Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium
The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk s...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Peyrot, Wouter J. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Umfang: |
10 |
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| Übergeordnetes Werk: |
Enthalten in: Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells - Xu, Qi ELSEVIER, 2016, a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry, Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:84 ; year:2018 ; number:2 ; day:15 ; month:07 ; pages:138-147 ; extent:10 |
| Links: |
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| DOI / URN: |
10.1016/j.biopsych.2017.09.009 |
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ELV043609287 |
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| 245 | 1 | 0 | |a Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium |
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| 520 | |a The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample. | ||
| 650 | 7 | |a Interaction |2 Elsevier | |
| 650 | 7 | |a Depression |2 Elsevier | |
| 650 | 7 | |a Genetics |2 Elsevier | |
| 650 | 7 | |a Polygenic risk |2 Elsevier | |
| 650 | 7 | |a Childhood trauma |2 Elsevier | |
| 650 | 7 | |a Meta-analysis |2 Elsevier | |
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10.1016/j.biopsych.2017.09.009 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000978.pica (DE-627)ELV043609287 (ELSEVIER)S0006-3223(17)31993-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.40 bkl Peyrot, Wouter J. verfasserin aut Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium 2018 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample. Interaction Elsevier Depression Elsevier Genetics Elsevier Polygenic risk Elsevier Childhood trauma Elsevier Meta-analysis Elsevier Van der Auwera, Sandra oth Milaneschi, Yuri oth Dolan, Conor V. oth Madden, Pamela A.F. oth Sullivan, Patrick F. oth Strohmaier, Jana oth Ripke, Stephan oth Rietschel, Marcella oth Nivard, Michel G. oth Mullins, Niamh oth Montgomery, Grant W. oth Henders, Anjali K. oth Heat, Andrew C. oth Fisher, Helen L. oth Dunn, Erin C. oth Byrne, Enda M. oth Air, Tracy A. oth Wray, Naomi R. oth Ripke, Stephan oth Mattheisen, Manuel oth Trzaskowski, Maciej oth Byrne, Enda M. oth Abdellaoui, Abdel oth Adams, Mark J. oth Agerbo, Esben oth Air, Tracy M. oth Andlauer, Till F.M. oth Bacanu, Silviu-Alin oth Bækvad-Hansen, Marie oth Beekman, Aartjan T.F. oth Bigdeli, Tim B. oth Binder, Elisabeth B. oth Blackwood, Douglas H.R. oth Bryois, Julien oth Buttenschøn, Henriette N. oth Bybjerg-Grauholm, Jonas oth Cai, Na oth Castelao, Enrique oth Christensen, Jane Hvarregaard oth Clarke, Toni-Kim oth Coleman, Jonathan R.I. oth Colodro-Conde, Lucía oth Couvy-Duchesne, Baptiste oth Craddock, Nick oth Crawford, Gregory E. oth Davies, Gail oth Deary, Ian J. oth Degenhardt, Franziska oth Derks, Eske M. oth Direk, Nese oth Dolan, Conor V. oth Dunn, Erin C. oth Eley, Thalia C. oth Escott-Price, Valentina oth Farnush oth Kiadeh, Farhadi Hassan oth Finucane, Hilary K. oth Forstner, Andreas J. oth Frank, Josef oth Gaspar, Héléna A. oth Gill, Michael oth Goes, Fernando S. oth Gordon, Scott D. oth Grove, Jakob oth Hall, Lynsey S. oth Hansen, Christine Søholm oth Hansen, Thomas F. oth Herms, Stefan oth Hicki, Ian B. oth Hoffmann, Per oth Homuth, Georg oth Horn, Carsten oth Hottenga, Jouke-Jan oth Hougaard, David M. oth Ising, Marcus oth Jansen, Rick oth Jorgenson, Eric oth Knowles, James A. oth Kohane, Isaac S. oth Kraft, Julia oth