Bio-derived cellulose nanofibril reinforced poly(N-isopropylacrylamide)-g-guar gum nanocomposite: An avant-garde biomaterial as a transdermal membrane
The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-p...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Dutta, Koushik [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018transfer abstract |
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| Schlagwörter: |
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| Umfang: |
18 |
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| Übergeordnetes Werk: |
Enthalten in: Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study - Fitzgerald, Emily ELSEVIER, 2020, the international journal for the science and technology of polymers, Oxford |
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| Übergeordnetes Werk: |
volume:135 ; year:2018 ; day:17 ; month:01 ; pages:85-102 ; extent:18 |
| Links: |
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| DOI / URN: |
10.1016/j.polymer.2017.12.015 |
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ELV041643739 |
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| 520 | |a The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. | ||
| 520 | |a The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. | ||
| 650 | 7 | |a N-isopropylacrylamide |2 Elsevier | |
| 650 | 7 | |a In-vitro drug release |2 Elsevier | |
| 650 | 7 | |a Guar gum |2 Elsevier | |
| 650 | 7 | |a Cellulose nanofibril |2 Elsevier | |
| 650 | 7 | |a Diltiazem hydrochloride |2 Elsevier | |
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| 700 | 1 | |a Das, Beauty |4 oth | |
| 700 | 1 | |a Orasugh, Jonathan Tersur |4 oth | |
| 700 | 1 | |a Mondal, Dipankar |4 oth | |
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| 700 | 1 | |a Rana, Dipak |4 oth | |
| 700 | 1 | |a Banerjee, Rajdeb |4 oth | |
| 700 | 1 | |a Mishra, Roshnara |4 oth | |
| 700 | 1 | |a Kar, Sumit |4 oth | |
| 700 | 1 | |a Chattopadhyay, Dipankar |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Fitzgerald, Emily ELSEVIER |t Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study |d 2020 |d the international journal for the science and technology of polymers |g Oxford |w (DE-627)ELV005093368 |
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10.1016/j.polymer.2017.12.015 doi GBV00000000000270A.pica (DE-627)ELV041643739 (ELSEVIER)S0032-3861(17)31170-9 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.63 bkl 44.69 bkl Dutta, Koushik verfasserin aut Bio-derived cellulose nanofibril reinforced poly(N-isopropylacrylamide)-g-guar gum nanocomposite: An avant-garde biomaterial as a transdermal membrane 2018transfer abstract 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. N-isopropylacrylamide Elsevier In-vitro drug release Elsevier Guar gum Elsevier Cellulose nanofibril Elsevier Diltiazem hydrochloride Elsevier Jute Elsevier Das, Beauty oth Orasugh, Jonathan Tersur oth Mondal, Dipankar oth Adhikari, Arpita oth Rana, Dipak oth Banerjee, Rajdeb oth Mishra, Roshnara oth Kar, Sumit oth Chattopadhyay, Dipankar oth Enthalten in Elsevier Science Fitzgerald, Emily ELSEVIER Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study 2020 the international journal for the science and technology of polymers Oxford (DE-627)ELV005093368 volume:135 year:2018 day:17 month:01 pages:85-102 extent:18 https://doi.org/10.1016/j.polymer.2017.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.63 Krankenpflege VZ 44.69 Intensivmedizin VZ AR 135 2018 17 0117 85-102 18 045F 540 |
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10.1016/j.polymer.2017.12.015 doi GBV00000000000270A.pica (DE-627)ELV041643739 (ELSEVIER)S0032-3861(17)31170-9 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.63 bkl 44.69 bkl Dutta, Koushik verfasserin aut Bio-derived cellulose nanofibril reinforced poly(N-isopropylacrylamide)-g-guar gum nanocomposite: An avant-garde biomaterial as a transdermal membrane 2018transfer abstract 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. N-isopropylacrylamide Elsevier In-vitro drug release Elsevier Guar gum Elsevier Cellulose nanofibril Elsevier Diltiazem hydrochloride Elsevier Jute Elsevier Das, Beauty oth Orasugh, Jonathan Tersur oth Mondal, Dipankar oth Adhikari, Arpita oth Rana, Dipak oth Banerjee, Rajdeb oth Mishra, Roshnara oth Kar, Sumit oth Chattopadhyay, Dipankar oth Enthalten in Elsevier Science Fitzgerald, Emily ELSEVIER Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study 2020 the international journal for the science and technology of polymers Oxford (DE-627)ELV005093368 volume:135 year:2018 day:17 month:01 pages:85-102 extent:18 https://doi.org/10.1016/j.polymer.2017.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.63 Krankenpflege VZ 44.69 Intensivmedizin VZ AR 135 2018 17 0117 85-102 18 045F 540 |
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10.1016/j.polymer.2017.12.015 doi GBV00000000000270A.pica (DE-627)ELV041643739 (ELSEVIER)S0032-3861(17)31170-9 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.63 bkl 44.69 bkl Dutta, Koushik verfasserin aut Bio-derived cellulose nanofibril reinforced poly(N-isopropylacrylamide)-g-guar gum nanocomposite: An avant-garde biomaterial as a transdermal membrane 2018transfer abstract 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. N-isopropylacrylamide Elsevier In-vitro drug release Elsevier Guar gum Elsevier Cellulose nanofibril Elsevier Diltiazem hydrochloride Elsevier Jute Elsevier Das, Beauty oth Orasugh, Jonathan Tersur oth Mondal, Dipankar oth Adhikari, Arpita oth Rana, Dipak oth Banerjee, Rajdeb oth Mishra, Roshnara oth Kar, Sumit oth Chattopadhyay, Dipankar oth Enthalten in Elsevier Science Fitzgerald, Emily ELSEVIER Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study 2020 the international journal for the science and technology of polymers Oxford (DE-627)ELV005093368 volume:135 year:2018 day:17 month:01 pages:85-102 extent:18 https://doi.org/10.1016/j.polymer.2017.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.63 Krankenpflege VZ 44.69 Intensivmedizin VZ AR 135 2018 17 0117 85-102 18 045F 540 |
| allfieldsGer |
