Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo
Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Chen, Ying Ying [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2018transfer abstract |
|---|
| Schlagwörter: |
|---|
| Umfang: |
11 |
|---|
| Übergeordnetes Werk: |
Enthalten in: MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata - Shterenlikht, Anton ELSEVIER, 2019, chemistry, biology and toxicology as related to environmental problems, Amsterdam [u.a.] |
|---|---|
| Übergeordnetes Werk: |
volume:210 ; year:2018 ; pages:577-587 ; extent:11 |
| Links: |
|---|
| DOI / URN: |
10.1016/j.chemosphere.2018.07.032 |
|---|
| Katalog-ID: |
ELV044034067 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | ELV044034067 | ||
| 003 | DE-627 | ||
| 005 | 20230626004528.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 181113s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.chemosphere.2018.07.032 |2 doi | |
| 028 | 5 | 2 | |a /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000998.pica |
| 035 | |a (DE-627)ELV044034067 | ||
| 035 | |a (ELSEVIER)S0045-6535(18)31290-6 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | 4 | |a 004 |a 620 |q VZ |
| 084 | |a 54.25 |2 bkl | ||
| 100 | 1 | |a Chen, Ying Ying |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo |
| 264 | 1 | |c 2018transfer abstract | |
| 300 | |a 11 | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. | ||
| 520 | |a Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. | ||
| 650 | 7 | |a Aryl hydrocarbon receptor |2 Elsevier | |
| 650 | 7 | |a Cadmium |2 Elsevier | |
| 650 | 7 | |a Co-exposure |2 Elsevier | |
| 650 | 7 | |a CYP1A1 |2 Elsevier | |
| 650 | 7 | |a TCDD |2 Elsevier | |
| 650 | 7 | |a Zebrafish |2 Elsevier | |
| 700 | 1 | |a Chan, King Ming |4 oth | |
| 773 | 0 | 8 | |i Enthalten in |n Elsevier Science |a Shterenlikht, Anton ELSEVIER |t MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata |d 2019 |d chemistry, biology and toxicology as related to environmental problems |g Amsterdam [u.a.] |w (DE-627)ELV002112701 |
| 773 | 1 | 8 | |g volume:210 |g year:2018 |g pages:577-587 |g extent:11 |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.chemosphere.2018.07.032 |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a GBV_ELV | ||
| 912 | |a SYSFLAG_U | ||
| 936 | b | k | |a 54.25 |j Parallele Datenverarbeitung |q VZ |
| 951 | |a AR | ||
| 952 | |d 210 |j 2018 |h 577-587 |g 11 | ||
| author_variant |
y y c yy yyc |
|---|---|
| matchkey_str |
chenyingyingchankingming:2018----:ouainotdmdaeidcinferfscpaadharaha |
| hierarchy_sort_str |
2018transfer abstract |
| bklnumber |
54.25 |
| publishDate |
2018 |
| allfields |
10.1016/j.chemosphere.2018.07.032 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000998.pica (DE-627)ELV044034067 (ELSEVIER)S0045-6535(18)31290-6 DE-627 ger DE-627 rakwb eng 004 620 VZ 54.25 bkl Chen, Ying Ying verfasserin aut Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. Aryl hydrocarbon receptor Elsevier Cadmium Elsevier Co-exposure Elsevier CYP1A1 Elsevier TCDD Elsevier Zebrafish Elsevier Chan, King Ming oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:210 year:2018 pages:577-587 extent:11 https://doi.org/10.1016/j.chemosphere.2018.07.032 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 210 2018 577-587 11 |
| spelling |
10.1016/j.chemosphere.2018.07.032 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000998.pica (DE-627)ELV044034067 (ELSEVIER)S0045-6535(18)31290-6 DE-627 ger DE-627 rakwb eng 004 620 VZ 54.25 bkl Chen, Ying Ying verfasserin aut Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. Aryl hydrocarbon receptor Elsevier Cadmium Elsevier Co-exposure Elsevier CYP1A1 Elsevier TCDD Elsevier Zebrafish Elsevier Chan, King Ming oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:210 year:2018 pages:577-587 extent:11 https://doi.org/10.1016/j.chemosphere.2018.07.032 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 210 2018 577-587 11 |
| allfields_unstemmed |
10.1016/j.chemosphere.2018.07.032 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000998.pica (DE-627)ELV044034067 (ELSEVIER)S0045-6535(18)31290-6 DE-627 ger DE-627 rakwb eng 004 620 VZ 54.25 bkl Chen, Ying Ying verfasserin aut Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. Aryl hydrocarbon receptor Elsevier Cadmium Elsevier Co-exposure Elsevier CYP1A1 Elsevier TCDD Elsevier Zebrafish Elsevier Chan, King Ming oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:210 year:2018 pages:577-587 extent:11 https://doi.org/10.1016/j.chemosphere.2018.07.032 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 210 2018 577-587 11 |