Kretzschmar, Warren W. oth Krogh, Jesper oth Kutalik, Zoltán oth Li, Yihan oth Lind, Penelope A. oth MacIntyre, Donald J. oth MacKinnon, Dean F. oth Maier, Robert M. oth Maier, Wolfgang oth Marchini, Jonathan oth Mbarek, Hamdi oth McGrath, Patrick oth McGuffin, Peter oth Medland, Sarah E. oth Mehta, Divya oth Middeldorp, Christel M. oth Mihailov, Evelin oth Milaneschi, Yuri oth Milani, Lili oth Mondimore, Francis M. oth Montgomery, Grant W. oth Mostafavi, Sara oth Mullins, Niamh oth Nauck, Matthias oth Ng, Bernard oth Nivard, Michel G. oth Nyholt, Dale R. oth O’Reilly, Paul F. oth Oskarsson, Hogni oth Owen, Michael J. oth Painter, Jodie N. oth Pedersen, Carsten Bøcker oth Pedersen, Marianne Giørtz oth Peterson, Roseann E. oth Pettersson, Erik oth Peyrot, Wouter J. oth Pistis, Giorgio oth Posthuma, Danielle oth Quiroz, Jorge A. oth Qvist, Per oth Rice, John P. oth Riley, Brien P. oth Rivera, Margarita oth Mirza, Saira Saeed oth Schoevers, Robert oth Schulte, Eva C. oth Shen, Ling oth Shi, Jianxin oth Shyn, Stanley I. oth Sigurdsson, Engilbert oth Sinnamon, Grant C.B. oth Smit, Johannes H. oth Smith, Daniel J. oth Stefansson, Hreinn oth Steinberg, Stacy oth Streit, Fabian oth Strohmaier, Jana oth Tansey, Katherine E. oth Teismann, Henning oth Teumer, Alexander oth Thompson, Wesley oth Thomson, Pippa A. oth Thorgeirsson, Thorgeir E. oth Traylor, Matthew oth Treutlein, Jens oth Trubetskoy, Vassily oth Uitterlinden, André G. oth Umbricht, Daniel oth Van der Auwera, Sandra oth van Hemert, Albert M. oth Viktorin, Alexander oth Visscher, Peter M. oth Wang, Yunpeng oth Webb, Bradley T. oth Weinsheimer, Shantel Marie oth Wellmann, Jürgen oth Willemsen, Gonneke oth Witt, Stephanie H. oth Wu, Yang oth Xi, Hualin S. oth Yang, Jian oth Zhang, Futao oth Arolt, Volker oth Baune, Bernhard T. oth Berger, Klaus oth Boomsma, Dorret I. oth Cichon, Sven oth Dannlowski, Udo oth de Geus, E.J.C. oth DePaulo, J. Raymond oth Domenici, Enrico oth Domschke, Katharina oth Esko, Tõnu oth Grabe, Hans J. oth Hamilton, Steven P. oth Hayward, Caroline oth Heath, Andrew C. oth Kendler, Kenneth S. oth Kloiber, Stefan oth Lewis, Glyn oth Li, Qingqin S. oth Lucae, Susanne oth Madden, Pamela A.F. oth Magnusson, Patrik K. oth Martin, Nicholas G. oth McIntosh, Andrew M. oth Metspalu, Andres oth Mors, Ole oth Mortensen, Preben Bo oth Müller-Myhsok, Bertram oth Nordentoft, Merete oth Nöthen, Markus M. oth O'Donovan, Michael C. oth Paciga, Sara A. oth Pedersen, Nancy L. oth Penninx, Brenda W.J.H. oth Perlis, Roy H. oth Porteous, David J. oth Potash, James B. oth Preisig, Martin oth Rietschel, Marcella oth Schaefer, Catherine oth Schulze, Thomas G. oth Smoller, Jordan W. oth Stefansson, Kari oth Tiemeier, Henning oth Uher, Rudolf oth Völzke, Henry oth Weissman, Myrna M. oth Werge, Thomas oth Lewis, Cathryn M. oth Levinson, Douglas F. oth Breen, Gerome oth Børglum, Anders D. oth Sullivan, Patrick F. oth Enthalten in Elsevier Science Xu, Qi ELSEVIER Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells 2016 a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry Amsterdam [u.a.] (DE-627)ELV01006897X volume:84 year:2018 number:2 day:15 month:07 pages:138-147 extent:10 https://doi.org/10.1016/j.biopsych.2017.09.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 84 2018 2 15 0715 138-147 10 |
| spelling |
