Genetic correlation between smoking behaviors and schizophrenia
Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never s...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Hartz, Sarah M. [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018transfer abstract |
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| Umfang: |
5 |
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| Übergeordnetes Werk: |
Enthalten in: Idiopathic Environmental Intolerance: A Treatment Model - Van den Bergh, Omer ELSEVIER, 2021, an international multidisciplinary journal, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:194 ; year:2018 ; pages:86-90 ; extent:5 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.schres.2017.02.022 |
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ELV042334926 |
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| 520 | |a Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. | ||
| 520 | |a Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. | ||
| 700 | 1 | |a Horton, Amy C. |4 oth | |
| 700 | 1 | |a Hancock, Dana B. |4 oth | |
| 700 | 1 | |a Baker, Timothy B. |4 oth | |
| 700 | 1 | |a Caporaso, Neil E. |4 oth | |
| 700 | 1 | |a Chen, Li-Shiun |4 oth | |
| 700 | 1 | |a Hokanson, John E. |4 oth | |
| 700 | 1 | |a Lutz, Sharon M. |4 oth | |
| 700 | 1 | |a Marazita, Mary L. |4 oth | |
| 700 | 1 | |a McNeil, Daniel W. |4 oth | |
| 700 | 1 | |a Pato, Carlos N. |4 oth | |
| 700 | 1 | |a Pato, Michele T. |4 oth | |
| 700 | 1 | |a Johnson, Eric O. |4 oth | |
| 700 | 1 | |a Bierut, Laura J. |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Van den Bergh, Omer ELSEVIER |t Idiopathic Environmental Intolerance: A Treatment Model |d 2021 |d an international multidisciplinary journal |g Amsterdam [u.a.] |w (DE-627)ELV005829860 |
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10.1016/j.schres.2017.02.022 doi GBV00000000000167A.pica (DE-627)ELV042334926 (ELSEVIER)S0920-9964(17)30111-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 150 VZ Hartz, Sarah M. verfasserin aut Genetic correlation between smoking behaviors and schizophrenia 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. Horton, Amy C. oth Hancock, Dana B. oth Baker, Timothy B. oth Caporaso, Neil E. oth Chen, Li-Shiun oth Hokanson, John E. oth Lutz, Sharon M. oth Marazita, Mary L. oth McNeil, Daniel W. oth Pato, Carlos N. oth Pato, Michele T. oth Johnson, Eric O. oth Bierut, Laura J. oth Enthalten in Elsevier Science Van den Bergh, Omer ELSEVIER Idiopathic Environmental Intolerance: A Treatment Model 2021 an international multidisciplinary journal Amsterdam [u.a.] (DE-627)ELV005829860 volume:194 year:2018 pages:86-90 extent:5 https://doi.org/10.1016/j.schres.2017.02.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 194 2018 86-90 5 045F 610 |
| spelling |
10.1016/j.schres.2017.02.022 doi GBV00000000000167A.pica (DE-627)ELV042334926 (ELSEVIER)S0920-9964(17)30111-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 150 VZ Hartz, Sarah M. verfasserin aut Genetic correlation between smoking behaviors and schizophrenia 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. Horton, Amy C. oth Hancock, Dana B. oth Baker, Timothy B. oth Caporaso, Neil E. oth Chen, Li-Shiun oth Hokanson, John E. oth Lutz, Sharon M. oth Marazita, Mary L. oth McNeil, Daniel W. oth Pato, Carlos N. oth Pato, Michele T. oth Johnson, Eric O. oth Bierut, Laura J. oth Enthalten in Elsevier Science Van den Bergh, Omer ELSEVIER Idiopathic Environmental Intolerance: A Treatment Model 2021 an international multidisciplinary journal Amsterdam [u.a.] (DE-627)ELV005829860 volume:194 year:2018 pages:86-90 extent:5 https://doi.org/10.1016/j.schres.2017.02.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 194 2018 86-90 5 045F 610 |
| allfields_unstemmed |
10.1016/j.schres.2017.02.022 doi GBV00000000000167A.pica (DE-627)ELV042334926 (ELSEVIER)S0920-9964(17)30111-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 150 VZ Hartz, Sarah M. verfasserin aut Genetic correlation between smoking behaviors and schizophrenia 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. Horton, Amy C. oth Hancock, Dana B. oth Baker, Timothy B. oth Caporaso, Neil E. oth Chen, Li-Shiun oth Hokanson, John E. oth Lutz, Sharon M. oth Marazita, Mary L. oth McNeil, Daniel W. oth Pato, Carlos N. oth Pato, Michele T. oth Johnson, Eric O. oth Bierut, Laura J. oth Enthalten in Elsevier Science Van den Bergh, Omer ELSEVIER Idiopathic Environmental Intolerance: A Treatment Model 2021 an international multidisciplinary journal Amsterdam [u.a.] (DE-627)ELV005829860 volume:194 year:2018 pages:86-90 extent:5 https://doi.org/10.1016/j.schres.2017.02.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 194 2018 86-90 5 045F 610 |
| allfieldsGer |
10.1016/j.schres.2017.02.022 doi GBV00000000000167A.pica (DE-627)ELV042334926 (ELSEVIER)S0920-9964(17)30111-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 150 VZ Hartz, Sarah M. verfasserin aut Genetic correlation between smoking behaviors and schizophrenia 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. Horton, Amy C. oth Hancock, Dana B. oth Baker, Timothy B. oth Caporaso, Neil E. oth Chen, Li-Shiun oth Hokanson, John E. oth Lutz, Sharon M. oth Marazita, Mary L. oth McNeil, Daniel W. oth Pato, Carlos N. oth Pato, Michele T. oth Johnson, Eric O. oth Bierut, Laura J. oth Enthalten in Elsevier Science Van den Bergh, Omer ELSEVIER Idiopathic Environmental Intolerance: A Treatment Model 2021 an international multidisciplinary journal Amsterdam [u.a.] (DE-627)ELV005829860 volume:194 year:2018 pages:86-90 extent:5 https://doi.org/10.1016/j.schres.2017.02.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 194 2018 86-90 5 045F 610 |
| allfieldsSound |
10.1016/j.schres.2017.02.022 doi GBV00000000000167A.pica (DE-627)ELV042334926 (ELSEVIER)S0920-9964(17)30111-1 DE-627 ger DE-627 rakwb eng 610 610 DE-600 150 VZ Hartz, Sarah M. verfasserin aut Genetic correlation between smoking behaviors and schizophrenia 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. Horton, Amy C. oth Hancock, Dana B. oth Baker, Timothy B. oth Caporaso, Neil E. oth Chen, Li-Shiun oth Hokanson, John E. oth Lutz, Sharon M. oth Marazita, Mary L. oth McNeil, Daniel W. oth Pato, Carlos N. oth Pato, Michele T. oth Johnson, Eric O. oth Bierut, Laura J. oth Enthalten in Elsevier Science Van den Bergh, Omer ELSEVIER Idiopathic Environmental Intolerance: A Treatment Model 2021 an international multidisciplinary journal Amsterdam [u.a.] (DE-627)ELV005829860 volume:194 year:2018 pages:86-90 extent:5 https://doi.org/10.1016/j.schres.2017.02.022 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U AR 194 2018 86-90 5 045F 610 |
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| abstract |
Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. |
| abstractGer |
Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. |
| abstract_unstemmed |
Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h 2 g ) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h 2 g =0.08, age of onset of smoking h 2 g =0.06, CPD h 2 g =0.06, nicotine dependence h 2 g =0.15, current/former smoker h 2 g =0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r g =0.14, CPD r g =0.12, and ever/never smoking r g =0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia. |
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