| allfieldsGer |
10.1016/j.chemosphere.2018.07.032 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000998.pica (DE-627)ELV044034067 (ELSEVIER)S0045-6535(18)31290-6 DE-627 ger DE-627 rakwb eng 004 620 VZ 54.25 bkl Chen, Ying Ying verfasserin aut Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. Aryl hydrocarbon receptor Elsevier Cadmium Elsevier Co-exposure Elsevier CYP1A1 Elsevier TCDD Elsevier Zebrafish Elsevier Chan, King Ming oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:210 year:2018 pages:577-587 extent:11 https://doi.org/10.1016/j.chemosphere.2018.07.032 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 210 2018 577-587 11 |
| allfieldsSound |
10.1016/j.chemosphere.2018.07.032 doi /cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000998.pica (DE-627)ELV044034067 (ELSEVIER)S0045-6535(18)31290-6 DE-627 ger DE-627 rakwb eng 004 620 VZ 54.25 bkl Chen, Ying Ying verfasserin aut Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo 2018transfer abstract 11 nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. Aryl hydrocarbon receptor Elsevier Cadmium Elsevier Co-exposure Elsevier CYP1A1 Elsevier TCDD Elsevier Zebrafish Elsevier Chan, King Ming oth Enthalten in Elsevier Science Shterenlikht, Anton ELSEVIER MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata 2019 chemistry, biology and toxicology as related to environmental problems Amsterdam [u.a.] (DE-627)ELV002112701 volume:210 year:2018 pages:577-587 extent:11 https://doi.org/10.1016/j.chemosphere.2018.07.032 Volltext GBV_USEFLAG_U GBV_ELV SYSFLAG_U 54.25 Parallele Datenverarbeitung VZ AR 210 2018 577-587 11 |
| language |
English |
| source |
Enthalten in MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata Amsterdam [u.a.] volume:210 year:2018 pages:577-587 extent:11 |
| sourceStr |
Enthalten in MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata Amsterdam [u.a.] volume:210 year:2018 pages:577-587 extent:11 |
| format_phy_str_mv |
Article |
| bklname |
Parallele Datenverarbeitung |
| institution |
findex.gbv.de |
| topic_facet |
Aryl hydrocarbon receptor Cadmium Co-exposure CYP1A1 TCDD Zebrafish |
| dewey-raw |
004 |
| isfreeaccess_bool |
false |
| container_title |
MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata |
| authorswithroles_txt_mv |
Chen, Ying Ying @@aut@@ Chan, King Ming @@oth@@ |
| publishDateDaySort_date |
2018-01-01T00:00:00Z |
| hierarchy_top_id |
ELV002112701 |
| dewey-sort |
14 |
| id |
ELV044034067 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV044034067</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230626004528.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">181113s2018 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.chemosphere.2018.07.032</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">/cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000998.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV044034067</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0045-6535(18)31290-6</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">004</subfield><subfield code="a">620</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">54.25</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Chen, Ying Ying</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">11</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Aryl hydrocarbon receptor</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cadmium</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Co-exposure</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">CYP1A1</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">TCDD</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Zebrafish</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chan, King Ming</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Shterenlikht, Anton ELSEVIER</subfield><subfield code="t">MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata</subfield><subfield code="d">2019</subfield><subfield code="d">chemistry, biology and toxicology