P113 Developing an assay to detect and quantify donor-derived dna in the blood and urine of solid organ transplant patients
Detection of circulating donor-derived cell-free DNA (cfDNA) as a non-invasive biomarker of graft injury shows tremendous potential for transplant monitoring. Increases in the amount of cfDNA in blood or urine indicate injury to the transplanted organ, including rejection. Also known as a liquid bio...
Ausführliche Beschreibung
Gespeichert in:
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Profaizer, Tracie [verfasserIn] |
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Englisch |
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2018transfer abstract |
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Enthalten in: Towards a Dynamic Understanding of Cadherin-Based Mechanobiology - Hoffman, Brenton D. ELSEVIER, 2015, official journal of the American Society for Histocompatibility and Immunogenetics (ASHI), Amsterdam [u.a.] |
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| Übergeordnetes Werk: |
volume:79 ; year:2018 ; pages:146 |
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10.1016/j.humimm.2018.07.171 |
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| 520 | |a Detection of circulating donor-derived cell-free DNA (cfDNA) as a non-invasive biomarker of graft injury shows tremendous potential for transplant monitoring. Increases in the amount of cfDNA in blood or urine indicate injury to the transplanted organ, including rejection. Also known as a liquid biopsy, this method is less invasive and more sensitive than an actual biopsy to detect early rejection. We proposed to develop a clinical test based on the detection and quantification of donor single-nucleotide polymorphisms (SNPs) using cfDNA extracted from plasma and urine of solid organ transplant patients. | ||
| 520 | |a Detection of circulating donor-derived cell-free DNA (cfDNA) as a non-invasive biomarker of graft injury shows tremendous potential for transplant monitoring. Increases in the amount of cfDNA in blood or urine indicate injury to the transplanted organ, including rejection. Also known as a liquid biopsy, this method is less invasive and more sensitive than an actual biopsy to detect early rejection. We proposed to develop a clinical test based on the detection and quantification of donor single-nucleotide polymorphisms (SNPs) using cfDNA extracted from plasma and urine of solid organ transplant patients. | ||
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Detection of circulating donor-derived cell-free DNA (cfDNA) as a non-invasive biomarker of graft injury shows tremendous potential for transplant monitoring. Increases in the amount of cfDNA in blood or urine indicate injury to the transplanted organ, including rejection. Also known as a liquid biopsy, this method is less invasive and more sensitive than an actual biopsy to detect early rejection. We proposed to develop a clinical test based on the detection and quantification of donor single-nucleotide polymorphisms (SNPs) using cfDNA extracted from plasma and urine of solid organ transplant patients. |
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Detection of circulating donor-derived cell-free DNA (cfDNA) as a non-invasive biomarker of graft injury shows tremendous potential for transplant monitoring. Increases in the amount of cfDNA in blood or urine indicate injury to the transplanted organ, including rejection. Also known as a liquid biopsy, this method is less invasive and more sensitive than an actual biopsy to detect early rejection. We proposed to develop a clinical test based on the detection and quantification of donor single-nucleotide polymorphisms (SNPs) using cfDNA extracted from plasma and urine of solid organ transplant patients. |
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Detection of circulating donor-derived cell-free DNA (cfDNA) as a non-invasive biomarker of graft injury shows tremendous potential for transplant monitoring. Increases in the amount of cfDNA in blood or urine indicate injury to the transplanted organ, including rejection. Also known as a liquid biopsy, this method is less invasive and more sensitive than an actual biopsy to detect early rejection. We proposed to develop a clinical test based on the detection and quantification of donor single-nucleotide polymorphisms (SNPs) using cfDNA extracted from plasma and urine of solid organ transplant patients. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV043926924</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230626004351.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">181113s2018 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.humimm.2018.07.171</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">GBV00000000000365.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV043926924</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0198-8859(18)30434-8</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">570</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">BIODIV</subfield><subfield code="q">DE-30</subfield><subfield code="2">fid</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Profaizer, Tracie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">P113 Developing an assay to detect and quantify donor-derived dna in the blood and urine of solid organ transplant patients</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018transfer abstract</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Detection of circulating donor-derived cell-free DNA (cfDNA) as a non-invasive biomarker of graft injury shows tremendous potential for transplant monitoring. Increases in the amount of cfDNA in blood or urine indicate injury to the transplanted organ, including rejection. Also known as a liquid biopsy, this method is less invasive and more sensitive than an actual biopsy to detect early rejection. We proposed to develop a clinical test based on the detection and quantification of donor single-nucleotide polymorphisms (SNPs) using cfDNA extracted from plasma and urine of solid organ transplant patients.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Detection of circulating donor-derived cell-free DNA (cfDNA) as a non-invasive biomarker of graft injury shows tremendous potential for transplant monitoring. Increases in the amount of cfDNA in blood or urine indicate injury to the transplanted organ, including rejection. Also known as a liquid biopsy, this method is less invasive and more sensitive than an actual biopsy to detect early rejection. We proposed to develop a clinical test based on the detection and quantification of donor single-nucleotide polymorphisms (SNPs) using cfDNA extracted from plasma and urine of solid organ transplant patients.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Margraf, Rebecca</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Delgado, Julio</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lazar-Molnar, Eszter</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kumanovics, Attila</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Hoffman, Brenton D. 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