<ce:italic>Leishmania donovani</ce:italic> PP2C: Kinetics, structural attributes and <ce:italic>in vitro</ce:italic> immune response
• LdPP2C is a monomer and most of the catalytic signature motif residues were identical to human PP2C. • LdPP2C dephosphorylates the substrate pNPP only in presence of Mn2+ and Mg2+. • Sanguinarine inhibits the enzymatic activity of LdPP2C non-competitively with respect to pNPP. • Aspartic acid is a...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Jakkula, Pranay [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2018 |
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| Schlagwörter: |
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| Umfang: |
13 |
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| Übergeordnetes Werk: |
Enthalten in: Novel heteroleptic iridium(III) complexes with a 2-(1H-pyrazol-5-yl)pyridine derivative containing a carbazole group as ancillary ligand: Synthesis and application for polymer light-emitting diodes - Tang, Huaijun ELSEVIER, 2014, Amsterdam |
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| Übergeordnetes Werk: |
volume:223 ; year:2018 ; pages:37-49 ; extent:13 |
| Links: |
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| DOI / URN: |
10.1016/j.molbiopara.2018.06.005 |
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| 520 | |a • LdPP2C is a monomer and most of the catalytic signature motif residues were identical to human PP2C. • LdPP2C dephosphorylates the substrate pNPP only in presence of Mn2+ and Mg2+. • Sanguinarine inhibits the enzymatic activity of LdPP2C non-competitively with respect to pNPP. • Aspartic acid is a key residue to coordinate the metal ions in LdPP2C. • LdPP2C triggers pro-inflammatory environment in macrophages by TNF-α, IL-6 and NO generation. | ||
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10.1016/j.molbiopara.2018.06.005 doi GBV00000000000318_01.pica (DE-627)ELV043710344 (ELSEVIER)S0166-6851(18)30047-1 DE-627 ger DE-627 rakwb eng 540 VZ 610 VZ 44.85 bkl Jakkula, Pranay verfasserin aut <ce:italic>Leishmania donovani</ce:italic> PP2C: Kinetics, structural attributes and <ce:italic>in vitro</ce:italic> immune response 2018 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • LdPP2C is a monomer and most of the catalytic signature motif residues were identical to human PP2C. • LdPP2C dephosphorylates the substrate pNPP only in presence of Mn2+ and Mg2+. • Sanguinarine inhibits the enzymatic activity of LdPP2C non-competitively with respect to pNPP. • Aspartic acid is a key residue to coordinate the metal ions in LdPP2C. • LdPP2C triggers pro-inflammatory environment in macrophages by TNF-α, IL-6 and NO generation. <ce:italic>Leishmania donovani</ce:italic> Elsevier PP2C Elsevier Structural characterization Elsevier Functional insights Elsevier Metal-dependent protein phosphatases Elsevier Qureshi, Rahila oth Iqbal, Atif oth Sagurthi, S.R. oth Qureshi, Insaf A. oth Enthalten in Elsevier Tang, Huaijun ELSEVIER Novel heteroleptic iridium(III) complexes with a 2-(1H-pyrazol-5-yl)pyridine derivative containing a carbazole group as ancillary ligand: Synthesis and application for polymer light-emitting diodes 2014 Amsterdam (DE-627)ELV017571006 volume:223 year:2018 pages:37-49 extent:13 https://doi.org/10.1016/j.molbiopara.2018.06.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_23 GBV_ILN_70 44.85 Kardiologie Angiologie VZ AR 223 2018 37-49 13 |
