Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition

Chronic liver disease is becoming a major cause of morbidity and mortality worldwide. During liver injury, hepatic stellate cells (HSCs) trans-differentiate into activated myofibroblasts, which produce extracellular matrix.

Gespeichert in:
Autor*in:

Nguyen, Giang [verfasserIn]

Park, So Young

Le, Cong Thuc

Park, Won Sun

Choi, Dae Hee

Cho, Eun-Hee

Format:

E-Artikel

Sprache:

Englisch

Erschienen:

2018

Schlagwörter:

Succinate

Metformin

Liver fibrosis

GPR91

Umfang:

8

Übergeordnetes Werk:

Enthalten in: Preparation and characterization of glass-ceramics via co-sintering of coal fly ash and oil shale ash-derived amorphous slag - Zhang, Zhikun ELSEVIER, 2019, BBRC, Orlando, Fla

Übergeordnetes Werk:

volume:495 ; year:2018 ; number:4 ; day:22 ; month:01 ; pages:2649-2656 ; extent:8

Links:

Volltext

DOI / URN:

10.1016/j.bbrc.2017.12.143

Katalog-ID:

ELV041614097

Nicht das Richtige dabei?

Schreiben Sie uns!