Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice
Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brain...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Rosenberg, Roger N. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018transfer abstract |
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| Umfang: |
11 |
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| Übergeordnetes Werk: |
Enthalten in: Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process - Li, Kuo ELSEVIER, 2020, official journal of the International Society for Neuroimmunology, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:322 ; year:2018 ; day:15 ; month:09 ; pages:15-25 ; extent:11 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.jneuroim.2018.05.017 |
|---|
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ELV043644694 |
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| 520 | |a Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. | ||
| 520 | |a Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. | ||
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10.1016/j.jneuroim.2018.05.017 doi GBV00000000000287A.pica (DE-627)ELV043644694 (ELSEVIER)S0165-5728(18)30131-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Rosenberg, Roger N. verfasserin aut Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. Fu, Min oth Lambracht-Washington, Doris oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:322 year:2018 day:15 month:09 pages:15-25 extent:11 https://doi.org/10.1016/j.jneuroim.2018.05.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 322 2018 15 0915 15-25 11 045F 610 |
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10.1016/j.jneuroim.2018.05.017 doi GBV00000000000287A.pica (DE-627)ELV043644694 (ELSEVIER)S0165-5728(18)30131-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Rosenberg, Roger N. verfasserin aut Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. Fu, Min oth Lambracht-Washington, Doris oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:322 year:2018 day:15 month:09 pages:15-25 extent:11 https://doi.org/10.1016/j.jneuroim.2018.05.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 322 2018 15 0915 15-25 11 045F 610 |
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10.1016/j.jneuroim.2018.05.017 doi GBV00000000000287A.pica (DE-627)ELV043644694 (ELSEVIER)S0165-5728(18)30131-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Rosenberg, Roger N. verfasserin aut Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. Fu, Min oth Lambracht-Washington, Doris oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:322 year:2018 day:15 month:09 pages:15-25 extent:11 https://doi.org/10.1016/j.jneuroim.2018.05.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 322 2018 15 0915 15-25 11 045F 610 |
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10.1016/j.jneuroim.2018.05.017 doi GBV00000000000287A.pica (DE-627)ELV043644694 (ELSEVIER)S0165-5728(18)30131-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Rosenberg, Roger N. verfasserin aut Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. Fu, Min oth Lambracht-Washington, Doris oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:322 year:2018 day:15 month:09 pages:15-25 extent:11 https://doi.org/10.1016/j.jneuroim.2018.05.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 322 2018 15 0915 15-25 11 045F 610 |
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10.1016/j.jneuroim.2018.05.017 doi GBV00000000000287A.pica (DE-627)ELV043644694 (ELSEVIER)S0165-5728(18)30131-0 DE-627 ger DE-627 rakwb eng 610 610 DE-600 530 VZ 43.13 bkl 50.17 bkl 58.53 bkl Rosenberg, Roger N. verfasserin aut Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. Fu, Min oth Lambracht-Washington, Doris oth Enthalten in Elsevier Science Li, Kuo ELSEVIER Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process 2020 official journal of the International Society for Neuroimmunology Amsterdam [u.a.] (DE-627)ELV005164184 volume:322 year:2018 day:15 month:09 pages:15-25 extent:11 https://doi.org/10.1016/j.jneuroim.2018.05.017 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OPC-GGO 43.13 Umwelttoxikologie VZ 50.17 Sicherheitstechnik VZ 58.53 Abfallwirtschaft VZ AR 322 2018 15 0915 15-25 11 045F 610 |
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Enthalten in Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process Amsterdam [u.a.] volume:322 year:2018 day:15 month:09 pages:15-25 extent:11 |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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ELV005164184 |
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610 - Medicine & health 530 - Physics |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice |
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(DE-627)ELV043644694 (ELSEVIER)S0165-5728(18)30131-0 |
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Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice |
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Rosenberg, Roger N. |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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Decomposition of polycarbonate/acrylonitrile-butadiene-styrene blends in e-waste packaging resin and recovery of debrominated carbon materials by supercritical water oxidation process |
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Rosenberg, Roger N. |
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Rosenberg, Roger N. |
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10.1016/j.jneuroim.2018.05.017 |
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610 530 |
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intradermal active full-length dna aβ42 immunization via electroporation leads to high anti-aβ antibody levels in wild-type mice |
| title_auth |
Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice |
| abstract |
Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. |
| abstractGer |
Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. |
| abstract_unstemmed |
Aβ immunotherapies with anti-Aβ antibody responses have high potential as possible prevention treatment for Alzheimer's disease. We have previously shown that active DNA Aβ1–42 immunization via gene gun delivery led to a non-inflammatory immune response resulting in decreased Aβ levels in brains of an immunized AD mouse model. To make DNA vaccination more applicable for clinical use, we used here intradermal electroporation. With fine tuning of the electropulse parameters, high antibody levels and low levels of inflammatory cytokines in the cellular immunoassays were observed. Full-length DNA Aβ1–42 immunization delivered via electroporation has potential to be used in the clinical setting. |
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| title_short |
Intradermal active full-length DNA Aβ42 immunization via electroporation leads to high anti-Aβ antibody levels in wild-type mice |
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https://doi.org/10.1016/j.jneuroim.2018.05.017 |
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Fu, Min Lambracht-Washington, Doris |
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