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10.1016/j.molbiopara.2018.06.005 doi GBV00000000000318_01.pica (DE-627)ELV043710344 (ELSEVIER)S0166-6851(18)30047-1 DE-627 ger DE-627 rakwb eng 540 VZ 610 VZ 44.85 bkl Jakkula, Pranay verfasserin aut <ce:italic>Leishmania donovani</ce:italic> PP2C: Kinetics, structural attributes and <ce:italic>in vitro</ce:italic> immune response 2018 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • LdPP2C is a monomer and most of the catalytic signature motif residues were identical to human PP2C. • LdPP2C dephosphorylates the substrate pNPP only in presence of Mn2+ and Mg2+. • Sanguinarine inhibits the enzymatic activity of LdPP2C non-competitively with respect to pNPP. • Aspartic acid is a key residue to coordinate the metal ions in LdPP2C. • LdPP2C triggers pro-inflammatory environment in macrophages by TNF-α, IL-6 and NO generation. <ce:italic>Leishmania donovani</ce:italic> Elsevier PP2C Elsevier Structural characterization Elsevier Functional insights Elsevier Metal-dependent protein phosphatases Elsevier Qureshi, Rahila oth Iqbal, Atif oth Sagurthi, S.R. oth Qureshi, Insaf A. oth Enthalten in Elsevier Tang, Huaijun ELSEVIER Novel heteroleptic iridium(III) complexes with a 2-(1H-pyrazol-5-yl)pyridine derivative containing a carbazole group as ancillary ligand: Synthesis and application for polymer light-emitting diodes 2014 Amsterdam (DE-627)ELV017571006 volume:223 year:2018 pages:37-49 extent:13 https://doi.org/10.1016/j.molbiopara.2018.06.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_23 GBV_ILN_70 44.85 Kardiologie Angiologie VZ AR 223 2018 37-49 13 |
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10.1016/j.molbiopara.2018.06.005 doi GBV00000000000318_01.pica (DE-627)ELV043710344 (ELSEVIER)S0166-6851(18)30047-1 DE-627 ger DE-627 rakwb eng 540 VZ 610 VZ 44.85 bkl Jakkula, Pranay verfasserin aut <ce:italic>Leishmania donovani</ce:italic> PP2C: Kinetics, structural attributes and <ce:italic>in vitro</ce:italic> immune response 2018 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • LdPP2C is a monomer and most of the catalytic signature motif residues were identical to human PP2C. • LdPP2C dephosphorylates the substrate pNPP only in presence of Mn2+ and Mg2+. • Sanguinarine inhibits the enzymatic activity of LdPP2C non-competitively with respect to pNPP. • Aspartic acid is a key residue to coordinate the metal ions in LdPP2C. • LdPP2C triggers pro-inflammatory environment in macrophages by TNF-α, IL-6 and NO generation. <ce:italic>Leishmania donovani</ce:italic> Elsevier PP2C Elsevier Structural characterization Elsevier Functional insights Elsevier Metal-dependent protein phosphatases Elsevier Qureshi, Rahila oth Iqbal, Atif oth Sagurthi, S.R. oth Qureshi, Insaf A. oth Enthalten in Elsevier Tang, Huaijun ELSEVIER Novel heteroleptic iridium(III) complexes with a 2-(1H-pyrazol-5-yl)pyridine derivative containing a carbazole group as ancillary ligand: Synthesis and application for polymer light-emitting diodes 2014 Amsterdam (DE-627)ELV017571006 volume:223 year:2018 pages:37-49 extent:13 https://doi.org/10.1016/j.molbiopara.2018.06.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_23 GBV_ILN_70 44.85 Kardiologie Angiologie VZ AR 223 2018 37-49 13 |
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10.1016/j.molbiopara.2018.06.005 doi GBV00000000000318_01.pica (DE-627)ELV043710344 (ELSEVIER)S0166-6851(18)30047-1 DE-627 ger DE-627 rakwb eng 540 VZ 610 VZ 44.85 bkl Jakkula, Pranay verfasserin aut <ce:italic>Leishmania donovani</ce:italic> PP2C: Kinetics, structural attributes and <ce:italic>in vitro</ce:italic> immune response 2018 13 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier • LdPP2C is a monomer and most of the catalytic signature motif residues were identical to human PP2C. • LdPP2C dephosphorylates the substrate pNPP only in presence of Mn2+ and Mg2+. • Sanguinarine inhibits the enzymatic activity of LdPP2C non-competitively with respect to pNPP. • Aspartic acid is a key residue to coordinate the metal ions in LdPP2C. • LdPP2C triggers pro-inflammatory environment in macrophages by TNF-α, IL-6 and NO generation. <ce:italic>Leishmania donovani</ce:italic> Elsevier PP2C Elsevier Structural characterization Elsevier Functional insights Elsevier Metal-dependent protein phosphatases Elsevier Qureshi, Rahila oth Iqbal, Atif oth Sagurthi, S.R. oth Qureshi, Insaf A. oth Enthalten in Elsevier Tang, Huaijun ELSEVIER Novel heteroleptic iridium(III) complexes with a 2-(1H-pyrazol-5-yl)pyridine derivative containing a carbazole group as ancillary ligand: Synthesis and application for polymer light-emitting diodes 2014 Amsterdam (DE-627)ELV017571006 volume:223 year:2018 pages:37-49 extent:13 https://doi.org/10.1016/j.molbiopara.2018.06.005 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_23 GBV_ILN_70 44.85 Kardiologie Angiologie VZ AR 223 2018 37-49 13 |