10.1016/j.biopsych.2017.09.009 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000978.pica (DE-627)ELV043609287 (ELSEVIER)S0006-3223(17)31993-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.40 bkl Peyrot, Wouter J. verfasserin aut Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium 2018 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample. Interaction Elsevier Depression Elsevier Genetics Elsevier Polygenic risk Elsevier Childhood trauma Elsevier Meta-analysis Elsevier Van der Auwera, Sandra oth Milaneschi, Yuri oth Dolan, Conor V. oth Madden, Pamela A.F. oth Sullivan, Patrick F. oth Strohmaier, Jana oth Ripke, Stephan oth Rietschel, Marcella oth Nivard, Michel G. oth Mullins, Niamh oth Montgomery, Grant W. oth Henders, Anjali K. oth Heat, Andrew C. oth Fisher, Helen L. oth Dunn, Erin C. oth Byrne, Enda M. oth Air, Tracy A. oth Wray, Naomi R. oth Ripke, Stephan oth Mattheisen, Manuel oth Trzaskowski, Maciej oth Byrne, Enda M. oth Abdellaoui, Abdel oth Adams, Mark J. oth Agerbo, Esben oth Air, Tracy M. oth Andlauer, Till F.M. oth Bacanu, Silviu-Alin oth Bækvad-Hansen, Marie oth Beekman, Aartjan T.F. oth Bigdeli, Tim B. oth Binder, Elisabeth B. oth Blackwood, Douglas H.R. oth Bryois, Julien oth Buttenschøn, Henriette N. oth Bybjerg-Grauholm, Jonas oth Cai, Na oth Castelao, Enrique oth Christensen, Jane Hvarregaard oth Clarke, Toni-Kim oth Coleman, Jonathan R.I. oth Colodro-Conde, Lucía oth Couvy-Duchesne, Baptiste oth Craddock, Nick oth Crawford, Gregory E. oth Davies, Gail oth Deary, Ian J. oth Degenhardt, Franziska oth Derks, Eske M. oth Direk, Nese oth Dolan, Conor V. oth Dunn, Erin C. oth Eley, Thalia C. oth Escott-Price, Valentina oth Farnush oth Kiadeh, Farhadi Hassan oth Finucane, Hilary K. oth Forstner, Andreas J. oth Frank, Josef oth Gaspar, Héléna A. oth Gill, Michael oth Goes, Fernando S. oth Gordon, Scott D. oth Grove, Jakob oth Hall, Lynsey S. oth Hansen, Christine Søholm oth Hansen, Thomas F. oth Herms, Stefan oth Hicki, Ian B. oth Hoffmann, Per oth Homuth, Georg oth Horn, Carsten oth Hottenga, Jouke-Jan oth Hougaard, David M. oth Ising, Marcus oth Jansen, Rick oth Jorgenson, Eric oth Knowles, James A. oth Kohane, Isaac S. oth Kraft, Julia oth Kretzschmar, Warren W. oth Krogh, Jesper oth Kutalik, Zoltán oth Li, Yihan oth Lind, Penelope A. oth MacIntyre, Donald J. oth MacKinnon, Dean F. oth Maier, Robert M. oth Maier, Wolfgang oth Marchini, Jonathan oth Mbarek, Hamdi oth McGrath, Patrick oth McGuffin, Peter oth Medland, Sarah E. oth Mehta, Divya oth Middeldorp, Christel M. oth Mihailov, Evelin oth Milaneschi, Yuri oth Milani, Lili oth Mondimore, Francis M. oth Montgomery, Grant W. oth Mostafavi, Sara oth Mullins, Niamh oth Nauck, Matthias oth Ng, Bernard oth Nivard, Michel G. oth Nyholt, Dale R. oth O’Reilly, Paul F. oth Oskarsson, Hogni oth Owen, Michael J. oth Painter, Jodie N. oth Pedersen, Carsten Bøcker oth Pedersen, Marianne Giørtz oth Peterson, Roseann E. oth Pettersson, Erik oth Peyrot, Wouter J. oth Pistis, Giorgio oth Posthuma, Danielle oth Quiroz, Jorge A. oth Qvist, Per oth Rice, John P. oth Riley, Brien P. oth Rivera, Margarita oth Mirza, Saira Saeed oth Schoevers, Robert oth Schulte, Eva C. oth Shen, Ling oth Shi, Jianxin oth Shyn, Stanley I. oth Sigurdsson, Engilbert oth Sinnamon, Grant C.B. oth Smit, Johannes H. oth Smith, Daniel J. oth Stefansson, Hreinn oth Steinberg, Stacy oth Streit, Fabian oth Strohmaier, Jana oth Tansey, Katherine E. oth Teismann, Henning oth Teumer, Alexander oth Thompson, Wesley oth Thomson, Pippa A. oth Thorgeirsson, Thorgeir E. oth Traylor, Matthew oth Treutlein, Jens oth Trubetskoy, Vassily oth Uitterlinden, André G. oth Umbricht, Daniel oth Van der Auwera, Sandra oth van Hemert, Albert M. oth Viktorin, Alexander oth Visscher, Peter M. oth Wang, Yunpeng oth Webb, Bradley T. oth Weinsheimer, Shantel Marie oth