Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity
Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracell...
Ausführliche Beschreibung
Autor*in: |
Fiedler, Tomas [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2018transfer abstract |
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Schlagwörter: |
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Umfang: |
5 |
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Übergeordnetes Werk: |
Enthalten in: Urological Diseases of the Byzantine Emperors (330-1453) - 2011, Amsterdam |
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Übergeordnetes Werk: |
volume:100 ; year:2018 ; pages:49-53 ; extent:5 |
Links: |
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DOI / URN: |
10.1016/j.biocel.2018.05.008 |
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ELV04339342X |
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520 | |a Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. | ||
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10.1016/j.biocel.2018.05.008 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000871.pica (DE-627)ELV04339342X (ELSEVIER)S1357-2725(18)30120-1 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.85 bkl Fiedler, Tomas verfasserin aut Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. Coagulation Elsevier Extracellular vesicles Elsevier Microvesicles Elsevier TNF Elsevier LPS Elsevier Mesenchymal stem cells Elsevier Rabe, Magdalena oth Mundkowski, Ralf G. oth Oehmcke-Hecht, Sonja oth Peters, Kirsten oth Enthalten in Elsevier Urological Diseases of the Byzantine Emperors (330-1453) 2011 Amsterdam (DE-627)ELV010616845 volume:100 year:2018 pages:49-53 extent:5 https://doi.org/10.1016/j.biocel.2018.05.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ AR 100 2018 49-53 5 |
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10.1016/j.biocel.2018.05.008 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000871.pica (DE-627)ELV04339342X (ELSEVIER)S1357-2725(18)30120-1 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.85 bkl Fiedler, Tomas verfasserin aut Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. Coagulation Elsevier Extracellular vesicles Elsevier Microvesicles Elsevier TNF Elsevier LPS Elsevier Mesenchymal stem cells Elsevier Rabe, Magdalena oth Mundkowski, Ralf G. oth Oehmcke-Hecht, Sonja oth Peters, Kirsten oth Enthalten in Elsevier Urological Diseases of the Byzantine Emperors (330-1453) 2011 Amsterdam (DE-627)ELV010616845 volume:100 year:2018 pages:49-53 extent:5 https://doi.org/10.1016/j.biocel.2018.05.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ AR 100 2018 49-53 5 |
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10.1016/j.biocel.2018.05.008 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000871.pica (DE-627)ELV04339342X (ELSEVIER)S1357-2725(18)30120-1 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.85 bkl Fiedler, Tomas verfasserin aut Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. Coagulation Elsevier Extracellular vesicles Elsevier Microvesicles Elsevier TNF Elsevier LPS Elsevier Mesenchymal stem cells Elsevier Rabe, Magdalena oth Mundkowski, Ralf G. oth Oehmcke-Hecht, Sonja oth Peters, Kirsten oth Enthalten in Elsevier Urological Diseases of the Byzantine Emperors (330-1453) 2011 Amsterdam (DE-627)ELV010616845 volume:100 year:2018 pages:49-53 extent:5 https://doi.org/10.1016/j.biocel.2018.05.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ AR 100 2018 49-53 5 |
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10.1016/j.biocel.2018.05.008 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000871.pica (DE-627)ELV04339342X (ELSEVIER)S1357-2725(18)30120-1 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.85 bkl Fiedler, Tomas verfasserin aut Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. Coagulation Elsevier Extracellular vesicles Elsevier Microvesicles Elsevier TNF Elsevier LPS Elsevier Mesenchymal stem cells Elsevier Rabe, Magdalena oth Mundkowski, Ralf G. oth Oehmcke-Hecht, Sonja oth Peters, Kirsten oth Enthalten in Elsevier Urological Diseases of the Byzantine Emperors (330-1453) 2011 Amsterdam (DE-627)ELV010616845 volume:100 year:2018 pages:49-53 extent:5 https://doi.org/10.1016/j.biocel.2018.05.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ AR 100 2018 49-53 5 |
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10.1016/j.biocel.2018.05.008 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000871.pica (DE-627)ELV04339342X (ELSEVIER)S1357-2725(18)30120-1 DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.85 bkl Fiedler, Tomas verfasserin aut Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity 2018transfer abstract 5 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. Coagulation Elsevier Extracellular vesicles Elsevier Microvesicles Elsevier TNF Elsevier LPS Elsevier Mesenchymal stem cells Elsevier Rabe, Magdalena oth Mundkowski, Ralf G. oth Oehmcke-Hecht, Sonja oth Peters, Kirsten oth Enthalten in Elsevier Urological Diseases of the Byzantine Emperors (330-1453) 2011 Amsterdam (DE-627)ELV010616845 volume:100 year:2018 pages:49-53 extent:5 https://doi.org/10.1016/j.biocel.2018.05.008 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA 44.85 Kardiologie Angiologie VZ AR 100 2018 49-53 5 |
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title_full |
Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity |
author_sort |
Fiedler, Tomas |
journal |
Urological Diseases of the Byzantine Emperors (330-1453) |
journalStr |
Urological Diseases of the Byzantine Emperors (330-1453) |
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eng |
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600 - Technology |
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marc |
publishDateSort |
2018 |
contenttype_str_mv |
zzz |
container_start_page |
49 |
author_browse |
Fiedler, Tomas |
container_volume |
100 |
physical |
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610 VZ 44.85 bkl |
format_se |
Elektronische Aufsätze |
author-letter |
Fiedler, Tomas |
doi_str_mv |
10.1016/j.biocel.2018.05.008 |
dewey-full |
610 |
title_sort |
adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity |
title_auth |
Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity |
abstract |
Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. |
abstractGer |
Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. |
abstract_unstemmed |
Extracellular vesicles are produced by a number of different cell types, among them mesenchymal stromal/stem cells (MSC) of different sources. It has been shown that extracellular vesicles of MSC exert similar therapeutic effects as the cells themselves. Here, we isolated and characterized extracellular vesicles produced by adipose-derived MSC (adMSC) in vitro upon stimulation with the proinflammatory substances lipopolysaccharide (LPS) and tumor necrosis factor (TNF). We found that the number of vesicles produced by adMSC does not change upon stimulation of the cells with LPS and TNF. Furthermore, adMSC-derived extracellular vesicles exert procoagulant activity independent of previous stimulation with LPS or TNF. We found evidence that the vesicles induce coagulation via both the intrinsic and the extrinsic pathway of coagulation. |
collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA |
title_short |
Adipose-derived mesenchymal stem cells release microvesicles with procoagulant activity |
url |
https://doi.org/10.1016/j.biocel.2018.05.008 |
remote_bool |
true |
author2 |
Rabe, Magdalena Mundkowski, Ralf G. Oehmcke-Hecht, Sonja Peters, Kirsten |
author2Str |
Rabe, Magdalena Mundkowski, Ralf G. Oehmcke-Hecht, Sonja Peters, Kirsten |
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ELV010616845 |
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author2_role |
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doi_str |
10.1016/j.biocel.2018.05.008 |
up_date |
2024-07-06T18:42:29.923Z |
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7.3997602 |