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Novel heteroleptic iridium(III) complexes with a 2-(1H-pyrazol-5-yl)pyridine derivative containing a carbazole group as ancillary ligand: Synthesis and application for polymer light-emitting diodes |
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Novel heteroleptic iridium(III) complexes with a 2-(1H-pyrazol-5-yl)pyridine derivative containing a carbazole group as ancillary ligand: Synthesis and application for polymer light-emitting diodes |
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eng |
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2018 |
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Jakkula, Pranay |
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Elektronische Aufsätze |
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Jakkula, Pranay |
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10.1016/j.molbiopara.2018.06.005 |
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540 610 |
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<ce:italic>leishmania donovani</ce:italic> pp2c: kinetics, structural attributes and <ce:italic>in vitro</ce:italic> immune response |
| title_auth |
<ce:italic>Leishmania donovani</ce:italic> PP2C: Kinetics, structural attributes and <ce:italic>in vitro</ce:italic> immune response |
| abstract |
• LdPP2C is a monomer and most of the catalytic signature motif residues were identical to human PP2C. • LdPP2C dephosphorylates the substrate pNPP only in presence of Mn2+ and Mg2+. • Sanguinarine inhibits the enzymatic activity of LdPP2C non-competitively with respect to pNPP. • Aspartic acid is a key residue to coordinate the metal ions in LdPP2C. • LdPP2C triggers pro-inflammatory environment in macrophages by TNF-α, IL-6 and NO generation. |
| abstractGer |
• LdPP2C is a monomer and most of the catalytic signature motif residues were identical to human PP2C. • LdPP2C dephosphorylates the substrate pNPP only in presence of Mn2+ and Mg2+. • Sanguinarine inhibits the enzymatic activity of LdPP2C non-competitively with respect to pNPP. • Aspartic acid is a key residue to coordinate the metal ions in LdPP2C. • LdPP2C triggers pro-inflammatory environment in macrophages by TNF-α, IL-6 and NO generation. |
| abstract_unstemmed |
• LdPP2C is a monomer and most of the catalytic signature motif residues were identical to human PP2C. • LdPP2C dephosphorylates the substrate pNPP only in presence of Mn2+ and Mg2+. • Sanguinarine inhibits the enzymatic activity of LdPP2C non-competitively with respect to pNPP. • Aspartic acid is a key residue to coordinate the metal ions in LdPP2C. • LdPP2C triggers pro-inflammatory environment in macrophages by TNF-α, IL-6 and NO generation. |
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GBV_USEFLAG_U GBV_ELV SYSFLAG_U SSG-OLC-PHA GBV_ILN_23 GBV_ILN_70 |
| title_short |
<ce:italic>Leishmania donovani</ce:italic> PP2C: Kinetics, structural attributes and <ce:italic>in vitro</ce:italic> immune response |
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https://doi.org/10.1016/j.molbiopara.2018.06.005 |
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Qureshi, Rahila Iqbal, Atif Sagurthi, S.R. Qureshi, Insaf A. |
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Qureshi, Rahila Iqbal, Atif Sagurthi, S.R. Qureshi, Insaf A. |
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10.1016/j.molbiopara.2018.06.005 |
| up_date |
2024-07-06T19:32:37.364Z |
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