Wellmann, Jürgen oth Willemsen, Gonneke oth Witt, Stephanie H. oth Wu, Yang oth Xi, Hualin S. oth Yang, Jian oth Zhang, Futao oth Arolt, Volker oth Baune, Bernhard T. oth Berger, Klaus oth Boomsma, Dorret I. oth Cichon, Sven oth Dannlowski, Udo oth de Geus, E.J.C. oth DePaulo, J. Raymond oth Domenici, Enrico oth Domschke, Katharina oth Esko, Tõnu oth Grabe, Hans J. oth Hamilton, Steven P. oth Hayward, Caroline oth Heath, Andrew C. oth Kendler, Kenneth S. oth Kloiber, Stefan oth Lewis, Glyn oth Li, Qingqin S. oth Lucae, Susanne oth Madden, Pamela A.F. oth Magnusson, Patrik K. oth Martin, Nicholas G. oth McIntosh, Andrew M. oth Metspalu, Andres oth Mors, Ole oth Mortensen, Preben Bo oth Müller-Myhsok, Bertram oth Nordentoft, Merete oth Nöthen, Markus M. oth O'Donovan, Michael C. oth Paciga, Sara A. oth Pedersen, Nancy L. oth Penninx, Brenda W.J.H. oth Perlis, Roy H. oth Porteous, David J. oth Potash, James B. oth Preisig, Martin oth Rietschel, Marcella oth Schaefer, Catherine oth Schulze, Thomas G. oth Smoller, Jordan W. oth Stefansson, Kari oth Tiemeier, Henning oth Uher, Rudolf oth Völzke, Henry oth Weissman, Myrna M. oth Werge, Thomas oth Lewis, Cathryn M. oth Levinson, Douglas F. oth Breen, Gerome oth Børglum, Anders D. oth Sullivan, Patrick F. oth Enthalten in Elsevier Science Xu, Qi ELSEVIER Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells 2016 a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry Amsterdam [u.a.] (DE-627)ELV01006897X volume:84 year:2018 number:2 day:15 month:07 pages:138-147 extent:10 https://doi.org/10.1016/j.biopsych.2017.09.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 84 2018 2 15 0715 138-147 10 |
| allfields_unstemmed |
10.1016/j.biopsych.2017.09.009 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000978.pica (DE-627)ELV043609287 (ELSEVIER)S0006-3223(17)31993-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.40 bkl Peyrot, Wouter J. verfasserin aut Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium 2018 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample. Interaction Elsevier Depression Elsevier Genetics Elsevier Polygenic risk Elsevier Childhood trauma Elsevier Meta-analysis Elsevier Van der Auwera, Sandra oth Milaneschi, Yuri oth Dolan, Conor V. oth Madden, Pamela A.F. oth Sullivan, Patrick F. oth Strohmaier, Jana oth Ripke, Stephan oth Rietschel, Marcella oth Nivard, Michel G. oth Mullins, Niamh oth Montgomery, Grant W. oth Henders, Anjali K. oth Heat, Andrew C. oth Fisher, Helen L. oth Dunn, Erin C. oth Byrne, Enda M. oth Air, Tracy A. oth Wray, Naomi R. oth Ripke, Stephan oth Mattheisen, Manuel oth Trzaskowski, Maciej oth Byrne, Enda M. oth Abdellaoui, Abdel oth Adams, Mark J. oth Agerbo, Esben oth Air, Tracy M. oth Andlauer, Till F.M. oth Bacanu, Silviu-Alin oth Bækvad-Hansen, Marie oth Beekman, Aartjan T.F. oth Bigdeli, Tim B. oth Binder, Elisabeth B. oth Blackwood, Douglas H.R. oth Bryois, Julien oth Buttenschøn, Henriette N. oth Bybjerg-Grauholm, Jonas oth Cai, Na oth Castelao, Enrique oth Christensen, Jane Hvarregaard oth Clarke, Toni-Kim oth Coleman, Jonathan R.I. oth Colodro-Conde, Lucía oth Couvy-Duchesne, Baptiste oth Craddock, Nick oth Crawford, Gregory E. oth Davies, Gail oth Deary, Ian J. oth Degenhardt, Franziska oth Derks, Eske M. oth Direk, Nese oth Dolan, Conor V. oth Dunn, Erin C. oth Eley, Thalia C. oth Escott-Price, Valentina oth Farnush oth Kiadeh, Farhadi Hassan oth Finucane, Hilary K. oth Forstner, Andreas J. oth Frank, Josef oth Gaspar, Héléna A. oth Gill, Michael oth Goes, Fernando S. oth Gordon, Scott D. oth Grove, Jakob oth Hall, Lynsey