as related to environmental problems</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV002112701</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:210</subfield><subfield code="g">year:2018</subfield><subfield code="g">pages:577-587</subfield><subfield code="g">extent:11</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.chemosphere.2018.07.032</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">54.25</subfield><subfield code="j">Parallele Datenverarbeitung</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">210</subfield><subfield code="j">2018</subfield><subfield code="h">577-587</subfield><subfield code="g">11</subfield></datafield></record></collection>
|
| author |
Chen, Ying Ying |
| spellingShingle |
Chen, Ying Ying ddc 004 bkl 54.25 Elsevier Aryl hydrocarbon receptor Elsevier Cadmium Elsevier Co-exposure Elsevier CYP1A1 Elsevier TCDD Elsevier Zebrafish Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo |
| authorStr |
Chen, Ying Ying |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)ELV002112701 |
| format |
electronic Article |
| dewey-ones |
004 - Data processing & computer science 620 - Engineering & allied operations |
| delete_txt_mv |
keep |
| author_role |
aut |
| collection |
elsevier |
| remote_str |
true |
| illustrated |
Not Illustrated |
| topic_title |
004 620 VZ 54.25 bkl Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo Aryl hydrocarbon receptor Elsevier Cadmium Elsevier Co-exposure Elsevier CYP1A1 Elsevier TCDD Elsevier Zebrafish Elsevier |
| topic |
ddc 004 bkl 54.25 Elsevier Aryl hydrocarbon receptor Elsevier Cadmium Elsevier Co-exposure Elsevier CYP1A1 Elsevier TCDD Elsevier Zebrafish |
| topic_unstemmed |
ddc 004 bkl 54.25 Elsevier Aryl hydrocarbon receptor Elsevier Cadmium Elsevier Co-exposure Elsevier CYP1A1 Elsevier TCDD Elsevier Zebrafish |
| topic_browse |
ddc 004 bkl 54.25 Elsevier Aryl hydrocarbon receptor Elsevier Cadmium Elsevier Co-exposure Elsevier CYP1A1 Elsevier TCDD Elsevier Zebrafish |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
k m c km kmc |
| hierarchy_parent_title |
MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata |
| hierarchy_parent_id |
ELV002112701 |
| dewey-tens |
000 - Computer science, knowledge & systems 620 - Engineering |
| hierarchy_top_title |
MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)ELV002112701 |
| title |
Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo |
| ctrlnum |
(DE-627)ELV044034067 (ELSEVIER)S0045-6535(18)31290-6 |
| title_full |
Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo |
| author_sort |
Chen, Ying Ying |
| journal |
MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata |
| journalStr |
MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata |
| lang_code |
eng |
| isOA_bool |
false |
| dewey-hundreds |
000 - Computer science, information & general works 600 - Technology |
| recordtype |
marc |
| publishDateSort |
2018 |
| contenttype_str_mv |
zzz |
| container_start_page |
577 |
| author_browse |
Chen, Ying Ying |
| container_volume |
210 |
| physical |
11 |
| class |
004 620 VZ 54.25 bkl |
| format_se |
Elektronische Aufsätze |
| author-letter |
Chen, Ying Ying |
| doi_str_mv |
10.1016/j.chemosphere.2018.07.032 |
| dewey-full |
004 620 |
| title_sort |
modulations of tcdd-mediated induction of zebrafish cyp1a1 and the ahr pathway by administering cd2+ in vivo |
| title_auth |
Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo |
| abstract |
Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. |
| abstractGer |
Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. |
| abstract_unstemmed |
Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general. |
| collection_details |
GBV_USEFLAG_U GBV_ELV SYSFLAG_U |
| title_short |
Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo |
| url |
https://doi.org/10.1016/j.chemosphere.2018.07.032 |
| remote_bool |
true |
| author2 |
Chan, King Ming |
| author2Str |
Chan, King Ming |
| ppnlink |
ELV002112701 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth |
| doi_str |
10.1016/j.chemosphere.2018.07.032 |
| up_date |
2024-07-06T20:24:28.460Z |
| _version_ |
