Acute and subchronic toxicities of the ethanol and hot-water extracts from Chinese sumac (Rhus chinensis Mill.) fruits by oral administration in rats
In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxici...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wu, Zihuan [verfasserIn] |
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E-Artikel |
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Englisch |
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2018transfer abstract |
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10 |
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| Übergeordnetes Werk: |
Enthalten in: Numerical simulations on static Vertical Axis Wind Turbine blade icing - Manatbayev, Rustem ELSEVIER, 2021, New York, NY [u.a.] |
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| Übergeordnetes Werk: |
volume:119 ; year:2018 ; pages:14-23 ; extent:10 |
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| DOI / URN: |
10.1016/j.fct.2018.06.009 |
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| 520 | |a In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life | ||
| 520 | |a In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life | ||
| 650 | 7 | |a Rhus chinensis Mill. |2 Elsevier | |
| 650 | 7 | |a Oral administration |2 Elsevier | |
| 650 | 7 | |a Histopathological assessment |2 Elsevier | |
| 650 | 7 | |a Subchronic toxicity |2 Elsevier | |
| 650 | 7 | |a Acute toxicity |2 Elsevier | |
| 700 | 1 | |a Ma, Yanli |4 oth | |
| 700 | 1 | |a Zhao, Lei |4 oth | |
| 700 | 1 | |a Cai, Shengbao |4 oth | |
| 700 | 1 | |a Cheng, Guiguang |4 oth | |
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10.1016/j.fct.2018.06.009 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001068.pica (DE-627)ELV043744729 (ELSEVIER)S0278-6915(18)30383-1 DE-627 ger DE-627 rakwb eng 530 620 VZ 52.56 bkl Wu, Zihuan verfasserin aut Acute and subchronic toxicities of the ethanol and hot-water extracts from Chinese sumac (Rhus chinensis Mill.) fruits by oral administration in rats 2018transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life Rhus chinensis Mill. Elsevier Oral administration Elsevier Histopathological assessment Elsevier Subchronic toxicity Elsevier Acute toxicity Elsevier Ma, Yanli oth Zhao, Lei oth Cai, Shengbao oth Cheng, Guiguang oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:119 year:2018 pages:14-23 extent:10 https://doi.org/10.1016/j.fct.2018.06.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 119 2018 14-23 10 |
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10.1016/j.fct.2018.06.009 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001068.pica (DE-627)ELV043744729 (ELSEVIER)S0278-6915(18)30383-1 DE-627 ger DE-627 rakwb eng 530 620 VZ 52.56 bkl Wu, Zihuan verfasserin aut Acute and subchronic toxicities of the ethanol and hot-water extracts from Chinese sumac (Rhus chinensis Mill.) fruits by oral administration in rats 2018transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life Rhus chinensis Mill. Elsevier Oral administration Elsevier Histopathological assessment Elsevier Subchronic toxicity Elsevier Acute toxicity Elsevier Ma, Yanli oth Zhao, Lei oth Cai, Shengbao oth Cheng, Guiguang oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:119 year:2018 pages:14-23 extent:10 https://doi.org/10.1016/j.fct.2018.06.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 119 2018 14-23 10 |
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10.1016/j.fct.2018.06.009 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001068.pica (DE-627)ELV043744729 (ELSEVIER)S0278-6915(18)30383-1 DE-627 ger DE-627 rakwb eng 530 620 VZ 52.56 bkl Wu, Zihuan verfasserin aut Acute and subchronic toxicities of the ethanol and hot-water extracts from Chinese sumac (Rhus chinensis Mill.) fruits by oral administration in rats 2018transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life Rhus chinensis Mill. Elsevier Oral administration Elsevier Histopathological assessment Elsevier Subchronic toxicity Elsevier Acute toxicity Elsevier Ma, Yanli oth Zhao, Lei oth Cai, Shengbao oth Cheng, Guiguang oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:119 year:2018 pages:14-23 extent:10 https://doi.org/10.1016/j.fct.2018.06.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 119 2018 14-23 10 |
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10.1016/j.fct.2018.06.009 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001068.pica (DE-627)ELV043744729 (ELSEVIER)S0278-6915(18)30383-1 DE-627 ger DE-627 rakwb eng 530 620 VZ 52.56 bkl Wu, Zihuan verfasserin aut Acute and subchronic toxicities of the ethanol and hot-water extracts from Chinese sumac (Rhus chinensis Mill.) fruits by oral administration in rats 2018transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life Rhus chinensis Mill. Elsevier Oral administration Elsevier Histopathological assessment Elsevier Subchronic toxicity Elsevier Acute toxicity Elsevier Ma, Yanli oth Zhao, Lei oth Cai, Shengbao oth Cheng, Guiguang oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:119 year:2018 pages:14-23 extent:10 https://doi.org/10.1016/j.fct.2018.06.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 119 2018 14-23 10 |
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10.1016/j.fct.2018.06.009 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000001068.pica (DE-627)ELV043744729 (ELSEVIER)S0278-6915(18)30383-1 DE-627 ger DE-627 rakwb eng 530 620 VZ 52.56 bkl Wu, Zihuan verfasserin aut Acute and subchronic toxicities of the ethanol and hot-water extracts from Chinese sumac (Rhus chinensis Mill.) fruits by oral administration in rats 2018transfer abstract 10 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life Rhus chinensis Mill. Elsevier Oral administration Elsevier Histopathological assessment Elsevier Subchronic toxicity Elsevier Acute toxicity Elsevier Ma, Yanli oth Zhao, Lei oth Cai, Shengbao oth Cheng, Guiguang oth Enthalten in Elsevier Manatbayev, Rustem ELSEVIER Numerical simulations on static Vertical Axis Wind Turbine blade icing 2021 New York, NY [u.a.] (DE-627)ELV005709407 volume:119 year:2018 pages:14-23 extent:10 https://doi.org/10.1016/j.fct.2018.06.009 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 52.56 Regenerative Energieformen alternative Energieformen VZ AR 119 2018 14-23 10 |
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Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. 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acute and subchronic toxicities of the ethanol and hot-water extracts from chinese sumac (rhus chinensis mill.) fruits by oral administration in rats |
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Acute and subchronic toxicities of the ethanol and hot-water extracts from Chinese sumac (Rhus chinensis Mill.) fruits by oral administration in rats |
| abstract |
In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life |
| abstractGer |
In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life |
| abstract_unstemmed |
In the present work, acute and subchronic toxicities of the ethanol and hot-water extracts from Rhus chinensis Mill. fruits were performed by oral administration in pathogen-free SD rats. Acute toxicity study was performed at a single dose of 5000 mg/kg for 14 consecutive days. And subchronic toxicity test was conducted by daily oral administration of those two extracts at doses of 312, 625, 1250 and 2500 mg/kg for 30 days. Acute toxicity study showed that the LD50 of the ethanol and hot-water extracts were over 5000 mg /kg. The results of subchronic toxicity showed that no significant adverse effect of those two extracts was observed at 312 and 625 mg/kg. However, the weight gains of rats were significantly inhibited at both 2500 mg/kg groups of the ethanol and hot-water extracts. Moreover, those two extracts exhibited toxicities to heart, liver, spleen and kidney in rats determined by hematological, serum biochemical and/or histological analyses when daily oral administration of 1250 mg/kg and 2500 mg/kg. No significant neurotoxicity was observed in all groups. The results concluded that the low concentration of those two extracts from R. chinensis Mill. fruits can be regarded as safe and used in daily life |
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Acute and subchronic toxicities of the ethanol and hot-water extracts from Chinese sumac (Rhus chinensis Mill.) fruits by oral administration in rats |
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