Tartaglia, Gian Gaetano oth Tolosa, Eduard oth Valldeoriola, Francesc oth Enthalten in Elsevier Science Aral, Efecan ELSEVIER Parkinsonism & related disorders 2022 official journal of the World Federation of Neurology Research Committee on Parkinsonism and Related Disorders Amsterdam [u.a.] (DE-627)ELV009218491 volume:46 year:2018 pages:16-23 extent:8 https://doi.org/10.1016/j.parkreldis.2017.10.010 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 42.13 Molekularbiologie VZ 44.33 Physiologische Chemie VZ AR 46 2018 16-23 8 045F 610 |
| language |
English |
| source |
Enthalten in Parkinsonism & related disorders Amsterdam [u.a.] volume:46 year:2018 pages:16-23 extent:8 |
| sourceStr |
Enthalten in Parkinsonism & related disorders Amsterdam [u.a.] volume:46 year:2018 pages:16-23 extent:8 |
| format_phy_str_mv |
Article |
| bklname |
Molekularbiologie Physiologische Chemie |
| institution |
findex.gbv.de |
| topic_facet |
Biomarker Parkinson's disease Progressive supranuclear palsy Atypical parkinsonisms Coenzyme Q10 Multiple system atrophy Cerebrospinal fluid |
| dewey-raw |
610 |
| isfreeaccess_bool |
false |
| container_title |
Parkinsonism & related disorders |
| authorswithroles_txt_mv |
Compta, Yaroslau @@aut@@ Giraldo, Darly M. @@oth@@ Muñoz, Esteban @@oth@@ Antonelli, Francesca @@oth@@ Fernández, Manel @@oth@@ Bravo, Paloma @@oth@@ Soto, Marta @@oth@@ Cámara, Ana @@oth@@ Torres, Ferran @@oth@@ Martí, María José @@oth@@ Ávila, Asunción @@oth@@ Bayés, Àngels @@oth@@ Botta-Orfila, Teresa @@oth@@ Caballol, Núria @@oth@@ Calopa, Matilde @@oth@@ Campdelacreu, Jaume @@oth@@ Ezquerra, Mario @@oth@@ de Fàbregues, Oriol @@oth@@ Fernández-Santiago, Rubén @@oth@@ Hernández-Vara, Jorge @@oth@@ Jaumà, Serge @@oth@@ Marchese, Domenica @@oth@@ Pagonabarraga, Javier @@oth@@ Pastor, Pau @@oth@@ Planellas, Lluís @@oth@@ Pont-Sunyer, Claustre @@oth@@ Puente, Víctor @@oth@@ Pujol, Montserrat @@oth@@ Saura, Josep @@oth@@ Tartaglia, Gian Gaetano @@oth@@ Tolosa, Eduard @@oth@@ Valldeoriola, Francesc @@oth@@ |
| publishDateDaySort_date |
2018-01-01T00:00:00Z |
| hierarchy_top_id |
ELV009218491 |
| dewey-sort |
3610 |
| id |
ELV041563425 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV041563425</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625235012.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180726s2018 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.parkreldis.2017.10.010</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBV00000000000089A.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV041563425</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1353-8020(17)30381-4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.13</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.33</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Compta, Yaroslau</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Biomarker</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Parkinson's disease</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Progressive supranuclear palsy</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Atypical parkinsonisms</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Coenzyme Q10</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Multiple system atrophy</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cerebrospinal fluid</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Giraldo, Darly M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Muñoz, Esteban</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Antonelli, Francesca</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fernández, Manel</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bravo, Paloma</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Soto, Marta</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cámara, Ana</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Torres, Ferran</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Martí, María José</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ávila, Asunción</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bayés, Àngels</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Botta-Orfila, Teresa</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Caballol, Núria</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Calopa, Matilde</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Campdelacreu, Jaume</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ezquerra, Mario</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">de Fàbregues, Oriol</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fernández-Santiago, Rubén</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hernández-Vara, Jorge</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jaumà, Serge</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Marchese, Domenica</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pagonabarraga, Javier</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pastor, Pau</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Planellas, Lluís</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pont-Sunyer, Claustre</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Puente, Víctor</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pujol, Montserrat</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Saura, Josep</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tartaglia, Gian Gaetano</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tolosa, Eduard</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Valldeoriola, Francesc</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Aral, Efecan