S. oth Hansen, Christine Søholm oth Hansen, Thomas F. oth Herms, Stefan oth Hicki, Ian B. oth Hoffmann, Per oth Homuth, Georg oth Horn, Carsten oth Hottenga, Jouke-Jan oth Hougaard, David M. oth Ising, Marcus oth Jansen, Rick oth Jorgenson, Eric oth Knowles, James A. oth Kohane, Isaac S. oth Kraft, Julia oth Kretzschmar, Warren W. oth Krogh, Jesper oth Kutalik, Zoltán oth Li, Yihan oth Lind, Penelope A. oth MacIntyre, Donald J. oth MacKinnon, Dean F. oth Maier, Robert M. oth Maier, Wolfgang oth Marchini, Jonathan oth Mbarek, Hamdi oth McGrath, Patrick oth McGuffin, Peter oth Medland, Sarah E. oth Mehta, Divya oth Middeldorp, Christel M. oth Mihailov, Evelin oth Milaneschi, Yuri oth Milani, Lili oth Mondimore, Francis M. oth Montgomery, Grant W. oth Mostafavi, Sara oth Mullins, Niamh oth Nauck, Matthias oth Ng, Bernard oth Nivard, Michel G. oth Nyholt, Dale R. oth O’Reilly, Paul F. oth Oskarsson, Hogni oth Owen, Michael J. oth Painter, Jodie N. oth Pedersen, Carsten Bøcker oth Pedersen, Marianne Giørtz oth Peterson, Roseann E. oth Pettersson, Erik oth Peyrot, Wouter J. oth Pistis, Giorgio oth Posthuma, Danielle oth Quiroz, Jorge A. oth Qvist, Per oth Rice, John P. oth Riley, Brien P. oth Rivera, Margarita oth Mirza, Saira Saeed oth Schoevers, Robert oth Schulte, Eva C. oth Shen, Ling oth Shi, Jianxin oth Shyn, Stanley I. oth Sigurdsson, Engilbert oth Sinnamon, Grant C.B. oth Smit, Johannes H. oth Smith, Daniel J. oth Stefansson, Hreinn oth Steinberg, Stacy oth Streit, Fabian oth Strohmaier, Jana oth Tansey, Katherine E. oth Teismann, Henning oth Teumer, Alexander oth Thompson, Wesley oth Thomson, Pippa A. oth Thorgeirsson, Thorgeir E. oth Traylor, Matthew oth Treutlein, Jens oth Trubetskoy, Vassily oth Uitterlinden, André G. oth Umbricht, Daniel oth Van der Auwera, Sandra oth van Hemert, Albert M. oth Viktorin, Alexander oth Visscher, Peter M. oth Wang, Yunpeng oth Webb, Bradley T. oth Weinsheimer, Shantel Marie oth Wellmann, Jürgen oth Willemsen, Gonneke oth Witt, Stephanie H. oth Wu, Yang oth Xi, Hualin S. oth Yang, Jian oth Zhang, Futao oth Arolt, Volker oth Baune, Bernhard T. oth Berger, Klaus oth Boomsma, Dorret I. oth Cichon, Sven oth Dannlowski, Udo oth de Geus, E.J.C. oth DePaulo, J. Raymond oth Domenici, Enrico oth Domschke, Katharina oth Esko, Tõnu oth Grabe, Hans J. oth Hamilton, Steven P. oth Hayward, Caroline oth Heath, Andrew C. oth Kendler, Kenneth S. oth Kloiber, Stefan oth Lewis, Glyn oth Li, Qingqin S. oth Lucae, Susanne oth Madden, Pamela A.F. oth Magnusson, Patrik K. oth Martin, Nicholas G. oth McIntosh, Andrew M. oth Metspalu, Andres oth Mors, Ole oth Mortensen, Preben Bo oth Müller-Myhsok, Bertram oth Nordentoft, Merete oth Nöthen, Markus M. oth O'Donovan, Michael C. oth Paciga, Sara A. oth Pedersen, Nancy L. oth Penninx, Brenda W.J.H. oth Perlis, Roy H. oth Porteous, David J. oth Potash, James B. oth Preisig, Martin oth Rietschel, Marcella oth Schaefer, Catherine oth Schulze, Thomas G. oth Smoller, Jordan W. oth Stefansson, Kari oth Tiemeier, Henning oth Uher, Rudolf oth Völzke, Henry oth Weissman, Myrna M. oth Werge, Thomas oth Lewis, Cathryn M. oth Levinson, Douglas F. oth Breen, Gerome oth Børglum, Anders D. oth Sullivan, Patrick F. oth Enthalten in Elsevier Science Xu, Qi ELSEVIER Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells 2016 a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry Amsterdam [u.a.] (DE-627)ELV01006897X volume:84 year:2018 number:2 day:15 month:07 pages:138-147 extent:10 https://doi.org/10.1016/j.biopsych.2017.09.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 84 2018 2 15 0715 138-147 10 |