1803862638288961536 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">ELV044034067</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230626004528.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">181113s2018 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.chemosphere.2018.07.032</subfield><subfield code="2">doi</subfield></datafield><datafield tag="028" ind1="5" ind2="2"><subfield code="a">/cbs_pica/cbs_olc/import_discovery/elsevier/einzuspielen/GBV00000000000998.pica</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)ELV044034067</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ELSEVIER)S0045-6535(18)31290-6</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">004</subfield><subfield code="a">620</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">54.25</subfield><subfield code="2">bkl</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Chen, Ying Ying</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Modulations of TCDD-mediated induction of zebrafish cyp1a1 and the AHR pathway by administering Cd2+ in vivo</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2018transfer abstract</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">11</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Trace metal ions such as cadmium (Cd2+) and trace organics typified by 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) are common co-contaminants in the environment and cause toxic effects in aquatic organisms that pose serious health risks. We studied the effects of Cd2+ on the regulation of cytochrome P450 1A1 (cyp1a1) gene-induction by TCDD using zebrafish embryos and larvae and adult zebrafish tissues. Our results showed that TCDD induced the cyp1a1 gene in all developmental stages and tissues of zebrafish, and the induction was higher in females than males. However, for the upstream genes (ahr2 and arnt2b) that mediate cyp1a1 gene induction in the zebrafish liver cell line was not induced by TCDD similar to the pattern of cyp1a1 in all investigated groups. After co-treatment with Cd2+, induction of the aryl hydrocarbon receptor pathway by TCDD was inhibited in the zebrafish larvae and the livers, intestines, kidneys and gills of adult zebrafish, but not in the embryos or brains of adult zebrafish, indicating that the toxicological effects of Cd2+ on TCDD are dependent on the developmental stages and tissue types. The present study confirms that Cd2+ blocks the TCDD-induced cyp1a1 gene in vivo but emphasizes that the effects are specific to the developmental stage, type of tissue and sex. The combined effects of Cd2+ and TCDD must be taken into consideration together with these parameters to accurately predict and assess cadmium and TCDD-induced toxicity in fish and carcinogenesis in animals in general.</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Aryl hydrocarbon receptor</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cadmium</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Co-exposure</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">CYP1A1</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">TCDD</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Zebrafish</subfield><subfield code="2">Elsevier</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chan, King Ming</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="n">Elsevier Science</subfield><subfield code="a">Shterenlikht, Anton ELSEVIER</subfield><subfield code="t">MPI vs Fortran coarrays beyond 100k cores: 3D cellular automata</subfield><subfield code="d">2019</subfield><subfield code="d">chemistry, biology and toxicology as related to environmental problems</subfield><subfield code="g">Amsterdam [u.a.]</subfield><subfield code="w">(DE-627)ELV002112701</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:210</subfield><subfield code="g">year:2018</subfield><subfield code="g">pages:577-587</subfield><subfield code="g">extent:11</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1016/j.chemosphere.2018.07.032</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ELV</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_U</subfield></datafield><datafield tag="936" ind1="b" ind2="k"><subfield code="a">54.25</subfield><subfield code="j">Parallele Datenverarbeitung</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">210</subfield><subfield code="j">2018</subfield><subfield code="h">577-587</subfield><subfield code="g">11</subfield></datafield></record></collection>
|
| score |
7.40125 |