ELSEVIER</subfield><subfield code="t">Parkinsonism & related disorders</subfield><subfield code="d">2022</subfield><subfield code="d">official journal of the World Federation of Neurology Research Committee on Parkinsonism and Related Disorders</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV009218491</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:46</subfield><subfield code="g">year:2018</subfield><subfield code="g">pages:16-23</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.parkreldis.2017.10.010</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">42.13</subfield><subfield code="j">Molekularbiologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.33</subfield><subfield code="j">Physiologische Chemie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">46</subfield><subfield code="j">2018</subfield><subfield code="h">16-23</subfield><subfield code="g">8</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| author |
Compta, Yaroslau |
| spellingShingle |
Compta, Yaroslau ddc 610 bkl 42.13 bkl 44.33 Elsevier Biomarker Elsevier Parkinson's disease Elsevier Progressive supranuclear palsy Elsevier Atypical parkinsonisms Elsevier Coenzyme Q10 Elsevier Multiple system atrophy Elsevier Cerebrospinal fluid Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy |
| authorStr |
Compta, Yaroslau |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV009218491 |
| format |
electronic Article |
| dewey-ones |
610 - Medicine & health |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
610 610 DE-600 610 VZ 42.13 bkl 44.33 bkl Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy Biomarker Elsevier Parkinson's disease Elsevier Progressive supranuclear palsy Elsevier Atypical parkinsonisms Elsevier Coenzyme Q10 Elsevier Multiple system atrophy Elsevier Cerebrospinal fluid Elsevier |
| topic |
ddc 610 bkl 42.13 bkl 44.33 Elsevier Biomarker Elsevier Parkinson's disease Elsevier Progressive supranuclear palsy Elsevier Atypical parkinsonisms Elsevier Coenzyme Q10 Elsevier Multiple system atrophy Elsevier Cerebrospinal fluid |
| topic_unstemmed |
ddc 610 bkl 42.13 bkl 44.33 Elsevier Biomarker Elsevier Parkinson's disease Elsevier Progressive supranuclear palsy Elsevier Atypical parkinsonisms Elsevier Coenzyme Q10 Elsevier Multiple system atrophy Elsevier Cerebrospinal fluid |
| topic_browse |
ddc 610 bkl 42.13 bkl 44.33 Elsevier Biomarker Elsevier Parkinson's disease Elsevier Progressive supranuclear palsy Elsevier Atypical parkinsonisms Elsevier Coenzyme Q10 Elsevier Multiple system atrophy Elsevier Cerebrospinal fluid |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
d m g dm dmg e m em f a fa m f mf p b pb m s ms a c ac f t ft m j m mj mjm a á aá à b àb t b o tbo n c nc m c mc j c jc m e me f o d fo fod r f s rfs j h v jhv s j sj d m dm j p jp p p pp l p lp c p s cps v p vp m p mp j s js g g t gg ggt e t et f v fv |
| hierarchy_parent_title |
Parkinsonism & related disorders |
| hierarchy_parent_id |
ELV009218491 |
| dewey-tens |
610 - Medicine & health |
| hierarchy_top_title |
Parkinsonism & related disorders |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV009218491 |
| title |
Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy |
| ctrlnum |
(DE-627)ELV041563425 (ELSEVIER)S1353-8020(17)30381-4 |
| title_full |
Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy |
| author_sort |
Compta, Yaroslau |
| journal |
Parkinsonism & related disorders |
| journalStr |
Parkinsonism & related disorders |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
600 - Technology |
| recordtype |
marc |
| publishDateSort |
2018 |
| contenttype_str_mv |
zzz |
| container_start_page |
16 |
| author_browse |
Compta, Yaroslau |
| container_volume |
46 |
| physical |
8 |
| class |
610 610 DE-600 610 VZ 42.13 bkl 44.33 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Compta, Yaroslau |
| doi_str_mv |
10.1016/j.parkreldis.2017.10.010 |
| dewey-full |
610 |
| title_sort |
cerebrospinal fluid levels of coenzyme q10 are reduced in multiple system atrophy |
| title_auth |
Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy |
| abstract |
The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. |
| abstractGer |
The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. |
| abstract_unstemmed |
The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA |
| title_short |
Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy |
| url |
https://doi.org/10.1016/j.parkreldis.2017.10.010 |
| remote_bool |
true |
| author2 |
Giraldo, Darly M. Muñoz, Esteban Antonelli, Francesca Fernández, Manel Bravo, Paloma Soto, Marta Cámara, Ana Torres, Ferran Martí, María José Ávila, Asunción Bayés, Àngels Botta-Orfila, Teresa Caballol, Núria Calopa, Matilde Campdelacreu, Jaume Ezquerra, Mario de Fàbregues, Oriol Fernández-Santiago, Rubén Hernández-Vara, Jorge Jaumà, Serge Marchese, Domenica Pagonabarraga, Javier Pastor, Pau Planellas, Lluís Pont-Sunyer, Claustre Puente, Víctor Pujol, Montserrat Saura, Josep Tartaglia, Gian Gaetano Tolosa, Eduard Valldeoriola, Francesc |
| author2Str |
Giraldo, Darly M. Muñoz, Esteban Antonelli, Francesca Fernández, Manel Bravo, Paloma Soto, Marta Cámara, Ana Torres, Ferran Martí, María José Ávila, Asunción Bayés, Àngels Botta-Orfila, Teresa Caballol, Núria Calopa, Matilde Campdelacreu, Jaume Ezquerra, Mario de Fàbregues, Oriol Fernández-Santiago, Rubén Hernández-Vara, Jorge Jaumà, Serge Marchese, Domenica Pagonabarraga, Javier Pastor, Pau Planellas, Lluís Pont-Sunyer, Claustre Puente, Víctor Pujol, Montserrat Saura, Josep Tartaglia, Gian Gaetano Tolosa, Eduard Valldeoriola, Francesc |