| allfieldsGer |
10.1016/j.biopsych.2017.09.009 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000978.pica (DE-627)ELV043609287 (ELSEVIER)S0006-3223(17)31993-5 DE-627 ger DE-627 rakwb eng 610 VZ 44.40 bkl Peyrot, Wouter J. verfasserin aut Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium 2018 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample. 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Raymond oth Domenici, Enrico oth Domschke, Katharina oth Esko, Tõnu oth Grabe, Hans J. oth Hamilton, Steven P. oth Hayward, Caroline oth Heath, Andrew C. oth Kendler, Kenneth S. oth Kloiber, Stefan oth Lewis, Glyn oth Li, Qingqin S. oth Lucae, Susanne oth Madden, Pamela A.F. oth Magnusson, Patrik K. oth Martin, Nicholas G. oth McIntosh, Andrew M. oth Metspalu, Andres oth Mors, Ole oth Mortensen, Preben Bo oth Müller-Myhsok, Bertram oth Nordentoft, Merete oth Nöthen, Markus M. oth O'Donovan, Michael C. oth Paciga, Sara A. oth Pedersen, Nancy L. oth Penninx, Brenda W.J.H. oth Perlis, Roy H. oth Porteous, David J. oth Potash, James B. oth Preisig, Martin oth Rietschel, Marcella oth Schaefer, Catherine oth Schulze, Thomas G. oth Smoller, Jordan W. oth Stefansson, Kari oth Tiemeier, Henning oth Uher, Rudolf oth Völzke, Henry oth Weissman, Myrna M. oth Werge, Thomas oth Lewis, Cathryn M. oth Levinson, Douglas F. oth Breen, Gerome oth Børglum, Anders D. oth Sullivan, Patrick F. oth Enthalten in Elsevier Science Xu, Qi ELSEVIER Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells 2016 a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry Amsterdam [u.a.] (DE-627)ELV01006897X volume:84 year:2018 number:2 day:15 month:07 pages:138-147 extent:10 https://doi.org/10.1016/j.biopsych.2017.09.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 84 2018 2 15 0715 138-147 10 |
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This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample. 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Raymond oth Domenici, Enrico oth Domschke, Katharina oth Esko, Tõnu oth Grabe, Hans J. oth Hamilton, Steven P. oth Hayward, Caroline oth Heath, Andrew C. oth Kendler, Kenneth S. oth Kloiber, Stefan oth Lewis, Glyn oth Li, Qingqin S. oth Lucae, Susanne oth Madden, Pamela A.F. oth Magnusson, Patrik K. oth Martin, Nicholas G. oth McIntosh, Andrew M. oth Metspalu, Andres oth Mors, Ole oth Mortensen, Preben Bo oth Müller-Myhsok, Bertram oth Nordentoft, Merete oth Nöthen, Markus M. oth O'Donovan, Michael C. oth Paciga, Sara A. oth Pedersen, Nancy L. oth Penninx, Brenda W.J.H. oth Perlis, Roy H. oth Porteous, David J. oth Potash, James B. oth Preisig, Martin oth Rietschel, Marcella oth Schaefer, Catherine oth Schulze, Thomas G. oth Smoller, Jordan W. oth Stefansson, Kari oth Tiemeier, Henning oth Uher, Rudolf oth Völzke, Henry oth Weissman, Myrna M. oth Werge, Thomas oth Lewis, Cathryn M. oth Levinson, Douglas F. oth Breen, Gerome oth Børglum, Anders D. oth Sullivan, Patrick F. oth Enthalten in Elsevier Science Xu, Qi ELSEVIER Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells 2016 a journal of psychiatric neuroscience : a publication of the Society of Biological Psychiatry Amsterdam [u.a.] (DE-627)ELV01006897X volume:84 year:2018 number:2 day:15 month:07 pages:138-147 extent:10 https://doi.org/10.1016/j.biopsych.2017.09.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA SSG-OPC-PHA 44.40 Pharmazie Pharmazeutika VZ AR 84 2018 2 15 0715 138-147 10 |
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Enthalten in Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells Amsterdam [u.a.] volume:84 year:2018 number:2 day:15 month:07 pages:138-147 extent:10 |