10.1016/j.polymer.2017.12.015 doi GBV00000000000270A.pica (DE-627)ELV041643739 (ELSEVIER)S0032-3861(17)31170-9 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.63 bkl 44.69 bkl Dutta, Koushik verfasserin aut Bio-derived cellulose nanofibril reinforced poly(N-isopropylacrylamide)-g-guar gum nanocomposite: An avant-garde biomaterial as a transdermal membrane 2018transfer abstract 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. N-isopropylacrylamide Elsevier In-vitro drug release Elsevier Guar gum Elsevier Cellulose nanofibril Elsevier Diltiazem hydrochloride Elsevier Jute Elsevier Das, Beauty oth Orasugh, Jonathan Tersur oth Mondal, Dipankar oth Adhikari, Arpita oth Rana, Dipak oth Banerjee, Rajdeb oth Mishra, Roshnara oth Kar, Sumit oth Chattopadhyay, Dipankar oth Enthalten in Elsevier Science Fitzgerald, Emily ELSEVIER Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study 2020 the international journal for the science and technology of polymers Oxford (DE-627)ELV005093368 volume:135 year:2018 day:17 month:01 pages:85-102 extent:18 https://doi.org/10.1016/j.polymer.2017.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.63 Krankenpflege VZ 44.69 Intensivmedizin VZ AR 135 2018 17 0117 85-102 18 045F 540 |
| allfieldsSound |
10.1016/j.polymer.2017.12.015 doi GBV00000000000270A.pica (DE-627)ELV041643739 (ELSEVIER)S0032-3861(17)31170-9 DE-627 ger DE-627 rakwb eng 540 540 DE-600 610 VZ 44.63 bkl 44.69 bkl Dutta, Koushik verfasserin aut Bio-derived cellulose nanofibril reinforced poly(N-isopropylacrylamide)-g-guar gum nanocomposite: An avant-garde biomaterial as a transdermal membrane 2018transfer abstract 18 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. N-isopropylacrylamide Elsevier In-vitro drug release Elsevier Guar gum Elsevier Cellulose nanofibril Elsevier Diltiazem hydrochloride Elsevier Jute Elsevier Das, Beauty oth Orasugh, Jonathan Tersur oth Mondal, Dipankar oth Adhikari, Arpita oth Rana, Dipak oth Banerjee, Rajdeb oth Mishra, Roshnara oth Kar, Sumit oth Chattopadhyay, Dipankar oth Enthalten in Elsevier Science Fitzgerald, Emily ELSEVIER Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study 2020 the international journal for the science and technology of polymers Oxford (DE-627)ELV005093368 volume:135 year:2018 day:17 month:01 pages:85-102 extent:18 https://doi.org/10.1016/j.polymer.2017.12.015 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.63 Krankenpflege VZ 44.69 Intensivmedizin VZ AR 135 2018 17 0117 85-102 18 045F 540 |
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Enthalten in Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study Oxford volume:135 year:2018 day:17 month:01 pages:85-102 extent:18 |
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Enthalten in Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study Oxford volume:135 year:2018 day:17 month:01 pages:85-102 extent:18 |
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Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study |
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bio-derived cellulose nanofibril reinforced poly(n-isopropylacrylamide)-g-guar gum nanocomposite: an avant-garde biomaterial as a transdermal membrane |
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Bio-derived cellulose nanofibril reinforced poly(N-isopropylacrylamide)-g-guar gum nanocomposite: An avant-garde biomaterial as a transdermal membrane |
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The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. |
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The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. |
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The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. |
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Bio-derived cellulose nanofibril reinforced poly(N-isopropylacrylamide)-g-guar gum nanocomposite: An avant-garde biomaterial as a transdermal membrane |
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The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly(N-isopropylacrylamide) was grafted into guar gum (GG-g-PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG-g-PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG-g-PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">N-isopropylacrylamide</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">In-vitro drug release</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Guar gum</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cellulose nanofibril</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Diltiazem hydrochloride</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Jute</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Das, Beauty</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Orasugh, Jonathan Tersur</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mondal, Dipankar</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Adhikari, Arpita</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rana, Dipak</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Banerjee, Rajdeb</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mishra, Roshnara</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kar, Sumit</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chattopadhyay, Dipankar</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Fitzgerald, Emily ELSEVIER</subfield><subfield code="t">Functional outcomes at 12 months for patients with traumatic brain injury, intracerebral haemorrhage and subarachnoid haemorrhage treated in an Australian neurocritical care unit: A prospective cohort study</subfield><subfield code="d">2020</subfield><subfield code="d">the international journal for the science and technology of polymers</subfield><subfield code="g">Oxford</subfield><subfield code="w">(DE-627)ELV005093368</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:135</subfield><subfield code="g">year:2018</subfield><subfield code="g">day:17</subfield><subfield code="g">month:01</subfield><subfield code="g">pages:85-102</subfield><subfield code="g">extent:18</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.polymer.2017.12.015</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.63</subfield><subfield code="j">Krankenpflege</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">44.69</subfield><subfield code="j">Intensivmedizin</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">135</subfield><subfield code="j">2018</subfield><subfield code="b">17</subfield><subfield code="c">0117</subfield><subfield code="h">85-102</subfield><subfield code="g">18</subfield></datafield><datafield tag="953" ind1=" " ind2=" "><subfield code="2">045F</subfield><subfield code="a">540</subfield></datafield></record></collection>
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