| ppnlink |
ELV009218491 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth oth |
| doi_str |
10.1016/j.parkreldis.2017.10.010 |
| up_date |
2024-07-06T20:28:15.432Z |
| _version_ |
1803862876288450560 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV041563425</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230625235012.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180726s2018 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.parkreldis.2017.10.010</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBV00000000000089A.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV041563425</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S1353-8020(17)30381-4</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">610</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">DE-600</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">42.13</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">44.33</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Compta, Yaroslau</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">8</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The finding of mutations of the COQ2 gene and reduced coenzyme Q10 levels in the cerebellum in multiple system atrophy (MSA) suggest that coenzyme Q10 is relevant to MSA pathophysiology. Two recent studies have reported reduced coenzyme Q10 levels in plasma and serum (respectively) of MSA patients compared to Parkinson's disease and/or control subjects, but with largely overlapping values, limited comparison with other parkinsonisms, or dependence on cholesterol levels. We hypothesized that cerebrospinal fluid (CSF) is reliable to assess reductions in coenzyme Q10 as a candidate biomarker of MSA.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Biomarker</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Parkinson's disease</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Progressive supranuclear palsy</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Atypical parkinsonisms</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Coenzyme Q10</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Multiple system atrophy</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cerebrospinal fluid</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Giraldo, Darly M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Muñoz, Esteban</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Antonelli, Francesca</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fernández, Manel</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bravo, Paloma</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Soto, Marta</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cámara, Ana</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Torres, Ferran</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Martí, María José</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ávila, Asunción</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bayés, Àngels</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Botta-Orfila, Teresa</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Caballol, Núria</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Calopa, Matilde</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Campdelacreu, Jaume</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ezquerra, Mario</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">de Fàbregues, Oriol</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fernández-Santiago, Rubén</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hernández-Vara, Jorge</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jaumà, Serge</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Marchese, Domenica</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pagonabarraga, Javier</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pastor, Pau</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Planellas, Lluís</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pont-Sunyer, Claustre</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Puente, Víctor</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pujol, Montserrat</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Saura, Josep</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tartaglia, Gian Gaetano</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tolosa, Eduard</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Valldeoriola, Francesc</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Aral, Efecan ELSEVIER</subfield><subfield code="t">Parkinsonism & related disorders</subfield><subfield code="d">2022</subfield><subfield code="d">official journal of the World Federation of Neurology Research Committee on Parkinsonism and Related Disorders</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV009218491</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:46</subfield><subfield code="g">year:2018</subfield><subfield code="g">pages:16-23</subfield><subfield code="g">extent:8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.parkreldis.2017.10.010</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">42.13</subfield><subfield code="j">Molekularbiologie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.33</subfield><subfield code="j">Physiologische Chemie</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">46</subfield><subfield code="j">2018</subfield><subfield code="h">16-23</subfield><subfield code="g">8</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">610</subfield></datafield></record></collection>
|
| score |
7.4030447 |