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Enthalten in Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells Amsterdam [u.a.] volume:84 year:2018 number:2 day:15 month:07 pages:138-147 extent:10 |
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Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells |
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Peyrot, Wouter J. @@aut@@ Van der Auwera, Sandra @@oth@@ Milaneschi, Yuri @@oth@@ Dolan, Conor V. @@oth@@ Madden, Pamela A.F. @@oth@@ Sullivan, Patrick F. @@oth@@ Strohmaier, Jana @@oth@@ Ripke, Stephan @@oth@@ Rietschel, Marcella @@oth@@ Nivard, Michel G. @@oth@@ Mullins, Niamh @@oth@@ Montgomery, Grant W. @@oth@@ Henders, Anjali K. @@oth@@ Heat, Andrew C. @@oth@@ Fisher, Helen L. @@oth@@ Dunn, Erin C. @@oth@@ Byrne, Enda M. @@oth@@ Air, Tracy A. @@oth@@ Wray, Naomi R. @@oth@@ Mattheisen, Manuel @@oth@@ Trzaskowski, Maciej @@oth@@ Abdellaoui, Abdel @@oth@@ Adams, Mark J. @@oth@@ Agerbo, Esben @@oth@@ Air, Tracy M. @@oth@@ Andlauer, Till F.M. @@oth@@ Bacanu, Silviu-Alin @@oth@@ Bækvad-Hansen, Marie @@oth@@ Beekman, Aartjan T.F. @@oth@@ Bigdeli, Tim B. @@oth@@ Binder, Elisabeth B. @@oth@@ Blackwood, Douglas H.R. @@oth@@ Bryois, Julien @@oth@@ Buttenschøn, Henriette N. @@oth@@ Bybjerg-Grauholm, Jonas @@oth@@ Cai, Na @@oth@@ Castelao, Enrique @@oth@@ Christensen, Jane Hvarregaard @@oth@@ Clarke, Toni-Kim @@oth@@ Coleman, Jonathan R.I. @@oth@@ Colodro-Conde, Lucía @@oth@@ Couvy-Duchesne, Baptiste @@oth@@ Craddock, Nick @@oth@@ Crawford, Gregory E. @@oth@@ Davies, Gail @@oth@@ Deary, Ian J. @@oth@@ Degenhardt, Franziska @@oth@@ Derks, Eske M. @@oth@@ Direk, Nese @@oth@@ Eley, Thalia C. @@oth@@ Escott-Price, Valentina @@oth@@ Farnush @@oth@@ Kiadeh, Farhadi Hassan @@oth@@ Finucane, Hilary K. @@oth@@ Forstner, Andreas J. @@oth@@ Frank, Josef @@oth@@ Gaspar, Héléna A. @@oth@@ Gill, Michael @@oth@@ Goes, Fernando S. @@oth@@ Gordon, Scott D. @@oth@@ Grove, Jakob @@oth@@ Hall, Lynsey S. @@oth@@ Hansen, Christine Søholm @@oth@@ Hansen, Thomas F. @@oth@@ Herms, Stefan @@oth@@ Hicki, Ian B. @@oth@@ Hoffmann, Per @@oth@@ Homuth, Georg @@oth@@ Horn, Carsten @@oth@@ Hottenga, Jouke-Jan @@oth@@ Hougaard, David M. @@oth@@ Ising, Marcus @@oth@@ Jansen, Rick @@oth@@ Jorgenson, Eric @@oth@@ Knowles, James A. @@oth@@ Kohane, Isaac S. @@oth@@ Kraft, Julia @@oth@@ Kretzschmar, Warren W. @@oth@@ Krogh, Jesper @@oth@@ Kutalik, Zoltán @@oth@@ Li, Yihan @@oth@@ Lind, Penelope A. @@oth@@ MacIntyre, Donald J. @@oth@@ MacKinnon, Dean F. @@oth@@ Maier, Robert M. @@oth@@ Maier, Wolfgang @@oth@@ Marchini, Jonathan @@oth@@ Mbarek, Hamdi @@oth@@ McGrath, Patrick @@oth@@ McGuffin, Peter @@oth@@ Medland, Sarah E. @@oth@@ Mehta, Divya @@oth@@ Middeldorp, Christel M. @@oth@@ Mihailov, Evelin @@oth@@ Milani, Lili @@oth@@ Mondimore, Francis M. @@oth@@ Mostafavi, Sara @@oth@@ Nauck, Matthias @@oth@@ Ng, Bernard @@oth@@ Nyholt, Dale R. @@oth@@ O’Reilly, Paul F. @@oth@@ Oskarsson, Hogni @@oth@@ Owen, Michael J. @@oth@@ Painter, Jodie N. @@oth@@ Pedersen, Carsten Bøcker @@oth@@ Pedersen, Marianne Giørtz @@oth@@ Peterson, Roseann E. @@oth@@ Pettersson, Erik @@oth@@ Peyrot, Wouter J. @@oth@@ Pistis, Giorgio @@oth@@ Posthuma, Danielle @@oth@@ Quiroz, Jorge A. @@oth@@ Qvist, Per @@oth@@ Rice, John P. @@oth@@ Riley, Brien P. @@oth@@ Rivera, Margarita @@oth@@ Mirza, Saira Saeed @@oth@@ Schoevers, Robert @@oth@@ Schulte, Eva C. @@oth@@ Shen, Ling @@oth@@ Shi, Jianxin @@oth@@ Shyn, Stanley I. @@oth@@ Sigurdsson, Engilbert @@oth@@ Sinnamon, Grant C.B. @@oth@@ Smit, Johannes H. @@oth@@ Smith, Daniel J. @@oth@@ Stefansson, Hreinn @@oth@@ Steinberg, Stacy @@oth@@ Streit, Fabian @@oth@@ Tansey, Katherine E. @@oth@@ Teismann, Henning @@oth@@ Teumer, Alexander @@oth@@ Thompson, Wesley @@oth@@ Thomson, Pippa A. @@oth@@ Thorgeirsson, Thorgeir E. @@oth@@ Traylor, Matthew @@oth@@ Treutlein, Jens @@oth@@ Trubetskoy, Vassily @@oth@@ Uitterlinden, André G. @@oth@@ Umbricht, Daniel @@oth@@ van Hemert, Albert M. @@oth@@ Viktorin, Alexander @@oth@@ Visscher, Peter M. @@oth@@ Wang, Yunpeng @@oth@@ Webb, Bradley T. @@oth@@ Weinsheimer, Shantel Marie @@oth@@ Wellmann, Jürgen @@oth@@ Willemsen, Gonneke @@oth@@ Witt, Stephanie H. @@oth@@ Wu, Yang @@oth@@ Xi, Hualin S. @@oth@@ Yang, Jian @@oth@@ Zhang, Futao @@oth@@ Arolt, Volker @@oth@@ Baune, Bernhard T. @@oth@@ Berger, Klaus @@oth@@ Boomsma, Dorret I. @@oth@@ Cichon, Sven @@oth@@ Dannlowski, Udo @@oth@@ de Geus, E.J.C. @@oth@@ DePaulo, J. Raymond @@oth@@ Domenici, Enrico @@oth@@ Domschke, Katharina @@oth@@ Esko, Tõnu @@oth@@ Grabe, Hans J. @@oth@@ Hamilton, Steven P. @@oth@@ Hayward, Caroline @@oth@@ Heath, Andrew C. @@oth@@ Kendler, Kenneth S. @@oth@@ Kloiber, Stefan @@oth@@ Lewis, Glyn @@oth@@ Li, Qingqin S. @@oth@@ Lucae, Susanne @@oth@@ Magnusson, Patrik K. @@oth@@ Martin, Nicholas G. @@oth@@ McIntosh, Andrew M. @@oth@@ Metspalu, Andres @@oth@@ Mors, Ole @@oth@@ Mortensen, Preben Bo @@oth@@ Müller-Myhsok, Bertram @@oth@@ Nordentoft, Merete @@oth@@ Nöthen, Markus M. @@oth@@ O'Donovan, Michael C. @@oth@@ Paciga, Sara A. @@oth@@ Pedersen, Nancy L. @@oth@@ Penninx, Brenda W.J.H. @@oth@@ Perlis, Roy H. @@oth@@ Porteous, David J. @@oth@@ Potash, James B. @@oth@@ Preisig, Martin @@oth@@ Schaefer, Catherine @@oth@@ Schulze, Thomas G. @@oth@@ Smoller, Jordan W. @@oth@@ Stefansson, Kari @@oth@@ Tiemeier, Henning @@oth@@ Uher, Rudolf @@oth@@ Völzke, Henry @@oth@@ Weissman, Myrna M. @@oth@@ Werge, Thomas @@oth@@ Lewis, Cathryn M. @@oth@@ Levinson, Douglas F. @@oth@@ Breen, Gerome @@oth@@ Børglum, Anders D. @@oth@@ |
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Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium |
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Peyrot, Wouter J. |
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Iptakalim induces mitochondria-dependent apoptosis in hypoxic rat pulmonary arterial smooth muscle cells |
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does childhood trauma moderate polygenic risk for depression? a meta-analysis of 5765 subjects from the psychiatric genomics consortium |
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Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium |
| abstract |
The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample. |
| abstractGer |
The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample. |
| abstract_unstemmed |
The heterogeneity of genetic effects on major depressive disorder (MDD) may be partly attributable to moderation of genetic effects by environment, such as exposure to childhood trauma (CT). Indeed, previous findings in two independent cohorts showed evidence for interaction between polygenic risk scores (PRSs) and CT, albeit in opposing directions. This study aims to meta-analyze MDD-PRS × CT interaction results across these two and other cohorts, while applying more accurate PRSs based on a larger discovery sample. |
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Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium |
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